156 results match your criteria navs

TRPV1 Responses in the Cerebellum Lobules VI, VII, VIII Using Electroacupuncture Treatment for Chronic Pain and Depression Comorbidity in a Murine Model.

Int J Mol Sci 2021 May 10;22(9). Epub 2021 May 10.

Graduate Institute of Acupuncture Science, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.

Depression is a prominent complex psychiatric disorder, usually complicated through expression of comorbid conditions, with chronic pain being among the most prevalent. This comorbidity is consistently associated with a poor prognosis and has been shown to negatively impact patient outcomes. With a global rise in this condition presenting itself, the importance of discovering long-term, effective, and affordable treatments is crucial. Read More

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German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia.

Brain Sci 2021 Apr 8;11(4). Epub 2021 Apr 8.

Department of Neurology, University Medical Center Freiburg, Breisacherstrasse 64, 79106 Freiburg, Germany.

Grammar provides the framework for understanding and producing language. In aphasia, an acquired language disorder, grammatical deficits are diversified and widespread. However, the few assessments for testing grammar in the German language do not consider current linguistic, psycholinguistic, and functional imaging data, which have been shown to be crucial for effective treatment. Read More

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Cannabidiol inhibits the skeletal muscle Nav1.4 by blocking its pore and by altering membrane elasticity.

J Gen Physiol 2021 May;153(5)

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.

Cannabidiol (CBD) is the primary nonpsychotropic phytocannabinoid found in Cannabis sativa, which has been proposed to be therapeutic against many conditions, including muscle spasms. Among its putative targets are voltage-gated sodium channels (Navs), which have been implicated in many conditions. We investigated the effects of CBD on Nav1. Read More

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Topical NAVS naphthalan for the treatment of oral lichen planus and recurrent aphthous stomatitis: A double blind, randomized, parallel group study.

PLoS One 2021 8;16(4):e0249862. Epub 2021 Apr 8.

Department of Oral Medicine, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

Aim: To evaluate the effectiveness of non-aromatic very rich in steranes (NAVS) naphthalan in the treatment of oral lichen planus (OLP) and recurrent aphthous stomatitis (RAS). Null hypothesis was that there would be no difference between NAVS and topical steroids in the treatment of OLP and RAS.

Methods: The study consisted of two sub-trials conducted as randomized, double-blind controlled studies: first included OLP patients and second patients with RAS. Read More

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Three-dimensional changes of the upper airway in patients with Class II malocclusion treated with functional appliances: a systematic review and meta-analysis.

Eur J Orthod 2021 Mar 3. Epub 2021 Mar 3.

Department of Orthodontics, Hebei Key Laboratory of Stomatology, Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang 050017, PR China.

Background/objective: To evaluate the three-dimensional (3D) changes of the upper airway in patients with Class II malocclusion treated with functional appliances (FAs).

Search Methods And Eligibility Criteria: A comprehensive search of seven electronic databases was conducted from the date of inception to 12 July 2020. Manual search was also performed in relevant Chinese and English periodicals. Read More

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Ca-Saturated calmodulin binds tightly to the N-terminal domain of A-type fibroblast growth factor homologous factors.

J Biol Chem 2021 Feb 24:100458. Epub 2021 Feb 24.

Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242-1109, USA. Electronic address:

Voltage-gated sodium channels (Nas) are tightly regulated by multiple conserved auxiliary proteins, including the four fibroblast growth factor homologous factors (FGFs), which bind the Na EF-hand like domain (EFL), and calmodulin (CaM), a multifunctional messenger protein that binds the Na IQ motif. The EFL domain and IQ motif are contiguous regions of Na cytosolic C-terminal domains (CTD), placing CaM and FGF in close proximity. However, whether the FGFs and CaM act independently, directly associate, or operate through allosteric interactions to regulate channel function is unknown. Read More

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February 2021

MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord.

Prog Neurobiol 2021 Jul 23;202:102024. Epub 2021 Feb 23.

The First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, 200092, China. Electronic address:

Voltage-gated sodium channels (Nas) 1.7, 1.8, and 1. Read More

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Phosphorylation of a chronic pain mutation in the voltage-gated sodium channel Nav1.7 increases voltage sensitivity.

J Biol Chem 2020 Dec 22. Epub 2020 Dec 22.

Institute of Physiology, RWTH Aachen University Hospital, Germany.

Mutations in voltage-gated sodium channels (Navs) can cause alterations in pain sensation, such as chronic pain diseases like inherited erythromelalgia (IEM). The IEM-causing mutation Nav1.7 p. Read More

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December 2020

Changes in Ion Selectivity Following the Asymmetrical Addition of Charge to the Selectivity Filter of Bacterial Sodium Channels.

Entropy (Basel) 2020 Dec 9;22(12). Epub 2020 Dec 9.

Department of Physics, Lancaster University, Lancaster LA1 4YW, UK.

Voltage-gated sodium channels (NaVs) play fundamental roles in eukaryotes, but their exceptional size hinders their structural resolution. Bacterial NaVs are simplified homologues of their eukaryotic counterparts, but their use as models of eukaryotic Na channels is limited by their homotetrameric structure at odds with the asymmetric Selectivity Filter (SF) of eukaryotic NaVs. This work aims at mimicking the SF of eukaryotic NaVs by engineering radial asymmetry into the SF of bacterial channels. Read More

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December 2020

Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation.

J Gen Physiol 2021 Jan;153(1)

Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD.

Voltage-gated sodium channels (NaVs) are membrane proteins responsible for the rapid upstroke of the action potential in excitable cells. There are nine human voltage-sensitive NaV1 isoforms that, in addition to their sequence differences, differ in tissue distribution and specific function. This review focuses on isoforms NaV1. Read More

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January 2021

Characterization of Vixotrigine, a Broad-Spectrum Voltage-Gated Sodium Channel Blocker.

Mol Pharmacol 2021 01;99(1):49-59

Biogen, Cambridge, Massachusetts (C.A.H., H.N.); Charles River Laboratories Cleveland, Inc., Cleveland, Ohio (Y.K.); Neuroservice, Aix-en-Provence, France (A.S., A.B., B.B.); and Department of Comparative Medicine, Yale University, New Haven, Connecticut (M.H.).

Voltage-gated sodium channels (Navs) are promising targets for analgesic and antiepileptic therapies. Although specificity between Nav subtypes may be desirable to target specific neural types, such as nociceptors in pain, many broadly acting Nav inhibitors are clinically beneficial in neuropathic pain and epilepsy. Here, we present the first systematic characterization of vixotrigine, a Nav blocker. Read More

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January 2021

Presynaptic NMDARs cooperate with local spikes toward GABA release from the reciprocal olfactory bulb granule cell spine.

Elife 2020 11 30;9. Epub 2020 Nov 30.

Neurophysiology, Institute of Zoology, Universität Regensburg, Regensburg, Germany.

In the rodent olfactory bulb the smooth dendrites of the principal glutamatergic mitral cells (MCs) form reciprocal dendrodendritic synapses with large spines on GABAergic granule cells (GC), where unitary release of glutamate can trigger postsynaptic local activation of voltage-gated Na-channels (Nas), that is a spine spike. Can such single MC input evoke reciprocal release? We find that unitary-like activation via two-photon uncaging of glutamate causes GC spines to release GABA both synchronously and asynchronously onto MC dendrites. This release indeed requires activation of Nas and high-voltage-activated Ca-channels (HVACCs), but also of NMDA receptors (NMDAR). Read More

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November 2020

Imaging of Non-atherosclerotic Vasculopathies.

J Clin Imaging Sci 2020 13;10:62. Epub 2020 Oct 13.

Department of Radiology, Penn State Health, Hershey, Pennsylvania, United States.

Non-atherosclerotic vasculopathies (NAVs) may present with various neurological symptoms ranging from headache, stroke, visual symptoms, and various types of intracranial hemorrhage. NAVs result from different etiologies which include collagenopathies, immunological, hematological, and infection mechanisms, and other rarer unidentifiable or idiopathic causes. NAV etiologies account for about 10-15% and 20-25% of adult and pediatric stroke cases, respectively, and therefore, diagnosing the underlying cause of NAV becomes clinically very important. Read More

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October 2020

A Novel Single-Domain Na-Selective Voltage-Gated Channel in Photosynthetic Eukaryotes.

Plant Physiol 2020 12 1;184(4):1674-1683. Epub 2020 Oct 1.

Marine Biological Association, The Laboratory, Citadel Hill, Plymouth PL1 2PB, United Kingdom

The evolution of Na-selective four-domain voltage-gated channels (4D-Nas) in animals allowed rapid Na-dependent electrical excitability, and enabled the development of sophisticated systems for rapid and long-range signaling. While bacteria encode single-domain Na-selective voltage-gated channels (BacNa), they typically exhibit much slower kinetics than 4D-Nas, and are not thought to have crossed the prokaryote-eukaryote boundary. As such, the capacity for rapid Na-selective signaling is considered to be confined to certain animal taxa, and absent from photosynthetic eukaryotes. Read More

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December 2020

Discovery of Vixotrigine: A Novel Use-Dependent Sodium Channel Blocker for the Treatment of Trigeminal Neuralgia.

ACS Med Chem Lett 2020 Sep 16;11(9):1678-1687. Epub 2020 Jul 16.

Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States.

Drugs that block voltage-gated sodium channels (Nas) have utility in treating conditions including pain, epilepsy, and cardiac arrhythmias and as anesthetics (Lancet Neurol.20109413424; Expert Opin. Ther. Read More

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September 2020

Kdr genotyping in Aedes aegypti from Brazil on a nation-wide scale from 2017 to 2018.

Sci Rep 2020 08 6;10(1):13267. Epub 2020 Aug 6.

Laboratório de Fisiologia e Controle de Artrópodes Vetores, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, RJ, Brazil.

Insecticide resistance is currently a threat to the control of Aedes agypti, the main vector of arboviruses in urban centers. Mutations in the voltage gated sodium channel (Na), known as kdr (knockdown resistance), constitute an important selection mechanism for resistance against pyrethroids. In the present study, we investigated the kdr distribution for the Val1016Ile and Phe1534Cys alterations in Ae. Read More

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Chemometric Models of Differential Amino Acids at the Naα and Naβ Interface of Mammalian Sodium Channel Isoforms.

Molecules 2020 Aug 3;25(15). Epub 2020 Aug 3.

Laboratory of Computational Molecular Simulations, Faculty of Chemical Sciences, BUAP, C.P. 72570 Puebla, Mexico.

(1) Background: voltage-gated sodium channels (Nas) are integral membrane proteins that allow the sodium ion flux into the excitable cells and initiate the action potential. They comprise an α (Naα) subunit that forms the channel pore and are coupled to one or more auxiliary β (Naβ) subunits that modulate the gating to a variable extent. (2) Methods: after performing homology in silico modeling for all nine isoforms (Na1. Read More

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Sulfoethylation of polysaccharides-A comparative study.

Carbohydr Polym 2020 Oct 5;246:116533. Epub 2020 Jun 5.

Institute of Organic Chemistry and Macromolecular Chemistry, Friedrich Schiller University of Jena, Centre of Excellence for Polysaccharide Research, Humboldtstraße 10, D-07743, Jena, Germany. Electronic address:

The heterogeneous sulfoethylation of cellulose, xylan, α-1,3-glucan, glucomannan, pullulan, curdlan, galactoglucomannan, and agarose was studied using sodium vinylsulfonate (NaVS) as reagent in presence of sodium hydroxide and iso-propanol (i-PrOH) as slurry medium. The influence of the concentration of polymer, water, and NaOH (solid or aqueous solution) on the degree of substitution (DS) was investigated. The sulfoethylation rendered the polysaccharides studied water-soluble. Read More

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October 2020

Recombinant production, bioconjugation and membrane binding studies ofPn3a, a selective Na1.7 inhibitor.

Biochem Pharmacol 2020 11 12;181:114148. Epub 2020 Jul 12.

Centre for Advanced Imaging, The University of Queensland, Australia. Electronic address:

Chronic pain is a common and often debilitating condition. Existing treatments are either inefficacious or associated with a wide range of side effects. The progress on developing safer and more effective analgesics has been slow, in large part due to our limited understanding of the physiological mechanisms underlying pain in different diseases. Read More

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November 2020

Comparison of Bromhexine and its Active Metabolite - Ambroxol as Potential Analgesics Reducing Oxaliplatin-induced Neuropathic Pain - Pharmacodynamic and Molecular Docking Studies.

Curr Drug Metab 2020 ;21(7):548-561

Department of Pharmacodynamics, Chair of Pharmacodynamics, Jagiellonian University Medical College, 9 Medyczna St., 30-688 Krakow, Poland.

Background: Painful peripheral neuropathy is a dose-limiting adverse effect of the antitumor drug oxaliplatin. The main symptoms of neuropathy: tactile allodynia and cold hyperalgesia, appear in more than 80% of patients on oxaliplatin therapy and are due to the overexpression of neuronal sodium channels (Navs) and neuroinflammation.

Objective: This study assessed antiallodynic and antihyperalgesic properties of two repurposed drugs with antiinflammatory and Nav-blocking properties (bromhexine and its pharmacologically active metabolite - ambroxol) in a mouse model of neuropathic pain induced by oxaliplatin. Read More

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January 2020

How a Scorpion Toxin Selectively Captures a Prey Sodium Channel: The Molecular and Evolutionary Basis Uncovered.

Mol Biol Evol 2020 11;37(11):3149-3164

Department of Toxicology and Pharmacology, University of Leuven (KU Leuven), Leuven, Belgium.

The growing resistance of insects to chemical pesticides is reducing the effectiveness of conventional methods for pest control and thus, the development of novel insecticidal agents is imperative. Scorpion toxins specific for insect voltage-gated sodium channels (Navs) have been considered as one of the most promising insecticide alternatives due to their host specificity, rapidly evoked toxicity, biodegradability, and the lack of resistance. However, they have not been developed for uses in agriculture and public health, mainly because of a limited understanding of their molecular and evolutionary basis controlling their phylogenetic selectivity. Read More

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November 2020

Evaluation of resistance to pyrethroid and organophosphate adulticides and kdr genotyping in Aedes aegypti populations from Roraima, the northernmost Brazilian State.

Parasit Vectors 2020 May 20;13(1):264. Epub 2020 May 20.

Laboratório de Fisiologia e Controle de Artrópodes Vetores, Instituto Oswaldo Cruz, FIOCRUZ, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ, Brazil.

Background: Roraima, the northernmost State in Brazil, borders Venezuela and Guyana. Although mostly covered by the tropical forests, the urban centers of this state are highly infested with Ae. aegypti and are endemic for dengue, Zika and chikungunya. Read More

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The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough.

Physiol Res 2020 03;69(Suppl 1):S7-S18

Department of Pathophysiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia.

An excessive, irritable, productive or non-productive coughing associated with airway inflammation belongs to pathological cough. Increased activation of airway vagal nociceptors in pathological conditions results from dysregulation of the neural pathway that controls cough. A variety of mediators associated with airway inflammation overstimulate these vagal airway fibers including C-fibers leading to hypersensitivity and hyperreactivity. Read More

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Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7.

J Biol Chem 2020 04 5;295(15):5067-5080. Epub 2020 Mar 5.

Institute for Molecular Bioscience, Centre for Pain Research, The University of Queensland, Brisbane, Queensland 4072, Australia

Huwentoxin-IV (HwTx-IV) is a gating modifier peptide toxin from spiders that has weak affinity for the lipid bilayer. As some gating modifier toxins have affinity for model lipid bilayers, a tripartite relationship among gating modifier toxins, voltage-gated ion channels, and the lipid membrane surrounding the channels has been proposed. We previously designed an HwTx-IV analogue (gHwTx-IV) with reduced negative charge and increased hydrophobic surface profile, which displays increased lipid bilayer affinity and activity at the voltage-gated sodium channel subtype 1. Read More

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A native prokaryotic voltage-dependent calcium channel with a novel selectivity filter sequence.

Elife 2020 02 25;9. Epub 2020 Feb 25.

Cellular and Structural Physiology Institute (CeSPI), Nagoya University, Nagoya, Japan.

Voltage-dependent Ca channels (Cavs) are indispensable for coupling action potentials with Ca signaling in living organisms. The structure of Cavs is similar to that of voltage-dependent Na channels (Navs). It is known that prokaryotic Navs can obtain Ca selectivity by negative charge mutations of the selectivity filter, but native prokaryotic Cavs had not yet been identified. Read More

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February 2020

Nano and Micro Unmanned Aerial Vehicles (UAVs): A New Grand Challenge for Precision Agriculture?

Curr Protoc Plant Biol 2020 03;5(1):e20103

Grup de Recerca en Biologia de les Plantes en Condicions Mediterrànies, Departament de Biologia, University of the Balearic Islands (UIB)/Instituto de investigaciones Agroambientales y de la Economía del Agua (INAGEA), Palma, Spain.

By collecting data at spatial and temporal scales that are inaccessible to satellite and field observation, unmanned aerial vehicles (UAVs) are revolutionizing a number of scientific and management disciplines. UAVs may be particularly valuable for precision agricultural applications, offering strong potential to improve the efficiency of water, nutrient, and disease management. However, some authors have suggested that the UAV industry has overhyped the potential value of this technology for agriculture, given that it is difficult for non-specialists to operate UAVs as well as to process and interpret the resulting data. Read More

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Veratridine: A Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels.

ACS Chem Neurosci 2020 02 17;11(3):418-426. Epub 2020 Jan 17.

Department of Chemistry , Stanford University , Stanford , California 94305 , United States.

Voltage-gated sodium ion channels (Nas) are integral to both neuronal and muscular signaling and are a primary target for a number of proteinaceous and small molecule toxins. Included among these neurotoxins is veratridine (VTD), a C-nor-D homosteroidal alkaloid from the seeds of members of the genus. VTD binds to Na within the pore region, causing a hyperpolarizing shift in the activation threshold in addition to reducing peak current. Read More

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February 2020

Component-Based Interactive Framework for Intelligent Transportation Cyber-Physical Systems.

Sensors (Basel) 2020 Jan 2;20(1). Epub 2020 Jan 2.

Information and Communication Engineering, DGIST, Daegu 42988, Korea.

While emerging technology for self-driving automation in vehicles progresses rapidly, the transition to an era of roads full of fully connected and automated vehicles (CAVs) may take longer than expected. Until then, it is inevitable that CAVs should coexist and interact with drivers of non-autonomous vehicles (NAVs) in urban roads. During this period of transition, it is critical to provide road safety with the mixed vehicular traffic and uncertainty caused by human drivers. Read More

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January 2020

Synthetic Approaches to Zetekitoxin AB, a Potent Voltage-Gated Sodium Channel Inhibitor.

Mar Drugs 2019 Dec 26;18(1). Epub 2019 Dec 26.

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology (TUAT), 2-24-16, Naka-cho, Koganei city, Tokyo 184-8588, Japan.

Voltage-gated sodium channels (Nas) are membrane proteins that are involved in the generation and propagation of action potentials in neurons. Recently, the structure of a complex made of a tetrodotoxin-sensitive (TTX-s) Na subtype with saxitoxin (STX), a shellfish toxin, was determined. STX potently inhibits TTX-s Na, and is used as a biological tool to investigate the function of Nas. Read More

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December 2019

Comparison of DNA and mRNA vaccines against cancer.

Drug Discov Today 2020 03 13;25(3):552-560. Epub 2019 Dec 13.

Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Dermatology, Harvard Medical School, Boston, MA 02115, USA; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South Africa. Electronic address:

Nucleic acid vaccines (NAVs) have recently been tested as a cancer therapy. DNA and mRNA vaccines deliver genetic information encoding tumor antigens (TAs) to the host, which then produces immune responses against cancer cells that express the TAs. Although NAVs are easy, safe, and simple to manufacture, they have not so far been considered viable alternatives to peptide vaccines. Read More

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