711,177 results match your criteria natural product


A liquid-culture-based screening approach to study compounds affecting inflammatory processes in .

Biol Chem 2021 Sep 20. Epub 2021 Sep 20.

Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg-University Mainz, D-55131Mainz, Germany.

Discovery of biomedical drugs makes use of novel biological sources of limited availability and is often in need of fast, small-scale initial screening approaches. Here, we present a screening, based on the reporter strain IG692, for identification of anti- and pro-inflammatory properties. The elaborated workflow is based on cultivation in fluid and by this, allows fast and reproducible seeding in 96 well plates. Read More

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September 2021

Can the Antivirals Remdesivir and Favipiravir Work Better Jointly? In Silico Insights.

Drug Res (Stuttg) 2021 Sep 17. Epub 2021 Sep 17.

Computational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit, Mauritius.

The proverb "Old is gold" is applicable in drug discovery and the proverb "All that Glitters is not Gold" is also appropriate. In the COVID-19 era, there has been a race for drugs to be effective against SARS-CoV-2. There are reports about the uses of Remdesivir and Favipiravir as existing antivirals against virus but none have been conclusive so far. Read More

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September 2021

Pertussis antibody levels in infants and their mothers receiving combined tetanus-diphtheria toxoid and acellular pertussis vaccine during pregnancy in Turkey.

Eur J Obstet Gynecol Reprod Biol 2021 Sep 2;265:212-216. Epub 2021 Sep 2.

Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Neonatology, Istanbul, Turkey.

Objective: Pertussis is an important cause of morbidity and mortality in infants under two months of age and these high risk babies are dependent on maternally derived antibodies until completion of their first immunization series. This study aimed to evaluate the vaccine response of late preterm and term newborns as well as their mothers who underwent combined tetanus-diphtheria toxoid and acellular pertussis (Tdap) vaccination during pregnancy.

Study Design: A total of 70 pregnant women were administered Tdap vaccine (Boostrix®, GSK) between 27 and 33 gestational weeks of pregnancy. Read More

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September 2021

Exploring presentations of sustainability by US synthetic biology companies.

PLoS One 2021 17;16(9):e0257327. Epub 2021 Sep 17.

School for the Future of Innovation in Society, Arizona State University, Tempe, AZ, United States of America.

The field of synthetic biology is increasingly being positioned as a key driver of a more sustainable, bio-based economy, and has seen rapid industry growth over the past 15 years. In this paper we undertake an exploratory investigation of the relationship between sustainability and synthetic biology, identifying and analyzing sustainability-related language on the public websites of 24, US-based synthetic biology companies. We observe that sustainability is a visible part of the self-presentation of the nascent synthetic biology industry, explicitly mentioned by 18 of the 24 companies. Read More

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September 2021

Chemical Proportionality within Molecular Networks.

Anal Chem 2021 Sep 17. Epub 2021 Sep 17.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, San Diego, California 92093, United States.

Molecular networking of non-targeted tandem mass spectrometry data connects structurally related molecules based on similar fragmentation spectra. Here, we report the ical portionality (ChemProp) contextualization of molecular networks. ChemProp scores the changes of abundance between two connected nodes over sequential data series (e. Read More

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September 2021

Total Synthesis of Cochlearol B via Intramolecular [2+2] Photocycloaddition.

Angew Chem Int Ed Engl 2021 Sep 17. Epub 2021 Sep 17.

Hoshi University, Synthetic Medicinal Chemistry, 2-4-41, Ebara, 142-8501, Shinagawa-ku, JAPAN.

Herein, we describe the first total synthesis of cochlearol B, a meroterpenoid natural product featuring a 4/5/6/6/6-fused pentacyclic structure. Key steps, oxidative cyclization and subsequent intramolecular [2+2] photocycloaddition, which constructed the pentacyclic structure in highly stereoselective manner, allowed efficient access to cochlearol B with the longest linear sequence of 16 steps, and in 9% overall yield. Single-crystal X-ray crystallographic analysis clearly confirmed the stereochemistry of cochlearol B. Read More

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September 2021

Microbial chondroitin sulfate in experimental knee osteoarthritis model investigation of chondroprotective effect.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5402-5411

Department of Surgical Medical Sciences, Inonu University, Malatya, Turkey.

Objective: Chondroitin sulfate (CS) is a glycosaminoglycan with proven anti-inflammatory, anti-apoptotic, anti-oxidant properties. CS increases type II collagen and proteoglycan synthesis in human joint chondrocytes. CS can reduce the production of pro-inflammatory mediators and proteases to improve the anabolic/catabolic balance of the extracellular cartilage matrix (ECM). Read More

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September 2021

Correction to: Occurrence of genes associated with virulence in Escherichia coli isolates from chicken carcasses at different stages of processing at a slaughterhouse.

Braz J Microbiol 2021 Sep 17. Epub 2021 Sep 17.

Laboratory of Avian Health and Technological Innovation, Institute for Veterinary Research Desidério Finamor (IPVDF), Postgraduate Program in Animal Health, Department of Agricultural Diagnosis and Research, Secretariat of AgricultureLivestock and Rural Development of Rio Grande Do Sul, Estrada do Conde, 6000, Sans Souci, Eldorado do Sul, RS, 92990-000, Brazil.

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September 2021

Phenylpropanoid-conjugated iridoid glucosides from leaves of Morinda morindoides.

J Nat Med 2021 Sep 17. Epub 2021 Sep 17.

Section of Pharmacognosy, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Three phenylpropanoid-conjugated iridoid glucosides, acetylgaertneric acid (1), acetyldehydrogaertneroside (2), and dehydrogaertneric acid (10), together with nine known related iridoid glucosides (3-9, 11, and 12), two coumaroyl alkaloids, one benzenoid, and three flavonoid glucosides were isolated from leaves of Morinda morindoides (Rubiaceae). Structures of these isolated compounds were determined using spectroscopic analysis. Compounds 1-18 and previously isolated compounds (19-29) were evaluated for anti-trypanosomal activity against Trypanosoma cruzi Tulahuen strain (trypomastigote and amastigote) together with cytotoxicity against host cells, new-born mouse heart cells. Read More

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September 2021

Polyphenolic Natural Products Active In Silico against SARS-CoV-2 Spike Receptor Binding Domains and Non-Structural Proteins - A Review.

Comb Chem High Throughput Screen 2021 Sep 16. Epub 2021 Sep 16.

Laboratory for Organic Reactivity, Discovery and Synthesis (LORDS), Research Center for the Natural and Applied Sciences, University of Santo Tomas, Manila, Espana Blvd., Manila 1015, Philippines.

The ongoing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has been proven to be more severe than the previous coronavirus outbreaks due to the virus' high transmissibility. With the emergence of new variants, this global phenomenon took on a more dramatic turn with many countries recently experiencing higher surges of confirmed cases and deaths. On top of this, the inadequacy of effective treatment options for COVID-19 aggravated the problem. Read More

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September 2021

Carbene-Catalyzed Activation of Formyl-phenylacetic Esters for Access to Chiral Dihydroisoquinolinones.

Org Lett 2021 Sep 17. Epub 2021 Sep 17.

Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China.

A carbene-catalyzed reaction to synthesize chiral dihydroisoquinolinones via an -quinodimethane (-QDM) intermediate is disclosed. -QDM reacts with cyclic sulfonic imines via annulation to afford highly enantioenriched dihydroisoquinolinone products. ESI-HRMS studies suggest a stepwise Mannich addition and acylation reaction pathway, and the pathways of the catalytic and uncatalyzed background reactions are evaluated via DFT calculations. Read More

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September 2021

A Single-Blinded Prospective Study on Using Botulinum Toxin Type A for Reducing Alar Mobility.

Aesthet Surg J 2021 Sep 17. Epub 2021 Sep 17.

Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China.

Background: With wide spread of instant social media, people desire a minimal invasive treatment to improve alar dynamic aesthetic but seldom practical procedures on reducing alar mobility have been conducted.

Objectives: This study aimed to verify effects of botulinum toxin on reducing nasal alar mobility and provide a supplemental treatment of rhinoplasty.

Methods: This single-blind and prospective study included a cohort of 20 participants with the desires of improving alar dynamic aesthetic. Read More

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September 2021

and comparison of three astilbin encapsulated zein nanoparticles with different outer shells.

Food Funct 2021 Sep 17. Epub 2021 Sep 17.

Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, China.

Three shell materials, lecithin (ZNP-L), chitosan (ZNP-CH) and sodium caseinate (ZNP-SC), were used to prepare core-shell zein nanoparticles. Astilbin was encapsulated as a model flavonoid to compare the influence of the shell materials on zein nanoparticles both and . The particle size was moderately increased by lecithin and sodium caseinate, but notably increased by chitosan. Read More

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September 2021

Synthesis of axially chiral biaryl thioglycosides through thiosugar-directed Pd-catalyzed asymmetric C-H activation.

Chem Commun (Camb) 2021 Sep 17. Epub 2021 Sep 17.

Université Paris-Saclay, CNRS, BioCIS, 92290, Châtenay-Malabry, France.

Herein we report for the first time that the thiosugar moiety can be used both as a directing group enabling the regioselective activation of a C-H bond of biaryl scaffolds and as a chiral source inducing axial chirality. Our approach enables the easy generation of complex thioglycoside atropoisomers, thus paving the way to new products of potential biological interest. Read More

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September 2021

Antifungal and insecticidal activities of rhein derivatives: synthesis, characterization and preliminary structure-activity relationship studies.

Nat Prod Res 2021 Sep 17:1-7. Epub 2021 Sep 17.

Hubei Engineering Technology Center for Pest Forewarning and Management, College of Agriculture, Yangtze University, Jingzhou, China.

There is an urgent need to replace highly polluting pesticides with environmentally friendly green pesticides of high efficiency and low toxicity, because of the growing concern for quality and safety of agricultural products. To discover new pesticides with diverse chemical structures from natural products, a series of rhein derivatives were designed, synthesized, and evaluated for their antifungal activity and insecticidal activity. The bioassay showed that some compounds exhibited moderate antifungal activity against , but lower activity against the other five pathogens. Read More

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September 2021

Quality assessment of Succus Bambusae oral liquids based on GC-MS fingerprints and chemometrics.

Rapid Commun Mass Spectrom 2021 Sep 17:e9200. Epub 2021 Sep 17.

College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Rationale: Succus Bambusae is consumed as a kind of herbal medicine and natural beverage in China. However, the current quality standards of Succus Bambusae are low and lack of safety indicators, which makes it difficult to effectively guarantee its quality. Therefore, it is of great significance to study the identification and quality control technology for the product. Read More

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September 2021

Analysis of hand environment factors contributing to the hand surface infection barrier imparted by lactic acid.

Skin Res Technol 2021 Sep 16. Epub 2021 Sep 16.

Personal Health Care Products Research Laboratories, Kao Corporation, Tokyo, Japan.

Background: Organic acids on the surface of human hands contribute to the barrier against transient pathogens. This is the first study to explore the synergistic contribution of lactic acid and other hand environment-related features on the antibacterial properties of the hand surface.

Materials And Methods: We estimated the contribution of fingerprint depth, skin pH, stratum corneum water content, skin temperature, and sweat rate of the hands to the infection barrier using an observational survey of 105 subjects. Read More

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September 2021

Heat shock treatment maintains the quality attributes of postharvest jujube fruits and delays their senescence process during cold storage.

J Food Biochem 2021 Sep 16:e13937. Epub 2021 Sep 16.

Hunan Provincial Key Laboratory for Fruits and Vegetables Storage Processing and Quality Safety, Hunan Agricultural Product Processing Institute, Hunan Academy of Agricultural Sciences, Changsha, China.

The effects of heat shock (HT), 1-methylcyclopropene (1-MCP), or their combination (HT + 1-MCP) on the quality of fresh jujube fruits during cold storage were studied. Among them, HT showed the best preservation effect on jujube fruits, which was more effective than others in inhibiting the increase of red index, decay incidence, and weight loss and delaying the decrease of firmness, soluble solids content (SSC), titratable acidity (TA), and ascorbic acid (AsA) content. Besides, it could delay the degradation rate of the cell wall to maintain the integrity of cell membrane, and keep the high activity of active oxygen scavenging enzymes. Read More

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September 2021

Effect of partial substitution of sodium salt on the quality of salted quail eggs.

J Food Biochem 2021 Sep 16:e13941. Epub 2021 Sep 16.

National Engineering Research Center of Seafood, School of Food Science and Technology, Dalian Polytechnic University, Dalian, PR China.

To improve the quality of salted quail eggs and solve the problem of excessive sodium content in salted eggs, we selected substitutes (K CO , CaCl , MgCl , ZnCl , and FeC H O ) to partially replace NaCl and study its effect on water migration, physicochemical properties, and textural characteristics. The low-field nuclear magnetic resonance technology (LF-NMR) was used to qualitatively analyze the moisture and proton content of quail eggs during the pickling process. The results showed that the relaxation curves of ZnCl and FeC H O7 groups were significantly different from those of other groups. Read More

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September 2021

Life cycle sustainability assessment of optimized biodiesel production from used rice bran oil employing waste derived-hydroxyapatite supported vanadium catalyst.

Environ Sci Pollut Res Int 2021 Sep 16. Epub 2021 Sep 16.

Chemical Engineering Department, Jadavpur University, Kolkata, 700032, India.

The present work encompasses the production of biodiesel from an inexpensive waste, viz., used rice bran oil (URBO) through concurrent esterification and transesterification reactions employing the prepared waste duck bone (WDB)-derived natural hydroxyapatite (NAHAp) supported vanadium impregnated solid catalyst (VNAHAp). The optimal VNAHAp catalyst possessed 92. Read More

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September 2021

Postharvest melatonin treatment inhibited longan ( Lour.) pericarp browning by increasing ROS scavenging ability and protecting cytomembrane integrity.

Food Sci Nutr 2021 Sep 5;9(9):4963-4973. Epub 2021 Jul 5.

College of Food and Biological Engineering/Institute of Food Science and Engineering Technology Hezhou University Hezhou China.

Postharvest melatonin treatments have been reported to improve the quality and storability, especially to inhibit browning in many fruits, but the effect had not been systematically investigated on longan fruit. In this study, the effect of 0.4 mM melatonin (MLT) dipping on the quality and pericarp browning of longan fruits stored at low temperature was investigated. Read More

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September 2021

Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms.

Oxid Med Cell Longev 2021 23;2021:6492346. Epub 2021 Aug 23.

Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.

Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer's disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on the bioavailability of coumarins; therefore, further investigations are necessitated to study the bioavailability of different coumarins which already showed good biological activities in previous studies. Read More

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Distinguishing feature of gut microbiota in Tibetan highland coronary artery disease patients and its link with diet.

Sci Rep 2021 Sep 16;11(1):18486. Epub 2021 Sep 16.

Department of Cardiology, Affiliated Hospital of Qinghai University, Xining, 810001, China.

The prevalence of coronary artery disease (CAD) in Tibetan Highlanders is lower than that in plain-living individuals, but the mechanism still unclear. Gut microbiota (GM) disorder is considered one of the potential factors involved in the pathogenesis of CAD, but the GM characteristics of Tibetan Highlanders suffering from CAD are unknown. We sequenced the V3-V4 region of the 16S ribosomal RNA of gut bacteria from fecal samples from Tibetan and Han CAD patients and healthy individuals inhabiting the Qinghai-Tibet Plateau, as well as from Han CAD patients and healthy individuals living at sea level, and we analyzed the GM characteristics of these subjects by bioinformatics analysis. Read More

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September 2021

Low temperature plasma irradiation products of sodium lactate solution that induce cell death on U251SP glioblastoma cells were identified.

Sci Rep 2021 Sep 16;11(1):18488. Epub 2021 Sep 16.

Center for Low-Temperature Plasma Sciences, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan.

Low-temperature plasma is being widely used in the various fields of life science, such as medicine and agriculture. Plasma-activated solutions have been proposed as potential cancer therapeutic reagents. We previously reported that plasma-activated Ringer's lactate solution exhibited selective cancer-killing effects, and that the plasma-treated L-sodium lactate in the solution was an anti-tumor factor; however, the components that are generated through the interactions between plasma and L-sodium lactate and the components responsible for the selective killing of cancer cells remain unidentified. Read More

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September 2021

Phosphorus-Containing Food Additives in the Food Supply-An Audit of Products on Supermarket Shelves.

J Ren Nutr 2021 Sep 14. Epub 2021 Sep 14.

Department of Food and Nutrition, University of Helsinki, Helsinki, Finland. Electronic address:

Objectives: Phosphorus (P)-containing food additives pose a risk for chronic kidney disease (CKD) patients. We aimed to investigate the prevalence of P-containing additives in the Finnish food supply across different food categories to evaluate their burden in CKD, reflecting the situation in Europe.

Methods: The dataset of 6,176 products was obtained in June-August 2019 from the foodie. Read More

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September 2021

Quantitative analysis of differentially expressed milk fat globule membrane proteins between donkey and bovine colostrum based on high-performance liquid chromatography with tandem mass spectrometry proteomics.

J Dairy Sci 2021 Sep 13. Epub 2021 Sep 13.

College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China; College of Bioscience and Biotechnology, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address:

This study was designed to provide novel insights into milk fat globule membrane (MFGM) proteins in donkey colostrum (DC) and bovine colostrum (BC) using quantitative proteomics. In total, 179 (DC) and 195 (BC) MFGM proteins were characterized, including 71 shared, 108 DC-specific, and 124 BC-specific proteins. Fifty-one shared proteins were selected as differentially expressed MFGM proteins, including 21 upregulated and 30 downregulated proteins in DC. Read More

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September 2021

Effects of mulberry pomace on physicochemical and textural properties of stirred-type flavored yogurt.

J Dairy Sci 2021 Sep 13. Epub 2021 Sep 13.

Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China; College of Bioscience and Bioengineering, Jiangxi Agricultural University, Nanchang, 330045, China. Electronic address:

Adding functional ingredients is an important method to develop functional dairy products. Mulberry pomace (MPo), a byproduct of mulberry fruit processing, is rich in phenolic compounds and anthocyanins and can be served as the functional ingredient in functional dairy products. The aim of this work was to prepare a functional flavored yogurt by incorporating MPo into stirred yogurt and to investigate the effects of MPo on the physicochemical and textural properties of the product during cold storage. Read More

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September 2021

Comparison of weight per volume and protein nitrogen units in non-standardized allergen extracts: implications for prescribing subcutaneous immunotherapy.

Allergy Asthma Clin Immunol 2021 Sep 16;17(1):92. Epub 2021 Sep 16.

Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Background: Allergen extracts used in subcutaneous immunotherapy can be standardized or non-standardized. Standardized extracts are available in specific biological potencies, presumably making their biological activity more consistent. The majority of allergen extracts are non-standardized and may have less consistent potencies. Read More

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September 2021

Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans.

Biotechnol Biofuels 2021 Sep 16;14(1):183. Epub 2021 Sep 16.

Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100, Copenhagen, Denmark.

Background: Endo-β-1,4-galactanases are glycoside hydrolases (GH) from the GH53 family belonging to the largest clan of GHs, clan GH-A. GHs are ubiquitous and involved in a myriad of biological functions as well as being widely used industrially. Endo-β-1,4-galactanases, in particular hydrolyse galactan and arabinogalactan in pectin, a major component of the primary plant cell wall, with important functions in plant defence and application in the food and other industries. Read More

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September 2021

Unleashing the Potential of Microbial Natural Products in Drug Discovery: Focusing on Streptomyces as Antimicrobials Goldmine.

Curr Top Med Chem 2021 Sep 16. Epub 2021 Sep 16.

Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan. China.

The natural product specialized metabolites produced by microbes and plants are the backbone of our current drugs. Ironically, we are in a golden age of understanding natural product biosynthesis, biochemistry, and engineering. These advances have the potential to usher in a new era of natural product exploration and development, taking full advantage of the unique and favorable properties of natural product compounds in drug discovery. Read More

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September 2021