235,439 results match your criteria nanoparticles


Tumor vasculature-targeting PEGylated peptide-drug conjugate prodrug nanoparticles improve chemotherapy and prevent tumor metastasis.

Eur J Med Chem 2021 Apr 5;219:113430. Epub 2021 Apr 5.

China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology Tianjin University of Science and Technology, No.29 of 13 th Avenue, TEDA, Tianjin, 300457, PR China. Electronic address:

Metastasis is the main cause of death in cancer patients; therefore, new strategies or technologies that can inhibit the growth of primary tumors and their metastatic spread are extremely valuable. In this study, we selected an E-selectin-binding peptide as a targeting ligand and an inhibitor of metastasis, and conjugated this peptide with SN38 and PEG to produce an amphiphilic PEGylated peptide-drug conjugate (PDC). Novel self-assembled nanoparticles were then formed by the amphiphilic conjugate. Read More

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Multifunctional nanoparticles as theranostic agents for therapy and imaging of breast cancer.

J Photochem Photobiol B 2020 Dec 29;218:112110. Epub 2020 Dec 29.

Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, Toronto, ON M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, Toronto, ON, M5B 1T8, Canada; Department of Physics, Ryerson University, Toronto, ON M5B 2K3, Canada. Electronic address:

Over the last decade, there has been significant developments in nanotechnology, in particular for combined imaging and therapeutic applications (theranostics). The core or shell of nanoemulsions (NEs) can be loaded with various therapeutic agents, including drugs with low solubility for effective treatment, or various imaging agents for specific imaging modalities (e.g. Read More

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December 2020

Corrigendum to 'Silver nanoparticles synthesis from Bacillus sp KFU36 and its anticancer effect in breast cancer MCF-7 cells via induction of apoptotic mechanism' [Journal of Photochemistry and Photobiology B: Biology, Volume 204, March 2020, 111786].

J Photochem Photobiol B 2021 Apr 14;218:112190. Epub 2021 Apr 14.

Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Saudi Arabia; Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt. Electronic address:

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CuO, ZnO, and γ-FeO nanoparticles modified the underground biomass and rhizosphere microbial community of Salvia miltiorrhiza (Bge.) after 165-day exposure.

Ecotoxicol Environ Saf 2021 Apr 14;217:112232. Epub 2021 Apr 14.

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China; Key Lab of Chinese Medicine Resources Conservation, National Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China; Engineering Research Center of Chinese Medicine Resource, Ministry of Education, Beijing 100193, China. Electronic address:

To investigate whether metal oxide nanoparticles exhibit toxicity or positive effects on medicinal plants, CuO, ZnO, and γ-FeO nanoparticles (NPs), at concentrations of 100 and 700 mg kg were introduced into the cultivation of Salvia miltiorrhiza (Bge.). Metal elemental contents, chemical constituents, biomass and the structure of the rhizosphere microbial community was used to estimate this effect. Read More

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Multifunctional ZnO@CuS nanoparticles cluster synergize chemotherapy and Photothermal therapy for tumor metastasis.

Nanomedicine 2021 Apr 14:102399. Epub 2021 Apr 14.

School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:

The poor drug delivery and unsatisfying therapeutic effects remain to be the primary challenges for cancer therapy. Nanosystem that combines multiple functions into a single platform is an ideal strategy. Here, a smart drug delivery nanoplatform (Z@C-D/P) based on ZnO@CuS nanoparticles, loaded with doxorubicin (DOX) and pirfenidone (PFD) was constructed. Read More

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A small molecule nanodrug consisting of pH-sensitive ortho ester-dasatinib conjugate for cancer therapy.

Eur J Pharm Biopharm 2021 Apr 14. Epub 2021 Apr 14.

Engineering Research Center for Biomedical Materials, School of Life Science, Anhui University, 111 Jiulong Road, Hefei, Anhui Province 230601, P. R. China. Electronic address:

The main objective of this paper is to develop a self-delivered prodrug system with nanoscale characteristics to enhance the efficacy of tumor therapy. The pH-sensitive prodrug was composed of ortho ester-linked dasatinib (DAS-OE), which was further self-assembled with or without doxorubicin (DOX) to obtain two carrier-free nanoparticles (DOX/DAS-OE NPs or DAS-OE NPs). The prodrug-based nanoparticles united the superiorities of small molecules and nano-assemblies together and displayed well-defined structure, uniform spherical shape, high drug loading ratio and on-demand drug release behavior. Read More

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Preparation of cellulose based wipes treated with antimicrobial and antiviral silver nanoparticles as novel effective high-performance coronavirus fighter.

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

Spinning and Weaving Engineering Department, Textile Industries Research Division, National Research Centre, 33 El Bohouth St., Dokki, P.O. 12622, Cairo, Egypt.

Coronaviruses (CoV) are a large family of viruses that cause illness ranging from the common cold to more severe diseases such as Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). We successful to prepare disinfectant cellulose-based wipes treated with antimicrobial and antiviral silver nanoparticles to be used for prevention of contamination and transmission of several pathogenic viruses and microbes to human in critical areas such as hospitals and healthcare centers especially coronavirus. In this work, the antimicrobial and antiviral activities of silver nanoparticles (AgNPs) prepared with four different techniques were investigated for the utilization as a disinfectant for cellulose-based wipes. Read More

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Green synthesis of bio-functionalized nano-particles for the application of copper removal - Characterization and modeling studies.

Environ Res 2021 Apr 14:111140. Epub 2021 Apr 14.

Environmental Engineering Laboratory, Department of Chemical Engineering, Annamalai University, Annamalai nagar - 608002, Tamilnadu, India.

Green technology for the synthesis of nanoparticles has gained momentum due to its cost-effectiveness and eco-friendly nature. In this research study, silver nanoparticles (AgNps) were synthesized using an eco-friendly biological method involving the use of marine algae, Halimeda gracilis. The surface properties of the synthesized silver nanoparticles were studied using UV-visible spectroscopy, Fourier transform infrared spectroscopy and scanning electron microscopy methods. Read More

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Polymeric lipid hybrid nanoparticles as a delivery system enhance the antitumor effect of Emodin in vitro and in vivo.

J Pharm Sci 2021 Apr 14. Epub 2021 Apr 14.

College of Pharmacy, Jinan University, Guangzhou, 510632, China; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, Guangzhou, 510632, China; Cancer Research Institute of Jinan University, Guangzhou, 510632, China; Interventional Cancer Institute of Chinese Integrative Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China. Electronic address:

This study aimed to evaluate the therapeutic efficacy of Emodin-loaded polymer lipid hybrid nanoparticles (E-PLNs) for breast cancer. The size, Zeta potential, surface morphology, encapsulation efficiency, stability, in vitro drug release of E-PLNs prepared by the nanoprecipitation method were characterized. The uptake, in-vitro cytotoxicities and apoptosis of free drug, E-PLNs were investigated against MCF-7 cells. Read More

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Heterochromatic Nonlinear Optical Responses in Upconversion Nanoparticles for Super-Resolution Nanoscopy.

Adv Mater 2021 Apr 17:e2008847. Epub 2021 Apr 17.

Institute for Biomedical Materials & Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia.

Point spread function (PSF) engineering by an emitter's response can code higher-spatial-frequency information of an image for microscopy to achieve super-resolution. However, complexed excitation optics or repetitive scans are needed, which explains the issues of low speed, poor stability, and operational complexity associated with the current laser scanning microscopy approaches. Here, the diverse emission responses of upconversion nanoparticles (UCNPs) are reported for super-resolution nanoscopy to improve the imaging quality and speed. Read More

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Silver nanoparticles effect on Artemia salina and Allium cepa organisms: influence of test dilution solutions on toxicity and particles aggregation.

Ecotoxicology 2021 Apr 17. Epub 2021 Apr 17.

Department of Chemical Engineering, Western Paraná State University, Rua da Faculdade 645, Jd. Santa Maria, Toledo, PR, 85903-000, Brazil.

The objective of this study was to evaluate the effects of AgNPs on Artemia salina and Allium cepa, evaluating the influence of the dilution solutions on the particle behavior. The AgNPs were synthesized by chemical reduction of AgNO (3 and 5 mmol L) with sodium borohydride and stabilized with PVA (polyvinyl alcohol) and CMC (sodium carboxymethyl cellulose). The toxicity of AgNPs was evaluated in Artemia salina (mortality) using Meyer's solution as a diluent and in Allium cepa (chromosomal aberrations) using reconstituted hard water. Read More

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Synthetic Routes to Single Chain Polymer Nanoparticles (SCNPs): Current Status and Perspectives.

Macromol Rapid Commun 2021 Apr 17:e2100035. Epub 2021 Apr 17.

Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

Recent advances in polymer science make it possible to create single chain polymer nanoparticles (SCNPs), which can mimic the folding of natural macromolecules, such as protein and nucleic acid, in terms of their native and functional state. Even though considerable progress has been done during the last years, the synthesis of relatively controlled SCNPs with a good folding accuracy is still challenging due to lack of appropriate chemical synthesis techniques. Different types of SCNPs are developed with enhanced properties and used for various applications, e. Read More

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Interaction of zinc oxide nanoparticles with soil: Insights into the chemical and biological properties.

Environ Geochem Health 2021 Apr 17. Epub 2021 Apr 17.

Southern Federal University, Rostov-on-Don, Russia, 344090.

Widespread use of zinc oxide nanoparticles (ZnO-NPs) threatens soil, plants, terrestrial and aquatic animals. Thus, it is essential to explore the fate and behavior of NPs in soil and also its mechanism of interaction with soil microbial biodiversity to maintain soil health and quality to accomplish essential ecosystem services. With this background, the model experiment was conducted in the greenhouse to study the impact of ZnO-NPs on soil taking maize as a test crop. Read More

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Study on surface enhanced Raman scattering of Au and Au@AlO spherical dimers based on 3D finite element method.

Sci Rep 2021 Apr 16;11(1):8391. Epub 2021 Apr 16.

College of Information Science and Engineering, Yanshan University, Qinhuangdao, 066004, China.

In this paper, the surface enhanced Raman scattering (SERS) characteristics of Au and Au@AlO nanoparticle dimers were calculated and analyzed by using finite element method (3D-FEM). Firstly, the electric field enhancement factors of Au nanoparticles at the dimer gap were optimized from three aspects: the incident angle of the incident light, the radius of nanoparticle and the distance of the dimer. Then, aluminum oxide is wrapped on the Au dimer. Read More

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Highly improved supercapacitance properties of MnFeO nanoparticles by MoS nanosheets.

Sci Rep 2021 Apr 16;11(1):8378. Epub 2021 Apr 16.

Condensed Matter Physics Group, Department of Basic Sciences, Tarbiat Modares University, Jalal-Ale-Ahmad Avenue, Tehran, Iran.

Manganese ferrite (MnFeO) nanoparticles were synthesized via a hydrothermal method and combined with exfoliated MoS nanosheets, and the nanocomposite was studied as a supercapacitor. X-ray diffractometry and Raman spectroscopy confirmed the crystalline structures and structural characteristics of the nanocomposite. Transmission electron microscopy images showed the uniform size distribution of MnFeO nanoparticles (~ 13 nm) on few-layer MoS nanosheets. Read More

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Apoptotic body-mediated intercellular delivery for enhanced drug penetration and whole tumor destruction.

Sci Adv 2021 Apr 16;7(16). Epub 2021 Apr 16.

Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.

Chemotherapeutic nanomedicines can exploit the neighboring effect to increase tumor penetration. However, the neighboring effect is limited, likely by the consumption of chemotherapeutic agents and resistance of internal hypoxic tumor cells. Here, we first propose and demonstrate that apoptotic bodies (ApoBDs) could carry the remaining drugs to neighboring tumor cells after apoptosis. Read More

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Self-organization of nanoparticles and molecules in periodic Liesegang-type structures.

Sci Adv 2021 Apr 16;7(16). Epub 2021 Apr 16.

Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada.

Chemical organization in reaction-diffusion systems offers a strategy for the generation of materials with ordered morphologies and structural hierarchy. Periodic structures are formed by either molecules or nanoparticles. On the premise of new directing factors and materials, an emerging frontier is the design of systems in which the precipitation partners are nanoparticles and molecules. Read More

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Rolling spinners on the water surface.

Sci Adv 2021 Apr 16;7(16). Epub 2021 Apr 16.

Research School of Physics, The Australian National University, Canberra, ACT 2601, Australia.

Angular momentum of spinning bodies leads to their remarkable interactions with fields, waves, fluids, and solids. Orbiting celestial bodies, balls in sports, liquid droplets above a hot plate, nanoparticles in optical fields, and spinning quantum particles exhibit nontrivial rotational dynamics. Here, we report self-guided propulsion of magnetic fast-spinning particles on a liquid surface in the presence of a solid boundary. Read More

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Selective colorimetric urine glucose detection by paper sensor functionalized with polyaniline nanoparticles and cell membrane.

Anal Chim Acta 2021 May 12;1158:338387. Epub 2021 Mar 12.

Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, South Korea; Interdisciplinary Graduate Program for Artificial Intelligence Smart Convergence Technology, Korea University, Sejong 30019, South Korea. Electronic address:

For the diabetes diagnosis, noninvasive methods are preferred to invasive methods; urine glucose measurement is an example of a noninvasive method. However, conventional noninvasive methods for urine glucose measurement are not intuitive. Furthermore, such methods exhibit low selectivity because they can detect interfering molecules in addition to glucose. Read More

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3D nitrogen-doped carbon nanofoam arrays embedded with PdCu alloy nanoparticles: Assembling on flexible microelectrode for electrochemical detection in cancer cells.

Anal Chim Acta 2021 May 17;1158:338420. Epub 2021 Mar 17.

Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science & Technology, Wuhan, 430074, China. Electronic address:

In this work, we developed a novel and facile strategy for the synthesis of a highly active and stable electrocatalyst based on PdCu alloy nanoparticles (PdCu-ANPs) embedded in 3D nitrogen-doped carbon (NC) nanofoam arrays (NFAs), which were assembled on flexible carbon fiber (CF) microelectrode for in situ sensitive electrochemical detection of biomarker HO in cancer cells. Our results showed that NC-NFAs support possessed a unique hierarchically porous architecture by integrating the macrospores in arrays scaffold within mesopores in individual NC nanofoam, which offered exceptionally large surface area for embedding high-density PdCu-ANPs in it as well as facilitated the mass transfer and molecular diffusion during the electrochemical reaction. Taking the advantages of the unique structural merit of NC-NFAs support and excellent electrocatalyitc properties of PdCu-ANPs that embedded in it, the resultant PdCu-ANPs/NC-NFAs modified CF microelectrode exhibited good electrochemical sensing performances towards HO including a wide linear range from 2. Read More

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Stealth PEGylated chitosan polyelectrolyte complex nanoparticles as drug delivery carrier.

J Biomater Sci Polym Ed 2021 Apr 16:1-15. Epub 2021 Apr 16.

Department of Pharmacy, Xi'an Medical University, Xi'an 710021, China.

PEGylated stealth nanoparticles have emerged as promising drug delivery carrier for cancer therapy. In this study, natural polycationic chitosan was grafted with poly(ethylene glycol) (PEG) to improve the water-solubility and long-circulation. Then PEGylated chitosan nanoparticles were formed by electrostatic interaction between sulfonic acid group of anionic functional polymer and protic amino group of PEGylated chitosan, using polyelectrolyte complex method. Read More

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Targeted antitumor comparison study between dopamine self-polymerization and traditional synthesis for nanoparticle surface modification in drug delivery.

Nanotechnology 2021 Apr 16. Epub 2021 Apr 16.

Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Medicinal Plant Development, Beijing, CHINA.

To improve the therapeutic efficacy of anticancer agents and extend their application, mussel-inspired chemical modifications have attracted considerable attention. Surface modification based on polydopamine (PDA) has been a facile and versatile method to immobilize biomolecules on substrates for targeted drug delivery. To better analyze pharmaceutical differences between PDA-based surface modification and traditional synthesis methods, we prepared two kinds of folate (FA)-targeted nanoparticles (NPs) loaded with paclitaxel (PTX). Read More

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Quantitative determination of creatinine from serum of prostate cancer patients by N-doped porous carbon antimony (Sb/NPC) nanoparticles.

Bioelectrochemistry 2021 Apr 5;140:107815. Epub 2021 Apr 5.

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address:

Creatinine is an indicator of hindrance in urination and renal insufficiency. Creatinine levels are the marker of the late stages of prostate cancer. Early and sensitive detection of creatinine can reduce deaths associated with prostate cancer. Read More

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A g-CN self-templated preparation of N-doped carbon nanosheets@Co-CoO/Carbon nanotubes as high-rate lithium-ion batteries' anode materials.

J Colloid Interface Sci 2021 Apr 5;597:1-8. Epub 2021 Apr 5.

Key Laboratory of Functional Small Organic Molecule, Ministry of Education, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China. Electronic address:

A novel N-doped graphene-like carbon nanosheets (CNs) and carbon nanotubes (CNTs)-encapsulated Co-CoO nanoparticles (NPs) (CN@Co-CoO/CNTs) were synthesized successfully by a simple hydrothermal and annealing method with graphite carbon nitride (g-CN) as self-template. By annealing Co/g-CN under N atmosphere, g-CN was transformed into CN/CNTs, and Co was reduced into CoNPs which were embedded in CNs. Further annealing in air, a shell of CoO was formed around CoNPs. Read More

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Ultrasensitive fluorescence immunosensor based on mesoporous silica and magnetic nanoparticles: Capture and release strategy.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 26;257:119749. Epub 2021 Mar 26.

Department of Agriculture and Natural Resources, Imam Khomeini International University, Qazvin, Iran.

Herein we designed a novel, highly sensitive, simple and amplified fluorescence immunosensing strategy for hepatitis B virus surface antigen (HBV surface antigen) (HBsAg) as a model based on the construction of a sandwich type probe. The operation mechanism of this immunosensing strategy is implemented by capturing and then stimulation-based-releasing of entrapped dye in the fluorescent capsules. The proposed probe is made by the FeO magnetic nanoparticle (FeO MNP) as a probe collector site and the Rhodamine B loaded-mesoporous silica nanoparticle (MSN-Rh. Read More

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Super-resolution fluorescence imaging of extracellular environments.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 1;257:119767. Epub 2021 Apr 1.

Department of Physics, Case Western Reserve University, Cleveland, OH 44106, USA; Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

The extracellular matrix (ECM) is an important biophysical environment that plays a role in a number of physiological processes. The ECM is highly dynamic, with changes occurring as local, nanoscale, physicochemical variations in physical confinement and chemistry from the perspective of biological molecules. The length and time scale of ECM dynamics are challenging to measure with current spectroscopic techniques. Read More

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Functionalization of silica-coated magnetic nanoparticles as powerful demulsifier to recover oil from oil-in-water emulsion.

Chemosphere 2021 Mar 29;279:130360. Epub 2021 Mar 29.

Department of Chemical Engineering, Qatar University, P. O. Box 2713, Doha, Qatar. Electronic address:

This study presents an innovative approach for the preparation of FeO nanoparticles covered with SiO shell (denoted as Fe-Si-MNP), which were used to recover oil recovery from oil-in-water emulsion (O/W-emul). The Fe-Si-MNP were prepared with differing silica layer thicknesses (5 nm [Fe-Si-1], 8 nm [Fe-Si-2], 10 nm [Fe-Si-3], and 15 nm [Fe-Si-4]) and tested for the percentage of oil separation (%S) under different dosages (D), oil concentration (D), surfactant dosages (D), and pH. The Fe-Si-MNP exhibited excellent %S, reliable stability, and high magnetization values ranging between 46. Read More

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Exposure-time-dependent subcellular staging of gold nanoparticles deposition and vesicle destruction in mice livers.

Nanomedicine 2021 Apr 13:102393. Epub 2021 Apr 13.

Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, 230027, PR China; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, PR China. Electronic address:

Several advances in nanomedicine have been accompanied by rising concerns about the bioaccumulation and toxicity of gold nanoparticles (AuNPs). Here, we assessed the in vivo fate of diversely sized AuNPs that were injected into mice as a computed tomography contrast agent and examined with multi-scale analyses across the organ, tissue, cell, and subcellular levels. After focusing on the strong detected accumulation in livers, our data revealed a set of three clear, exposure-time-dependent patterns based on i) AuNPs deposit morphology and ii) readily identifiable phenotypes for AuNP-impacted subcellular vesicles. Read More

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Identification of main influencing factors on the protein corona composition of PLGA and PLA nanoparticles.

Eur J Pharm Biopharm 2021 Apr 13. Epub 2021 Apr 13.

Institute of Pharmaceutical Technology and Biopharmacy University of Muenster Corrensstr.4848149 Muenster, Germany. Electronic address:

Poly(DL-lactic-co-glycolic acid) and poly(DL-lactic acid) are widely used for the preparation of nanoparticles due to favorable characteristics for medical use like biodegradability and controllable degradation behavior. The contact with different media like human plasma or serum leads to the formation of a protein corona that determines the NP's in vivo processing. In this study, the impact of surface end group identity, matrix polymer hydrophobicity, molecular weight, and incubation medium on the protein corona composition was evaluated. Read More

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A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos.

Adv Drug Deliv Rev 2021 Apr 13. Epub 2021 Apr 13.

School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK. Electronic address:

Extracellular vesicles (EVs) are complex nanoparticles required for the intercellular transfer of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural platform for the enhanced targeting and functional transfer of therapeutics across complex and often impenetrable biological boundaries (e.g. Read More

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