363,491 results match your criteria neck cancer


Pheophorbide co-encapsulated with Cisplatin in folate-decorated PLGA nanoparticles to treat nasopharyngeal carcinoma: Combination of chemotherapy and photodynamic therapy.

Colloids Surf B Biointerfaces 2021 Sep 18;208:112100. Epub 2021 Sep 18.

Department of Otolaryngology, Head and Neck Surgery, The 901st Hospital of the Joint Logistics Support Force of PLA, Hefei, Anhui 230031, China. Electronic address:

The adverse effect and drug resistance of Cisplatin (CDDP) could be potential reduced by delivering in targeted nanoparticles and by combining with adjuvant therapy such as photodynamic therapy. In this study, F/CDPR-NP was formulated and characterized for all the physicochemical, biological and in vivo analysis. The results obtained from various in vitro and biological studies showed that encapsulation of CDDP and PBR in PLGA nanoparticles results in controlled release of encapsulated drugs and exhibited significantly low cell viability in CNE-1 and HNE-1 cancer cells. Read More

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September 2021

Nasopharyngeal cancer in monozygotic twins: A case report and review of the role of genetics and the environment.

Int J Surg Case Rep 2021 Sep 6;87:106371. Epub 2021 Sep 6.

Department of Otolaryngology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Introduction And Importance: Nasopharyngeal carcinoma (NPC) is considered a rare malignant head and neck tumour. However, the importance of genetics and environmental factors in the epidemiology of NPC is still unclear. Twins represent an excellent study population for genetic epidemiology; this is especially true of monozygotic-type twins because they are genetically identical. Read More

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September 2021

Patterns of extrasellar invasive growth of pituitary adenomas with normal sellar cavity size.

Clin Neurol Neurosurg 2021 Sep 10;209:106942. Epub 2021 Sep 10.

Department of Neurosurgery, Pauline Braathen Neurological Institute, 2950 Cleveland Clinic Blvd, Weston, FL 33331, USA. Electronic address:

Background: Pituitary adenomas (PAs) are among the most common brain tumors which characteristically become symptomatic due to the mass effect on surrounding structures and/or hormonal imbalances. This study describes 28 cases of PAs with an extrasellar invasive growth (EIG) at the early stage of tumor growth with normal sellar cavity size.

Methods: 1200 cases of PAs either treated medically or via Endoscopic transsphenoidal surgery were reviewed during a 10-year period. Read More

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September 2021

Superior Semicircular Canal Dehiscence Outcomes in a Consecutive Series of 229 Surgical Repairs with Middle Cranial Fossa Craniotomy.

World Neurosurg 2021 Sep 18. Epub 2021 Sep 18.

Department of Head and Neck Surgery, Ronald Reagan UCLA Medical Center, University of California, Los Angeles, CA, United States.

Background: Superior semicircular canal dehiscence (SSCD) is the appearance of a third mobile window between the middle fossa and the superior semicircular canal. Surgical management is indicated in patients with persistent and debilitating symptoms. The purpose of this study was to evaluate the association between preoperative variables that may impact postoperative symptomatic resolution. Read More

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September 2021

Comment on "Effect of a perioperative immune-enhancing diet in clean-contaminated head and neck cancer surgery: A randomized controlled trial" (Int J Surg 2021; 93:106051).

Authors:
Zhouying Huang

Int J Surg 2021 Sep 18:106114. Epub 2021 Sep 18.

Laboratory Department, YiWu Central Hospital, Zhejiang, 322000, China. Electronic address:

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September 2021

Intragenic NF1 deletions in sinonasal mucosal malignant melanoma.

Pigment Cell Melanoma Res 2021 Sep 21. Epub 2021 Sep 21.

Dept Head and Neck Cancer, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Centro de Investigación Biomédica en Red (CIBER-ONC), Edf. FINBA, N-1 F49, C/ Avenida de Roma s/n, 33011, Oviedo, Spain.

Mucosal malignant melanoma (MMM) is a rare and aggressive tumor. Despite effective local therapies, tumor recurrence and metastasis remain frequent. The genetics of MMM remain incompletely understood. Read More

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September 2021

Immune-related adverse events are associated with improved response, progression-free survival, and overall survival for patients with head and neck cancer receiving immune checkpoint inhibitors.

Cancer 2021 Sep 21. Epub 2021 Sep 21.

Departments of Oncology and Otolaryngology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.

Background: The authors hypothesized that patients developing immune-related adverse events (irAEs) while receiving immune checkpoint inhibition (ICI) for recurrent/metastatic head and neck cancer (HNC) would have improved oncologic outcomes.

Methods: Patients with recurrent/metastatic HNC received ICI at 2 centers. Univariate and multivariate logistic regression, Kaplan-Meier methods, and Cox proportional hazards regression were used to associate the irAE status with the overall response rate (ORR), progression-free survival (PFS), and overall survival (OS) in cohort 1 (n = 108). Read More

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September 2021

Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer.

JCI Insight 2021 Sep 21. Epub 2021 Sep 21.

Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, San Francisco, United States of America.

The epidermal growth factor receptor (EGFR) inhibitor cetuximab is the only FDA-approved oncogene-targeting therapy for head and neck squamous cell carcinoma (HNSCC). Despite variable treatment response, no biomarkers exist to stratify patients for cetuximab therapy in HNSCC. Here, we applied unbiased hierarchical clustering to reverse phase protein array (RPPA) molecular profiles from patient-derived xenograft (PDX) tumors, which revealed two PDX clusters defined by protein networks associated with EGFR inhibitor resistance. Read More

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September 2021

Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase.

Bioengineered 2021 Dec;12(1):7119-7130

Department of Otolaryngology & Head and Neck, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning City, P.R. China.

Our previous studies have elucidated a possible connection between long intergenic non-protein coding RNA 2570 (LINC02570) and nasopharyngeal carcinoma (NPC). However, the precise mechanism by which LINC02570 promotes NPC remains unknown. We used quantitative polymerase chain reaction (qPCR) to detect LINC02570 expression in nasopharyngeal cell lines, NPC tissues, and chronic rhinitis tissues. Read More

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December 2021

Human Papillomavirus-Negative Oropharyngeal Cancer Survival Outcomes Based on Primary Treatment: National Cancer Database Analysis.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211047169. Epub 2021 Sep 21.

Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.

Objective: To compare survival outcomes between primary surgery and primary radiation therapy (RT) in patients with human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma (OPSCC).

Study Design: A retrospective observational cohort study.

Setting: National Cancer Database. Read More

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September 2021

Cognitive Impairment and Delirium in Older Patients Undergoing Major Head and Neck Surgery.

Otolaryngol Head Neck Surg 2021 Sep 21:1945998211045293. Epub 2021 Sep 21.

Department of Medicine, University Health Network, University of Toronto, Toronto, Canada.

The study objective was to measure the prevalence and predictors of cognitive impairment (CI) and delirium. Adults undergoing major head and neck cancer surgery completed the Clock Draw Test to screen for CI, defined as a score of 0 or 1. Postoperative delirium was recorded. Read More

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September 2021

Comparison of PET-CT, CT and MRI scan in initial staging and management of head and neck cancers.

Eur Arch Otorhinolaryngol 2021 Sep 21. Epub 2021 Sep 21.

Clinical Oncology, University Hospital of Leicester, Leicester, UK.

Background: To evaluate the utility of positron-emission tomography (FDG PET) in initial staging and management of head and neck cancers.

Methods: This is a retrospective study of 99 treatment naïve head and neck cancer patients treated between January 2017 and December 2020 at a tertiary teaching centre. Change in initial staging and management was noted based on PET scan compared to cross-sectional imaging (CT and MRI). Read More

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September 2021

Localized Angiosarcoma, Not One Disease: A Retrospective Single-Center Study on Prognosis Depending on the Primary Site and Etiology.

Sarcoma 2021 10;2021:9960085. Epub 2021 Sep 10.

Department of Medical Oncology, Sarcoma Center, West German Cancer Center, University Hospital Essen, Essen, Germany.

Background: Angiosarcomas are rare and heterogeneous tumors with poor prognosis. The clinical subtypes are classified depending on the primary site and etiology.

Methods: We conducted a retrospective, monocentric study of 136 patients with localized AS between May 1985 and November 2018. Read More

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September 2021

Loneliness, social isolation, and pain following the COVID-19 outbreak: data from a nationwide internet survey in Japan.

Sci Rep 2021 Sep 20;11(1):18643. Epub 2021 Sep 20.

Cancer Control Center, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

The aim of cross-sectional study was to investigate the association between loneliness, increased social isolation, and pain following the COVID-19 outbreak. A total of 25,482 participants, aged 15-79 years, were assessed using an internet survey; the University of California, Los Angeles Loneliness Scale (Version 3), Short Form 3-item (UCLA-LS3-SF3) was used to assess loneliness, and a modified item of the UCLA-LS3-SF3 was used to measure the perception of increased social isolation during the pandemic. The outcome measures included the prevalence/incidence of pain (i. Read More

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September 2021

Cardiac metastasis in a patient with oral squamous cell carcinoma.

BMJ Case Rep 2021 Sep 20;14(9). Epub 2021 Sep 20.

Department Oral and Maxillofacial Surgery, University Hospitals Leuven, Leuven, Flanders, Belgium.

A 55-year-old man initially presented with an undifferentiated, HPV-p16-negative squamous cell carcinoma (SCC) in the left tonsillar region (cT4a N0 M0), which was treated with a combination of radiotherapy and chemotherapy. Several months later, the patient developed osteoradionecrosis on the left side of the mandible as well as a second primary lesion at the left base of the tongue. Surgical resection and mandibular reconstruction with a free vascularised fibula flap was performed. Read More

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September 2021

Supporting the next generation of scientists to lead cancer immunology research.

Cancer Immunol Res 2021 Sep 20. Epub 2021 Sep 20.

Medicine, Weill Cornell Medicine.

Recent success in the use of immunotherapy for a broad range of cancers has propelled the field of cancer immunology to the forefront of cancer research. As more and more young investigators join the community of cancer immunologists, the Arthur L. Irving Family Foundation Cancer Immunology Symposium provided a platform to bring this expanding and vibrant community together and support the development of the future leaders in the field. Read More

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September 2021

Increased risk of cerebrovascular mortality in head and neck cancer survivors aged ≥ 65 years treated with definitive radiotherapy: a population-based cohort study.

Radiat Oncol 2021 Sep 20;16(1):185. Epub 2021 Sep 20.

Department of Neurosurgery, the First Affiliated Hospital of Xiamen University, Xiamen, 361003, People's Republic of China.

Background: To investigate the relationship between radiotherapy (RT) and the risk of cerebrovascular mortality (CVM) in head and neck cancer (HNC) survivors aged ≥ 65 years.

Methods: Patients with HNC survivors aged ≥ 65 years diagnosed between 2000 and 2012 were included from the Surveillance, Epidemiology, and End Results database. Kaplan-Meier analysis, Log-rank tests, and Cox proportional-hazards regression models were performed for statistical analyses. Read More

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September 2021

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle.

mBio 2021 Sep 21:e0116321. Epub 2021 Sep 21.

Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA.

During the human papillomavirus 16 (HPV16) life cycle, the E2 protein interacts with host factors to regulate viral transcription, replication, and genome segregation/retention. Our understanding of host partner proteins and their roles in E2 functions remains incomplete. Here we demonstrate that CK2 phosphorylation of E2 on serine 23 promotes interaction with TopBP1 and and that E2 is phosphorylated on this residue during the HPV16 life cycle. Read More

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September 2021

Extrapulmonary manifestations and complications of severe acute respiratory syndrome coronavirus 2 infection: a systematic review.

Singapore Med J 2021 Sep 21. Epub 2021 Sep 21.

Division of Rheumatology, Department of Medicine, National University Hospital, Singapore.

Introduction: We aimed to describe the extrapulmonary manifestations of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, including their frequency, onset with respect to respiratory symptoms, pathogenesis and association with disease severity.

Methods: We searched the MEDLINE and Embase databases for SARS-CoV-2-related studies. Meta-analysis, observational studies, case series and case reports published in English or Chinese between 1 January and 1 May 2020 were included. Read More

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September 2021

A retrospective review of cancer surveillance in 100 head and neck cancer patients: Is there scope for a more tailored approach?

Clin Otolaryngol 2021 Sep 20. Epub 2021 Sep 20.

Freeman Hospital, Newcastle.

1. There is a considerable burden to outpatient head and neck cancer (HaNC) surveillance, and it is unclear to what extent the current recommendations facilitate the detection of HaNC. 2. Read More

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September 2021

A cross-sectional assessment of long-term effects in adolescent and young adult head and neck cancer survivors treated with radiotherapy.

J Cancer Surviv 2021 Sep 20. Epub 2021 Sep 20.

BC Cancer - Vancouver Centre, Vancouver, BC, Canada.

Purpose: Adolescent and young adult (AYA) head and neck (H&N) cancer survivors are at risk of long-term complications. A cross-sectional study of survivors recalled for clinical evaluation was performed to evaluate late effects in this population.

Methods: Surviving patients who had been diagnosed with H&N cancer between the ages of 15 and 39 years and treated with radiation therapy (RT) in British Columbia between 1970 and 2010 were invited to participate in this study. Read More

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September 2021

HSP70i to subdue autoimmunity and support anti-tumor responses.

Cell Stress Chaperones 2021 Sep 20. Epub 2021 Sep 20.

Department of Dermatology & Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.

Developing immunosuppressive therapies for autoimmune diseases comes with a caveat that immunosuppression may promote the risk of developing other conditions or diseases. We have previously shown that biolistic delivery of an expression construct encoding inducible HSP70 (HSP70i) with one amino acid modification in the dendritic cell (DC) activating moiety 435-445 (HSP70i) to mouse skin resulted in significant immunosuppressive activity of autoimmune vitiligo, associated with fewer tissue infiltrating T cells. To prepare HSP70i as a potential therapeutic for autoimmune vitiligo, in this study we evaluated whether and how biolistic delivery of HSP70i in mice affects anti-tumor responses. Read More

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September 2021

Rare clear cell odontogenic carcinoma associated with impacted tooth in a young patient: case report and literature review.

Oral Maxillofac Surg 2021 Sep 20. Epub 2021 Sep 20.

Departament of Dental Clinic, Federal University of Ceara, Fortaleza, Ceará, Brazil.

Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor. It is characterized by showing, on histopathological examination, clusters of vacuolated and clear tumor cells with epithelial differentiation surrounded by fibrocollagenous stroma and fibroblasts. The present study presents a rare clinical case of mandibular CCOC associated with an impacted tooth in a 26-year-old woman surgically treated with mandibulectomy and reconstruction with iliac crest bone graft. Read More

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September 2021

Sub-millisecond 2D MRI of the vocal fold oscillation using single-point imaging with rapid encoding.

MAGMA 2021 Sep 20. Epub 2021 Sep 20.

Department of Radiology, Medical Physics, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objective: The slow spatial encoding of MRI has precluded its application to rapid physiologic motion in the past. The purpose of this study is to introduce a new fast acquisition method and to demonstrate feasibility of encoding rapid two-dimensional motion of human vocal folds with sub-millisecond resolution.

Method: In our previous work, we achieved high temporal resolution by applying a rapidly switched phase encoding gradient along the direction of motion. Read More

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September 2021

Effectiveness of Educational Practices in University Students' Knowledge about Sun Protection and Its Relation to Sunlight Exposure: An Exploratory Study in a Portuguese Higher Education Institution.

Eur J Investig Health Psychol Educ 2020 Jul 15;10(3):720-732. Epub 2020 Jul 15.

Higher School of Education, Communication and Sport, CI&DEI, Polytechnic Institute of Guarda, Research Unit for Inland Development, Polytechnic of Guarda, 6300-559 Guarda, Portugal.

Nowadays, there is worldwide recognition that health and educational outcomes are inextricably linked. It is also recognized that health education comprises opportunities to improve health literacy, including the improvement of knowledge and the development of life skills to promote individual health. It is also known that the behavioral practices regarding sun exposure are an important risk factor for skin cancer. Read More

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Toxicities Caused by Head and Neck Cancer Treatments and Their Influence on the Development of Malnutrition: Review of the Literature.

Eur J Investig Health Psychol Educ 2020 Oct 2;10(4):935-949. Epub 2020 Oct 2.

Faculty of Health, University of Canberra, Bruce, 2617 ACT, Australia.

Malnutrition poses a significant problem for oncology patients, resulting in fatalities within this population. Patients with head and neck cancer (HNC) are at high risk, with up to 90% developing malnutrition. Common treatments used for HNC can often lead to adverse side effects, including oral health conditions, gastrointestinal upsets, and several metabolic changes. Read More

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October 2020

Head and neck lymphoedema-research challenges during the COVID-19 pandemic.

Br J Community Nurs 2021 Oct;26(Sup10):S6-S15

Advanced Team Leader, Occupational Therapy, Princess Alexandra Hospital, Australia.

Management of secondary head and neck lymphoedema has undergone little research investigation. Its treatment is time and labour intensive and involves multiple therapeutic modalities without a clear understanding of which is most effective. This study aimed to determine the feasibility of a randomised controlled trial comparing two therapeutic modalities to manage head and neck lymphoedema. Read More

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October 2021

Prognostic Indicators of Survival in Sinonasal Diffuse Large B-Cell Lymphoma: A National Cancer Database Analysis.

Laryngoscope 2021 Sep 20. Epub 2021 Sep 20.

Rush Sinus Program, Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, U.S.A.

Objectives/hypothesis: This study offers an update on the epidemiologic and prognostic factors and treatment-specific outcomes in patients diagnosed with sinonasal diffuse large B-cell lymphoma (DLBCL).

Study Design: Retrospective cohort study.

Methods: National Cancer Database was queried from 2004 to 2016 for patients with sinonasal DLBCL. Read More

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September 2021

Higher serum alkaline phosphatase value indicates the need for bone mineral density testing in non-metastatic prostate cancer patients undergoing androgen deprivation therapy.

Jpn J Clin Oncol 2021 Sep 20. Epub 2021 Sep 20.

Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

Purpose: Osteoporosis is a well-known adverse effect of androgen deprivation therapy for prostate cancer. This study aimed to reveal the factors associated with the diagnosis of osteoporosis in prostate cancer patients undergoing androgen deprivation therapy.

Methods: This retrospective cross-sectional study included 106 prostate cancer patients treated with androgen deprivation therapy. Read More

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September 2021