5,156 results match your criteria nanoparticles rapidly

Application of Artificial Neural Network as a nonhazardous alternative on kinetic analysis and modeling for green synthesis of cobalt nanocatalyst from Ocimum tenuiflorum.

J Hazard Mater 2021 Mar 24;416:125720. Epub 2021 Mar 24.

Department of Applied Science and Technology, Alagappa College of Technology, Anna University, Chennai 600025, India.

The present paper is dedicated to analyze non-hazardous kinetic behaviour and modelling of green synthesized cobalt nanocatalyst (CoNCs), using an Artificial Neural Network (ANN). In order to supplement the trace metal in other applications, CoNCs were rapidly synthesized with a Cobalt sulphate solution at room temperature between 30 and 35 ºC at pH 7.2 under less reaction time. Read More

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Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates.

NPJ Vaccines 2021 Apr 9;6(1):50. Epub 2021 Apr 9.

Duke Human Vaccine Institute, Duke School of Medicine, Durham, NC, USA.

The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and are being tested for SARS-CoV-2 in humans. A critical question is how mRNA-LNP vaccine immunogenicity compares to that of traditional adjuvanted protein vaccines in primates. Read More

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Time-connectivity superposition and the gel/glass duality of weak colloidal gels.

Proc Natl Acad Sci U S A 2021 Apr;118(15)

Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Direction des Énergies, Institut des Sciences et Technologies pour une Economie Circulaire des Énergies bas Carbone, Département de Recherche sur les Technologies pour l'Enrichissement, le Démantèlement et les Déchets, Service d'Études des Technologies pour l'Assainissement-Démantèlement et l'Étanchéité, Laboratoire d'Études des Ciments et Bitumes pour le Conditionnement, Université Montpellier, 30207 Bagnols-sur-Cèze, France.

Colloidal gels result from the aggregation of Brownian particles suspended in a solvent. Gelation is induced by attractive interactions between individual particles that drive the formation of clusters, which in turn aggregate to form a space-spanning structure. We study this process in aluminosilicate colloidal gels through time-resolved structural and mechanical spectroscopy. Read More

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In vitro evaluation of curcumin-loaded chitosan-hydroxyapatite nanocarriers as a potential system for effective treatment of cancer.

J Biomater Sci Polym Ed 2021 Apr 6:1-16. Epub 2021 Apr 6.

Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Alborz, Iran.

Nanotechnology has many potential applications in cancer treatment. For example, nano-drug delivery systems (NDDS) with high bioavailability, biodegradability, and biocompatibility have been developed, in order to increase the therapeutic effects of anti-cancer drugs. Among these NDDS, high-performance hydroxyapatite nanoparticles are rapidly advancing in the targeted cancer treatment due to their numerous benefits. Read More

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Antioxidant thioether core-crosslinked nanoparticles prevent the bilateral spread of secondary injury to protect spatial learning and memory in a controlled cortical impact mouse model of traumatic brain injury.

Biomaterials 2021 Mar 22;272:120766. Epub 2021 Mar 22.

Department of Biological Systems Engineering, University of Nebraska - Lincoln, 200LW Chase Hall, Lincoln, NE, 68583, USA. Electronic address:

The secondary phase of traumatic brain injury (TBI) is partly caused by the release of excess reactive oxygen species (ROS) from the primary injury. However, there are currently no therapies that have been shown to reduce the secondary spread of injury beyond the primary insult. Nanoparticles offer the ability to rapidly accumulate and be retained in injured brain for improved target engagement. Read More

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Predictive modelling of hypoxic head and neck cancers during fractionated radiotherapy with gold nanoparticle radiosensitisation.

Med Phys 2021 Apr 5. Epub 2021 Apr 5.

Department of Physics, University of Adelaide, North Terrace, Adelaide, South Australia, Australia.

Purpose: Intrinsic radioresistance and increased proliferation rates in head and neck cancers (HNCs) are associated with negative radiotherapy (RT) treatment responses. The use of gold nanoparticles (AuNPs) as radiosensitisers could enable total radiation dose reduction and lowered radiation-toxicity. AuNP radiosensitisation may overcome hypoxia-induced radioresistence and treatment-induced accelerated repopulation of cancer cells in HNCs, improving radiotherapy outcomes. Read More

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Silver nanoparticles: synthesis, characterisation and biomedical applications.

Ahmad Almatroudi

Open Life Sci 2020 19;15(1):819-839. Epub 2020 Nov 19.

Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah, 51452, Saudi Arabia.

Nanotechnology is a rapidly growing field due to its unique functionality and a wide range of applications. Nanomedicine explores the possibilities of applying the knowledge and tools of nanotechnology for the prevention, treatment, diagnosis and control of disease. In this regard, silver nanoparticles with diameters ranging from 1 to 100 nm are considered most important due to their unique properties, ability to form diverse nanostructures, their extraordinary range of bactericidal and anticancer properties, wound healing and other therapeutic abilities and their cost-effectiveness in production. Read More

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November 2020

Untargeted analysis of pure snail slime and snail slime-induced Au nanoparticles metabolome with MALDI FT-ICR MS.

J Mass Spectrom 2021 May;56(5):e4722

Dipartimento di Scienze, Università degli Studi della Basilicata, Potenza, Italy.

Chronic wounds result from the failure of the normal wound healing process. Any delay during the tissue repair process could be defined as chronic wound healing, potentially having a highly detrimental impact on human health. To face this problem, in the last years, the use of different technologies alternative to therapeutic agents is gaining more attention. Read More

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Biocompatible valproic acid-coupled nanoparticles attenuate lipopolysaccharide-induced inflammation.

Int J Pharm 2021 Apr 1:120567. Epub 2021 Apr 1.

Institute of Biochemistry and Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University of Jena, Hans-Knöll-Straße 2, 07745 Jena, Germany. Electronic address:

Inflammatory diseases like sepsis are associated with dysregulated gene expression, often caused by an imbalance of epigenetic regulators, such as histone acetyltransferases (HATs) and histone deacetylases (HDACs), and consequently, altered epigenetic chromatin signatures or aberrant posttranslational modifications of signalling proteins and transcription factors. Thus, HDAC inhibitors (HDACi) are a promising class of anti-inflammatory drugs. Recently, an efficient drug delivery system carrying the class I/IIa selective HDACi valproic acid (VPA) was developed to circumvent common disadvantages of free drug administration, e. Read More

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Reactive oxygen species and glutathione dual responsive nanoparticles for enhanced prostate cancer therapy.

Mater Sci Eng C Mater Biol Appl 2021 Apr 11;123:111956. Epub 2021 Feb 11.

Department of Urology, Kidney and Urology Center, Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China. Electronic address:

Docetaxel (DTX)-based chemotherapy of prostate cancer is still confronted with significant challenges due to insufficient drug accumulation at the tumor sites and the systemic side effects on normal cells and organs. Tumor microenvironment-responsive nanosized drug delivery systems have shown enormous potential to improve the anticancer efficacy and minimize the systemic side effects of chemotherapeutics. However, most of the currently redox-responsive nanoparticles respond only to single stimuli, which compromise the treatment effect. Read More

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LipoParticles: Lipid-Coated PLA Nanoparticles Enhanced In Vitro mRNA Transfection Compared to Liposomes.

Pharmaceutics 2021 Mar 12;13(3). Epub 2021 Mar 12.

UMR 5305: Laboratoire de Biologie Tissulaire et d'Ingénierie Thérapeutique, Institut de Biologie et Chimie des Protéines, CNRS/Université Claude Bernard Lyon 1, 7 passage du Vercors, CEDEX 07, 69367 Lyon, France.

The approval of two mRNA vaccines as urgent prophylactic treatments against Covid-19 made them a realistic alternative to conventional vaccination methods. However, naked mRNA is rapidly degraded by the body and cannot effectively penetrate cells. Vectors capable of addressing these issues while allowing endosomal escape are therefore needed. Read More

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Experimental Evolution of Magnetite Nanoparticle Resistance in .

Nanomaterials (Basel) 2021 Mar 19;11(3). Epub 2021 Mar 19.

Department of Biology, North Carolina A&T State University, Greensboro, NC 27411, USA.

Both ionic and nanoparticle iron have been proposed as materials to control multidrug-resistant (MDR) bacteria. However, the potential bacteria to evolve resistance to nanoparticle bacteria remains unexplored. To this end, experimental evolution was utilized to produce five magnetite nanoparticle-resistant (FeNP) populations of . Read More

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Therapeutic Potential of Green Synthesized Copper Nanoparticles Alone or Combined with Meglumine Antimoniate (Glucantime) in Cutaneous Leishmaniasis.

Nanomaterials (Basel) 2021 Mar 31;11(4). Epub 2021 Mar 31.

Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad 68149-93165, Iran.

Background: In recent years, the focus on nanotechnological methods in medicine, especially in the treatment of microbial infections, has increased rapidly.

Aim: The present study aims to evaluate in vitro and in vivo antileishmanial effects of copper nanoparticles (CuNPs) green synthesized by fruit extract alone and combined with meglumine antimoniate (MA).

Methods: CuNPs were green synthesized by methanolic extract. Read More

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Artificial Neural Network-Based Prediction of the Optical Properties of Spherical Core-Shell Plasmonic Metastructures.

Nanomaterials (Basel) 2021 Mar 4;11(3). Epub 2021 Mar 4.

Department of Electrical and Computer Engineering, University of Alberta, 9211-116 St, Edmonton, AB T6G 1H9, Canada.

The substitution of time- and labor-intensive empirical research as well as slow finite difference time domain (FDTD) simulations with revolutionary techniques such as artificial neural network (ANN)-based predictive modeling is the next trend in the field of nanophotonics. In this work, we demonstrated that neural networks with proper architectures can rapidly predict the far-field optical response of core-shell plasmonic metastructures. The results obtained with artificial neural networks are comparable with FDTD simulations in accuracy but the speed of obtaining them is between 100-1000 times faster than FDTD simulations. Read More

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Fate of β-Carotene within Loaded Delivery Systems in Food: State of Knowledge.

Antioxidants (Basel) 2021 Mar 10;10(3). Epub 2021 Mar 10.

Department of Agriculture and Environmental Sciences, National Institute of Food Technology Entrepreneurship and Management, Kundli, Sonepat 131 028, Haryana, India.

Nanotechnology has opened new opportunities for delivering bioactive agents. Their physiochemical characteristics, i.e. Read More

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Plasma Synthesis of Advanced Metal Oxide Nanoparticles and Their Applications as Transparent Conducting Oxide Thin Films.

Molecules 2021 Mar 7;26(5). Epub 2021 Mar 7.

Department of Metallurgical Engineering, University of Utah, Salt Lake City, UT 84112, USA.

This article reviews and summarizes work recently performed in this laboratory on the synthesis of advanced transparent conducting oxide nanopowders by the use of plasma. The nanopowders thus synthesized include indium tin oxide (ITO), zinc oxide (ZnO) and tin-doped zinc oxide (TZO), aluminum-doped zinc oxide (AZO), and indium-doped zinc oxide (IZO). These oxides have excellent transparent conducting properties, among other useful characteristics. Read More

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Study on the Technology of Monodisperse Droplets by a High-Throughput and Instant-Mixing Droplet Microfluidic System.

Materials (Basel) 2021 Mar 7;14(5). Epub 2021 Mar 7.

State Key Laboratory of New Ceramics and Fine Processing, Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing 100084, China.

In this study, we report a novel high-throughput and instant-mixing droplet microfluidic system that can prepare uniformly mixed monodisperse droplets at a flow rate of mL/min designed for rapid mixing between multiple solutions and the preparation of micro-/nanoparticles. The system is composed of a magneton micromixer and a T-junction microfluidic device. The magneton micromixer rapidly mixes multiple solutions uniformly through the rotation of the magneton, and the mixed solution is sheared into monodisperse droplets by the silicone oil in the T-junction microfluidic device. Read More

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Solar-Assisted, Fast, and Recovery of Crude Oil Spill by a Superhydrophobic and Photothermal Sponge.

ACS Appl Mater Interfaces 2021 Apr 1. Epub 2021 Apr 1.

Institute of Nano and Biopolymeric Materials, Department of Polymeric Materials, Key Laboratory of Advanced Civil Engineering Materials (Ministry of Education), School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai 201804, China.

Development of a functional sorbent for effective crude oil absorption is essential to address large-scale spilling incidents. Herein, we demonstrate a facile method for preparing a superhydrophobic and photothermal PDMS/CuS/PDA@MF sponge through sequential depositions of PDA, CuS nanoparticles, and a PDMS layer onto a melamine sponge. The optimized composite sponge exhibits a superhydrophobic surface property, high absorption capacity for oils, robust recycling, and excellent photothermal conversion performance. Read More

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Dasatinib self-assembled nanoparticles decorated with hyaluronic acid for targeted treatment of tumors to overcome multidrug resistance.

Drug Deliv 2021 Dec;28(1):670-679

School of Pharmacy, Bengbu Medical College, Bengbu, China.

Multidrug resistance (MDR) and lack of targeting specificity are the main reasons why traditional drug therapies fail and produce toxic side effects in cancer chemotherapy. In order to increase targeting specificity and maximize therapeutic efficacy, new intelligent drug delivery systems are needed. In this study, we prepared the hyaluronic acid (HA) conjugated dasatinib (DAS) and D-α-tocopherol acid polyethylene glycolsuccinate (TPGS) copolymer nanoparticles (THD-NPs). Read More

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December 2021

Determination of Organochlorine Pesticides in Green Leafy Vegetable Samples via FeO Magnetic Nanoparticles Modified QuEChERS Integrated to Dispersive Liquid-Liquid Microextraction Coupled with Gas Chromatography-Mass Spectrometry.

J Anal Methods Chem 2021 13;2021:6622063. Epub 2021 Mar 13.

College of Chemistry and Chemical Engineering, Xingtai University, Xingtai 054001, China.

A fast method based on FeO magnetic nanoparticles (FeO MNPs) modified QuEChERS integrated to dispersive liquid-liquid microextraction (DLLME) coupled with gas chromatography-mass spectrometry was established for the determination of 8 organochlorine pesticides (OCPs) in green leafy vegetables. The factors involved in the purification by QuEChERS and concentration by DLLME were optimized. In the QuEChERS process, FeO MNPs were used as a new impurity adsorbent after the sample extraction procedure by acetonitrile, which achieved phase separation rapidly. Read More

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Synergistic and On-Demand Release of Ag-AMPs Loaded on Porous Silicon Nanocarriers for Antibacteria and Wound Healing.

ACS Appl Mater Interfaces 2021 Mar 31. Epub 2021 Mar 31.

Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.

Due to the abuse of antibiotics, antimicrobial resistance is rapidly emerging and becoming a major global risk for public health. Thus, there is an urgent need for reducing the use of antibiotics, finding novel treatment approaches, and developing controllable release systems. In this work, a dual synergistic antibacterial platform with on-demand release ability based on silver nanoparticles (AgNPs) and antimicrobial peptide (AMP) coloaded porous silicon (PSi) was developed. Read More

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Conclusion and Perspective.

Adv Exp Med Biol 2021 ;1309:289-292

Department of Bioscience and Biotechnology, Konkuk University, Seoul, South Korea.

Nanotechnology is a rapidly growing area of development by numerous research groups across the world with its potential applications gaining recognition since the 1950s across various fields. During the last decade of the twentieth century, researchers have actively engaged in the synthesis of nanoparticles and investigation of their physicochemical properties. Advancing the research momentum forward at the beginning of the twenty-first century, rapid development of nanoscience allowed to demonstrate unprecedented advantages of the nanomaterials and its applications in a wide range of fields. Read More

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Entrapment of nano-ZnO into alginate/polyvinyl alcohol beads with different crosslinking ions for fertilizer applications.

Int J Biol Macromol 2021 Mar 27;181:349-356. Epub 2021 Mar 27.

Sustainable Infrastructure Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand; Department of Chemical Engineering, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address:

Zinc oxide nanoparticles (nano-ZnO) are attractive as fertilizer materials but high concentrations may negatively affect the environment. To reduce their dispersion in the environment we entrapped nano-ZnO in biodegradable polymer beads consisting of alginate and polyvinyl alcohol (PVA). The alginate/PVA/ZnO beads were prepared via ionotropic gelation using two different crosslinking ions (Ca and Zn), and the effect of alginate crosslinking ion and PVA content on bead structure, water absorption, water retention and zinc release was investigated. Read More

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Microwave-assisted synthesis of hierarchically porous CoO/rGO nanocomposite for low-temperature acetone detection.

J Colloid Interface Sci 2021 Mar 15;594:690-701. Epub 2021 Mar 15.

The State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address:

Acetone sensors with high response and excellent selectivity are of enormous demand for monitoring the diabetes. This paper has reported a novel porous 3D hierarchical CoO/rGO nanocomposite synthesized by a microwave-assisted method, by which CoO nanoparticles are rapidly and uniformly anchored on rGO nanosheets. The phase composition, surface morphology of the CoO/rGO composites and the effect of rGO on their acetone-sensing performance were systematically investigated. Read More

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Green synthesis of metal nanoparticles using microorganisms and their application in the agrifood sector.

J Nanobiotechnology 2021 Mar 26;19(1):86. Epub 2021 Mar 26.

Department of Industrial Environmental and Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), P.O.BOX: 14155-6343, 1497716316, Tehran, Iran.

The agricultural sector is currently facing many global challenges, such as climate change, and environmental problems such as the release of pesticides and fertilizers, which will be exacerbated in the face of population growth and food shortages. Therefore, the need to change traditional farming methods and replace them with new technologies is essential, and the application of nanotechnology, especially green technology offers considerable promise in alleviating these problems. Nanotechnology has led to changes and advances in many technologies and has the potential to transform various fields of the agricultural sector, including biosensors, pesticides, fertilizers, food packaging and other areas of the agricultural industry. Read More

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Facile fabrication and characterization of kraft lignin@FeO nanocomposites using pH driven precipitation: Effects on increasing lignin content.

Int J Biol Macromol 2021 Mar 22;181:313-321. Epub 2021 Mar 22.

Department of Chemical and Materials Engineering, University of Dayton, 300 College Park, Dayton, OH 45469-0256, USA; Integrative Science and Engineering Center, University of Dayton, 300 College Park, Dayton, OH 45469, USA. Electronic address:

This work offers a facile fabrication method for lignin nanocomposites through the assembly of kraft lignin onto magnetic nanoparticles (FeO) based on pH-driven precipitation, without needing organic solvents or lignin functionalization. Kraft lignin@FeO multicore nanocomposites fabrication proceeded using a simple, pH-driven precipitation technique. An alkaline solution for kraft lignin (pH 12) was rapidly injected into an aqueous-based FeO nanoparticle colloidal suspension (pH 7) under constant mixing conditions, allowing the fabrication of lignin magnetic nanocomposites. Read More

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