784 results match your criteria near-total thyroidectomy


Risk Factors for Contralateral Occult Carcinoma in Patients With Unilateral Papillary Thyroid Carcinoma: A Retrospective Study and Meta-Analysis.

Front Endocrinol (Lausanne) 2021 12;12:675643. Epub 2021 Jul 12.

Department of Endocrinology and Metabolism, Institute of Endocrinology, National Health Commission Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.

Background: Bilateral lesions are common in papillary thyroid carcinoma (PTC). For patients with unilateral PTC, occult carcinoma that is not detected preoperatively, but pathologically after surgery, might remain in the contralateral lobe. In this situation, inadequate surgical extent could cause relapse and even lead to re-operation. Read More

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Clinical impact of radioactive iodine dose selection based on the number of metastatic lymph nodes in patients with papillary thyroid carcinoma: A multicenter retrospective cohort study.

Clin Endocrinol (Oxf) 2021 Jun 29. Epub 2021 Jun 29.

Department of Nuclear Medicine, Kyungpook National University, School of Medicine and Chilgok Hospital, Daegu, Republic of Korea.

Objective: The aim of this study is to investigate whether the number of metastatic lymph nodes (LNs) could be used as a basis in the radioactive iodine (RAI) dose selection for patients with papillary thyroid carcinoma (PTC).

Patients: A total of 595 patients with PTC who received first RAI therapy after total or near-total thyroidectomy and had no evidence of disease in treatment response assessment were retrospectively enroled from five hospitals. The patients were classified into two subgroups based on the number of metastatic LNs (>5). Read More

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Natural Course of the American Thyroid Association Response to Therapy Statuses (Dynamic Risk Stratification) in Differentiated Thyroid Cancer.

Eur Thyroid J 2021 Jun 1;10(3):198-207. Epub 2020 Dec 1.

Department of Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

The concept of response to therapy in differentiated thyroid cancer (DTC) was introduced as a dynamic risk stratification used to assess the status of the disease at the time of the evaluation during the follow-up and the risk of recurrence in the future. Our aim in this study was to evaluate the natural course over time of different response to therapy statuses.

Methods: We studied 501 nonselected DTC patients (102 males and 399 females) with a median age of 37 years (interquartile range [IQR] 29-48). Read More

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Central lymph node dissection and permanent hypoparathyroidism after total thyroidectomy for papillary thyroid cancer: population-based study.

Br J Surg 2021 Jun;108(6):684-690

Department of Clinical Sciences, Lund University, Lund, Sweden.

Background: Papillary thyroid cancer is treated with total/near-total thyroidectomy (TT) with or without central lymph node dissection (CLND), depending on risk factors and tumour size. Balancing the risk of disease recurrence and surgical morbidity remains a challenge. A population-based nationwide study was undertaken to evaluate the risk of permanent hypoparathyroidism associated with CLND. Read More

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Progressive changes in the major salivary gland after radioiodine therapy for differentiated thyroid cancer: a single-center retrospective ultrasound cohort study.

Ultrasound Med Biol 2021 Jun 16. Epub 2021 Jun 16.

Department of Nuclear Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China 510282. Electronic address:

This study aimed to determine the prevalence of radioiodine-induced salivary gland damage by evaluating progressive changes in salivary glands using ultrasound. Four hundred forty-six patients with differentiated thyroid carcinoma who underwent total or near-total thyroidectomy and postoperative radioiodine therapy were retrospectively reviewed. From the first to the fifth follow-up visits, the positive rate of major salivary gland changes on ultrasound gradually increased from 2. Read More

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Factors Associated with Malignancy in Patients with Maximal Thyroid Nodules ≥2 Cm.

Cancer Manag Res 2021 4;13:4473-4482. Epub 2021 Jun 4.

Department of Thyroid Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People's Republic of China.

Purpose: The relationship between large thyroid nodules and the risk of malignancy is controversial. This study aimed to examine the relationship between thyroid nodule size and the risk of malignancy of maximal thyroid nodules ≥2 cm and the risk of accompanied by occult thyroid carcinoma.

Methods: This was a retrospective study of patients who underwent near-total or total thyroidectomy for thyroid nodules from January 2016 to January 2019 at the First Affiliated Hospital,Zhejiang University School of Medicine. Read More

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Frequency of Hypomagnesaemia following Total and Near-total Thyroidectomy and its relationship with Hypocalcaemia.

J Coll Physicians Surg Pak 2021 May;30(5):571-575

Department of Surgery Unit 1, Benazir Bhutto Hospital, Rawalpindi, Pakistan.

Objective: To determine the frequency of hypomagnesaemia in patients undergoing thyroidectomy and evaluate its relationship with postoperative hypocalcaemia.

Study Design: Observational, cross-sectional study.

Place And Duration Of Study: Surgical Unit 1, Benazir Bhutto Hospital, Rawalpindi, Pakistan from April 2017 to May 2019. Read More

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Association of same-day discharge with hospital readmission after pediatric thyroidectomy.

Pediatr Surg Int 2021 May 20. Epub 2021 May 20.

Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, 1001 Main Street, Buffalo, NY, 14203, USA.

Background: Studies have demonstrated that same-day discharge (SDD) following thyroid resection is safe and feasible in adults but there are no similar studies in the pediatric age group. The purpose of this study is to evaluate the influence of SDD on 30-day readmission rates following thyroid surgery in pediatric patients.

Methods: This retrospective cohort study used the American College of Surgeons National Surgical Quality Improvement Program-Pediatric database to evaluate 30-day readmission rates among patients < 19 years of age who underwent thyroid resection between 2012 and 2017. Read More

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Effects of thyroid-stimulating hormone suppression after thyroidectomy for thyroid cancer on bone mineral density in postmenopausal women: a systematic review and meta-analysis.

BMJ Open 2021 05 13;11(5):e043007. Epub 2021 May 13.

Center for Obesity and Metabolic Diseases, Korea University Anam Hospital, Seoul, The Republic of Korea.

Objectives: We assessed thyroid-stimulating hormone (TSH) suppression effects on bone mineral density (BMD) in postmenopausal women who underwent thyroidectomy.

Data Sources: PubMed, EMBASE, Cochrane Library, Web of Science and SCOPUS were searched from inception to 24 February 2021.

Study Selection: Case-control studies were included. Read More

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Benefits and harms of hemithyroidectomy, total or near-total thyroidectomy in 1-4 cm differentiated thyroid cancer.

Clin Endocrinol (Oxf) 2021 May 4. Epub 2021 May 4.

Department of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, China.

Objective: For 1-4 cm differentiated thyroid cancer (DTC), current ATA guideline recommended hemithyroidectomy (HT) as an acceptable alternative initial procedure to total or near-total thyroidectomy (TT). The aim of this study was to evaluate benefits and harms of HT, TT in 1-4 cm DTC.

Design: Retrospective cohort study. Read More

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Radioiodine Remnant Ablation for Differentiated Thyroid Cancer: A Systematic Review and Meta-analysis.

JAMA Otolaryngol Head Neck Surg 2021 Jun;147(6):544-552

Department of Surgery, Galway University Hospitals, Galway, Ireland.

Importance: Postoperative radioactive iodine (RAI) remnant ablation for differentiated thyroid cancer (DTC) facilitates the early detection of recurrence and represents an adjuvant therapy that targets persistent microscopic disease. The optimal activity of RAI in low- and intermediate-risk DTC remains controversial.

Objective: To evaluate the long-term cure rate of different RAI activities in low- and intermediate-risk DTC. Read More

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Total versus near-total thyroidectomy in Graves' disease: a systematic review and meta-analysis of comparative studies.

Gland Surg 2021 Feb;10(2):729-738

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Background: Total thyroidectomy (TT), near-total thyroidectomy (NT), and subtotal thyroidectomy (ST) are three surgical procedures for Graves' disease (GD) patients, but most previous studies have only evaluated the complications of TT versus ST or TT/NT versus ST; there is not a meta-analysis of NT versus TT, so whether NT is superior to TT for GD patients still unclear.

Methods: We comprehensively searched PubMed, Embase, Web of Science, and the Cochrane Library, without restriction to region, publication type, or language, on 10 June, 2020. We conducted this systematic review and meta-analysis of all included studies assessing the two surgical procedures. Read More

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February 2021

Trends and Outcomes of Surgical Management of Primary Papillary Carcinoma in the Pediatric Population.

J Surg Res 2021 Jul 6;263:207-214. Epub 2021 Mar 6.

Section of Endocrine Surgery, Columbia University Irving Medical Center, New York, New York. Electronic address:

Background: Childhood papillary thyroid cancer is more aggressive than carcinomas in adults. Current American Thyroid Association pediatric guidelines recommend a total or near-total thyroidectomy for all pediatric patients without gross evidence of lymph node metastases. Our objective is to analyze trends in the surgical management of pediatric papillary thyroid cancer and assess how well the guidelines are implemented. Read More

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Update on the systemic management of radioactive iodine refractory differentiated thyroid cancer (Review).

Mol Clin Oncol 2021 Feb 24;14(2):35. Epub 2020 Dec 24.

Department of Radiation Oncology, Regional Cancer Center, Medical College Campus, Trivandrum, 695011 Kerala, India.

The incidence of differentiated thyroid cancer (DTC) has increased over the last few decades, though it remains to be a rare disease. The prognosis of DTC is excellent; its treatment includes surgery (near-/total thyroidectomy), which is usually followed by remnant thyroid bed ablation using radio-iodine, as well as a risk-stratified follow-ups, including hormone replacement. Treatment of patients who are non-responsive to radioactive iodine (RAI) remains a challenge. Read More

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February 2021

Low-intermediate dose of lenvatinib in anaplastic thyroid cancer is highly effective and safe.

BMJ Case Rep 2020 Dec 22;13(12). Epub 2020 Dec 22.

Deparment of Surgery, UO Pathology, University of Pisa, Pisa, Toscana, Italy.

We report two cases of anaplastic thyroid cancer (ATC) which had a very good response to a treatment with lenvatinib at 14 mg. A 73-year-old man with ATC stage IVB was operated on, undergoing a near-total thyroidectomy, and the pathological remnant tissue showed a quick and partial response to treatment with the drug. The patient had a single metastasis in the brain after 9 months, but then died due to bronchopneumonia after undergoing a neurosurgical intervention for the complete removal of the lesion. Read More

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December 2020

Clinical association of CXCR4 in primary tumor of papillary thyroid cancer and response to iodine-131 treatment.

Nucl Med Commun 2021 Apr;42(4):396-401

Division of Nuclear Medicine, Department of Radiology.

Object: Papillary thyroid cancer (PTC) has an excellent prognosis. However, patients with such, if refract to radioiodine treatment, increase recurrent and mortality rates. Tumor aggressiveness in primary tumor of PTC expresses CXCR4 chemokine receptor. Read More

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Papillary thyroid carcinoma presenting as a functioning thyroid nodule: report of 2 rare cases.

Authors:
Liang Hu Yijun Wu

Int J Clin Exp Pathol 2020 1;13(11):2895-2906. Epub 2020 Nov 1.

Department of Thyroid Surgery, The First Hospital Affiliated to Zhejiang University, School of Medicine No. 79 Qingchun Road, Hangzhou 310000, P. R. China.

Introduction: Autonomously functioning thyroid nodules (AFTNs) are generally benign, whereas papillary thyroid carcinomas (PTCs) are mostly non-functioning. Graves' disease (GD) is the most common cause of hyperthyroidism (HD), followed by hyperfunctional adenoma or Plummer's disease. GD with AFTNs is called Marine-Lenhart syndrome, a relatively rare syndrome. Read More

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November 2020

Narrative review of proving the causal link of recurrent laryngeal nerve injury and thyroidectomy: a medico legal appraisal.

Gland Surg 2020 Oct;9(5):1564-1572

Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.

The recurrent laryngeal nerve (RLN) injuries are frequent complications related to thyroid surgery determining patient complaints and malpractice litigations. In the present work, the authors provide a brief review on the peculiarities of RLN injuries associated with thyroidectomy to highlight the various aspects of medicolegal assessment of causal link between surgery and nerve damage. The characteristics of thyroid disease, the anatomical peculiarities of surgery site and the nerve identification and preservation are factors that mostly influence the liability admission or rejection. Read More

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October 2020

Hemithyroidectomy for Thyroid Cancer: A Review.

Medicina (Kaunas) 2020 Nov 3;56(11). Epub 2020 Nov 3.

Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Thyroid cancer incidence is on the rise; however, fortunately, the death rate is stable. Most persons with well-differentiated thyroid cancer have a low risk of recurrence at the time of diagnosis and can expect a normal life expectancy. Over the last two decades, guidelines have recommended less aggressive therapy for low-risk cancer and a more personalized approach to treatment of thyroid cancer overall. Read More

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November 2020

ERADICATION OF PAPILLARY THYROID CARCINOMA IN A PATIENT RECEIVING PEMETREXED AND BEVACIZUMAB.

AACE Clin Case Rep 2020 Sep-Oct;6(5):e247-e251. Epub 2020 Jun 23.

Endocrinology, CoxHealth, Springfield, Missouri.

Objective: To report a 66-year-old female patient whose medical management for advanced-stage, high-grade serous carcinoma of the ovary (HGSC-O) might have treated concomitant papillary thyroid carcinoma (PTC) diagnosed by fine-needle aspiration (FNA).

Methods: Patient evaluation and management consisted of positron emission tomography (PET) scans, thyroid ultrasounds, FNA biopsies, and thyroid function tests.

Results: The patient presented to the endocrinology clinic while undergoing treatment for HGSC-O with a PET scan revealing increased uptake in the thyroid gland. Read More

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Predictive factors of contralateral occult carcinoma in patients with papillary thyroid carcinoma: a retrospective study.

Gland Surg 2020 Aug;9(4):872-878

Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: The surgical approach toward unilateral papillary thyroid carcinoma (PTC) has been in controversy. One of the concerns is the existence of contralateral occult carcinoma, which could cause relapse and even lead to re-operation if not dealt with. This study aims to find out risk factors related to contralateral occult PTC, in order to facilitate in surgical approach decision for PTC. Read More

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Central lymph node dissection and permanent hypoparathyroidism after total thyroidectomy for papillary thyroid cancer: population-based study.

Br J Surg 2020 Sep 16. Epub 2020 Sep 16.

Department of Clinical Sciences, Lund University, Lund, Sweden.

Background: Papillary thyroid cancer is treated with total/near-total thyroidectomy (TT) with or without central lymph node dissection (CLND), depending on risk factors and tumour size. Balancing the risk of disease recurrence and surgical morbidity remains a challenge. A population-based nationwide study was undertaken to evaluate the risk of permanent hypoparathyroidism associated with CLND. Read More

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September 2020

Long-term follow-up of differentiated thyroid carcinoma in children and adolescents.

J Pediatr Endocrinol Metab 2020 Nov;33(11):1431-1441

Nuclear Medicine Department, Hospital Universitari de la Vall d'Hebron, Universitat Autónoma de Barcelona, Barcelona, Spain.

Objectives The aims were to analyze the clinical features, response to treatment, prognostic factors and long-term follow-up of children and adolescents with differentiated thyroid carcinoma (DTC). Methods Eighty patients with DTC were studied retrospectively. All underwent total or near-total thyroidectomy, and in 75 cases, ablative iodine therapy was recommended. Read More

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November 2020

Elimination of Locoregional Recurrences and Skin Metastases in Papillary Thyroid Cancer by Ethanol Ablation and Mohs Surgery.

J Endocr Soc 2020 Aug 6;4(8):bvaa095. Epub 2020 Jul 6.

Division of Endocrinology, Department of Internal Medicine, Mayo Clinic and College of Medicine, Rochester, Minnesota.

Ultrasound-guided percutaneous ethanol ablation procedures for locoregional recurrences in papillary thyroid carcinoma (PTC) can be repeatedly performed over years. Skin metastases (SM) from PTC generally portend a lethal prognosis. Our patient case report demonstrates the innovative use in low-risk PTC (LRPTC) of treatment modalities designed to prevent neck re-explorations and capable of eliminating both locoregional recurrences and SM. Read More

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External Beam Radiotherapy for Medullary Thyroid Cancer Following Total or Near-Total Thyroidectomy.

Otolaryngol Head Neck Surg 2021 01 4;164(1):97-103. Epub 2020 Aug 4.

Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Stanford University Stanford, California, USA.

Objectives: Medullary thyroid carcinoma (MTC) often presents with advanced disease and takes an aggressive course as compared with more well-differentiated thyroid cancers. The role of adjuvant therapy, specifically external beam radiotherapy (EBRT), remains disputed. This study investigated the impact of EBRT on survival in MTC. Read More

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January 2021

Surgical treatment of children Graves' disease with huge goiter-a case report and literature review.

Gland Surg 2020 Apr;9(2):467-473

Breast and Thyroid Surgical Department, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing 400000, China.

Graves' disease is the most common cause of hyperthyroidism in children. The surgery treatment for children Graves' disease with huge goiter is high risk and controversial. A 14-year-old girl suffered Graves' disease with huge goiter and failed to the antithyroid drug therapy for nearly 4 years was surgically treated with total thyroidectomy. Read More

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The impact of radioactive iodine treatment on survival among papillary thyroid cancer patients according to the 7th and 8th editions of the AJCC/TNM staging system: a SEER-based study.

Updates Surg 2020 Sep 27;72(3):871-884. Epub 2020 Apr 27.

Department of Nuclear Medicine, Tianjin Medical University General Hospital, Anshan Road No. 154, Heping District, Tianjin, 300052, People's Republic of China.

Papillary thyroid cancer is a very common endocrine malignancy. The 8th American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system introduced major changes. We conducted this retrospective cohort analysis to assess the benefits of radioactive iodine (RAI) according to different stratification of patients. Read More

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September 2020

Total Thyroidectomy Versus Lobectomy in Small Nodules Suspicious for Papillary Thyroid Cancer: Cost-Effectiveness Analysis.

Laryngoscope 2020 12 2;130(12):2922-2926. Epub 2020 Apr 2.

Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana, U.S.A.

Objectives/hypothesis: Recent American Thyroid Association Guidelines recommend either near-total/total thyroidectomy or lobectomy for patients with a thyroid nodule suspicious for papillary thyroid cancer (PTC) on fine-needle aspiration (FNA) biopsy (Bethesda V). In this analysis, we aim to assess the cost-effectiveness of lobectomy in comparison to total thyroidectomy.

Study Design: Cost-effectiveness analysis. Read More

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December 2020

Distant metastases from pathologically proven benign follicular nodules of the thyroid: clinicopathological features and predictors of long-term survival.

Endocrine 2020 07 18;69(1):113-125. Epub 2020 Mar 18.

Department of Nuclear Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 200233, Shanghai, China.

Objective: Distant metastases are rarely observed in patients with initial pathologically proven benign follicular nodules of the thyroid. This study aimed to evaluate the clinicopathological features and independent variables associated with survival in such patients with distant metastases.

Methods: In total, 10,992 consecutive differentiated thyroid cancer (DTC) patients treated with I after total or near-total thyroidectomy from 2000 to 2018 were retrospectively reviewed. Read More

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Predicting Postthyroidectomy Hypocalcemia: Improving Predictive Ability of Parathyroid Hormone Level.

Am Surg 2020 Feb;86(2):121-126

We performed a retrospective study of our large patient cohort aiming to examine the ability to predict postthyroidectomy hypocalcemia. A retrospective review of patients who underwent total or near-total thyroidectomy at our institution between 2008 and 2018 was performed. Postoperative hypocalcemia was defined as Ca level <8. Read More

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February 2020