37,658 results match your criteria nanoparticle state


Tumor vasculature-targeting PEGylated peptide-drug conjugate prodrug nanoparticles improve chemotherapy and prevent tumor metastasis.

Eur J Med Chem 2021 Apr 5;219:113430. Epub 2021 Apr 5.

China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, College of Biotechnology Tianjin University of Science and Technology, No.29 of 13 th Avenue, TEDA, Tianjin, 300457, PR China. Electronic address:

Metastasis is the main cause of death in cancer patients; therefore, new strategies or technologies that can inhibit the growth of primary tumors and their metastatic spread are extremely valuable. In this study, we selected an E-selectin-binding peptide as a targeting ligand and an inhibitor of metastasis, and conjugated this peptide with SN38 and PEG to produce an amphiphilic PEGylated peptide-drug conjugate (PDC). Novel self-assembled nanoparticles were then formed by the amphiphilic conjugate. Read More

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Heterochromatic Nonlinear Optical Responses in Upconversion Nanoparticles for Super-Resolution Nanoscopy.

Adv Mater 2021 Apr 17:e2008847. Epub 2021 Apr 17.

Institute for Biomedical Materials & Devices (IBMD), Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia.

Point spread function (PSF) engineering by an emitter's response can code higher-spatial-frequency information of an image for microscopy to achieve super-resolution. However, complexed excitation optics or repetitive scans are needed, which explains the issues of low speed, poor stability, and operational complexity associated with the current laser scanning microscopy approaches. Here, the diverse emission responses of upconversion nanoparticles (UCNPs) are reported for super-resolution nanoscopy to improve the imaging quality and speed. Read More

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Silver nanoparticles effect on Artemia salina and Allium cepa organisms: influence of test dilution solutions on toxicity and particles aggregation.

Ecotoxicology 2021 Apr 17. Epub 2021 Apr 17.

Department of Chemical Engineering, Western Paraná State University, Rua da Faculdade 645, Jd. Santa Maria, Toledo, PR, 85903-000, Brazil.

The objective of this study was to evaluate the effects of AgNPs on Artemia salina and Allium cepa, evaluating the influence of the dilution solutions on the particle behavior. The AgNPs were synthesized by chemical reduction of AgNO (3 and 5 mmol L) with sodium borohydride and stabilized with PVA (polyvinyl alcohol) and CMC (sodium carboxymethyl cellulose). The toxicity of AgNPs was evaluated in Artemia salina (mortality) using Meyer's solution as a diluent and in Allium cepa (chromosomal aberrations) using reconstituted hard water. Read More

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Synthetic Routes to Single Chain Polymer Nanoparticles (SCNPs): Current Status and Perspectives.

Macromol Rapid Commun 2021 Apr 17:e2100035. Epub 2021 Apr 17.

Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

Recent advances in polymer science make it possible to create single chain polymer nanoparticles (SCNPs), which can mimic the folding of natural macromolecules, such as protein and nucleic acid, in terms of their native and functional state. Even though considerable progress has been done during the last years, the synthesis of relatively controlled SCNPs with a good folding accuracy is still challenging due to lack of appropriate chemical synthesis techniques. Different types of SCNPs are developed with enhanced properties and used for various applications, e. Read More

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Engineered Protein Photo-Thermal Hydrogels for Outstanding In Situ Tongue Cancer Therapy.

Adv Mater 2021 Apr 16:e2100619. Epub 2021 Apr 16.

Department of Geriatric Dentistry, Beijing Laboratory of Biomedical Materials, Peking University School and Hospital of Stomatology, Beijing, 100081, China.

Surgical excision is the main choice for tongue cancer treatment. However, the physiological functions of oral and maxillofacial regions might be severely impaired and high risk of tongue tumor recurrence cannot be avoided. It is thus becoming urgently important to develop alternative strategies for tongue cancer therapy. Read More

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Photocatalytic Surface Restructuring in Individual Silver Nanoparticles.

ACS Catal 2021 Mar 3;11(6):3478-3486. Epub 2021 Mar 3.

DIFFER-Dutch Institute for Fundamental Energy Research, De Zaale 20, 5612 AJ Eindhoven, The Netherlands.

Light absorption and scattering by metal nanoparticles can drive catalytic reactions at their surface via the generation of hot charge carriers, elevated temperatures, and focused electromagnetic fields. These photoinduced processes can substantially alter the shape, surface structure, and oxidation state of surface atoms of the nanoparticles and therefore significantly modify their catalytic properties. Information on such local structural and chemical change in plasmonic nanoparticles is however blurred in ensemble experiments, due to the typical large heterogeneity in sample size and shape distributions. Read More

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Enhancement of X-ray-Excited Red Luminescence of Chromium-Doped Zinc Gallate via Ultrasmall Silicon Carbide Nanocrystals.

Chem Mater 2021 Apr 18;33(7):2457-2465. Epub 2021 Mar 18.

Wigner Research Centre for Physics, Institute for Solid State Physics and Optics, P.O. Box 49, Budapest H-1525, Hungary.

X-ray-activated near-infrared luminescent nanoparticles are considered as new alternative optical probes due to being free of autofluorescence, while both their excitation and emission possess a high penetration efficacy . Herein, we report silicon carbide quantum dot sensitization of trivalent chromium-doped zinc gallate nanoparticles with enhanced near-infrared emission upon X-ray and UV-vis light excitation. We have found that a ZnGaO shell is formed around the SiC nanoparticles during seeded hydrothermal growth, and SiC increases the emission efficiency up to 1 order of magnitude due to band alignment that channels the excited electrons to the chromium ion. Read More

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One-pot synthesis of zinc oxide nanoparticles via chemical precipitation for bromophenol blue adsorption and the antifungal activity against filamentous fungi.

Sci Rep 2021 Apr 15;11(1):8305. Epub 2021 Apr 15.

Department of Chemistry, University of the Free State, Bloemfontein, South Africa.

In this research, zinc oxide nanoparticles (ZnONPs) were prepared via a facile one-pot chemical precipitation approach and applied in the adsorption of bromophenol blue (BRB) and as antifungal agents against the filamentous fungi and plant pathogens; Alternaria alternata CGJM3078, Alternaria alternata CGJM3006 and Fusarium verticilliodes CGJM3823. The ZnONPs were characterized by the UV-Vis, FTIR, XRD, TGA, BET, SEM, TEM, and EDX techniques, which showed efficient synthesis. The characteristics ZnO UV-Vis absorption band was observed at 375 nm, while the XRD showed an average ZnONPs crystalline size of 47. Read More

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A previously unknown way of heme detoxification in the digestive tract of cats.

Sci Rep 2021 Apr 15;11(1):8290. Epub 2021 Apr 15.

Laboratory of Proteomics and Metabolomics, International Tomography Center SB RAS, Institutskaya str. 3a, Novosibirsk, 630090, Russia.

Free heme is a highly toxic molecule for a living organism and its detoxification is a very important process, especially for carnivorous animals. Here we report the discovery of a previously unknown process for neutralizing free heme in the digestive tract of domestic cats. The cornerstone of this process is the encapsulation of heme into carbonated hydroxyapatite nanoparticles, followed by their excretion with faeces. Read More

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Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment.

Carbohydr Polym 2021 Jul 27;263:117998. Epub 2021 Mar 27.

State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School, Chengdu University of Traditional Chinese Medicine, Chengdu, 611130, China. Electronic address:

Herein, dual-bioresponsive of Rhein (RH) in promoting colonic mucous damage repair and controlling inflammatory reactions were combined by the dual-targeting (intestinal epithelial cells and macrophages) oral nano delivery strategy for effective therapy of ulcerative colitis (UC). Briefly, two carbohydrates, calcium pectinate (CP) and hyaluronic acid (HA) were used to modify lactoferrin (LF) nanoparticles (NPs) to encapsulate RH (CP/HA/RH-NPs). CP layer make CP/HA/RH-NPs more stable and protect against the destructive effects of the gastrointestinal environment and then release HA/RH-NPs to colon lesion site. Read More

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Co-encapsulation of collagenase type I and silibinin in chondroitin sulfate coated multilayered nanoparticles for targeted treatment of liver fibrosis.

Carbohydr Polym 2021 Jul 24;263:117964. Epub 2021 Mar 24.

State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Key Laboratory of Industrial Biotechnology and Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, School of Life Sciences, Hubei University, Wuhan, 430062, China. Electronic address:

Components of the extracellular matrix (ECM) are overexpressed in fibrotic liver. Collagen is the main component of the liver fibrosis stroma. Here we demonstrate that chondroitin sulfate coated multilayered 50-nm nanoparticles encapsulating collagenase and silibinin (COL + SLB-MLPs) break down the dense collagen stroma, while silibinin inhibits activated hepatic stellate cells. Read More

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Autism-associated synaptic vesicle transcripts are differentially expressed in maternal plasma exosomes of physiopathologic pregnancies.

J Transl Med 2021 Apr 15;19(1):154. Epub 2021 Apr 15.

Sino-US Center of Translational Medicine for Development Disabilities, Southern Medical University, Guangzhou, 510515, China.

Background: During intrauterine development, the formation and function of synaptic vesicles (SVs) are thought to be fundamental conditions essential for normal development of the brain. Lacking advanced technology during the intrauterine period, such as longitudinal real-time monitoring of the SV-associated transcripts (SVATs), which include six pairs of lncRNA-mRNA, has limited acquisition of the dynamic gene expression profile (GEP) of SVATs. We previously reported the differential expression of SVATs in the peripheral blood of autistic children. Read More

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Bacteria compete with hematite nanoparticles during their uptake by the ciliate Tetrahymena thermophila.

J Hazard Mater 2021 Jun 11;411:125098. Epub 2021 Jan 11.

State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu Province 210046, People's Republic of China. Electronic address:

Bacterial accumulation of engineered nanoparticles (NPs) result in their transfer along the food chain. However, there are a lot of NPs not associated with bacteria. Whether bacteria, as representative biotic particles, influence the biological uptake of these non-associated NPs in aquatic ecosystems is unclear. Read More

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Development of a multifunctional system based on CoFe2O4@polyacrylic acid NPs conjugated to folic acid and loaded with doxorubicin for cancer theranostics.

Nanotechnology 2021 Apr 15. Epub 2021 Apr 15.

Shahid Bahonar University of Kerman, Kerman, Iran (the Islamic Republic of).

In this work, a multifunctional theranostic nanocomposite based on CoFe2O4@polyacrylic acid (PAA)‑Folic Acid (FA) Doxorubicin (Dox)load NPs was designed for the multifunctional cancer treatment. Several techniques such as TEM, DLS, ζ‑potential, vibrating sample magnetometer (VSM), XRD, and UV‑Vis spectrophotometer were applied for investigating physicochemical properties of the nanosystem. The percentage of the loaded drug, loading efficiency, in vitro release (pH 5. Read More

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Selective target protein detection using a decorated nanopore into a microfluidic device.

Biosens Bioelectron 2021 Mar 31;183:113195. Epub 2021 Mar 31.

Université Paris-Saclay, Univ Evry, CNRS, LAMBE, 91025, Evry-Courcouronnes, France. Electronic address:

Solid-state nanopores provide a powerful tool to electrically analyze nanoparticles and biomolecules at single-molecule resolution. These biosensors need to have a controlled surface to provide information about the analyte. Specific detection remains limited due to nonspecific interactions between the molecules and the nanopore. Read More

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Mild magnetic nanoparticle hyperthermia promotes the disaggregation and microglia-mediated clearance of Beta-amyloid plaques.

Nanomedicine 2021 Apr 13:102397. Epub 2021 Apr 13.

School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA; Department of Biological Sciences, Kent State University, Kent, OH 44242, USA. Electronic address:

The formation of beta-amyloid (Aβ) plaques is a classical hallmark of Alzheimer's disease (AD) that is associated with the promotion of neuroinflammation and subsequent neurotoxicity. Given the limited therapeutic options for targeting and clearing Aβ plaques in AD, there is an urgent need to develop effective approaches to reduce plaque accumulation. The objective of this study was to validate mild magnetic nanoparticle (MNP) hyperthermia technology as a strategy to clear Aβ deposits and determine the impact on microglia functionality. Read More

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Ultrawhite BaSO Paints and Films for Remarkable Daytime Subambient Radiative Cooling.

ACS Appl Mater Interfaces 2021 Apr 15. Epub 2021 Apr 15.

School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.

Radiative cooling is a passive cooling technology that offers great promises to reduce space cooling cost, combat the urban island effect, and alleviate the global warming. To achieve passive daytime radiative cooling, current state-of-the-art solutions often utilize complicated multilayer structures or a reflective metal layer, limiting their applications in many fields. Attempts have been made to achieve passive daytime radiative cooling with single-layer paints, but they often require a thick coating or show partial daytime cooling. Read More

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Surface Fingerprinting of Faceted Metal Oxides and Porous Zeolite Catalysts by Probe-Assisted Solid-State NMR Approaches.

Acc Chem Res 2021 Apr 15. Epub 2021 Apr 15.

State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Key Laboratory of Magnetic Resonance in Biological Systems, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences, Wuhan 430071, P. R. China.

ConspectusAcid catalysis in heterogeneous systems such as metal oxides and porous zeolites has been widely involved in various catalytic processes for chemical and petrochemical industries. In acid-catalyzed reactions, the performance (e.g. Read More

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Facile, Smart, and Degradable Metal-Organic Framework Nanopesticides Gated with Fe-Tannic Acid Networks in Response to Seven Biological and Environmental Stimuli.

ACS Appl Mater Interfaces 2021 Apr 15. Epub 2021 Apr 15.

Key Laboratory of Mesoscopic Chemistry (Ministry of Education), State Key Laboratory of Coordination Chemistry, and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, People's Republic of China.

Nanopesticides were selected as one of the top 10 emerging technologies in chemistry that will change our world in 2019. Facile, smart, and degradable metal-organic framework MIL-101(Fe) nanopesticides gated with Fe-tannic acid (TA) networks are created using a universal strategy. The capping of the Fe-TA network gatekeepers is instinctively oriented by the coordinatively unsaturated Fe sites on the surfaces of the MIL-101(Fe) nanocarriers; thus, their combination is perfectly matched. Read More

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Monitoring Reaction Intermediates in Plasma-Driven SO, NO, and NO Remediation Chemistry Using In Situ SERS Spectroscopy.

Anal Chem 2021 Apr 15. Epub 2021 Apr 15.

Department of Physics and Astronomy, University of Southern California, Los Angeles, California 90089, United States.

In situ surface-enhanced Raman scattering (SERS) spectroscopy is used to identify the key reaction intermediates during the plasma-based removal of NO and SO under dry and wet conditions on Ag nanoparticles. Density functional theory (DFT) calculations are used to confirm the experimental observations by calculating the vibrational modes of the surface-bound intermediate species. Here, we provide spectroscopic evidence that the wet plasma increases the SO and the NO removal through the formation of highly reactive OH radicals, driving the reactions to HSO and HNO, respectively. Read More

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Electrostatic Interaction to Achieve Hierarchical Interpenetrating Electroconductive Networks of Silicon Anodes for Fast Lithium Storage.

Chemistry 2021 Apr 15. Epub 2021 Apr 15.

Donghua University, College of Materials Science and Engineering, CHINA.

Recently, the frequency of combining MXene with unique properties such as metal-level conductivity and large specific surface area with silicon to obtain excellent electrochemical performance has greatly increased. Undoubtedly, the introduction of MXene can improve the conductivity of silicon and the cycling stability of electrodes after elaborate structure design. However, most of the exhaustive contacts can only achieve the improvement of electrode conductivity on the plane. Read More

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Ultrafine MoP Nanoparticle Splotched Nitrogen-Doped Carbon Nanosheets Enabling High-Performance 3D-Printed Potassium-Ion Hybrid Capacitors.

Adv Sci (Weinh) 2021 Apr 2;8(7):2004142. Epub 2021 Feb 2.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Innovation Center for Textile Science and Technology Donghua University Shanghai 201620 P. R. China.

Size engineering is deemed to be an adoptable method to boost the electrochemical properties of potassium-ion storage; however, it remains a critical challenge to significantly reduce the nanoparticle size without compromising the uniformity. In this work, a series of MoP nanoparticle splotched nitrogen-doped carbon nanosheets (MoP@NC) is synthesized. Due to the coordinate and hydrogen bonds in the water-soluble polyacrylamide hydrogel, MoP is uniformly confined in a 3D porous NC to form ultrafine nanoparticles which facilitate the extreme exposure of abundant three-phase boundaries (MoP, NC, and electrolyte) for ionic binding and storage. Read More

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Embracing Defects and Disorder in Magnetic Nanoparticles.

Adv Sci (Weinh) 2021 Apr 15;8(7):2002682. Epub 2021 Feb 15.

Department of Physics and Materials Science University of Luxembourg 162A avenue de la FaÏencerie Luxembourg L-1511 Grand Duchy of Luxembourg.

Iron oxide nanoparticles have tremendous scientific and technological potential in a broad range of technologies, from energy applications to biomedicine. To improve their performance, single-crystalline and defect-free nanoparticles have thus far been aspired. However, in several recent studies, defect-rich nanoparticles outperform their defect-free counterparts in magnetic hyperthermia and magnetic particle imaging (MPI). Read More

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Validation of a coupled electromagnetic and thermal model for estimating temperatures during magnetic nanoparticle hyperthermia.

Int J Hyperthermia 2021 ;38(1):611-622

Department of Mechanical Engineering, The Pennsylvania State University - Harrisburg, Middletown, PA, USA.

Purpose: Alternating magnetic field (AMF) tissue interaction models are generally not validated. Our aim was to develop and validate a coupled electromagnetic and thermal model for estimating temperatures in large organs during magnetic nanoparticle hyperthermia (MNH).

Materials And Methods: Coupled finite element electromagnetic and thermal model validation was performed by comparing the results to experimental data obtained from temperatures measured in homogeneous agar gel phantoms exposed to an AMF at fixed frequency (155 ± 10 kHz). Read More

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January 2021

Structural and Physical-Chemical Characterization of Redox Active CeONanoparticles Synthesized by the Precipitation in the Water-Alcohol Solutions.

Nanotechnology 2021 Apr 14. Epub 2021 Apr 14.

Solid-State Chemistry, V I Vernadsky Institute of General and Inorganic Chemistry National Academy of Sciences of Ukraine, Kyiv, UKRAINE.

A set of cerium dioxide nanoparticles (CeONPs) was synthesized by the precipitation in the water-alcohol solutions under the conditions when the physical-chemical parameters of synthesized NPs were controlled by changing the ratio of the reaction components. The sizes of CeONPs are controlled largely by the dielectric constant of the reaction solution. Increase of the percentage of Ceions at the surface was observed with a concomitant reduction of the NPs sizes. Read More

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Dynamics of the Chemically Driven Densification of Barium Titanate Using Molten Hydroxides.

Nano Lett 2021 Apr 14. Epub 2021 Apr 14.

Materials Research Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.

Molten hydroxides, often used for crystal growth and nanoparticle synthesis, have recently been applied for the single step densification of several inorganic materials under moderate uniaxial pressures and 1000 °C below their usual sintering temperatures. The latter approach, termed cold sintering process (CSP), is a mechanochemically driven process that enables the densification of inorganic materials through a dissolution-precipitation creep mechanism. In this study, we report the main densification mechanisms of BaTiO in a NaOH-KOH eutectic mixture. Read More

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Zeolite-Encapsulated Ultrasmall Cu/ZnO Nanoparticles for the Hydrogenation of CO to Methanol.

ACS Appl Mater Interfaces 2021 Apr 14. Epub 2021 Apr 14.

School of Materials Science and Engineering, Tianjin Key Laboratory of Metal and Molecule-Based Material Chemistry, National Institute for Advanced Materials, Nankai University, Tianjin 300350, China.

Selective hydrogenation of CO to methanol is a "two birds, one stone" technology to mitigate the greenhouse effect and solve the energy demand-supply deficit. Cu-based catalysts can effectively catalyze this reaction but suffer from low catalytic stability caused by the sintering of Cu species. Here, we report a series of zeolite-fixed catalysts Cu/ZnO()@Na-ZSM-5 ( is the mass ratios of Cu/Zn in the catalysts) with core-shell structures to overcome this issue and strengthen the transformation. Read More

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A SnO Quantum Dots Embedded Carbon Nanocage Network with Ultrahigh Li Storage Capacity.

ACS Nano 2021 Apr 14. Epub 2021 Apr 14.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Linggong Road 2, Ganjingzi District, Dalian 116024, P. R. China.

Tin-based materials with high specific capacity have been studied as high-performance anodes for energy storage devices. Herein, a SnO ( = 0, 1, 2) quantum dots@carbon hybrid is designed and prepared by a binary oxide-induced surface-targeted coating of ZIF-8 followed by pyrolysis approach, in which SnO quantum dots (under 5 nm) are dispersed uniformly throughout the nitrogen-containing carbon nanocage. Each nanocage is cross-linked to form a highly conductive framework. Read More

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Solvent effects on host-guest residence time and kinetics: further insights from metadynamics simulation of Toussaintine-A unbiding from chitosan nanoparticle.

J Mol Model 2021 Apr 14;27(5):127. Epub 2021 Apr 14.

Chemistry Department, College of Natural and Applied Sciences, University of Dar es Salaam, P.O.Box 35061, Dar es Salaam, Tanzania.

Solvents play an important role in host-guest intermolecular interactions. The kinetics and residence time of Toussaintine-A (TouA) unbinding from chitosan was investigated by means of well-tempered metadynamics and thermodynamic integration using two solvents, polar aprotic (DMSO), and polar protic (water). The kinetic rates were found to be strongly dependent on the solvent polarity; hence, the unbinding rate proceeded much faster in DMSO compared to water. Read More

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Biodegradable polyelectrolyte/magnetite capsules for MR imaging and magnetic targeting of tumors.

Nanotheranostics 2021 2;5(3):362-377. Epub 2021 Apr 2.

Molecular and Preclinical Imaging Centres, Department of Molecular Biotechnology and Health Sciences, University of Torino, 10126 Torino, Italy.

The tireless research for effective drug delivery approaches is prompted by poor target tissue penetration and limited selectivity against diseased cells. To overcome these issues, various nano- and micro-carriers have been developed so far, but some of them are characterized by slow degradation time, thus hampering repeated drug administrations. The aim of this study was to pursue a selective delivery of magnetic biodegradable polyelectrolyte capsules in a mouse breast cancer model, using an external magnetic field. Read More

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