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Understanding Holism in the light of principle underlying practice of Unani Medicine.

Rev Environ Health 2021 May 13. Epub 2021 May 13.

Central Council for Research in Unani Medicine, New Delhi, India.

The holistic Unani medicine is fundamentally different from the reductionist conventional medicine. It asserts the self-integration amongst its basic disciplines, without considering them underlying principles of Unani system of medicine cannot be understood. The diagnosis, selection of drugs, and plan of treatment is also overlooked. Read More

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Fire safety and emergency evacuation guidelines for intensive care units and operating theatres: for use in the event of fire, flood, power cut, oxygen supply failure, noxious gas, structural collapse or other critical incidents: Guidelines from the Association of Anaesthetists and the Intensive Care Society.

Anaesthesia 2021 May 13. Epub 2021 May 13.

Health and Safety Executive.

The need to evacuate an ICU or operating theatre complex during a fire or other emergency is a rare event but one potentially fraught with difficulty: Not only is there a risk that patients may come to harm but also that staff may be injured and unable to work. Designing newly-built or refurbished ICUs and operating theatre suites is an opportunity to incorporate mandatory fire safety features and improve the management and outcomes of such emergencies: These include well-marked manual fire call points and oxygen shut off valves (area valve service units); the ability to isolate individual zones; multiple clear exit routes; small bays or side rooms; preference for ground floor ICU location and interconnecting routes with operating theatres; separate clinical and non-clinical areas. ICUs and operating theatre suites should have a bespoke emergency evacuation plan and route map that is readily available. Read More

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A prospective cohort study of ambient air pollution exposure and risk of uterine leiomyomata.

Hum Reprod 2021 May 13. Epub 2021 May 13.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Study Question: To what extent are ambient concentrations of particulate matter <2.5 microns (PM2.5), nitrogen dioxide (NO2) and ozone (O3) associated with risk of self-reported physician-diagnosed uterine leiomyomata (UL)?

Summary Answer: In this large prospective cohort study of Black women, ambient concentrations of O3, but not PM2. Read More

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Typical Crossmodal Numerosity Perception in Preterm Newborns.

Multisens Res 2021 May 12:1-22. Epub 2021 May 12.

Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, 56128 Calambrone, Pisa, Italy.

Premature birth is associated with a high risk of damage in the parietal cortex, a key area for numerical and non-numerical magnitude perception and mathematical reasoning. Children born preterm have higher rates of learning difficulties for school mathematics. In this study, we investigated how preterm newborns (born at 28-34 weeks of gestation age) and full-term newborns respond to visual numerosity after habituation to auditory stimuli of different numerosities. Read More

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Corrigendum to "High prevalence and persistence of carbapenem and colistin resistance in livestock farm environments in China".

J Hazard Mater 2021 May 11;417:125951. Epub 2021 May 11.

Beijing Advance Innovation Center for Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.

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Effects of soil lead exposure and land use characteristics on neurodevelopment among children under 3 years of age in northern Taiwan.

Environ Pollut 2021 May 4;286:117288. Epub 2021 May 4.

School of Public Health, Taipei Medical University, Taipei, Taiwan; Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan; Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. Electronic address:

Lead (Pb) exposure increases the risks of neurodevelopmental disorders in children. Child-specific activities and land use scenarios may lead to elevated opportunities for Pb exposure through the soil. Therefore, we investigated hair and fingernail Pb concentrations among young children in northern Taiwan, in relation to soil Pb pollution and land use characteristics. Read More

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Organ and tissue-specific distribution of selected polycyclic aromatic hydrocarbons (PAHs) in ApoE-KO mouse.

Environ Pollut 2021 Apr 24;286:117219. Epub 2021 Apr 24.

State Key Laboratory of Environment Simulation, School of Environment, Beijing Normal University, No. 19 Xinjiekouwai Street, Beijing, 100875, China. Electronic address:

Polycyclic aromatic hydrocarbons (PAHs) are one of the most prevalent classes of environmental pollutants resulting from the incomplete combustion of hydrocarbons. Exposure to PAHs is implicated in the pathogenesis of the cardiovascular disease, pulmonary disease, and even cancer. However, little is known about organ- and tissue-specific distribution patterns of PAHs in animals at macro-tissue and microscopic levels. Read More

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Astaxanthin and its gold nanoparticles mitigate cadmium toxicity in rice by inhibiting cadmium translocation and uptake.

Sci Total Environ 2021 May 3;786:147496. Epub 2021 May 3.

National Key Laboratory of Rice Biology, Institute of Crop Sciences, Zhejiang University, Hangzhou, China. Electronic address:

Cadmium (Cd) is one of the main heavy metal in rice, Cd uptake by cereal crops from soil leads to toxicity in plants and pose serious health risks due to human body's accumulation through the food chain. Astaxanthin, a natural and anti-oxidative oxycarotenoid, is widely distributed in various microorganisms and seafood. In this study, we demonstrated that astaxanthin in the form of gold nanoparticles (Ast-AuNPs) can efficiently alleviate Cd toxicity to a greater extent in hydroponically grown rice plants than single astaxanthin. Read More

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A multicenter cohort study of osimertinib compared with afatinib as first-line treatment for EGFR-mutated non-small-cell lung cancer from practical dataset: CJLSG1903.

ESMO Open 2021 May 10;6(3):100115. Epub 2021 May 10.

Department of Respiratory Medicine, Matsunami General Hospital, Kasamatsu, Gifu, Japan.

Background: FLAURA, the prospective trial of osimertinib as a first-line therapy compared with first-generation epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), did not show superior survival benefit for osimertinib in either the subgroup of Asians or the subgroup with the L858R mutation. In addition, the superiority of osimertinib compared with second-generation EGFR-TKI is thus far unclear.

Patients And Methods: We reviewed the clinical data of all consecutive patients who were treated with osimertinib or afatinib as first-line therapy between May 2016 and October 2019 from 15 institutions in Japan. Read More

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Sleep in hospitalized children and adolescents: A scoping review.

Sleep Med Rev 2021 Apr 26;59:101496. Epub 2021 Apr 26.

Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet & Department of Clinical Medicine, University of Copenhagen, Denmark.

Hospitalized children and adolescents are at risk of short sleep and subsequent adverse health effects, but little is known about actual sleep duration, the factors that cause sleep disturbances in an inpatient pediatric setting, and what has been done to promote sleep in this population. The aim of this review was to systematically identify, categorize, and synthesize the literature on sleep in children and adolescents in an inpatient setting. We searched five electronic databases (PubMed, CENTRAL, CINAHL, PsycINFO, and Scopus) and of the 3770 references identified, 28 were eligible for inclusion. Read More

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"A decade's worth of work in a matter of days": The journey to telehealth for the whole population in Australia.

Int J Med Inform 2021 May 7;151:104483. Epub 2021 May 7.

Australian Government Department of Health, Australia.

Introduction: Internationally the COVID-19 pandemic has triggered a dramatic and unprecedented shift in telehealth uptake as a means of protecting healthcare consumers and providers through remote consultation modes. Early in the pandemic, Australia implemented a comprehensive and responsive set of policy measures to support telehealth. Initially targeted at protecting vulnerable individuals, including health professionals, this rapidly expanded to a "whole population" approach as the pandemic evolved. Read More

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Proton beam therapy for children and adolescents and young adults (AYAs): JASTRO and JSPHO Guidelines.

Cancer Treat Rev 2021 Apr 16;98:102209. Epub 2021 Apr 16.

Department of Orthopaedic Oncology, Shizuoka Cancer Center Hospital, Nagaizumi, Shizuoka, Japan.

Children and adolescents and young adults (AYAs) with cancer are often treated with a multidisciplinary approach. This includes use of radiotherapy, which is important for local control, but may also cause adverse events in the long term, including second cancer. The risks for limited growth and development, endocrine dysfunction, reduced fertility and second cancer in children and AYAs are reduced by proton beam therapy (PBT), which has a dose distribution that decreases irradiation of normal organs while still targeting the tumor. Read More

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Biomarkers of poly- and perfluoroalkyl substances (PFAS) in Sub-Arctic and Arctic communities in Canada.

Int J Hyg Environ Health 2021 May 10;235:113754. Epub 2021 May 10.

School of Public Health and Health Systems, Faculty of Applied Health Sciences, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada. Electronic address:

Polyfluoroalkyl substances and perfluoroalkyl substances (PFAS) are a family of anthropogenic chemicals that are used in food packaging, waterproof clothing, and firefighting foams for their water and oil resistant properties. Though levels of some PFAS appear to be decreasing in Canada's south, environmental levels have been increasing in the Arctic due to long-range transport. However, the implications of this on human exposures in sub-Arctic and Arctic populations in Canada have yet to be established. Read More

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Quality of life after sepsis and its association with mortality among sepsis survivors in South Korea: A population level cohort study.

J Crit Care 2021 May 3;64:193-198. Epub 2021 May 3.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

Purpose: This study aimed to investigate the incidence and effect of quality of life (QOL) change in Korean sepsis survivors.

Materials And Methods: Using the National Health Insurance claim database of South Korea, we included adult sepsis survivors who were primarily diagnosed with sepsis between 2010 and 2018 and survived for more than 1 year after diagnosis. QOL change was defined using three criteria: decrease in annual income level, newly acquired disability, and increase in underlying comorbidities after sepsis. Read More

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The Burden of Caring for and Treating Glaucoma: The Patient Perspective.

Ophthalmol Glaucoma 2021 May 10. Epub 2021 May 10.

Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA; Center for Eye Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA.

Purpose: To understand the treatment burden experienced by patients receiving care for primary open-angle glaucoma.

Design: Semi-structured, one-on-one, qualitative interviews PARTICIPANTS: Patients with primary open-angle glaucoma and age ≥40 who were scheduled for a follow-up glaucoma appointment at the Kellogg Eye Center (Ann Arbor, Michigan, USA). Researchers used purposeful sampling to ensure that there was representation of a range of ages, disease stages, total number of medical conditions, distance traveled to clinic, history of prior glaucoma surgery, employment, and education. Read More

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Burosumab treatment for fibrous dysplasia.

Bone 2021 May 10:116004. Epub 2021 May 10.

Metabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Background: Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare mosaic disorder of Gα activation. Fibroblast Growth Factor 23 (FGF23)-mediated hypophosphatemia is a feature of FD/MAS that has been associated with poor skeletal outcomes. Standard therapy includes oral phosphorus and vitamin D analogs; however, treatment is limited by potential adverse renal and gastrointestinal effects. Read More

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Ambulatory activity in stroke survivors associated with functional outcome and quality of life: an observational cohort study.

Ann Phys Rehabil Med 2021 May 10:101540. Epub 2021 May 10.

The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia; Department of Neurology, Austin Health, Heidelberg, Victoria, Australia.

Background: Physical activity is beneficial in stroke prevention and recovery. Understanding activity dynamics and its effect on outcome after stroke is important to improve recommendations and develop interventions.

Objectives: We examined serial changes in daily ambulatory activity (AA) averaged over 1 week in people with subacute to chronic stroke and its association with functional outcome (modified Rankin scale [mRS]) and quality of life (EQ-5D-3L). Read More

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Navigated repetitive transcranial magnetic stimulation improves the outcome of postsurgical paresis in glioma patients - A randomized, double-blinded trial.

Brain Stimul 2021 May 10. Epub 2021 May 10.

Department of Neurosurgery, Technical University of Munich, Germany, School of Medicine, Klinikum Rechts der Isar, Germany; TUM Neuroimaging Center, Technical University of Munich, Germany, School of Medicine, Klinikum Rechts der Isar, Germany. Electronic address:

Background: Navigated repetitive transcranial magnetic stimulation (nrTMS) is effective therapy for stroke patients. Neurorehabilitation could be supported by low-frequency stimulation of the non-damaged hemisphere to reduce transcallosal inhibition.

Objective: The present study examines the effect of postoperative nrTMS therapy of the unaffected hemisphere in glioma patients suffering from acute surgery-related paresis of the upper extremity (UE) due to subcortical ischemia. Read More

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Residential proximity to tree canopy and preterm birth in black women.

Am J Obstet Gynecol MFM 2021 May 10:100391. Epub 2021 May 10.

Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI; Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI. Electronic address:

Objective: There are significant racial disparities in obstetric outcomes with the incidence of preterm birth (PTB) being the highest in non-Hispanic black women. The presence of green space, such as forests and parks, is now widely viewed as a health-promoting characteristic of residential environments. The objective of this study was to examine the association between proximity of tree canopy to a prenatal residential address and the rates of PTB in non-Hispanic black women in Milwaukee, WI. Read More

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Real-life experience with ceftolozane/tazobactam in Canada; results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry.

J Glob Antimicrob Resist 2021 May 10. Epub 2021 May 10.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Objectives: Ceftolozane/tazobactam is a cephalosporin/β-lactamase inhibitor combination with activity against Gram-negative bacilli. We report the use of ceftolozane/tazobactam in Canada using a national registry.

Methods: The CLEAR registry uses REDCap (Research Electronic Data Capture) (online survey, https://is. Read More

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Masculinity and misinformation: Social dynamics of liver fluke infection risk in Thailand.

Parasitol Int 2021 May 10:102382. Epub 2021 May 10.

Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Thailand.

Liver fluke infection through the consumption of raw or undercooked freshwater fish is a major public health problem in the Mekong Region. Despite the extensive efforts of liver fluke health campaigns, Northeast Thailand still reports high human infection prevalence as consumption of raw fish dishes has diminished but not ceased. This study examines the roles of social-cultural factors, particularly the influences of masculinity and misinformation, on liver fluke infection risk. Read More

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Trends in Pediatric Primary Care Visits during the COVID-19 Pandemic.

Acad Pediatr 2021 May 10. Epub 2021 May 10.

Department of Pediatrics, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. Electronic address:

Objective: Months after the declaration of the COVID-19 national emergency, visits among children remained suppressed for unclear reasons, which we sought to understand by examining child visit rates.

Methods: Using de-identified claims data for children <18 years old from OptumLabs® Data Warehouse, a large commercial claims database, we compared monthly primary care visit and vaccination rates from January-October 2020 to January-October 2018 and 2019. Visit rates were analyzed by visit reason and by the month after (e. Read More

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Guidelines that use the GRADE approach often fail to provide complete economic information for recommendations: a Systematic Survey.

J Clin Epidemiol 2021 May 10. Epub 2021 May 10.

Michael G. DeGroote Cochrane Canada and McMaster GRADE Centres, Hamilton, Ontario, Canada; Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Ontario, Canada; Department of Medicine, Hamilton, Ontario, Canada.

Objective: Little is known about how developers and panel members report cost and cost effectiveness considerations in GRADE guideline Evidence-to-Decision (EtD) frameworks. A systematic survey was conducted to explore approaches and factors contributing to variability in economic information reporting.

Study Design And Setting: Guideline organization websites were systematically searched to create a convenience sample of guidelines. Read More

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Outbreak investigation of symptomatic SARS-COV-2 VOC 202012/01-lineage B.1.1.7 infection in healthcare workers, Italy.

Clin Microbiol Infect 2021 May 10. Epub 2021 May 10.

Department of Biomedical Sciences and Human Oncology-Hygiene Section, University of Bari, Bari, Italy. Electronic address:

Objectives: In December 2020, Italy began a national immunization campaign using the BNT162b2 mRNA COVID-19 vaccine, prioritizing healthcare workers (HCWs). Immune serum from vaccinated subjects seems to (largely) retain titres of neutralizing antibodies, even against SARS-CoV-2 VOC 202012/01-lineage B.1. Read More

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In vivo fitness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains in murine infection is associated with treatment failure in human infections.

Clin Microbiol Infect 2021 May 10. Epub 2021 May 10.

Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, National Institute for Antibiotic Resistance and Infection Control, Israel Ministry of Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Mortality among patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections varies between studies. We examined whether in vivo fitness of CRAB strains is associated with clinical outcomes in patients with CRAB infections.

Methods: Isolates were collected from patients enrolled in the AIDA trial with hospital-acquired pneumonia, bloodstream infections, and/or urinary tract infections caused by CRAB. Read More

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Initial Clinical Trial of A Novel Pulmonary Valved Conduit.

Semin Thorac Cardiovasc Surg 2021 May 10. Epub 2021 May 10.

Department of Cardiac Surgery, University Hospital, University of Zürich, Switzerland.

Valved allografts and xenografts for reconstruction of the right ventricular outflow tract (RVOT) lack durability and do not grow. We report the first clinical use of a completely bioabsorbable valved conduit (Xeltis pulmonary valve - XPV) in children. Twelve children (six male), median age five (two to twelve) years and median weight 17 (10 to 43) kg, underwent RVOT reconstruction with the XPV. Read More

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Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases.

Bioorg Med Chem Lett 2021 May 10:128099. Epub 2021 May 10.

Research Institute for Medical and Health sciences, University of Sharjah, P.O. Box 27272, Sharjah, UAE; College of Pharmacy, University of Sharjah, P.O. Box 27272, Sharjah, UAE. Electronic address:

SARS-CoV-2 caused dramatic health, social and economic threats to the globe. With this threat, the expectation of future outbreak, and the shortage of anti-viral drugs, scientists were challenged to develop novel antivirals. The objective of this study is to develop novel anti-SARS-CoV-2 compounds with dual activity by targeting valuable less-mutated enzymes. Read More

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Huprine Y - tryptophan heterodimers with potential implication to Alzheimer's disease treatment.

Bioorg Med Chem Lett 2021 May 10:128100. Epub 2021 May 10.

Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic; Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic. Electronic address:

The search for novel and effective therapeutics for Alzheimer's disease (AD) is the main quest that remains to be resolved. The goal is to find a disease-modifying agent able to confront the multifactorial nature of the disease positively. Herewith, a family of huprineY-tryptophan heterodimers was prepared, resulting in inhibition of cholinesterase and neuronal nitric oxide synthase enzymes, with effect against amyloid-beta (Aβ) and potential ability to cross the blood-brain barrier. Read More

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Sarcopenia is independently associated with parietal atrophy in older adults.

Exp Gerontol 2021 May 10:111402. Epub 2021 May 10.

Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Division of Neurology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Pharmacy, Tajen University, Pingtung, Taiwan. Electronic address:

Introduction: As populations age, sarcopenia becomes a major health problem among adults aged 65 years and older. However, little information is available about the relationship between sarcopenia and brain structure abnormalities. The objective of this study was to investigate associations between sarcopenia and brain atrophy in older adults and relationships with regional brain areas. Read More

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Kidney-Related Research in the United States: A Position Statement From the National Kidney Foundation and the American Society of Nephrology.

Am J Kidney Dis 2021 May 10. Epub 2021 May 10.

Department of Medicine, Division of Nephrology and Hypertension, Beth Israel Deaconess Medical Center, Boston MA,; Departments of Public Health Science and Medicine, Loyola University Chicago, Maywood, IL and Edward Hines VA Medical Center, Hines, IL. Electronic address:

Kidney disease is an important U.S. public health problem because it affects over 37 million Americans, and Medicare expenditures for patients with chronic kidney disease now alone exceed 130 billion dollars annually. Read More

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