359 results match your criteria n = 20 doac

Effect of t (11;14) Abnormality on Outcomes of Patients With Newly Diagnosed Multiple Myeloma in the Connect MM Registry.

Clin Lymphoma Myeloma Leuk 2021 Aug 29. Epub 2021 Aug 29.

Department of Hematology/Oncology, Indiana University, Indianapolis, IN.

Background: The t (11;14) (q13;32) translocation [t (11;14)] is present in ∼20% of patients with newly diagnosed multiple myeloma (NDMM), but studies examining its prognostic ability have yielded divergent results, and data are lacking on outcomes from first-line therapy.

Patients And Methods: Data from the Connect MM Registry, a large US, multicenter, prospective observational cohort study of patients with NDMM were used to examine the effect of t (11;14) status on first-line therapy outcomes in the Overall population (n = 1574) and race groups (African American [AA] vs. non-African American [NAA]). Read More

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Frequency drift in MR spectroscopy at 3T.

Neuroimage 2021 11 24;241:118430. Epub 2021 Jul 24.

School of Health Sciences, Purdue University, West Lafayette, IN USA.

Purpose: Heating of gradient coils and passive shim components is a common cause of instability in the B field, especially when gradient intensive sequences are used. The aim of the study was to set a benchmark for typical drift encountered during MR spectroscopy (MRS) to assess the need for real-time field-frequency locking on MRI scanners by comparing field drift data from a large number of sites.

Method: A standardized protocol was developed for 80 participating sites using 99 3T MR scanners from 3 major vendors. Read More

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November 2021

Brain proton magnetic resonance spectroscopy and neurodevelopment after preterm birth: a systematic review.

Pediatr Res 2021 May 5. Epub 2021 May 5.

Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.

Background: Preterm infants are at risk of neurodevelopmental impairments. At present, proton magnetic resonance spectroscopy (H-MRS) is used to evaluate brain metabolites in asphyxiated term infants. The aim of this review is to assess associations between cerebral H-MRS and neurodevelopment after preterm birth. Read More

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Proton Magnetic Resonance Spectroscopy of N-acetyl Aspartate in Chronic Schizophrenia, First Episode of Psychosis and High-Risk of Psychosis: A Systematic Review and Meta-Analysis.

Neurosci Biobehav Rev 2020 12 14;119:255-267. Epub 2020 Oct 14.

Medical Research Council London Institute of Medical Sciences, Hammersmith Hospital, London W12 0NN; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN; Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London, SE5 8AF, UK.

N-acetyl-aspartate (NAA) is a readily measured marker of neuronal metabolism. Previous analyses in schizophrenia have shown NAA levels are low in frontal, temporal and thalamic regions, but may be underpowered to detect effects in other regions, in high-risk states and in first episode psychosis. We searched for magnetic resonance spectroscopy studies comparing NAA in chronic schizophrenia, first episode psychosis and high risk of psychosis to controls. Read More

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December 2020

Magnetic Resonance Spectroscopy following Mild Traumatic Brain Injury: A Systematic Review and Meta-Analysis on the Potential to Detect Posttraumatic Neurodegeneration.

Neurodegener Dis 2020 1;20(1):2-11. Epub 2020 Jul 1.

Department of Geriatric Psychiatry, Psychiatric Hospital Zurich, University of Zurich, Zurich, Switzerland,

Introduction: Traumatic brain injury (TBI) is the most relevant external risk factor for dementia and a major global health burden. Mild TBI (mTBI) contributes to up to 90% of all TBIs, and the classification "mild" often misrepresents the patient's burden who suffer from neuropsychiatric long-term sequelae. Magnetic resonance spectroscopy (MRS) allows in vivo detection of compromised brain metabolism although it is not routinely used after TBI. Read More

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Application of H-MRS in end-stage renal disease with depression.

BMC Nephrol 2020 06 15;21(1):225. Epub 2020 Jun 15.

Department of Medical Imaging Center, The Affiliated Hospital of Qingdao University, 16 Jiang-Su Road, Qingdao, PR China.

Background: To investigate the metabolite changes in the frontal lobe of the end-stage renal disease (ESRD) patients with depression using proton magnetic resonance spectroscopy (H-MRS).

Methods: All subjects were divided into three groups: ESRD patients with depression (30 cases), ESRD patients without depression (27 cases) and 32 normal subjects. ESRD with depression patients were further divided into two groups according to the severity of depression: 14 cases of ESRD with severe depression group (Hamilton Depression Rating Scale (HAMD) score ≥ 35) and 16 cases of ESRD with mild to moderate depression group (20 ≤ HAMD score<35). Read More

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Detection of Colorectal Cancer and Advanced Adenoma by Liquid Biopsy (Decalib Study): The ddPCR Challenge.

Cancers (Basel) 2020 Jun 6;12(6). Epub 2020 Jun 6.

University of Poitiers, 86000 Poitiers, France.

Background: In most countries, participation in colorectal cancer (CRC) screening programs with the immunological fecal occult blood test (iFOBT) is low. Mutations of RAS and BRAF occur early in colorectal carcinogenesis and "liquid biopsy" allows detection of mutated circulating tumor DNA (ctDNA). This prospective study aims to evaluate the performance of RAS and BRAF-mutated ctDNA in detecting CRC and advanced adenomas (AA). Read More

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Effects of Endovascular Stent-Assisted Angioplasty on Cellular Metabolism in the Hippocampus of Elderly Patients with Symptomatic Vertebrobasilar Artery Stenosis.

Med Sci Monit 2020 May 11;26:e922131. Epub 2020 May 11.

Department of Neurology, The Third People's Hospital of Hangzhou, Hangzhou, Zhejiang, China (mainland).

BACKGROUND Cerebral artery stenosis is closely related to cognitive function, and angioplasty can improve the cognitive function of elderly patients with vertebrobasilar artery stenosis. The specific mechanism, however, is not clear. This study explored the effect of angioplasty on cellular metabolism in the hippocampus of elderly patients with symptomatic vertebrobasilar artery stenosis. Read More

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Intermittent theta-burst stimulation moderates interaction between increment of N-Acetyl-Aspartate in anterior cingulate and improvement of unipolar depression.

Brain Stimul 2020 Jul - Aug;13(4):943-952. Epub 2020 Mar 27.

Department of Psychiatry and Psychotherapy, University of Marburg, Germany; Marburg Center for Mind, Brain and Behavior, MCMBB, University of Marburg, Germany.

Background: Intermittent theta-burst stimulation (iTBS), a novel repetitive transcranial magnetic stimulation (rTMS) technique, appears to have antidepressant effects when applied over left dorsolateral prefrontal cortex (DLPFC). However, its underlying neurobiological mechanisms are unclear. Proton magnetic resonance spectroscopy (H-MRS) provides in vivo measurements of cerebral metabolites altered in major depressive disorder (MDD) like N-acetyl-aspartate (NAA) and choline-containing compounds (Cho). Read More

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December 2020

Plasma N-Acetylaspartate Is Related to Age, Obesity, and Glucose Metabolism: Effects of Antidiabetic Treatment and Bariatric Surgery.

Front Endocrinol (Lausanne) 2020 17;11:216. Epub 2020 Apr 17.

C.N.R. Institute of Clinical Physiology, Pisa, Italy.

N-acetylaspartate (NAA) is synthesized only by neurons and is involved in neuronal metabolism and axonal myelination. NAA is the strongest signal on brain magnetic resonance spectroscopy, and its concentration have been associated with cognitive dysfunction in neurodegenerative diseases, obesity, and type 2 diabetes (T2D). We explored the impact of obesity and T2D on circulating NAA as well as the impact of bariatric surgery and antidiabetic treatments. Read More

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Neurometabolic Remodeling in Chronic Hiv Infection: a Five-Year Follow-up Multi-Voxel Mrs Study.

Sci Rep 2019 12 24;9(1):19799. Epub 2019 Dec 24.

University of Novi Sad, Faculty of Medicine Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia.

There is a lack of data about the long-term follow-up changes in neurometabolic profile and neuropsychological performance of HIV-positive subjects under continuous antiretroviral therapy (cART). The aim of the study was to assess changes in neurometabolic profile in chronically-infected, HIV-positive subjects during a five-year follow-up period, using multi-voxel proton magnetic resonance spectroscopy (H-MRS). Nineteen neurologically asymptomatic, aviremic, HIV-positive subjects, underwent multi-voxel 2D MRS on a 3 T MR unit and synchronous neurocognitive assessment in a five-year follow-up period. Read More

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December 2019

Value of CA-125 Glycoprotein in Predicting Acute Appendicitis; a Diagnostic Accuracy Study.

Arch Acad Emerg Med 2019 6;7(1):e24. Epub 2019 Apr 6.

Emergency Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Carcinogen antigen 125 (CA-125) is a glycoprotein antigen, which has shown potentials in predicting peritoneal inflammation. The aim of this study is to determine the value of CA-125 in predicting acute appendicitis (AA).

Methods: This prospective diagnostic accuracy study was conducted on 15 - 70 year-old patients with acute abdominal pain, suspected to AA, referred to emergency department. Read More

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Age-related Brain Metabolic Changes up to Seventh Decade in Healthy Humans : Whole-brain Magnetic Resonance Spectroscopic Imaging Study.

Clin Neuroradiol 2020 Sep 26;30(3):581-589. Epub 2019 Jul 26.

Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Purpose: To study brain metabolic changes under normal aging and to collect reference data for the study of neurodegenerative diseases.

Methods: A total of 55 healthy subjects aged 20-70 years (n ≥ 5 per age decade for each gender) underwent whole-brain magnetic resonance spectroscopic imaging at 3T after completing a DemTect test and the Beck depressions inventory II to exclude cognitive impairment and mental disorder. Regional concentrations of N-acetylaspartate (NAA), choline-containing compounds (Cho), total creatine (tCr), glutamine and glutamate (Glx), and myo-inositol (mI) were determined in 12 brain regions of interest (ROIs). Read More

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September 2020

Effects of the antidepressant medication duloxetine on brain metabolites in persistent depressive disorder: A randomized, controlled trial.

PLoS One 2019 19;14(7):e0219679. Epub 2019 Jul 19.

Institute for the Developing Mind, Children's Hospital Los Angeles, Los Angeles, CA, United States of America.

Background: To assess whether patients with Persistent Depressive Disorder (PDD) have abnormal levels of N-acetyl-aspartate (NAA) and whether those levels normalize following treatment with the antidepressant medication duloxetine. Furthermore, we conducted post hoc analyses of other important brain metabolites to understand better the cellular and physiological determinants for changes in NAA levels.

Methods: We acquired proton (1H) magnetic resonance spectroscopic imaging (MRSI) data on a 3 Tesla (3T), GE Magnetic Resonance Imaging (MRI) scanner in 41 patients (39. Read More

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Cervical spondylotic myelopathy: Changes of fractional anisotropy in the spinal cord and magnetic resonance spectroscopy of the primary motor cortex in relation to clinical symptoms and their duration.

Eur J Radiol 2019 Jul 16;116:55-60. Epub 2019 Apr 16.

Department of Neurosurgery, RWTH Aachen University, Pauwelsstr. 30, 52074 Aachen, Germany.

Objective: To determine the changes in fractional anisotropy (FA) at the proximal spinal cord and in magnetic resonance spectroscopy (MRS) of the precentral gyrus in patients with cervical spondylotic myelopathy (CSM) with respect to clinical symptoms and their duration.

Material And Methods: 20 patients with CSM (7 female; mean age 64.6 ± 10. Read More

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High-Density Plasmonic Nanoparticle Arrays Deposited on Nanoporous Anodic Alumina Templates for Optical Sensor Applications.

Nanomaterials (Basel) 2019 Apr 3;9(4). Epub 2019 Apr 3.

Institute of Chemical Physics, University of Latvia, 19 Raina Blvd., LV-1586 Riga, Latvia.

This study demonstrates a new, robust, and accessible deposition technique of metal nanoparticle arrays (NPAs), which uses nanoporous anodic alumina (NAA) as a template for capillary force-assisted convective colloid (40, 60, and 80 nm diameter Au) assembly. The NPA density and nanoparticle size can be independently tuned by the anodization conditions and colloid synthesis protocols. This enables production of non-touching variable-density NPAs with controllable gaps in the 20-60 nm range. Read More

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Choline Compounds of the Frontal Lobe and Temporal Glutamatergic System in Bipolar and Schizophrenia Proton Magnetic Resonance Spectroscopy Study.

Dis Markers 2018 25;2018:3654894. Epub 2018 Nov 25.

Department of Psychiatry, Medical University of Białystok, Plac Brodowicza 1, 16-070 Choroszcz, Poland.

Purpose: Modern neuroimaging techniques allow investigating brain structures and substances involved in the pathophysiology of mental disorders, trying to find new markers of these disorders. To better understanding of the pathophysiology and differential diagnosis of schizophrenia and bipolar disorder, this study was conducted to assess the neurochemical alterations in the frontal and temporal lobes in hospitalized patients with schizophrenia and bipolar disorder.

Methods: Twenty-one subjects with schizophrenia (paranoid and differentiated types), 16 subjects with bipolar I disorder (manic, depressive, and mixed episode), and 20 healthy subjects were studied. Read More

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The Effect of a High-Dose Vitamin B Multivitamin Supplement on the Relationship between Brain Metabolism and Blood Biomarkers of Oxidative Stress: A Randomized Control Trial.

Nutrients 2018 Dec 1;10(12). Epub 2018 Dec 1.

Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia.

A diet rich in B-group vitamins is essential for optimal body and brain function, and insufficient amounts of such vitamins have been associated with higher levels of neural inflammation and oxidative stress, as marked by increased blood plasma homocysteine. Neural biomarkers of oxidative stress quantified through proton magnetic spectroscopy (1H-MRS) are not well understood, and the relationship between such neural and blood biomarkers is seldom studied. The current study addresses this gap by investigating the direct effect of 6-month high-dose B-group vitamin supplementation on neural and blood biomarkers of metabolism. Read More

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December 2018

Magnetic resonance spectroscopy assessment of brain injury after moderate hypothermia in neonatal encephalopathy: a prospective multicentre cohort study.

Lancet Neurol 2019 01 15;18(1):35-45. Epub 2018 Nov 15.

Neonatal-Perinatal Medicine, Wayne State University, Detroit, MI, USA.

Background: In neonatal encephalopathy, the clinical manifestations of injury can only be reliably assessed several years after an intervention, complicating early prognostication and rendering trials of promising neuroprotectants slow and expensive. We aimed to determine the accuracy of thalamic proton magnetic resonance (MR) spectroscopy (MRS) biomarkers as early predictors of the neurodevelopmental abnormalities observed years after neonatal encephalopathy.

Methods: We did a prospective multicentre cohort study across eight neonatal intensive care units in the UK and USA, recruiting term and near-term neonates who received therapeutic hypothermia for neonatal encephalopathy. Read More

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January 2019

Proton magnetic resonance spectroscopy lactate/N-acetylaspartate within 2 weeks of birth accurately predicts 2-year motor, cognitive and language outcomes in neonatal encephalopathy after therapeutic hypothermia.

Arch Dis Child Fetal Neonatal Ed 2019 Jul 15;104(4):F424-F432. Epub 2018 Oct 15.

Institute for Women's Health, University College London, London, UK.

Objective: Brain proton (H) magnetic resonance spectroscopy (MRS) lactate/N-acetylaspartate (Lac/NAA) peak area ratio is used for prognostication in neonatal encephalopathy (NE). At 3 Tesla in NE babies, the objectives were to assess: (1) sensitivity and specificity of basal ganglia and thalamus (BGT) H MRS Lac/NAA for the prediction of Bayley III outcomes at 2 years using optimised metabolite fitting (Tarquin) with threonine and total NAA; (2) prediction of motor outcome with diffusion-weighted MRI; (3) BGT Lac/NAA correlation with the National Institute of Child Health and Human Development (NICHD) MRI score.

Subjects And Methods: 55 (16 inborn, 39 outborn) infants at 39w+5 d (35w+5d-42w+0d) with NE admitted between February 2012 and August 2014 to University College London Hospitals for therapeutic hypothermia underwent MRI and H MRS at 3T on day 2-14 (median day 5). Read More

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The Significance of Low Titre Antigliadin Antibodies in the Diagnosis of Gluten Ataxia.

Nutrients 2018 Oct 5;10(10). Epub 2018 Oct 5.

Departments of Gastroenterology, Sheffield Teaching Hospitals NHS Trust, Sheffield S10 2JF, UK.

Background: Patients with gluten ataxia (GA) without enteropathy have lower levels of antigliadin antibodies (AGA) compared to patients with coeliac disease (CD). Magnetic Resonance Spectroscopy (NAA/Cr area ratio) of the cerebellum improves in patients with GA following a strict gluten-free diet (GFD). This is associated with clinical improvement. Read More

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October 2018

Magnetic resonance (MR) spectroscopic measurement of γ-aminobutyric acid (GABA) in major depression before and after electroconvulsive therapy.

Acta Neuropsychiatr 2019 Feb 6;31(1):17-26. Epub 2018 Aug 6.

1Center of Functionally Integrative Neuroscience,Aarhus University Hospital,Aarhus, Denmark.

Objective: Prior studies suggest that a dysregulation of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) is involved in the pathophysiology of major depression. We aimed to elucidate changes in cortical GABA content in relation to depression and electroconvulsive therapy (ECT) using magnetic resonance spectroscopy (MRS).

Methods: In total, 11 patients with major depression or depressive episode of bipolar disorder (mean pre-ECT Ham-17 of 26) and 11 healthy subjects were recruited. Read More

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February 2019

Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain.

Biol Sex Differ 2018 07 25;9(1):34. Epub 2018 Jul 25.

Nutrition in Prevention and Therapy, Institute for Nutritional Sciences, University of Giessen, Wilhelmstr. 20, 35392, Giessen, Germany.

Background: Alzheimer's disease (AD) is the most common form of dementia, and it affects more women than men. Mitochondrial dysfunction (MD) plays a key role in AD, and it is detectable at an early stage of the degenerative process in peripheral tissues, such as peripheral mononuclear blood cells (PBMCs). However, whether these changes are also reflected in cerebral energy metabolism and whether sex-specific differences in mitochondrial function occur are not clear. Read More

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Establishment and Phytochemical Analysis of a Callus Culture from (Asteraceae) and Its Anti-Inflammatory Activity.

Molecules 2018 May 25;23(6). Epub 2018 May 25.

Centro de Investigaciones Químicas-IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Chamilpa, Cuernavaca, Morelos 62209, Mexico.

A protocol was established to produce bioactive compounds in a callus culture of by using 1 mg L NAA with 0.1 mg L KIN. The phytochemical study of the EtOAc extract obtained from the callus biomass, allowed the isolation and characterization of eleven secondary metabolites, of which dihydrobenzofuran () and 3-epilupeol (), showed important anti-inflammatory activity. Read More

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Risk factors associated with allergic sensitization and asthma phenotypes among poultry farm workers.

Am J Ind Med 2018 06 25;61(6):515-523. Epub 2018 Mar 25.

Division of Occupational Medicine and Centre for Environmental and Occupational Health Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, Western Cape, South Africa.

Background: This study investigated the risk factors for occupational allergic sensitization and various asthma phenotypes in poultry-workers.

Methods: A cross-sectional study of 230 workers used a modified ECRHS questionnaire, spirometry, FeNO, Phadiatop, and sIgE to poultry farming related allergens.

Results: Worker's mean age was 37 ± 9 years, 68% male, 43% current-smokers, 34% atopic, and 5% casual-workers. Read More

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Quantification of glutathione transverse relaxation time T using echo time extension with variable refocusing selectivity and symmetry in the human brain at 7 Tesla.

J Magn Reson 2018 05 1;290:1-11. Epub 2018 Mar 1.

Department of Biomedical Engineering, Columbia University Fu Foundation School of Engineering and Applied Science, 1210 Amsterdam Ave., New York, NY 10027, United States; Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, United States; Department of Radiology, Columbia University College of Physicians and Surgeons, 622 W 168 Street, New York, NY 10032, United States; Department of Neurology, Yale University School of Medicine, 330 Cedar Street, New Haven, CT 06520, United States.

Glutathione (GSH) is an endogenous antioxidant implicated in numerous biological processes, including those associated with multiple sclerosis, aging, and cancer. Spectral editing techniques have greatly facilitated the acquisition of glutathione signal in living humans via proton magnetic resonance spectroscopy, but signal quantification at 7 Tesla is still hampered by uncertainty about the glutathione transverse decay rate T relative to those of commonly employed quantitative references like N-acetyl aspartate (NAA), total creatine, or water. While the T of uncoupled singlets can be derived in a straightforward manner from exponential signal decay as a function of echo time, similar estimation of signal decay in GSH is complicated by a spin system that involves both weak and strong J-couplings as well as resonances that overlap those of several other metabolites and macromolecules. Read More

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Improved resolution of glutamate, glutamine and γ-aminobutyric acid with optimized point-resolved spectroscopy sequence timings for their simultaneous quantification at 9.4 T.

NMR Biomed 2018 Jan 3;31(1). Epub 2017 Nov 3.

Department of Oncology, University of Alberta, Edmonton, AB, Canada.

Glutamine (Gln), glutamate (Glu) and γ-aminobutyric acid (GABA) are relevant brain metabolites that can be measured with magnetic resonance spectroscopy (MRS). This work optimizes the point-resolved spectroscopy (PRESS) sequence echo times, TE and TE , for improved simultaneous quantification of the three metabolites at 9.4 T. Read More

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January 2018

Detection and application of neurochemical profile by multiple regional H-MRS in Parkinson's disease.

Brain Behav 2017 09 13;7(9):e00792. Epub 2017 Aug 13.

Department of Neurologythe Second Affiliated Hospital of Shantou University Medical College Shantou Guangdong China.

Introduction: The accurate diagnosis and monitoring of idiopathic Parkinson disease (PD), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy (H-MRS). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of H-MRS. Read More

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September 2017

Hippocampal metabolism and prefrontal brain structure: A combined 1H-MR spectroscopy, neuropsychological, and voxel-based morphometry (VBM) study.

Brain Res 2017 Dec 9;1677:14-19. Epub 2017 Sep 9.

Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany; Department of Psychiatry and Psychotherapy, Philipps University Marburg & Marburg University Hospital/UKGM, Marburg, Germany. Electronic address:

Hippocampal structural and functional integrity impacts on multiple remote areas of the brain, and this connectivity is central to multiple cognitive functions in healthy and disease. We studied associations of hippocampal metabolic markers N-acetyl aspartate (NAA) and glutamate (Glu and Glx; assessed with 1H magnetic resonance spectroscopy) and brain grey matter (studied with voxel-based morphometry, VBM) in 20 healthy subjects. We found a significant correlation between right hippocampal NAA and left ventrolateral prefrontal cortical grey matter (TFCE, p<0. Read More

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December 2017

Spatial Relationship of Glioma Volume Derived from F-FET PET and Volumetric MR Spectroscopy Imaging: A Hybrid PET/MRI Study.

J Nucl Med 2018 04 28;59(4):603-609. Epub 2017 Aug 28.

Institute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, Jülich, Germany.

PET imaging of amino acid transport using -(2-F-fluoroethyl)-l-tyrosine (F-FET) and proton MR spectroscopy (MRS) imaging of cell turnover measured by the ratio of choline to -acetyl-aspartate (Cho/NAA) may provide additional information on tumor extent of cerebral gliomas compared with anatomic imaging; however, comparative studies are rare. In this prospective study, 41 patients (16 women, 25 men; mean age ± SD, 48 ± 14 y) with cerebral gliomas (World Health Organization [WHO] grade II: 10 [including 1 patient with 2 lesions], WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid PET/MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in F-FET PET and MRS imaging of Cho/NAA, determined by simultaneously acquired, 3-dimensional spatially resolved MRS imaging data, were compared. Read More

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