189,638 results match your criteria n = 7 tbi + vehicle


Acné en el recién nacido.

Bol Med Hosp Infant Mex 2021 ;78(5):443-449

Servicio de Dermatología Pediátrica, Hospital General de México Dr. Eduardo Liceaga, Secretaría de Salud. Ciudad de México, México.

Neonatal acne (NA) is a transitory dermatosis that occurs between the second and fourth weeks of life in 20% of children. This condition is more frequent in males, with a male-female ratio of 4.5:1. Read More

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January 2021

The Impact of Fitness Status on Vascular and Baroreceptor Function in Healthy Women and Men.

J Vasc Res 2021 Sep 27:1-8. Epub 2021 Sep 27.

School of Human Kinetics, Trinity Western University, Langley, British Columbia, Canada.

Background: Chronic endurance exercise training elicits desirable physiological adaptations in the cardiovascular system. The volume of exercise training required to generate healthy adaptations is unclear. This study assessed the effects of differing exercise training levels on arterial stiffness, compliance, and autonomic function. Read More

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September 2021

LEFTY-PITX2 signaling pathway is critical for generation of mature and ventricular cardiac organoids in human pluripotent stem cell-derived cardiac mesoderm cells.

Biomaterials 2021 Sep 21;278:121133. Epub 2021 Sep 21.

Department of Cardiology, Cardiovascular Center, College of Medicine, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea. Electronic address:

The generation of mature ventricular cardiomyocytes (CMs) resembling adult CMs from human pluripotent stem cells (hPSCs) is necessary for disease modeling and drug discovery. To investigate the effect of self-organizing capacity on the generation of mature cardiac organoids (COs), we generated cardiac mesoderm cell-derived COs (CMC-COs) and CM-derived COs (CM-COs) and evaluated COs. CMC-COs exhibited more organized sarcomere structures and mitochondria, well-arranged t-tubule structures, and evenly distributed intercalated discs. Read More

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September 2021

Keratinocyte membrane-mediated nanodelivery system with dissolving microneedles for targeted therapy of skin diseases.

Biomaterials 2021 Sep 23;278:121142. Epub 2021 Sep 23.

Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:

There is a lack of actively targeting drug delivery carriers for the topical treatment of epidermal diseases, which results in drug waste and an increased incidence of toxic side effects in the clinic. We recently discovered that epidermal cells (HaCaT cells) have homologous targeting functions and developed HaCaT cell membrane-coated pH-sensitive micelles for therapeutic active targeting of skin disease. We encapsulated shikonin in these biomimetic nanocarriers and found that the nanocarriers accumulated mainly in the active epidermis when delivered with karaya gum-fabricated water-soluble microneedles. Read More

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September 2021

Rod-like NiCoCO·2HO in-situ formed on rGO by an interface induced engineering: Extraordinary rate and cycle performance as an anode in lithium-ion and sodium-ion half/full cells.

J Colloid Interface Sci 2021 Sep 14;607(Pt 2):1153-1162. Epub 2021 Sep 14.

College of Chemistry, Zhengzhou University, Zhengzhou University, Zhengzhou 450001, China. Electronic address:

Transition metal oxalates have attracted wide attention due to the characteristics of the conversion reaction as anode materials in lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs), However, there are huge volume expansion and sluggish circulation dynamics during the reversible Li and Na insertion/extraction process, which would lead to unsatisfactory reversible capacity and stability. In order to solve these problems, a rod-like structure NiCoCO·2HO is in-situ formed on the reduced graphene oxide layer (NiCoCO·2HO/rGO) in a glycol-water mixture medium via an interface induced engineering strategy. Benefitting from the synergistic cooperation of nano-diameter rod-like structure and high conductive rGO networks, the experimental results show that the prepared NiCoCO·2HO/rGO electrode has predominant rate performance and ultra-long cycle stability. Read More

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September 2021

Reinforcing the tetracene-based two-dimensional CH sheet by decorating the Li, Na, and K atoms for hydrogen storage and environmental application -A DFT study.

Environ Res 2021 Sep 24:112114. Epub 2021 Sep 24.

Department of Physics, Bharathiar University, Coimbatore, 641046, Tamil Nadu, India. Electronic address:

To meet the increasing need of energy resources, hydrogen (H) is being considered as a promising candidate for energy carrier that has motivated research into appropriate storage materials among scientists. Thus, in this study for the first time, zig-zag and armchair edged tetracene based porous carbon sheet (CH) is investigated for H storage using the density functional theory. To explore the hydrogen storage capacity, the hydrogen molecule is initially positioned parallel to the CH sheet at three different sites, resulting in lower adsorption energies of -0. Read More

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September 2021

A microfluidic system for precisely reproducing physiological blood pressure and wall shear stress to endothelial cells.

Analyst 2021 Sep 27;146(19):5913-5922. Epub 2021 Sep 27.

School of Optoelectronic Engineering and Instrumentation Science, Dalian University of Technology, No. 2, Linggong Rd., Dalian 116024, Liaoning Province, China.

To reproduce hemodynamic stress microenvironments of endothelial cells is of vital significance, by which one could exploit the quantitative impact of hemodynamic stresses on endothelial function and seek innovative approaches to prevent circulatory system diseases. Although microfluidic technology has been regarded as an effective method to create physiological microenvironments, a microfluidic system to precisely reproduce physiological arterial hemodynamic stress microenvironments has not been reported yet. In this paper, a novel microfluidic chip consisting of a cell culture chamber with on-chip afterload components designed by the principle of input impedance to mimic the global hemodynamic behaviors is proposed. Read More

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September 2021

Influenza A virus segments five and six can harbor artificial introns allowing expanded coding capacity.

PLoS Pathog 2021 Sep 27;17(9):e1009951. Epub 2021 Sep 27.

Department of Molecular Genetics and Microbiology Duke University School of Medicine Durham, North Carolina, United States of America.

Influenza A viruses encode their genomes across eight, negative sense RNA segments. The six largest segments produce mRNA transcripts that do not generally splice; however, the two smallest segments are actively spliced to produce the essential viral proteins NEP and M2. Thus, viral utilization of RNA splicing effectively expands the viral coding capacity without increasing the number of genomic segments. Read More

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September 2021

NMR Relaxation Rates of Quadrupolar Aqueous Ions from Classical Molecular Dynamics Using Force-Field Specific Sternheimer Factors.

J Chem Theory Comput 2021 Sep 27. Epub 2021 Sep 27.

Sorbonne Université CNRS, Physico-Chimie des Électrolytes et Nanosystèmes Interfaciaux, F-75005 Paris, France.

The nuclear magnetic resonance (NMR) relaxation of quadrupolar nuclei is governed by the electric field gradient (EFG) fluctuations at their position. In classical molecular dynamics (MD), the electron cloud contribution to the EFG can be included via the Sternheimer approximation, in which the full EFG at the nucleus that can be computed using quantum density functional theory (DFT) is considered to be proportional to that arising from the external, classical charge distribution. In this work, we systematically assess the quality of the Sternheimer approximation as well as the impact of the classical force field (FF) on the NMR relaxation rates of aqueous quadrupolar ions at infinite dilution. Read More

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September 2021

Radiological and clinical features of screening-detected pulmonary invasive mucinous adenocarcinoma.

Interact Cardiovasc Thorac Surg 2021 Sep 27. Epub 2021 Sep 27.

Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul, South Korea.

Objectives: The current understanding of pulmonary invasive mucinous adenocarcinoma is largely based on studies of advanced stage patients and data about early-stage invasive mucinous adenocarcinoma are sparse. We evaluated the radiological and clinical features of screening-detected early-stage invasive mucinous adenocarcinoma (SD-IMA).

Methods: Data from 91 patients who underwent surgical treatment for SD-IMA (≤3 cm) from 2013 to 2019 were reviewed retrospectively. Read More

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September 2021

Exploring the emerging of electronic and magnetic properties with adatom adsorption on a novel semiconductor monolayer: NP.

Phys Chem Chem Phys 2021 Sep 27. Epub 2021 Sep 27.

Department of Physics, Shanghai Normal University, Shanghai 200234, P. R. China.

The effect of adsorbed adatoms on the structural stability and electronic properties of monolayer NP have been systematically studied first-principles simulation methods. It is found that pristine NP is an indirect 0.21 eV band gap semiconductor, with a pleated honeycomb-like structure similar to phosphorene. Read More

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September 2021

Clinical Characteristic in Primary Progressive Aphasia in Relation to Alzheimer's Disease Biomarkers.

J Alzheimers Dis 2021 Sep 22. Epub 2021 Sep 22.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Primary progressive aphasia (PPA) is associated with amyloid-β (Aβ) pathology. However, clinical feature of PPA based on Aβ positivity remains unclear.

Objective: We aimed to assess the prevalence of Aβ positivity in patients with PPA and compare the clinical characteristics of patients with Aβ-positive (A+) and Aβ-negative (A-) PPA. Read More

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September 2021

Additive Destabilization of Porous Magnesium Borohydride Framework with Core-Shell Structure.

Small 2021 Sep 27:e2101989. Epub 2021 Sep 27.

The Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.

Design of interfaces with thermodynamic and kinetic specificity is of great importance for hydrogen storage from both an applied and fundamental perspective. Here, in order to destabilize the metal hydride and protect the dehydrogenated products from oxidizing, a unique core-shell structure of porous Mg(BH ) -based framework with a thin layer (no more than 5 nm) of MgCl additives on the surface, has been proposed and synthesized via a wet-chemical method. The local structure and electronic state of the present complex system are systematically investigated to understand the correlation between the distribution of additives and dehydrogenation property of Mg(BH ) . Read More

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September 2021

Synthesis, Crystal and Electronic Structures of a Thiophosphinoyl- and Amino-Substituted Metallated Ylide.

ChemistryOpen 2021 Sep 27. Epub 2021 Sep 27.

Faculty of Chemistry and Biochemistry, Ruhr-University Bochum, Universitätsstraße 150, 44801, Bochum, Germany.

α-Metallated ylides have revealed themselves to be versatile reagents for the introduction of ylide groups. Herein, we report the synthesis of the thiophosphinoyl and piperidyl (Pip) substituted α-metallated ylide [Ph (Pip)P=C-P(S)Ph ]M (M=Li, Na, K) through a four-step synthetic procedure starting from diphenylmethylphosphine sulfide. Metallation of the ylide intermediate was successfully accomplished with different alkali metal bases delivering the lithium, sodium and potassium salts, the latter isolable in high yields. Read More

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September 2021

Metal-based electrocatalysts for room-temperature Na-S batteries.

Mater Horiz 2021 Sep 27. Epub 2021 Sep 27.

Yangtze Delta Region Institute (Huzhou), University of Electronic Science and Technology of China, Huzhou 313001, P. R. China.

Room-temperature sodium-sulfur (RT Na-S) batteries have recently captured intensive research attention from the community and are regarded as one of promising next-generation energy storage devices since they not only integrate the advantages in high abundance and low commercial cost of elemental Na/S but also exhibit exceptionally high theoretical capacity and energy density. Whereas, the notorious shuttle effect of soluble intermediates and sluggish kinetics remain two main obstacles for RT Na-S batteries to step into new developmental stage. Recently, impressive advancements of metal-based electrocatalysts have offered a viable solution to stabilize S cathodes and unlocked new opportunities for RT Na-S batteries. Read More

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September 2021

Structural determination of arginine-linked cisplatin complexes IRMPD action spectroscopy: arginine binds to platinum NO binding mode.

Phys Chem Chem Phys 2021 Sep 27. Epub 2021 Sep 27.

Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.

Cisplatin, (NH)PtCl, has been known as a successful metal-based anticancer drug for more than half a century. Its analogue, Argplatin, arginine-linked cisplatin, (Arg)PtCl, is being investigated because it exhibits reactivity towards DNA and RNA that differs from that of cisplatin. In order to understand the basis for its altered reactivity, the deprotonated and sodium cationized forms of Argplatin, [(Arg-H)PtCl] and [(Arg)PtCl + Na], are examined by infrared multiple photon dissociation (IRMPD) action spectroscopy in the IR fingerprint and hydrogen-stretching regions. Read More

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September 2021

Validation of Self-Monitoring Devices Supporting Sodium Intake Reduction: An Experimental Feeding Study Using Standardized Low-Salt and High-Salt Meals among Healthy Japanese Volunteers.

Ann Nutr Metab 2021 Sep 23:1-10. Epub 2021 Sep 23.

Laboratory of Pharmaceutical Regulatory Science, Faculty of Practical Pharmaceutical Sciences, School of Pharmacy, Nihon University, Chiba, Japan.

Introduction: Although several approaches for approximating daily Na intake and the Na/K ratio using casual urine are available, the most useful method remains unclear during daily practice and at home.

Methods: Twenty-seven participants measured their casual urinary Na/K ratio repeatedly using a Na/K ratio monitor and also measured overnight urine once daily using a monitoring device which delivers on-site feedback to estimate their salt intake under unrestricted, low-salt (LS) (6 g/day), and high-salt (HS) (12 g/day) diets.

Results: The monitoring method utilizing overnight urine to estimate daily Na remained insensitive, resulting in significant overestimation during the LS diet and underestimation during the HS diet periods; estimated salt intake during the LS and HS diet periods plateaued at 7-8 g/day and 9-10 g/day within 3 day; mean estimated salt intake was 11. Read More

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September 2021

Salt-Sensitivity of Blood Pressure in Blacks and Women: A role of Inflammation, Oxidative Stress and ENaC.

Antioxid Redox Signal 2021 Sep 25. Epub 2021 Sep 25.

Vanderbilt University Medical Center, 12328, 2220 Pierce Ave, 536 RRB, Nashville, Tennessee, United States, 37232-2102;

Significance: Salt-sensitivity of blood pressure (SSBP) is an independent risk factor for mortality and morbidity due to cardiovascular disease, and disproportionately affects blacks and women. Several mechanisms have been proposed including exaggerated activation of sodium transporters in the kidney leading to salt retention and water. Recent advances: Recent studies have found that in addition to the renal epithelium, myeloid immune cells can sense sodium via the epithelial Na+ channel (ENaC), which leads to activation of the NADPH oxidase enzyme complex, increased fatty acid oxidation, and production of isolevuglandins (IsoLGs). Read More

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September 2021

Unraveling the Role of Fluorinated Alkyl Carbonate Additives in Improving Cathode Performance in Sodium-Ion Batteries.

ACS Appl Mater Interfaces 2021 Sep 26. Epub 2021 Sep 26.

Department of Chemistry, Bar-Ilan University, Ramat Gan 5290002, Israel.

A key issue in the development of sustainable Na-ion batteries (NIBs) is the stability of the electrolyte solution and its ability to form effective passivation layers on both cathode and anode. In this regard, the use of fluorine-based additives is considered a promising direction for improving electrode performance. Fluoroethylene carbonate (FEC) and -difluoroethylene carbonate (DFEC) were demonstrated as additives or cosolvents that form effective passivating surface films in Li-ion batteries. Read More

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September 2021

Heavily Tungsten Doped Sodium Thioantimonate Solid State Electrolytes with Exceptionally Low Activation Energy for Ionic Diffusion.

Angew Chem Int Ed Engl 2021 Sep 26. Epub 2021 Sep 26.

The University of Texas at Austin, Department of Mechanical Engineering, 2501 Speedway, 78712-1591, Austin, UNITED STATES.

This study puts forward a powerful strategy based on multiple synergistic design rules for modifying the structure of solid-state electrolytes (SSEs) to reduce the cation diffusion activation energy. Two heavily W-doped sodium thioantimonate SSEs, Na 2.895 W 0. Read More

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September 2021

Design Principles of Sodium/Potassium Protection Layer for High-Power High-Energy Sodium/Potassium-Metal Batteries in Carbonate Electrolytes: a Case Study of Na Te/K Te.

Adv Mater 2021 Sep 27:e2106353. Epub 2021 Sep 27.

Hefei National Laboratory for Physical Sciences at the Microscale, Department of Materials Science and Engineering, CAS Key Laboratory of Materials for Energy Conversion, National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui, 230026, China.

The sodium (potassium)-metal anodes combine low-cost, high theoretical capacity, and high energy density, demonstrating promising application in sodium (potassium)-metal batteries. However, the dendrites' growth on the surface of Na (K) has impeded their practical application. Herein, density functional theory (DFT) results predict Na Te/K Te is beneficial for Na /K transport and can effectively suppress the formation of the dendrites because of low Na /K migration energy barrier and ultrahigh Na /K diffusion coefficient of 3. Read More

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September 2021

ZnO and TiO Nanocolloids: State of Mechanisms that Regulating the Motility of the Gastrointestinal Tract and the Hepatobiliary System.

ACS Omega 2021 Sep 9;6(37):23960-23976. Epub 2021 Sep 9.

Institute of High Technologies, Taras Shevchenko National University of Kyiv, 64, Volodymyrska Str, 01033 Kyiv, Ukraine.

Using the transmission electron microscopy (TEM)/high-resolution TEM (HRTEM) and selected area electron diffraction (SAED) methods, it was shown that the nanocolloids of ZnO contain hydrolyzed ZnO nanoparticles (NPs). Typically, the nanocrystalline ZnO/Zn(OH) core is covered by an amorphous shell of zinc hydroxides, preventing the encapsulated crystal core from dissolving. Similar studies were carried out with TiO nanocolloids. Read More

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September 2021

Effective Modified Xanthan Gum Fluid Loss Agent for High-Temperature Water-Based Drilling Fluid and the Filtration Control Mechanism.

ACS Omega 2021 Sep 7;6(37):23788-23801. Epub 2021 Sep 7.

School of Engineering and Technology, China University of Geosciences (Beijing), Beijing 100083, P.R. China.

Xanthan gum (XG) was widely used as an oilfield chemical treatment agent because of its environmental protection and diverse functions. With the increased drilling depth and formation complexity, the shortcomings such as poor solubility and low resistance to temperature were gradually exposed. In this study, a modified XG derivative XG--AAA was synthesized by grafting XG with acrylic acid (AA), acrylamide (AM), and 2-acrylamido-2-methylpropane sulfonic acid (AMPS). Read More

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September 2021

Synergistic Anti-inflammatory and Neuroprotective Effects of and Z Alleviate Diabetes-Induced Hippocampal Changes in Male Albino Rats: Structural and Molecular Evidence.

Front Cell Dev Biol 2021 8;9:727049. Epub 2021 Sep 8.

Medical Histology and Cell Biology Department, Faculty of Medicine, Damietta University, Damietta, Egypt.

Depression has been reported as a common comorbidity in diabetes mellitus although the underlying mechanism responsible for this is not well known. Although both ginger and cinnamon has anti-diabetic, antioxidant, and neuroprotective properties, their efficacy in inhibiting neuroinflammation, when simultaneously administrated, has not been investigated yet. The study was designed to assess the synergistic effect of and Z on regulating blood glucose, improve hippocampal structural changes and depressive-like alternations in diabetic rats, and try to identify the mechanism behind this effect. Read More

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September 2021

Reliability of mobile application-based cephalometric analysis for chair side evaluation of orthodontic patient in clinical practice.

J Orthod Sci 2021 4;10:16. Epub 2021 Aug 4.

Department of Orthodontics and Dentofacial Orthopaedics, I.T.S. Center for Dental Studies and Research, Muradnagar, Ghaziabad, Uttar Pradesh, India.

Objectives: The purpose of this study was to evaluate the accuracy and reliability of Mobile Application-Based Software for chair side cephalometric analysis.

Materials And Method: Pretreatment lateral cephalograms of 20 patients (10 males and 10 females) were selected randomly and were traced manually and also using Application-based software (One Ceph). 20 angular and three linear parameters were measured both manually and with the software in all the patients. Read More

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Animal, Human, and Na MRI Imaging Evidence for the Negative Impact of High Dietary Salt in Children.

Curr Pediatr Rep 2021 Sep 18:1-8. Epub 2021 Sep 18.

Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC USA.

Purpose Of The Review: Conditions typically prevalent in adults such as hypertension, kidney stones, osteoporosis, and chronic kidney disease are increasing among adolescents and young adults (AYA). The purpose of this review is to describe the association of these conditions to a high salt diet among pediatric patients.

Recent Findings: We present animal, human, and Na MRI evidence associated with the negative impact of high dietary salt in children. Read More

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September 2021

Eigenmode operation of piezoelectric resonant gyroscopes.

Microsyst Nanoeng 2020 30;6:108. Epub 2020 Nov 30.

School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30308 USA.

The theory of eigenmode operation of Coriolis vibratory gyroscopes and its implementation on a thin-film piezoelectric gyroscope is presented. It is shown analytically that the modal alignment of resonant gyroscopes can be achieved by applying a rotation transformation to the actuation and sensing directions regardless of the transduction mechanism. This technique is especially suitable for mode matching of piezoelectric gyroscopes, obviating the need for narrow capacitive gaps or DC polarization voltages. Read More

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November 2020

The 96-week clinical outcomes after cessation of nucleos(t)ide analog treatment in chronic hepatitis B patients.

Gastroenterol Rep (Oxf) 2021 Aug 10;9(4):313-322. Epub 2021 Apr 10.

Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.

Background: Chronic hepatitis B (CHB) patients have a high virological relapse rate after cessation of nucleos(t)ide analog (NA) treatment, but the clinical outcome remains unclear. This study aimed to investigate the 96-week clinical outcomes and the risk factors for relapse in CHB after cessation of NAs.

Methods: This study was a prospective trial; 74 eligible patients were enrolled. Read More

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High Na Environments Impair Phagocyte Oxidase-Dependent Antibacterial Activity of Neutrophils.

Front Immunol 2021 10;12:712948. Epub 2021 Sep 10.

Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg and University of Regensburg, Regensburg, Germany.

Infection and inflammation can augment local Na abundance. These increases in local Na levels boost proinflammatory and antimicrobial macrophage activity and can favor polarization of T cells towards a proinflammatory Th17 phenotype. Although neutrophils play an important role in fighting intruding invaders, the impact of increased Na on the antimicrobial activity of neutrophils remains elusive. Read More

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September 2021

Increased Sodium Concentration in Substantia Nigra in Early Parkinson's Disease: A Preliminary Study With Ultra-High Field (7T) MRI.

Front Neurol 2021 9;12:715618. Epub 2021 Sep 9.

APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France.

Pathophysiology of idiopathic Parkinson's disease (iPD) is complex and still misunderstood. At a time when treatments with disease-modifying potential are being developed, identification of early markers of neurodegeneration is essential. Intracerebral sodium accumulation could be one of them. Read More

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September 2021