5,845 results match your criteria necropsy day

Waterhouse-Friderichsen syndrome in a cat with Klebsiella spp. infection.

J Vet Emerg Crit Care (San Antonio) 2021 May 5. Epub 2021 May 5.

Department of Clinical Science and Services, The Royal Veterinary College, Hatfield, UK.

Objective: To describe a case of Waterhouse-Friderichsen syndrome of adrenocortical failure in a cat with Klebsiella spp. infection.

Case Summary: A 12-year-old male neutered domestic short-haired cat was referred for respiratory failure requiring mechanical ventilation. Read More

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Unusual Presentation of Atrial Myxoma: A Case Report and Review of the Literature.

Am J Case Rep 2021 May 3;22:e931437. Epub 2021 May 3.

Division of Anatomical Pathology, Stellenbosch University, National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.

BACKGROUND Although rare, atrial myxoma is the most common benign cardiac tumor. The recognized triad of presenting symptoms relates to constitutional, embolic, and obstructive effects produced by the tumor. However, the presentation may be non-specific and mimic other diseases, confounding diagnosis. Read More

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Fertility and early embryonic development toxicity assessment of naringin in Sprague-Dawley rats.

Regul Toxicol Pharmacol 2021 Apr 29;123:104938. Epub 2021 Apr 29.

Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, PR China. Electronic address:

Naringin is a dihydroflavonoid abundantly existed in grapefruit and related citrus species. The double directional adjusting function of estrogenic and anti-estrogenic activities of naringin and its aglycone naringenin has raised concern about possible risks of unwanted interference with endocrine regulation. Herein we assessed the safety of naringin on fertility and early embryonic development toxicity in Sprague-Dawley rats. Read More

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End-of-Life Care: A Multimodal and Comprehensive Curriculum for Graduating Medical Students Utilizing Experiential Learning Opportunities.

MedEdPORTAL 2021 Apr 27;17:11149. Epub 2021 Apr 27.

Associate Professor, Department of Medicine and Physiology, Pulmonary and Critical Care, Johns Hopkins University School of Medicine; Co-Director, TRIPLE.

Introduction: End-of-life (EOL) care is an essential skill for most physicians and health care providers, yet there continues to be an educational gap in medical education literature for these skills. The Johns Hopkins School of Medicine developed the Transition to Residency, Internship, and Preparation for Life Events (TRIPLE) curriculum with the primary goal of preparing graduating medical students for life after medical school.

Methods: The EOL module was one of many within the TRIPLE curriculum and consisted of two half-day sessions that targeted EOL care, death, dying, and communication skills. Read More

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Hijacking of the aircraft OK ADN L410 TURBOLET on June 8, 1972 - Forensic Medical Notes.

Cesk Patol 2021 ;57(1):11-16

On 8 June 1972, the Czechoslovak OK DNN aircraft carrier L410 Turbolet was delivered to the regular line Marianske Lazne - Prague to the Federal Republic of Germany. About 8 minutes after the launch from Marianske Lazne Airport, the likely head of the group of kidnappers threw the captain of the plane. During the fight with one of the passenger, the head of the group of kidnappers killed the captain of the aircraft by a shot from 7. Read More

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Secondary pulmonary hypoplasia associated with calcified Meckel´s diverticulum with osseous metaplasia.

Cesk Patol 2021 ;57(1):44-48

In this paper, we report autopsy findings of a 1-day old full-term mature female neonate with pulmonary hypoplasia diagnosed postnatally. Death was attributed to acute respiratory failure due to hyaline membrane disease. We describe pathological features of calcified Meckels diverticulum with osseous metaplasia and inflammatory changes in adjacent peritoneum. Read More

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Accuracy of Medical Examiner's Assessment for Near-Real-Time Surveillance of Fatal Drug Overdoses, King County, Washington, March 2017-February 2018.

Public Health Rep 2021 Apr 28:333549211008455. Epub 2021 Apr 28.

7285 Prevention Division, Public Health-Seattle & King County, Seattle, WA, USA.

Objectives: Up-to-date information on the occurrence of drug overdose is critical to guide public health response. The objective of our study was to evaluate a near-real-time fatal drug overdose surveillance system to improve timeliness of drug overdose monitoring.

Methods: We analyzed data on deaths in the King County (Washington) Medical Examiner's Office (KCMEO) jurisdiction that occurred during March 1, 2017-February 28, 2018, and that had routine toxicology test results. Read More

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[Case report: death of a 2-year-old girl with postmortem diagnosis of a rare coronary artery vasculitis typical for Kawasaki syndrome].

Rechtsmedizin (Berl) 2021 Apr 23:1-5. Epub 2021 Apr 23.

Institut für Rechtsmedizin, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Deutschland.

Coronary artery autoimmune vasculitis (Kawasaki syndrome) is at least in Germany a very rare condition, that typically manifests in childhood. The symptoms are often unspecific and complications with vascular aneurysms, thrombosis and myocardial infarction can occur. Multiple cases of Kawasaki-like symptoms in children with positive SARS-CoV‑2 test results have been reported during the course of the COVID-19 pandemic the past year. Read More

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Intestinal obstruction and ischemia by necrotic annular Meckel's diverticulum: Case report and review of the literature.

Int J Surg Case Rep 2021 Apr 20;82:105897. Epub 2021 Apr 20.

General Surgery Department, San Salvatore Hospital, Paternò, Catania, Italy.

Introduction And Importance: Meckel's diverticulum (MD) is a vestigial remnant of the omphalomesenteric duct, representing the most common congenital malformation of the gastrointestinal tract. Diagnosis of MD is a challenge because of its rarity and frequent asymptomaticity. Radiological exams generally aren't useful for its diagnosis. Read More

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Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients - A PET/MR study.

Neuroimage Clin 2021 Apr 7;30:102665. Epub 2021 Apr 7.

Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.

Traumatic brain injury (TBI) and repeated sports-related concussions (rSRCs) are associated with an increased risk for neurodegeneration. Autopsy findings of selected cohorts of long-term TBI survivors and rSRC athletes reveal increased tau aggregation and a persistent neuroinflammation. To assess in vivo tau aggregation and neuroinflammation in young adult TBI and rSRC cohorts, we evaluated 9 healthy controls (mean age 26 ± 5 years; 4 males, 5 females), 12 symptomatic athletes (26 ± 7 years; 6 males, 6 females) attaining ≥3 previous SRCs, and 6 moderate-to severe TBI patients (27 ± 7 years; 4 males, 2 females) in a combined positron emission tomography (PET)/magnetic resonance (MR) scanner ≥6 months post-injury. Read More

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Comparative Study: Postmortem Long-Term Stability of Endogenous GHB in Cardiac Blood, Femoral Blood, Vitreous Humor, Cerebrospinal Fluid, and Urine with and Without Sodium Fluoride Stabilization.

J Anal Toxicol 2021 Apr 24. Epub 2021 Apr 24.

Institute of Forensic Medicine, University Hospital Bonn.

The interpretation of postmortem γ-hydroxybutyric acid (GHB) concentrations is challenging due to endogenous existence and postmortem GHB-production in body tissues and fluids. As an additional complication, formation of GHB was also described in stored postmortem samples. We examined cardiac blood, femoral blood, vitreous humor, cerebrospinal fluid, and urine of eight different corpses (male/female 5/3, aged 33-92 years, postmortem interval 1-6 days) where no intake of GHB or one of its precursors was assumed. Read More

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Unusual cutaneous presentation in a corrosive acid ingestion.

J Forensic Sci 2021 Apr 24. Epub 2021 Apr 24.

Regional Forensic Science Laboratory, Jodhpur, India.

Corrosive digestive tract injuries are considered to be a source of morbidity and mortality worldwide. The cases of acid ingestion in Forensic Medicine practice are not infrequent. Corrosive ingestion usually presents with injuries over the face, oropharynx, esophagus, and gastrointestinal tract. Read More

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Coronary artery thromboembolism from left appendage mural thrombus- a rare complication from atrial fibrillation.

Forensic Sci Med Pathol 2021 Apr 23. Epub 2021 Apr 23.

Northern Forensic Pathology Service of New Zealand, Auckland, New Zealand.

A 54-year-old man with recurrent, persistent atrial fibrillation was found dead unexpectedly. He was reportedly non-compliant with his medications and was not on anti-coagulant therapy. He was found dead in his residence after complaining of abdominal discomfort a day prior to death. Read More

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Prolonged survival of a patient with aortogastric fistula treated with combined surgery and endovascular stent placement: A case report.

Int J Surg Case Rep 2021 Apr 23;81:105815. Epub 2021 Mar 23.

Department of Surgery, National Center for Global Health and Medicine, Tokyo, Japan. Electronic address:

Introduction: Aortogastric tube fistula is a rare and fatal complication of esophagectomy. The treatment for aortogastric tube fistula with active infection is challenging, wherein a contamination around the fistula can cause a high risk of aneurysm and recurrence of bleeding, even if large amount of bleeding is controlled immediately.

Presentation Of Case: We present a case of a 54-year-old male patient who underwent lower esophagectomy for esophageal squamous cell carcinoma 22 years ago. Read More

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Toxicological evaluation of aqueous extract of the traditional Chinese formula Qing Hao Gan Cao.

Toxicol Res (Camb) 2021 Mar 15;10(2):183-191. Epub 2021 Feb 15.

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, PR China.

(QHGC), a Chinese medicinal formula containing and , has been used to treat sunstroke and as an antiviral agent for more than 800 years. It has not previously been subject to a toxicological safety evaluation in acute and subacute (28 days) studies. Therefore, the acute and subacute toxicity of an aqueous extract of QHGC were evaluated . Read More

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Extended single-dose toxicity study of [At]NaAt in mice for the first-in-human clinical trial of targeted alpha therapy for differentiated thyroid cancer.

Ann Nucl Med 2021 Apr 19. Epub 2021 Apr 19.

Institute for Radiation Sciences, Osaka University, Suita, Japan.

Objective: Astatine (At) is a promising alpha emitter as an alternative to iodine (I). We are preparing the first-in-human (FIH) clinical trial of targeted alpha therapy for differentiated thyroid cancer in consultation with Pharmaceuticals and Medical Devices Agency. Here, we performed an extended single-dose toxicity examination under a reliability standard, as a preclinical safety assessment of [At]NaAt to determine the FIH dose. Read More

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A case of hyperprogressive disease following atezolizumab therapy for pulmonary pleomorphic carcinoma with epidermal growth factor receptor mutation.

Respir Med Case Rep 2021 31;33:101405. Epub 2021 Mar 31.

Department of Respiratory Medicine, Tokyo Saiseikai Central Hospital, 1-4-17 Mita, Minato-ku, Tokyo, 108-0073, Japan.

A 66-year old man with non-smoking history was diagnosed with pulmonary pleomorphic carcinoma of the right lower lobe. The carcinoma metastasized to the brain, lungs, pleura, and mediastinal lymph nodes. It was positive for ) L858R mutation, and tumor cells highly expressed programmed death-ligand 1(PD-L1). Read More

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Twice Negative PCR in a Patient With Herpes Simplex Virus Type 1 (HSV-1) Encephalitis.

Neurohospitalist 2021 Jan 22;11(1):66-70. Epub 2020 Jul 22.

Division of Neurology, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Alberta, Canada.

Untreated herpes simplex virus type 1 (HSV-1) encephalitis is associated with high mortality. Missed cases can have devastating consequences. Detection of HSV-1 in cerebrospinal fluid (CSF) with polymerase chain reaction (PCR) is reported to have high sensitivity and specificity and is considered the diagnostic gold standard for HSV-1 encephalitis. Read More

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January 2021

13-Weeks subchronic toxicity of isoquercitrin-γ-cyclodextrin (IQC-γCD) molecular inclusion complex in Sprague-Dawley rats.

Food Chem Toxicol 2021 Apr 15;152:112217. Epub 2021 Apr 15.

Tsukuba Institute, BoZo Research Center Inc., 8 Okubo, Tsukuba-shi, Ibaraki, 300-2611, Japan.

Flavonoids such as quercetin and its glycoside Isoquercitrin and are abundantly present in the diet and have various pharmacological effects. However, limited data about its potential toxicity is available. In this study, we aim to evaluate the subchronic toxicity of the isoquercitrin-γ-cyclodextrin (IQC-γCD) molecular inclusion complex (SunActive® QCD/EN) in Sprague-Dawley (SD) rats. Read More

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Effect of the dose on the toxicokinetics of a quaternary mixture of rare earth elements administered to rats.

Toxicol Lett 2021 Apr 19;345:46-53. Epub 2021 Apr 19.

Department of Environmental and Occupational Health, Chair in Toxicological Risk Assessment and Management, and Public Health Research Center (CReSP), University of Montreal, Roger-Gaudry Building, U424, P.O. Box 6128, Main Station, Montreal, QC, H3C 3J7, Canada. Electronic address:

Large human biomonitoring studies are starting to assess exposure to rare earth elements (REEs). Yet, there is a paucity of data on the toxicokinetics of these substances to help interpret biomonitoring data. The objective of the study was to document the effect of the administered dose on the toxicokinetics of REEs. Read More

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STAT6-Dependent Exacerbation of House Dust Mite-Induced Allergic Airway Disease in Mice by Multi-Walled Carbon Nanotubes.

NanoImpact 2021 Apr 13;22. Epub 2021 Mar 13.

Toxicology Program, Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695 U.S.A.

There is increasing evidence that inhaled multi-walled carbon nanotubes (MWCNTs) can have harmful effects on the respiratory system. Rodent studies suggest that individuals with asthma may be susceptible to the adverse pulmonary effects of MWCNTs. Asthma is an allergic lung disease characterized by a T2 immune response that results in chronic airway disease characterized by eosinophilic lung inflammation, airway mucous cell metaplasia, and airway fibrosis. Read More

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Effects of ethanol and nicotine co-administration on follicular atresia and placental histo-morphology in the first-generation mice pups during intrauterine development and lactation periods.

Toxicol Rep 2021 2;8:793-803. Epub 2021 Apr 2.

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

This study is evaluating the effects of ethanol and nicotine exposure during pregnancy and lactation on placenta histology and follicular atresia in the first-generation (f1) mice pups. The experimental groups were 5 groups of NMRI pregnant mice, including: control, vehicle (received normal saline) ethanol (3 g/kg/day, 20 % v/v intraperitoneally), nicotine (1 mg/kg/day, subcutaneously), and ethanol plus nicotine which received both. Pregnant animals in each group were then divided into two groups, one group for examining the placenta that was treated for 18 days and the other group for the ovary of one-day-old (PND1) and fifty-six-day-old (PND56) female offspring who were treated for 42 days (during intrauterine development and lactation). Read More

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Improvement in plasma D-dimer level in severe SARS-CoV-2 infection can be an indicator of fibrinolysis suppression: Case reports.

Medicine (Baltimore) 2021 Apr;100(15):e25255

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Rationale: Fibrinolysis shutdown associated with severe thrombotic complications is a recently recognized syndrome that was previously seldom investigated in patients with severe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It presents a unique therapeutic dilemma, as anticoagulation with heparin alone is insufficient to address the imbalance in fibrinolysis. And while the use of fibrinolytic agents could limit the disease severity, it is often associated with bleeding complications. Read More

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Acute colonic pseudo-obstruction and rapid septic progression after transabdominal preperitoneal hernia repair: a case report.

BMC Surg 2021 Apr 12;21(1):191. Epub 2021 Apr 12.

Division of Surgery, Kenpoku Medical Center, Takahagi Kyodo Hospital, 1006-9, Agehocho, Kamitezuna, Takahagi, Ibaraki, Japan.

Background: Acute colonic pseudo-obstruction (ACPO) is a rare condition observed in patients with some underlying medical or surgical conditions. To the best of our knowledge, this is the first case report of a patient with ACPO development and rapid septic progression after laparoscopic inguinal hernia repair.

Case Presentation: A 78-year-old man who underwent transabdominal preperitoneal hernia repair (TAPP) for right inguinal hernia presented with difficulty in defecation and abdominal distension. Read More

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Thirteen-week subcutaneous repeated dose toxicity study of butylparaben and its toxicokinetics in rats.

Arch Toxicol 2021 Apr 12. Epub 2021 Apr 12.

Department of Pharmacy, College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan, Chungnam, 31116, Republic of Korea.

Parabens are widely used preservatives in cosmetics and pharmaceutical products and are approved as food additives. These chemicals have been considered safe for many years. However, the literature classifies parabens as endocrine-disrupting chemicals, and an assessment of their influence on the endocrine system and systemic toxicity is important. Read More

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An Orthotopic Mouse Model of Ovarian Cancer using Human Stroma to Promote Metastasis.

J Vis Exp 2021 03 23(169). Epub 2021 Mar 23.

Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh; Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Womens' Hospital, University of Pittsburgh Medical Center;

Ovarian cancer is characterized by early, diffuse metastasis with 70% of women having metastatic disease at the time of diagnosis. While elegant transgenic mouse models of ovarian cancer exist, these mice are expensive and take a long time to develop tumors. Intraperitoneal injection xenograft models lack human stroma and do not accurately model ovarian cancer metastasis. Read More

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Invasive Mucinous Adenocarcinoma of the Lung Presenting With Multiple Cavities.

Cureus 2021 Mar 10;13(3):e13795. Epub 2021 Mar 10.

Department of Respiratory Medicine, Kobe Red Cross Hospital, Kobe, JPN.

A 78-year-old woman presented to our hospital with a two-week history of productive cough. Chest computed tomography (CT) showed bilateral multiple pulmonary nodules with cavities. Although the cytology of her sputum revealed adenocarcinoma, she refused any treatment. Read More

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Early onset bioprosthetic tricuspid valve stenosis in a case with cardiac sarcoidosis: Pathological findings based on autopsy.

J Cardiol Cases 2021 Apr 8;23(4):173-176. Epub 2021 Feb 8.

Division of Cardiovascular Surgery, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.

A 60-year-old woman with cardiac sarcoidosis developed recurrent and refractory right heart failure 26 months after tricuspid valve replacement. Echocardiography revealed thickened and immobile cusp with increased diastolic tricuspid gradient of 8-10 mmHg, consistent with bioprosthetic tricuspid stenosis (TS). Prolonged intravenous injection of dobutamine and carperitide, with intermittent intravenous furosemide, was necessary at multiple times. Read More

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Real-time fouling monitoring and membrane autopsy analysis in forward osmosis for wastewater reuse.

Water Res 2021 Jun 1;197:117098. Epub 2021 Apr 1.

Graduate School of Water Resources, Sungkyunkwan University (SKKU), 2066, Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do 16419, South Korea. Electronic address:

Forward osmosis process in emerging technology which can applicable in wastewater reuse and desalination simultaneously. In this study, the development of fouling on the FO membrane surface was monitored in real-time. The investigation of fouling layer physical and chemical characteristics was assessed by performance evaluation and in-depth analysis of fouling layer. Read More

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An unusual case of haemorrhagic bursa in a pullet flock associated with a genogroup 2 infectious bursal disease virus.

Avian Pathol 2021 Apr 27:1-8. Epub 2021 Apr 27.

Food Animal Health Research Program, Department of Veterinary Preventive Medicine, The Ohio State University/OARDC, Wooster, OH, USA.

An unusual case of infectious bursal disease (IBD) was observed in eight-week-old commercial caged pullets. This flock (House 1) exhibited a one-day spike in mortality. On gross necropsy examination, enlarged, diffusely haemorrhagic bursas were observed. Read More

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