6,138 results match your criteria n=40 -control


Effect of ultrasound-guided pulsed radiofrequency on intercostal neuralgia after lung cancer surgery: A retrospective study.

Medicine (Baltimore) 2021 May;100(19):e25338

Department of Ultrasound, 4th (Xing Yuan) Hospital of Yulin, Yulin, Shaanxi, China.

Abstract: This retrospective study investigated the effect of ultrasound-guided pulsed radiofrequency (UGPRF) on intercostal neuralgia (ICN) after lung cancer surgery (LCS).This retrospective observational study analyzed the outcome data of UGPRF on ICN in 80 patients with LCS. All those patients were allocated into a treatment group (n = 40) and a control group (n = 40). Read More

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Prospective, Single-Center Comparison of Transcranial Direct Current Stimulation Plus Electroacupuncture and Standard Analgesia in Patients After Total Knee Arthroplasty: Effect on Rehabilitation and Functional Recovery.

Med Sci Monit 2021 Jun 9;27:e930363. Epub 2021 Jun 9.

Department of Rehabilitation Medicine, The Affiliated Huai'an Hospital of Xuzhou Medical University and the Second People's Hospital of Huai'an, Huai'an, Jiangsu, China (mainland).

BACKGROUND The aim of this prospective study was to compare transcranial direct current stimulation (tDCS) plus electroacupuncture with standard analgesia in patients after total knee arthroplasty (TKA) to determine the effects on rehabilitation and functional recovery. MATERIAL AND METHODS Eighty patients with osteoarthritis of the knee who underwent TKA were included in the study. They were divided into experimental (n=40) and control groups (n=40) according to postoperative analgesia method. Read More

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Pioglitazone and/or irbesartan ameliorate COPD-induced endothelial dysfunction in side stream cigarette smoke-exposed mice model.

Life Sci 2021 Jun 5:119706. Epub 2021 Jun 5.

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt. Electronic address:

Aims: Cigarette smoking (CS) is the main cause of chronic obstructive pulmonary disease (COPD). Endothelial dysfunction is related to the severity of pulmonary disease in COPD. This study aimed to evaluate the effectiveness of single and combined administration of pioglitazone (Pio) and irbesartan (Irb) against COPD-induced endothelial dysfunction in mice and the involvement of NO and HS in their effects. Read More

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Prospective study of stereotactic body radiation therapy for hepatocellular carcinoma on waitlist for liver transplant.

Hepatology 2021 Jun 6. Epub 2021 Jun 6.

Department of Surgery, The University of Hong Kong.

Background & Aims: There is no prospective data on stereotactic body radiation therapy (SBRT) as a bridge to liver transplantation for hepatocellular carcinoma (HCC). This study aimed to evaluate the efficacy and safety of SBRT as bridging therapy, with comparison to transarterial chemoembolization (TACE) and high intensity focused ultrasound (HIFU).

Approach And Results: Patients were prospectively enrolled for SBRT under a standardized protocol from July 2015, and compared to a retrospective cohort of patients who underwent TACE or HIFU from 2010. Read More

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Blood RNA signature RISK4LEP predicts leprosy years before clinical onset.

EBioMedicine 2021 Jun 2;68:103379. Epub 2021 Jun 2.

Department of Infectious Diseases and Leiden University Medical Center, Leiden, The Netherlands. Electronic address:

Background: Leprosy, a chronic infectious disease caused by Mycobacterium leprae, is often late- or misdiagnosed leading to irreversible disabilities. Blood transcriptomic biomarkers that prospectively predict those who progress to leprosy (progressors) would allow early diagnosis, better treatment outcomes and facilitate interventions aimed at stopping bacterial transmission. To identify potential risk signatures of leprosy, we collected whole blood of household contacts (HC, n=5,352) of leprosy patients, including individuals who were diagnosed with leprosy 4-61 months after sample collection. Read More

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Effect of timing, technique and molecular features on brain control with local therapies in oncogene-driven lung cancer.

ESMO Open 2021 Jun 2;6(3):100161. Epub 2021 Jun 2.

Department of Thoracic Oncology, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; National Center for Tumor Diseases (NCT), Heidelberg, Germany. Electronic address:

Background: The improved efficacy of tyrosine kinase inhibitors (TKI) mandates reappraisal of local therapy (LT) for brain metastases (BM) of oncogene-driven non-small-cell lung cancer (NSCLC).

Patients And Methods: This study included all epidermal growth factor receptor-mutated (EGFR, n = 108) and anaplastic lymphoma kinase-rearranged (ALK, n = 33) TKI-naive NSCLC patients diagnosed with BM in the Thoraxklinik Heidelberg between 2009 and 2019. Eighty-seven patients (62%) received early LT, while 54 (38%) received delayed (n = 34; 24%) or no LT (n = 20; 14%). Read More

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Micro-computed tomographic analysis of the marginal adaptation of a calcium silicate-based cement to radicular dentin after removal of three different intracanal medicaments - An study.

J Conserv Dent 2020 Nov-Dec;23(6):598-603. Epub 2021 Feb 11.

Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India.

Context: This study focuses on the marginal adaptation of a calcium silicate-based cement to the root dentin after retrieval of different intracanal medicaments.

Aim: This study compared the marginal adaptation of a calcium silicate-based cement to radicular dentin in the apical third of the root canal following the use of three different intracanal medicaments.

Materials And Methods: Forty single-rooted premolar teeth ( = 40) were decoronated 13 mm above the root apices; then, 3 mm of the root tips were resected to standardize the root length. Read More

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February 2021

Do Hernias Contribute to Increased Severity of Aneurysmal Disease among Abdominal Aortic Aneurysm Patients?

Aorta (Stamford) 2021 Jun 3. Epub 2021 Jun 3.

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.

Background:  Connective tissue disorders could contribute to the pathogenesis of both abdominal aortic aneurysms (AAA) and hernias. We tested the hypothesis that hernias in AAA patients contribute to increased severity of the aneurysmal disease.

Methods:  A questionnaire was used to collect information from 195 AAA patients divided into four groups: (1) survivors ( = 22) of ruptured AAA, (2) patients ( = 90) after elective open repair, (3) patients ( = 43) after elective endovascular repair (EVAR), and (4) patients ( = 40) under surveillance of AAA. Read More

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Assessment of the Macular Microvasculature in High Myopes With Swept Source Optical Coherence Tomographic Angiography.

Front Med (Lausanne) 2021 17;8:619767. Epub 2021 May 17.

Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore.

The risk of pathologic myopia (PM) increases with worsening myopia and may be related to retinal microvasculature alterations. To evaluate this, we analyzed the macular microvasculature of myopes with swept source-optical coherence tomographic angiography (SS-OCTA) in adolescent and young adult Singaporeans. This is a prevalent case-control study including 93 young Chinese from the Strabismus, Amblyopia and Refractive error in Singaporean children (STARS, = 45) study and the Singapore Cohort Study of Risk Factors for Myopia (SCORM, = 48) studies. Read More

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First Report of Root Rot Caused by the Fusarium oxysporum Species Complex on Codonopsis pilosula in China.

Plant Dis 2021 Jun 2. Epub 2021 Jun 2.

Northwest Institute of Eco-Environment and Resources, 34737, Chinese Academy of Science, Lanzhou, Gansu, China;

Codonopsis pilosula Franch., also known as Dangshen, is an important medicinal plant in China. It is widely cultivated for a major income of local farmers in Dingxi, Gansu Province. Read More

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Evaluation of the effectiveness of a training program for coping with PMS symptoms based on IMB model in university students.

Women Health 2021 Jun 1:1-12. Epub 2021 Jun 1.

Department of Nursing, Faculty of Health Sciences, Yildirim Beyazit University, Ankara, Turkey.

Premenstrual syndrome (PMS) is a common health problem that adversely affects young women's quality of life. This paper evaluated the effectiveness of a "Training Program for Coping with PMS Symptoms based on Information-Motivation-Behavioral Skills (IMB) model" in university nursing students. This controlled intervention study was conducted between September 2017 and February 2018. Read More

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Humoral and Mucosal Antibody Response to RSV Structural Proteins in RSV-Infected Adult Hematopoietic Cell Transplant (HCT) Recipients.

Viruses 2021 May 26;13(6). Epub 2021 May 26.

Department of Molecular Virology & Microbiology, Baylor College of Medicine, Houston, TX 77030, USA.

Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in infants, the elderly, and immunocompromised patients. RSV antibodies play a role in preventing reinfection and in clearance of RSV, but data regarding the levels of viral protein-specific antibodies elicited and their contribution to patient recovery from RSV-induced disease are limited. We prospectively enrolled a cohort of RSV-infected adult hematopoietic cell transplant (HCT) recipients ( = 40). Read More

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Urine and Plasma Metabolome of Healthy Adults Consuming the DASH (Dietary Approaches to Stop Hypertension) Diet: A Randomized Pilot Feeding Study.

Nutrients 2021 May 22;13(6). Epub 2021 May 22.

Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.

We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc analysis of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 weeks of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatography/mass spectrometry. Read More

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Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese Women in Relation to Body Composition, Blood Pressure, Lipid Profile, and Insulin Resistance.

Biomolecules 2021 May 4;11(5). Epub 2021 May 4.

Department of Human Nutrition and Dietetics, Poznan University of Life Science, ul. Wojska Polskiego 31, 60-624 Poznan, Poland.

The objective of this study was to evaluate serum, hair, and urinary trace element and mineral content in normal-weight and obese women in relation to metabolic risk factors. A total of 80 women aged 30-70 y.o. Read More

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Self-reported memory and executive function in adult non-clinical hoarders.

Appl Neuropsychol Adult 2021 Jun 1:1-6. Epub 2021 Jun 1.

Hoarding Research Group, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

Hoarding is the excessive acquisition of, and failure to discard of, large numbers of items, leading to personal distress. Impairments on memory and executive functions have been systematically associated with hoarding behavior, predominantly focusing upon clinical (mainly middle-aged-elderly) patients with hoarding and/or PTSD. We were interested in hoarding-related memory and executive problems in younger non-clinical hoarders or non-hoarders, based on their scores. Read More

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Taste and Smell Function in Head and Neck Cancer Survivors.

Chem Senses 2021 May 29. Epub 2021 May 29.

Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, USA.

Survivors of head and neck squamous cell cancers (HNSCC) frequently complain of taste dysfunction long after radiation therapy is completed, which contradicts findings from most sensory evaluation studies, which predict dysfunction should resolve few months after treatment. Therefore, it remains unclear whether taste and smell function fully recovers in HNSCC survivors. We evaluated HNSCC survivors (n=40; age 63±12 years, mean ± standard deviation) who received radiation therapy between 6 months and 10 years before recruitment and compared their responses to those of a healthy control group (n=20) equivalent in age, sex, race, smoking history, and body mass index. Read More

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Prophylactic administration of diphenhydramine/paracetamol reduced emergence agitation and postoperative pain following maxillofacial surgeries: a randomized controlled trial.

Eur Arch Otorhinolaryngol 2021 May 27. Epub 2021 May 27.

Department of Oral and Maxillofacial Surgery, Dental School, Tehran University of Medical Sciences, Tehran, Iran.

Background: Emergence agitation after maxillofacial surgeries is an anxious and problematic complication for the surgeon and anesthesiologist that may lead to self-extubation, haemorrhage, and surgical destruction. In this study, we investigated the effects of preemptive administration of diphenhydramine on emergence agitation and quality of recovery after maxillofacial surgery in adult patients.

Methods: Eighty-five patients undergoing maxillofacial surgery were randomized into two groups. Read More

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The Interaction Analysis of SNP Variants and DNA Methylation Identifies Novel Methylated Pathogenesis Genes in Congenital Heart Diseases.

Front Cell Dev Biol 2021 4;9:665514. Epub 2021 May 4.

Institute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Congenital heart defect (CHD) is a rare and complicated disease with a high mortality rate. Its etiology remains unclear and includes many aspects. DNA methylation has been indicated to be involved in heart development in the early stage of life, and aberrant methylation level was related to CHDs. Read More

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Efficacy and safety of sofosbuvir/velpatasvir versus the standard of care in adults hospitalized with COVID-19: a single-centre, randomized controlled trial.

J Antimicrob Chemother 2021 May 25. Epub 2021 May 25.

Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Objectives: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the COVID-19 pandemic. The majority of patients experience asymptomatic to mild self-limited disease, but some cases progress to respiratory and multi-organ failure. However, so far, no approved antiviral therapy has been available for treatment of COVID-19. Read More

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REM Sleep Behavior Disorder in Parkinson's Disease: Change in Cognitive, Psychiatric, and Functional Outcomes from Baseline to 16-47-Month Follow-Up.

Arch Clin Neuropsychol 2021 May 25. Epub 2021 May 25.

Research Service, VA San Diego Healthcare System, San Diego, CA, USA.

Objective: Rapid Eye Movement Sleep Behavior Disorder (RBD) is common in Parkinson's Disease (PD) and is associated with cognitive impairment; however, the majority of the evidence on the impact of RBD on multidomain cognitive batteries in PD is cross-sectional. This study evaluated the longitudinal impact of probable RBD (pRBD) on cognitive, psychiatric, and functional outcomes in people with PD.

Method: Case-control study. Read More

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A specially designed medical screen for children suffering from burns: A randomized trial of a distraction-type therapy.

Burns 2020 May 30. Epub 2020 May 30.

Department of Burn Surgery, The First Hospital of Jilin University, Chaoyang District, Xinmin Street, Street 71, Changchun City, Jilin Province 130021, China. Electronic address:

Objective: To evaluate the impact of the specially designed medical dressing screen during wound dressing changes of children who suffered burns to their hand or foot.

Design: Randomized controlled trial.

Setting: Burns and Plastic Reconstruction Unit. Read More

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Effect of Age and Sodium Alendronate on Femoral Fracture Repair: Biochemical and Biomechanical Study in Rats.

Front Cell Dev Biol 2021 5;9:558285. Epub 2021 May 5.

Department of Dentistry, Federal University of Parana, Curitiba, Brazil.

Background: Bisphosphonates are drugs widely used to reduce bone resorption, increase bone mineral density and control age-related bone loss. Although there are studies reporting differences in bone structure between young and old adults, it is still difficult to predict changes related to bone aging. The aim of this study was to evaluate the effect of age and sodium alendronate on bone repair of femoral fractures in rats. Read More

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The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats.

Int J Vitam Nutr Res 2021 May 24:1-11. Epub 2021 May 24.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

The effect of carvacrol (CAR) on oxidative stress, inflammation, and liver dysfunction induced by lipopolysaccharide (LPS) was explored. The rats (n=40) were daily injected (2 weeks) by saline as control, LPS (1 mg/kg, i.p. Read More

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Nephrologist Follow-Up versus Usual Care after an Acute Kidney Injury Hospitalization (FUSION).

Clin J Am Soc Nephrol 2021 May 21. Epub 2021 May 21.

R Wald, St Michael's Hospital, Toronto, Canada.

Background And Objectives: Survivors of acute kidney injury (AKI) are at higher risk of chronic kidney disease and death, but few patients see a nephrologist following hospital discharge. Our objectives during this 2-year vanguard phase were to determine the feasibility of randomizing survivors of AKI to early follow-up with a nephrologist or usual care, as well as to collect data on care processes and outcomes.

Design, Setting, Participants, And Measurements: We performed a randomized controlled trial in patients hospitalized with Kidney Disease Improving Global Outcomes (KDIGO) stage 2-3 AKI at 4 hospitals in Toronto, Canada. Read More

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METHYLENE BLUE FOR TREATMENT OF HOSPITALIZED COVID-19 PATIENTS: A RANDOMIZED, CONTROLLED, OPEN-LABEL CLINICAL TRIAL, PHASE 2.

Rev Invest Clin 2021 ;73(3):190-198

Department of Biochemistry, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Background: There is no pharmacological intervention on the treatment of hypoxemia and respiratory distress in COVID-19 patients.

Objective: The objective of the study was to study the effect of the reduced form of methylene blue (MB) on the improvement of oxygen saturation (SpO) and respiratory rate (RR).

Methods: In an academic medical center, 80 hospitalized patients with severe COVID-19 were randomly assigned to receive either oral MB along with standard of care (SOC) (MB group, n = 40) or SOC only (SOC group, n=40). Read More

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Sequential therapy for kidney-tonifying via traditional Chinese medicine effectively improves the reproductive potential and quality of life of women with decreased ovarian reserve: a randomized controlled study.

Am J Transl Res 2021 15;13(4):3165-3173. Epub 2021 Apr 15.

Department of Surgery, Tianjin Public Security Hospital Tianjin City, China.

Objective: To investigate the effect of sequential therapy for kidney-tonifying via traditional Chinese medicine (TCM) on improving the fecundity and quality of life (QOL) of women with decreased ovarian reserve (DOR).

Methods: A prospective and randomized controlled study was conducted, in which 80 infertile patients with DOR were selected in our hospital and randomly divided into the test group (n=40) and the control group (n=40). The control group was given sequential therapy of artificial menstrual cycle via administration of estrogen and progesterone, and the test group received sequential therapy for kidney-tonifying via TCM. Read More

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Application effects of targeted nursing model in patients undergoing thyroid surgery and its influence on patients' negative emotions.

Am J Transl Res 2021 15;13(4):2822-2830. Epub 2021 Apr 15.

Department of Surgery, Donghu Branch of The Second Affiliated Hospital of Hainan Medical University Haikou 570100, Hainan Province, China.

Objective: To explore the effectiveness of a targeted nursing model for patients undergoing thyroid surgery, and to analyse the influence of intervention on the negative emotions of patients.

Methods: Eighty patients who received thyroid surgery in our hospital were enrolled and divided into a study group (n=40, given targeted nursing) and a control group (n=40, given routine surgical nursing) according to the difference of intervention measures. The postoperative bed-leaving time, hospitalization time, medical expenses, drainage tube indwelling time and incidence of postoperative adverse reactions were compared between the two groups. Read More

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An analysis of the dynamic changes in the self-efficacy and quality of life of elderly patients with chronic obstructive pulmonary disease following community-based rehabilitation.

Am J Transl Res 2021 15;13(4):2745-2751. Epub 2021 Apr 15.

Department of Respiration, Nantong Hospital of Traditional Chinese Medicine Nantong 226000, Jiangsu, China.

Objective: This study aimed to investigate the effects of community-based rehabilitation (CBR) on the self-efficacy and quality of life in elderly patients with chronic obstructive pulmonary disease (COPD).

Method: Eighty-one elderly patients with COPD admitted to our hospital were recruited as the study cohort and were randomly divided into a control group (n=41) and a study group (n=40). The control group underwent outpatient rehabilitative treatment, and the study group additionally underwent CBR. Read More

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The therapeutic value of arthroscopic microfracture technique in combination with platelet-rich plasma injection for knee cartilage injury.

Am J Transl Res 2021 15;13(4):2694-2701. Epub 2021 Apr 15.

Trauma Department of Orthopedics, The First Affiliated Hospital of University of South China Hengyang City, Hunan Province, China.

Objective: The purpose of this study was to analyze the efficacy of platelet-rich plasma (PRP) injection combined with arthroscopic microfracture technique for knee cartilage injury.

Methods: Seventy-nine patients with knee cartilage injury were randomly divided into a control group (CG, n=39) and an observation group (OBG, n=40). Both of the groups were treated with the arthroscopic microfracture technique, and the OBG was additionally treated with PRP injection. Read More

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TP53 mutations increase radioresistance in rhabdomyosarcoma and Ewing sarcoma.

Br J Cancer 2021 May 20. Epub 2021 May 20.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: p53 plays a key role in the DNA repair process and response to ionising radiation. We sought to determine the clinical phenotype of TP53 mutations and p53 pathway alterations in patients with rhabdomyosarcoma (RMS) and Ewing sarcoma (ES) treated with radiation.

Methods: Of patients with available genomic sequencing, we identified 109 patients with RMS and ES treated to a total of 286 radiation sites. Read More

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