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Long-term surgical outcomes of intracranial epidermoid tumors: impact of extent of resection on recurrence and functional outcomes in 63 patients.

J Neurosurg 2021 Oct 15:1-9. Epub 2021 Oct 15.

Departments of1Neurologic Surgery and.

Objective: The authors' objective was to reevaluate the role of microsurgery for epidermoid tumors by examining the associations between extent of resection (EOR), tumor control, and clinical outcomes.

Methods: This was a retrospective study of patients with microsurgically treated intracranial epidermoid tumors. The recurrence-free and intervention-free rates were calculated using the Kaplan-Meier method. Read More

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October 2021

Editorial. Decision-making in the surgical management of a vestibular schwannoma: when timing is everything (cum sincere omnia).

J Neurosurg 2021 Oct 15:1-2. Epub 2021 Oct 15.

1Division of Otology/Neurotology, Department of Otolaryngology-Head and Neck Surgery, University Health Network, University of Toronto, Ontario, Canada.

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October 2021

Defining clinically significant tumor size in vestibular schwannoma to inform timing of microsurgery during wait-and-scan management: moving beyond minimum detectable growth.

J Neurosurg 2021 Oct 15:1-9. Epub 2021 Oct 15.

1Department of Otolaryngology-Head and Neck Surgery.

Objective: Detection of vestibular schwannoma (VS) growth during observation leads to definitive treatment at most centers globally. Although ≥ 2 mm represents an established benchmark of tumor growth on serial MRI studies, 2 mm of linear tumor growth is unlikely to significantly alter microsurgical outcomes. The objective of the current work was to ascertain where the magnitude of change in clinical outcome is the greatest based on size. Read More

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October 2021

Impact of COVID-19 on presentation, staging, and treatment of head and neck mucosal squamous cell carcinoma.

Am J Otolaryngol 2021 Oct 8;43(1):103263. Epub 2021 Oct 8.

Department of Otolaryngology Head and Neck Surgery, Vanderbilt University Medical Center, 7th floor 1215 21st Ave S, Nashville, TN 37232, USA.

Objectives: During the COVID-19 pandemic, maintenance of safe and timely oncologic care has been challenging. The goal of this study is to compare presenting symptoms, staging, and treatment of head and neck mucosal squamous cell carcinoma during the pandemic with an analogous timeframe one year prior.

Materials And Methods: Retrospective cohort study at a single tertiary academic center of new adult patients evaluated in a head and neck surgical oncology clinic from March -July 2019 (pre-pandemic control) and March - July 2020 (COVID-19 pandemic). Read More

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October 2021

Value of intraoperative pathological diagnosis in decision-making regarding resection of well-differentiated retropharyngeal liposarcoma: A case report.

Int J Surg Case Rep 2021 Oct 4;88:106466. Epub 2021 Oct 4.

Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Japan.

Introduction And Importance: Preoperative diagnosis of well-differentiated liposarcoma (WDLS) in the retropharyngeal space is challenging because of the difficulty in obtaining a biopsy tissue specimen that will yield the microscopic findings necessary for a definitive pathological diagnosis. This report describes a case of retropharyngeal WDLS that was successfully diagnosed intraoperatively, which allowed radical resection.

Case Presentation: The patient was a 60-year-old man suspected of having a lipomatous tumor in the retropharyngeal space. Read More

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October 2021

Conservative approach for treatment of Grisel's syndrome after resection of lympahadenitis tuberculosis of the neck: A rare case report.

Int J Surg Case Rep 2021 Oct 1;88:106452. Epub 2021 Oct 1.

Orthopaedic and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. Electronic address:

Introduction: Grisel's syndrome is a rare condition characterized by nontraumatic rotatory subluxation of the atlantoaxial joint, which was caused by previous inflammation around the head and neck. It is usually seen in children and signed as torticollis. There was no consensus for management, yet early diagnosis and treatment is paramount. Read More

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October 2021

Short-term ozone exposure and metabolic status in metabolically healthy obese and normal-weight young adults: A viewpoint of inflammatory pathways.

J Hazard Mater 2021 Oct 8;424(Pt B):127462. Epub 2021 Oct 8.

Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.

Unhealthy metabolic status increases risks of cardiovascular and other diseases. This study aims to explore whether there is a link between O and metabolic health indicators through a viewpoint of inflammatory pathways. 49 metabolically healthy normal-weight (MH-NW) and 39 metabolically healthy obese (MHO) young adults aged 18-26 years were recruited from a panel study with three visits. Read More

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October 2021

S100A11 regulates nasal epithelial cell remodeling and inflammation in CRSwNPs via the RAGE-mediated AMPK-STAT3 pathway.

Mol Immunol 2021 Oct 12;140:35-46. Epub 2021 Oct 12.

Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250022, China. Electronic address:

Abnormal remodeling of the nasal mucosal epithelium and persistent chronic inflammation are important pathological features of chronic sinusitis with nasal polyps (CRSwNPs). In order to explore the molecular regulation mechanism of CRSwNPs, we performed iTRAQ protein profile analysis on 18 clinical samples collected (9 patients with nasal polyps and 9 healthy patients) and found that S100A11, a Ca2+-binding protein, was significantly higher in CRSwNPs. Subsequently, we demonstrated that S100A11 was mainly located in nasal mucosal epithelial cells and is up-regulated in human nasal epithelial stem/progenitor cells (hNESPCs) from CRSwNPs patients and CRSwNPs epithelial cell model established with S. Read More

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October 2021

The impact of positive resection margins on survival requires further study?

Oral Oncol 2021 Oct 12;122:105568. Epub 2021 Oct 12.

Department of Head and Neck Surgical Oncology and Robotic Surgery, HealthCare Global (HCG) Cancer Centre, Bangalore, Karnataka, India.

Squamous cell carcinoma of oral cavity is usually treated by surgery followed by adjuvant treatment. In most standard cancer institutions, margin analysis is a key barometer for measuring the quality of surgical resection. Many studies reported that positive margins have at least a 50% reduction in the overall survival. Read More

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October 2021

IL-33 receptor expression on myeloid and plasmacytoid dendritic cells after allergen challenge in patients with allergic rhinitis.

Int Immunopharmacol 2021 Oct 12;101(Pt B):108233. Epub 2021 Oct 12.

Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

The diversity of immune responses in allergic diseases is critically mediated by dendritic cells (DCs), including myeloid and plasmacytoid DCs. Allergen inhalation increased the release of IL-33 from patients with allergic rhinitis (AR), which affecting the downstream cells by binding to its receptor (ST2). However, the effects of inhaled allergens on the expression of ST2 by DCs and IL-33 on the function of mDCs are unknown. Read More

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October 2021

The impact of confinement on orthopaedic and trauma surgical activity.

Orthop Traumatol Surg Res 2021 Oct 12:103113. Epub 2021 Oct 12.

Institut de Chirurgie Réparatrice Locomoteur et du Sport (ICR); Groupe KANTYS; 7 avenue durante, 06000 Nice, France.

Introduction: On the 16th of March 2020, in the face of a health emergency declared in France, the government imposed containment measures whose impact on orthopaedic and trauma surgery remains to be demonstrated. The hypothesis of this study was that confinement reduced orthopaedic and trauma surgical activity. The main objective was to assess orthopaedic and trauma surgical activity during confinement and to compare it to the activity outside confinement. Read More

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October 2021

Distinct tumor-infiltrating lymphocyte landscapes are associated with clinical outcomes in localized non-small cell lung cancer.

Ann Oncol 2021 Oct 12. Epub 2021 Oct 12.

Department of Biostatistics.

Background: Despite the importance of tumor-infiltrating T lymphocytes (TILs) in cancer biology, the relationship between TIL phenotypes and their prognostic relevance for localized non-small cell lung cancer (NSCLC) has not been well established.

Patients And Methods: Fresh tumor and normal adjacent tissue was prospectively collected from 150 patients with localized NSCLC. Tissue was comprehensively characterized by high-dimensional flow cytometry of TILs integrated with immunogenomic data from multiplex immunofluorescence, TCR sequencing, exome sequencing, RNA sequencing, targeted proteomics, and clinicopathologic features. Read More

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October 2021

Green synthesized colloidal silver is devoid of toxic effects on primary human nasal epithelial cells in vitro.

Food Chem Toxicol 2021 Oct 12:112606. Epub 2021 Oct 12.

Department of Surgery-Otolaryngology Head and Neck Surgery, Basil Hetzel Institute for Translational Health Research, Central Adelaide Local Health Network, Woodville, South, Australia; The University of Adelaide, Adelaide, Australia. Electronic address:

Evaluating the safety of previously fabricated and effective green synthetized colloidal silver (GSCS) on the mucosal barrier structure and function is essential prior to conduct human trials. The GSCS was applied to primary human nasal epithelial cells (HNECs) grown in an air-liquid interface (ALI) culture. Epithelial barrier integrity was evaluated by measuring the transepithelial electrical resistance (TEER) and fluorescein isothiocyanate (FITC)-dextran paracellular permeability. Read More

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October 2021

LBP as a biomarker in oral and maxillofacial tumors.

Oral Dis 2021 Oct 15. Epub 2021 Oct 15.

School of Life Science and Technology, Wuhan Polytechnic University, Hubei, China.

Oral and Maxillofacial tumors (OMTs), such as oral squamous cell carcinoma (SCC), pleomorphic adenoma and ameloblastoma, are common head and neck tumors. Lipopolysaccharide binding protein (LBP) is a type I acute reactive protein, which participates in body inflammatory response modulation through lipopolysaccharide (LPS)-induced signaling pathway by targeting macrophages (expressing cluster of differentiation 204 (CD204). Although it is well established that LBP is associated with the development of multiple types of cancer, little is known about the role of LBP in OMTs. Read More

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October 2021

Avoid the In-Out-In Posterosuperior Femoral Neck Screw: the Use of the Piriformis Fossa Radiographic Landmark.

J Orthop Trauma 2021 Oct 13. Epub 2021 Oct 13.

Department of Orthopedic Surgery, Prisma Health - Upstate, Greenville, SC.

Objectives: The most common screw placement across the femoral neck is the inverted triangle. The posterosuperior screw has high incidence of cortical breach, creating an in-out-in (IOI) screw. This study examined the use of the radiographic landmark of the piriformis fossa (PF) to prevent screws being placed IOI. Read More

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October 2021

Factors relating to bone mineral density in young and middle-aged patients with ankylosing spondylitis.

Chin Med J (Engl) 2021 Oct 13. Epub 2021 Oct 13.

Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Graduate School, Second Military Medical University, Shanghai 200433, China University of Queensland Diamantina Institute, University of Queensland, Brisbane, Australia Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing 100083, China Beijing Tsinghua Chang Gung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China.

Background: Ankylosing spondylitis (AS) is a common chronic progressive rheumatic disease. The aim of this study was to explore factors influencing abnormal bone mineral density (BMD) in young and middle-aged patients with AS.

Methods: From July 2014 to August 2018, hospitalized patients with AS and health examinees in the health examination center of our clinics, ranging in age from 20 to 50 years, were monitored. Read More

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October 2021

Demographics of and Costs to Users of Chiropractic Services in the United States with Neck or Back Pain not Meeting Guideline-Based Minimum Treatment Frequency Thresholds.

Altern Ther Health Med 2021 Oct 15. Epub 2021 Oct 15.

Context: Acceptance of chiropractic services as an effective therapy for neck or back pain has been well established with randomized controlled trials (RCTs); however, there have been limited observations made on the treatment frequency patterns seen in the real world.

Objective: The purpose of this study is to identify chiropractic users with neck or back pain who did not meet recommended treatment frequency guidelines and examine their demographics and chiropractic costs.

Design: In this cross-sectional retrospective study, the nationally representative 2017 Medical Expenditure Panel Survey database was used. Read More

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October 2021

Establishing an Endoscopic Chronic Subglottic Stenosis Rabbit Model.

Laryngoscope 2021 Oct 15. Epub 2021 Oct 15.

Division of Pediatric Otolaryngology-Head and Neck Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Objectives/hypothesis: To develop a reproducible and consistent chronic subglottic stenosis (SGS) in an endoscopic animal model.

Study Design: Prospective study.

Methods: We conducted a prospective study using New Zealand white rabbits. Read More

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October 2021

Quantifying Neck Fibrosis and Its Functional Implications: Development of the Neck Fibrosis Scale.

Laryngoscope 2021 Oct 15. Epub 2021 Oct 15.

Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.

Objective: Despite increasing recognition of the importance of functional outcomes for patients with head and neck cancer, post-treatment neck fibrosis remains poorly understood. We sought to develop and validate a patient reported outcome measure for head and neck cancer patients with neck fibrosis.

Study Design: Prospective multiphase cross-sectional study. Read More

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October 2021

State of the Science in Tracheal Stents: A Scoping Review.

Laryngoscope 2021 Oct 15. Epub 2021 Oct 15.

Department of Otolaryngology-Head and Neck Surgery, Brooke Army Medical Center, JBSA Fort Sam Houston, San Antonio, Texas, U.S.A.

Objective: Recent material science advancements are driving tracheal stent innovation. We sought to assess the state of the science regarding materials and preclinical/clinical outcomes for tracheal stents in adults with benign tracheal disease.

Methods: A comprehensive literature search in April 2021 identified 556 articles related to tracheal stents. Read More

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October 2021

Radiological appearance of physical elder abuse.

Eur Geriatr Med 2019 Dec 9;10(6):871-878. Epub 2019 Oct 9.

Department of Radiology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, University of Health Sciences, Ziraat mah. Şehit Ömer Halisdemir cad. No: 20, Altındağ/Ankara, Turkey.

Purpose: The aim of the study was to determine the radiologic imaging characteristics of the trauma-related lesions of elderly patients determined to be abused, and to raise awareness among all types of physicians, foremost radiologists, about elder abuse.

Methods: Clinical records and radiological images of 92 patients with the diagnosis of elder abuse were retrospectively evaluated in terms of age, gender, the reason for admission to the hospital, the presence or absence of comorbid disease(s), bone fracture location and number, characteristics of the fracture(s), the presence or absence of soft-tissue damage or old fracture(s), and the mortality.

Results: Of the patients, 85. Read More

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December 2019

Septoplasty with and without additional sinonasal surgery: postoperative sequelae and the use of prophylactic antibiotics.

Eur Arch Otorhinolaryngol 2021 Oct 15. Epub 2021 Oct 15.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland.

Purpose: One of the most common complications after septoplasty is a postoperative infection. We investigated the number of postoperative infections and unplanned postoperative visits (UPV) in septoplasties with and without additional nasal surgery at our institution and evaluated the role of antibiotic prophylaxis.

Methods: We collected data of all consecutive 302 septoplasty or septocolumelloplasty patients operated during the year 2018 at the Department of Otorhinolaryngology-Head and Neck Surgery, HUS Helsinki University Hospital (Helsinki, Finland). Read More

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October 2021

Long non-coding RNA AFAP1-AS1 promotes thyroid cancer progression by sponging miR-204-3p and upregulating DUSP4.

J Biochem 2021 Oct 15. Epub 2021 Oct 15.

Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Chinese Medical University, Beijing 100730, China.

Long non-coding RNA (lncRNA) actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), shows crucial regulatory function in tumor progression. Nonetheless, the biological function and underlying mechanism of AFAP1-AS1 in the progression of thyroid cancer is still unclear. Expressions of AFAP1-AS1, miR-204-3p, and DUSP4 were quantified utilizing qRT-PCR and/or Western blot. Read More

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October 2021

The Affordable Care Act's young adult mandate was associated with a reduction in pain prevalence.

Authors:
Duy Do Morgan Peele

Pain 2021 Nov;162(11):2693-2704

Population Studies Center, University of Pennsylvania, Philadelphia, PA, United States.

Abstract: Pain is a major health problem among U.S. young adults. Read More

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November 2021

Targeted Neoadjuvant Intra-arterial Chemotherapy in Lacrimal Gland Adenoid Cystic Carcinoma: A Histological Correlation Using Apoptotic Tumor Markers.

Ophthalmic Plast Reconstr Surg 2021 Oct 13. Epub 2021 Oct 13.

Department of Ocular Oncology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY Department of Pathology, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY Department of Otolaryngology Head and Neck Surgery, Columbia University Irving Medical Center, New York, NY Department of Ophthalmology, New York University Langone Medical Center, New York, NY Department of Pathology, New York University Langone Medical Center, New York, NY Department of Neurosurgery, Weill Cornell Medicine, New York-Presbyterian Hospital, New York, NY.

Neoadjuvant intra-arterial cytoreductive chemotherapy is used for the treatment of lacrimal gland adenoid cystic carcinomas (ACC) to improve outcomes in this condition with an otherwise dismal prognosis. We share our experience in the management of an advanced case of ACC using a novel, highly targeted intra-arterial cytoreductive chemotherapy delivery technique involving both the internal and external carotid circulation, with an attempt to correlate the effect histologically. Refinement of the chemotherapy delivery using the tumor's vascular anatomy and appropriate blood vessel selection may lead to future globe sparing procedures without compromising survival. Read More

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October 2021

Corneal Neurotization via Dual Nerve Autografting.

Ophthalmic Plast Reconstr Surg 2021 Oct 13. Epub 2021 Oct 13.

Oculofacial, Orbital and Aesthetic Plastic Surgery, Department of Ophthalmology, Pacific Eye Associates, California Pacific Medical Center, San Francisco, California Division of Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University, Stanford, California, U.S.A.

Corneal neurotization is a fast-evolving surgical procedure for sensory reinnervation in neurotrophic keratopathy. After neurotization, prior reports document return of corneal sensation on average 8 months after surgery with 38 mm of sensation gain measured via cochet bonnet esthesiometer testing. Here, the authors describe a dual nerve grafting approach via simultaneous parallel sural nerve grafts from both the supratrochelar and supraorbital nerves to the affected contralateral cornea with return of sensation by postoperative week 11. Read More

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October 2021

Preclinical Implementation of a Steerable, Da Vinci Xi ® Compatible CO2-Laser Fiber Carrier for Transoral Robotic Surgery (TORS): a Cadaveric Feasibility Study.

Int J Med Robot 2021 Oct 15:e2342. Epub 2021 Oct 15.

Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.

Introduction: Monopolar electrocautery is the most common dissection and coagulation tool during transoral robotic surgery (TORS) but causes significant collateral tissue damage as opposed to CO laser. We aimed at combining both modalities in one robotic instrument arm.

Methods: We developed a steerable CO -laser fiber carrier serving as an add-on to the existing Endowrist® monopolar spatula of the Da Vinci Xi. Read More

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October 2021

In Reference to Quantifying Tinnitus Suppression in Cochlear Implantation Using Tinnitus Interval-Limited Tracking.

Laryngoscope 2021 Oct 15. Epub 2021 Oct 15.

Department of Otolaryngology - Head and Neck Surgery, Drexel University College of Medicine, Philadelphia, Pennsylvania, U.S.A.

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October 2021

Puerarin alleviates the ototoxicity of gentamicin by inhibiting the mitochondria‑dependent apoptosis pathway.

Mol Med Rep 2021 Dec 15;24(6). Epub 2021 Oct 15.

Department of Otolaryngology‑Head and Neck Surgery, Anhui Provincial Hospital, Hefei, Anhui 230001, P.R. China.

Gentamicin (GM) is a commonly used antibiotic, and ototoxicity is one of its side effects. Puerarin (PU) is an isoflavone in kudzu roots that exerts a number of pharmacological effects, including antioxidative and free radical scavenging effects. The present study investigated whether PU could protect against GM‑induced ototoxicity in C57BL/6J mice and House Ear Institute‑Organ of Corti 1 (HEI‑OC1) cells. Read More

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December 2021

The prevalence and symptoms of temporomandibular disorders in head and neck cancer patients.

Acta Odontol Scand 2021 Oct 15:1-6. Epub 2021 Oct 15.

Department of Oral and Maxillofacial Surgery, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Objectives: This retrospective patient survey aimed to assess the prevalence of temporomandibular disorders (TMD) before and after curative oncological treatment and to identify possible risk factors.

Materials And Methods: Patients with squamous cell carcinoma in the tonsil or base of the tongue were included ( = 217). Medical records were collected to assess TMD prevalence before oncological treatment and at 6- and 12-month follow-up. Read More

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October 2021