57,643 results match your criteria nanoparticle delivery


Engineering nanomedicines to inhibit hypoxia-inducible Factor-1 for cancer therapy.

Cancer Lett 2022 Jan 15. Epub 2022 Jan 15.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Hypoxia-inducible factor-1 (HIF-1), an essential promoter of tumor progression, has attracted increasing attention as a therapeutic target. In addition to hypoxic cellular conditions, HIF-1 activation can be triggered by cancer treatment, which causes drug tolerance and therapeutic failure. To date, a series of effective strategies have been explored to suppress HIF-1 function, including silencing the HIF-1α gene, inhibiting HIF-1α protein translation, degrading HIF-1α protein, and inhibiting HIF-1 transcription. Read More

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January 2022

Mesoporous [email protected]@gold nanoparticles as "on/off" optical biosensor and pH-sensitive theranostic platform against cancer.

Int J Biol Macromol 2022 Jan 15. Epub 2022 Jan 15.

Biosensor Research Center (BRC), Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address:

A cancer nanotheranostic system was fabricated based on mesoporous [email protected]@gold ([email protected]@Au) nanosystem targeted by aptamer toward the MUC-1 positive tumor cells. Subsequently, curcumin as an efficient herbal anticancer drug was first encapsulated into chitosan-triphosphate nanoparticles and then the resulted nanoparticle was loaded into the nanosystem ([email protected]@Au-Apt). The nanosystem successful fabrication was approved at each synthesis step through FTIR, XRD, BET, DLS, FE-SEM, HRTEM, and fluorescence spectroscopy. Read More

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January 2022

Novel ROS-responsive marine biomaterial fucoidan nanocarriers with AIE effect and chemodynamic therapy.

Int J Biol Macromol 2022 Jan 15. Epub 2022 Jan 15.

Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs, School of Pharmacy, Yantai University, Yantai 264005, PR China. Electronic address:

Chemodynamic therapy (CDT) has been widely used in the treatment of many kinds of tumors, which can effectively induce tumor cell apoptosis by using produced reactive oxygen species (ROS). In this paper, ROS-sensitive multifunctional marine biomaterial natural polysaccharide nanoparticles were designed. Aggregation-induced emission (AIE) molecules tetraphenylethylene (TPE) labeled and caffeic acid (CA) modified fucoidan (FUC) amphiphilic carrier material (CA-FUC-TK-TPE, CFTT) was fabricated, in which the thioketal bond(TK) was used as the linkage arm between TPE and fucoidan chain, giving the CFTT material ROS sensitivity. Read More

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January 2022

Polysorbate-coated mesoporous silica nanoparticles as an efficient carrier for improved rivastigmine brain delivery.

Brain Res 2022 Jan 15:147786. Epub 2022 Jan 15.

Department of clinical sciences, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

Targeted delivery of neurological therapeutic to the brain has been attracting more and more attention to the treatment of central nervous system (CNS) diseases. Nonetheless, the main obstacle in this road map is the existence of a blood-brain barrier (BBB) which limits the penetration efficiency of most CNS drugs into the brain parenchyma. This present investigation describes a facile synthetic strategy to prepare a highly biocompatible calcium-doped mesoporous silica nanoparticles (MSNs) functionalized by polysorbate-80 (PS) as targeting ligand to deliver rivastigmine (RV) into the brain via crossing the BBB. Read More

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January 2022

Benchmarking a Microfluidic-Based Filtration for Isolating Biological Particles.

Authors:
Fatih Inci

Langmuir 2022 Jan 18. Epub 2022 Jan 18.

UNAM - National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey.

Isolating particles from complex fluids is a crucial approach in multiple fields including biomedicine. In particular, biological matrices contain a myriad of distinct particles with different sizes and structures. Extracellular vesicles (EVs), for instance, are nanosized particles carrying vital information from donor to recipient cells, and they have garnered significant impact on disease diagnostics, drug delivery, and theranostics applications. Read More

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January 2022

Surface Modification of Nanoparticles Enhances Drug Delivery to the Brain and Improves Survival in a Glioblastoma Multiforme Murine Model.

Bioconjug Chem 2022 Jan 18. Epub 2022 Jan 18.

Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa 52242, United States.

Glioblastoma multiforme (GBM) is the most malignant type of brain tumor and has an extremely poor prognosis. Current treatment protocols lack favorable outcomes, and alternative treatments with superior efficacy are needed. In this study, we demonstrate that loading paclitaxel (PTX) in a polymeric, nanoparticulate delivery system is capable of improving its brain accumulation and therapeutic activity. Read More

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January 2022

Multienzyme-like Reactivity Cooperatively Impairs Glutathione Peroxidase 4 and Ferroptosis Suppressor Protein 1 Pathways in Triple-Negative Breast Cancer for Sensitized Ferroptosis Therapy.

ACS Nano 2022 Jan 18. Epub 2022 Jan 18.

Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, People's Republic of China.

Ferroptosis is a recently discovered route of regulated cell death that offers the opportunities for the treatment of chemotherapy-resistant tumor indications, but its efficacy can be affected by the glutathione peroxidase 4 (GPX4) and ferroptosis suppressor protein 1 (FSP1) antioxidant mechanisms, posing significant challenges for its clinical translation. In this study, we report a Cu-tetra(4-carboxyphenyl)porphyrin chloride(Fe(III)) (Cu-TCPP(Fe)) metal organic framework (MOF)-based nanosystem for the efficient incorporation of Au nanoparticles (NPs) and RSL3, which can demonstrate enzyme-like activities to universally suppress the antiferroptotic pathways in tumor cells for amplifying ferroptotic damage. Herein, Cu-TCPP(Fe) MOF nanosheets were integrated with Au NPs nucleation and loaded with RSL3 π-π stacking, which were eventually modified with polyethylene glycol (PEG) and iRGD for tumor-targeted drug delivery. Read More

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January 2022

Specific Silencing of Microglial Gene Expression in the Rat Brain by Nanoparticle-Based Small Interfering RNA Delivery.

ACS Appl Mater Interfaces 2022 Jan 18. Epub 2022 Jan 18.

Department of Endocrinology and Metabolism, Laboratory of Endocrinology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centre (UMC), location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.

Microglia are the major innate immune cells in the brain and are essential for maintaining homeostasis in a neuronal microenvironment. Currently, a genetic tool to modify microglial gene expression in specific brain regions is not available. In this report, we introduce a tailor-designed method that uses lipid and polymer hybridized nanoparticles (LPNPs) for the local delivery of small interfering RNAs (siRNAs), allowing the silencing of specific microglial genes in the hypothalamus. Read More

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January 2022

Application of starch-based nanoparticles and cyclodextrin for prebiotics delivery and controlled glucose release in the human gut: a review.

Crit Rev Food Sci Nutr 2022 Jan 18:1-12. Epub 2022 Jan 18.

State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, China.

Starches are a major constituent of staple foods and are the main source of energy in the human diet (55-70%). In the gastrointestinal tract, starches are hydrolyzed into glucose by α-amylase and α-glucosidase, which leads to a postprandial glucose elevation. High levels of blood glucose levels over sustained periods may promote type 2 diabetes mellitus (T2DM) and obesity. Read More

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January 2022

Nose-to-brain drug delivery for the treatment of Alzheimer's Disease: Current advancements and challenges.

Expert Opin Drug Deliv 2022 Jan 18. Epub 2022 Jan 18.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER-Guwahati), Sila, Changsari, Kamrup, Guwahati, Assam, India, 781101.

Introduction: The irreversible destruction of neurons, progressive loss of memory and cognitive behavior, high cost of therapy, and impact on society desire a better, effective, and affordable treatment of AD. The nose-to-brain drug delivery approach holds a great potential to access the brain without any hindrance of BBB and result in higher bioavailability thus better therapeutic efficacy of anti-AD drugs.

Areas Covered: The present review article highlighted the current facts and worldwide statistics of AD and its detailed etiology. Read More

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January 2022

Opsonin-Deficient Nucleoproteic Corona Endows UnPEGylated Liposomes with Stealth Properties .

ACS Nano 2022 Jan 18. Epub 2022 Jan 18.

Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy.

For several decades, surface grafted polyethylene glycol (PEG) has been a go-to strategy for preserving the synthetic identity of liposomes in physiological milieu and preventing clearance by immune cells. However, the limited clinical translation of PEGylated liposomes is mainly due to the protein corona formation and the subsequent modification of liposomes' synthetic identity, which affects their interactions with immune cells and blood residency. Here we exploit the electric charge of DNA to generate unPEGylated liposome/DNA complexes that, upon exposure to human plasma, gets covered with an opsonin-deficient protein corona. Read More

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January 2022

Engineering Cellular Membrane for Dual Mode Therapy Using NIR Responsive Photosensitizer and Reversible Topoisomerase Inhibition Activity.

ACS Appl Bio Mater 2022 Jan 18. Epub 2022 Jan 18.

Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.

Extensive research over past few decades has highlighted the challenges of chemotherapy and prompted the need for multimodality therapy because chemotherapy alone cannot fully eradicate the tumor due to physiological barriers in its effective delivery and systemic side effects. It can be mitigated by adopting nanoparticles as more effective delivery method, but none of them completely prevents drug toxicities. Utilizing multiple therapeutic modes such as phototherapy that can act synergistically with chemotherapy in controlling tumor growth, while reducing the overall dosage, could become a preferred route for cancer management. Read More

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January 2022

Transdermal delivery of poly-hyaluronic acid-based spherical nucleic acids for chemogene therapy.

Nanoscale 2022 Jan 18. Epub 2022 Jan 18.

Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, People's Republic of China.

Spherical nucleic acid (SNA), as a good gene delivery system, has a good application prospect for transdermal administration in skin disorder treatment. However, most of the traditional SNA core materials are non-degradable materials, so it is worthy of further research. Herein, we report a spherical nucleic acid based on poly-hyaluronic acid (PHA) for the co-delivery of a typical chemotherapeutic drug, doxorubicin (DOX), and an antisense oligonucleotide (ASO) against the tissue inhibitor of metalloproteinases 1 (TIMP-1) for the treatment of hypertrophic scars (HS) which are caused by abnormal fibroblast proliferation. Read More

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January 2022

Nanoparticle-based non-viral CRISPR delivery for enhanced immunotherapy.

Chem Commun (Camb) 2022 Jan 18. Epub 2022 Jan 18.

School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea.

The CRISPR Cas9 system has received considerable attention due to its simplicity, efficiency, and high precision for gene editing. The development of various therapeutic applications of the CRISPR system is under active research. In particular, its proven effects and promise in immunotherapy are of note. Read More

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January 2022

Encapsulation of Curcumin in a Ternary Nanocomplex Prepared with Carboxymethyl Short Linear Glucan-Sodium-Caseinate-Pectin Via Electrostatic Interactions.

J Food Sci 2022 Jan 17. Epub 2022 Jan 17.

Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China.

This work chemically modified short linear glucan (SLG) by introducing a surface carboxymethyl group to obtain carboxymethylated SLG (CMSLG), then prepared CMSLG-based ternary nanocomplex particles based on electrostatic interactions with sodium-caseinate (NaCas) and pectin. These nanocomplex particles are homogeneous, generally exhibiting sizes of <200 nm with spherical shape and negative surface charge. In addition, the results showed the increase in both the mass ratio of CMSLG and NaCas and the synthesis temperature can improve the colloidal stability of nanocomplex particles when they are exposed to simulated gastrointestinal fluids containing digestive enzymes. Read More

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January 2022

Exosomes and COVID-19: challenges and opportunities.

Comp Clin Path 2022 Jan 13:1-8. Epub 2022 Jan 13.

Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Coronavirus disease 2019 or COVID-19, starting from Wuhan, China, in December 2019, is a pandemic situation affecting millions worldwide and has exerted a huge burden on healthcare infrastructure. Therefore, there is an urgent need to understand the molecular mechanisms underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and design novel effective therapeutic strategies for combating this pandemic. In this regard, special attention has been paid to the exosomes. Read More

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January 2022

Protein transfection via spherical nucleic acids.

Nat Protoc 2022 Jan 17. Epub 2022 Jan 17.

Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL, USA.

The efficient transfection of functional proteins into cells can serve as a means for regulating cellular processes toward solving fundamental challenges in biology and medicine. However, the use of proteins as effective intracellular agents is hindered by their low cellular uptake and susceptibility to degradation. Over the past 15 years, our group has been developing spherical nucleic acids (SNAs), nanoparticles functionalized with a dense radially oriented shell of nucleic acids. Read More

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January 2022

Glucose sensitive konjac glucomannan/concanavalin A nanoparticles as oral insulin delivery system.

Int J Biol Macromol 2022 Jan 13. Epub 2022 Jan 13.

School of Life Science, South China Normal University, Guangzhou 510631, China; Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal University, Guangzhou 510631, China; South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research, Panyu Central Hospital, Guangzhou 510631, China; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China. Electronic address:

Compared with injection, oral drug delivery is a better mode of administration because of its security, low pain and simplicity. Insulin is the first choice for clinical treatment of type 1 diabetes, but, because insulin inability to resist gastrointestinal (GI) digestion results in poor oral bioavailability of insulin. Herein, we developed a targeted oral delivery system for diabetes. Read More

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January 2022

The TFAMoplex-Conversion of the Mitochondrial Transcription Factor A into a DNA Transfection Agent.

Adv Sci (Weinh) 2022 Jan 17:e2104987. Epub 2022 Jan 17.

Swiss Federal Institute of Technology Zurich (ETHZ), Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg 3, Zurich, 8093, Switzerland.

Non-viral gene delivery agents, such as cationic lipids, polymers, and peptides, mainly rely on charge-based and hydrophobic interactions for the condensation of DNA molecules into nanoparticles. The human protein mitochondrial transcription factor A (TFAM), on the other hand, has evolved to form nanoparticles with DNA through highly specific protein-protein and protein-DNA interactions. Here, the properties of TFAM are repurposed to create a DNA transfection agent by means of protein engineering. Read More

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January 2022

3D printing of nanocomposite pills through desktop vat photopolymerization (stereolithography) for drug delivery reasons.

3D Print Med 2022 Jan 17;8(1). Epub 2022 Jan 17.

Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER)-Guwahati, Changsari, Assam, 781101, India.

Background: The desktop vat polymerization process or stereolithography printing is an ideal approach to develop multifunctional nanocomposites wherein a conventional solid dosage form is used as a reservoir for compliant administration of drug-loaded nanocarriers.

Methods: In this study, a nanocomposite drug delivery system, that is, hydrogel nanoparticles of an approved nutraceutical, berberine entrapped within vat photopolymerized monoliths, was developed for drug delivery applications. For the fabrication of the nanocomposite drug delivery systems/pills, a biocompatible vat photopolymerized resin was selected as an optimum matrix capable of efficiently delivering berberine from stereolithography mediated 3D printed nanocomposite pill. Read More

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January 2022

Drug delivery to the intestinal lymph by oral formulations.

Pharm Dev Technol 2022 Jan 17:1-61. Epub 2022 Jan 17.

School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.

Oral drug delivery systems (DDS) targeting lymphocytes in intestinal lymphatic vessels, ducts, and nodes are useful for treating diverse diseases. The intestinal lymph harbors numerous lymphocyte subsets, and DDS containing lipids such as triglycerides and fatty acids can deliver drugs to the lymph through the chylomicron pathway. DDS are efficient, thus allowing the administration of reduced drug doses, which mitigate systemic adverse effects. Read More

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January 2022

A drift on liposomes to proliposomes: recent advances and promising approaches.

J Liposome Res 2022 Jan 17:1-15. Epub 2022 Jan 17.

School of Engineering and Technology, National Forensic Sciences University, Gandhinagar, India.

Liposomes are nano-structured vesicles, made up of phospholipids that provide active ingredients at the site of action at a predetermined rate and add the advantage of the sustained-release formulation. Liposomes have stability issues that tend to agglomerate and fuse upon storage, which reflects their drawback. Hence to overcome the aggregation, fusion, hydrolysis, and/or oxidation problems associated with liposomes a new technology named Proliposomes has been introduced. Read More

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January 2022

Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption.

Drug Deliv 2022 Dec;29(1):305-315

School of Life Science, Yantai University, Yantai, P. R. China.

Oral drug delivery to treat diabetes is being increasingly researched. The mucus and the epithelial cell layers hinder drug delivery. We designed a self-ablating nanoparticle to achieve smart oral delivery to overcome the gastrointestinal barrier. Read More

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December 2022

Utilizing RNA nanotechnology to construct negatively charged and ultrasound-responsive nanodroplets for targeted delivery of siRNA.

Drug Deliv 2022 Dec;29(1):316-327

Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, People's Republic of China.

Ultrasound nanodroplets (NDs) have been reported as a promising nanocarrier for siRNA delivery depending on its unique strengths of sonoporation. Presently, common means for NDs-mediated siRNA delivery is through electrostatic interaction, but challenges like cationic toxicity still exist. In this study, we demonstrated a novel strategy to construct negatively charged and ultrasound (US)-responsive O-carboxymethyl chitosan (O-CMS) NDs as a siRNA targeted delivery system through three-way junction of bacteriophage phi29 DNA packaging motor (3WJ-pRNA) nanotechnology. Read More

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December 2022

Synthesis, characterization and evaluation of aqueous Zn-based quantum dots for bioapplications.

Dalton Trans 2022 Jan 17. Epub 2022 Jan 17.

Inorganic Chemistry Laboratory, Chemistry Department, National and Kapodistrian University of Athens, Panepistimiopolis, Zografou 157 71, Greece.

Semiconducting nanoparticles called quantum dots (Qds) present unique optoelectronic properties based on their extremely small size, composition, and spherical shape, which make them suitable for use as diagnostic and theranostic agents in biological samples. The main scope of the fabrication of Qds is real-time diagnosis, therapy, drug delivery, and and tracking, presenting strong resistance to photobleaching. In this work, quantum dots such as ZnO, ZnSe, ZnS, and doped ZnS : Mn and ZnS : Cd were developed a simple sol-gel synthesis in an aqueous solution. Read More

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January 2022

Novel lncRNA AL033381.2 Promotes Hepatocellular Carcinoma Progression by Upregulating PRKRA Expression.

Oxid Med Cell Longev 2022 7;2022:1125932. Epub 2022 Jan 7.

Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, China.

Hepatocellular carcinoma (HCC) is a common malignant tumor that is characterized by aggressiveness and poor prognosis. Accumulating evidence indicates that oxidative stress plays a crucial role in carcinogenesis, whereas the potential mechanism between oxidative stress and carcinogenic effects remains elusive. In recent years, long noncoding RNAs (lncRNAs) in cancers have attracted extensive attention and have been shown to be involved in oxidative stress response and carcinogenesis. Read More

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January 2022

Polymeric nanoparticles as therapeutic agents against coronavirus disease.

J Nanopart Res 2022 10;24(1):12. Epub 2022 Jan 10.

Nanotechnology Engineering Department, Alberto Luiz Coimbra Institute for Graduate Studies and Research in Engineering, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Nanotechnology has the potential to improve the combat against life-threatening conditions. Considering the COVID-19 scenario, and future outbreaks, nanotechnology can play a pivotal role in several steps, ranging from disinfection protocols, manufacture of hospital clothes, to implementation of healthcare settings. Polymeric nanoparticles are colloidal particles with size ranging from 10 to 999 nm, composed of natural or synthetic polymers. Read More

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January 2022

SPIONs self-assembly and magnetic sedimentation in quadrupole magnets: Gaining insight into the separation mechanisms.

Sep Purif Technol 2022 Jan 22;280. Epub 2021 Sep 22.

William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 West Woodruff Avenue, Columbus, OH 43210, United States.

Superparamagnetic iron oxide nanoparticles (SPIONs) are currently popular materials experiencing rapid development with potential application value, especially in biomedical and chemical engineering fields. Examples include wastewater management, bio-detection, biological imaging, targeted drug delivery and biosensing. While not exclusive, magnetically driven isolation methods are typically required to separate the desired entity from the media in specific applications and in their manufacture and/or quality control. Read More

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January 2022

Development and evaluation of a cream containing solid lipid nanoparticles loaded with Vitamin E.

Pak J Pharm Sci 2021 Nov;34(6):2109-2119

Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, RAK Medical & Health Science University, Ras al Khaimah, UAE.

Solid lipid nanoparticles (SLNs) have several potential applications in the topical drug delivery. The current project aimed to prepare and characterize SLNs loaded with vitamin E for topical administration and incorporating the prepared SLNs in a cream base. Further, the permeation of prepared SLNs was studied through a synthetic membrane and the release profiles were compared with vitamin E cream. Read More

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November 2021

Development and Evaluation of a Polyherbal Broad Spectrum Sunscreen formulation using Solid Lipid Nanoparticles of Safranal.

J Cosmet Dermatol 2022 Jan 16. Epub 2022 Jan 16.

Lloyd Institute of Technology and Management (Pharm.), Greater Noida.

UV absorption properties of bioactive agents has lead to their screening and development to provide photo protection. Safranal is one such secondary plant metabolite obtained from Saffron (Crocus sativus) and reported to possess antioxidant and antisolar properties. The objective of this research was to design a suitable delivery system for the topical delivery of Safranal and to develop broad spectrum polyherbal sun protection cream with mild photoprotection. Read More

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January 2022