Search Our Scientific Publications & Authors

Front Pharmacol 2021 2;12:678611. Epub 2021 Jul 2.

Bioactive Natural Product Laboratory, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

The present study is aimed at developing a synergistic combination to enhance learning and memory in Alzheimer's patients with the help of eight common medicinal plants used in the AYUSH system. Aqueous and hydroalcoholic extracts of eight medicinal plants from the AYUSH system of medicine were prepared. These were subjected to anticholinesterase activity, to find out the combination index of synergistic combination. Read More

J Pharm Biomed Anal 2021 Jul 2;204:114238. Epub 2021 Jul 2.

Chemical Laboratory Second Laboratory, Jiangsu Institute for Drug and Food Control, Nanjing, China; NMPA Key Laboratory for Impurity Profile of Chemical Drugs, National Medical Products Administration, Beijing, China. Electronic address:

Oleic acid is a pharmaceutical excipient and has been widely used in many dosage forms. It remains unclear in terms of the fatty acids (FAs) profile. In this study, a sensitive and direct method based on high-performance liquid chromatography coupled with charged aerosol detector (HPLC-CAD) was developed to study the compositions of oleic acid. Read More

Int J Legal Med 2021 Jul 3. Epub 2021 Jul 3.

Department of Senior Healthcare, Graduate School, Eulji University, 712, Dongil-ro, Uijeongbu-si, Gyeonggi-do, 11759, Republic of Korea.

Bloodstains are frequently encountered at crime scenes and they provide important evidence about the incident, such as information about the victim or suspect and the time of death or other events. Efforts have been made to identify the age of the bloodstain's donor through genomic approaches, but there are some limitations, such as the availability of databases and the quality dependence of DNA. There is a need for the development of a tool that can obtain information at once from a small blood sample. Read More

Membranes (Basel) 2021 Jun 30;11(7). Epub 2021 Jun 30.

Department of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

Lipopeptides have been extensively studied as potential antimicrobial agents. In this study, we focused on the C-KYR lipopeptide, a modified version of the KYR tripeptide with myristic acid at the N-terminus. Here, membrane perturbation of live treated with the parent KYR and C-KYR peptides was compared at the nanoscale level using AFM imaging. Read More

Int J Environ Res Public Health 2021 06 16;18(12). Epub 2021 Jun 16.

Department of Human Nutrition and Metabolomics, Pomeranian Medical University, 71-460 Szczecin, Poland.

Ischemic stroke is a leading cause of motor impairment and psychosocial disability. Although free fatty acids (FFA) have been proven to affect the risk of stroke and potentially dementia, the evidence of their impact on cognitive functions in stroke patients is lacking. We aimed to establish such potential relationships. Read More

J Biotechnol 2021 Aug 28;337:24-34. Epub 2021 Jun 28.

College of Food Science and Technology, South China University of Technology, Guangzhou, 510006, PR China. Electronic address:

A thermostable T1 lipase from Geobacillus zalihae exhibits broad substrate specificity and good potential application in fats and oils. However, structural insight into the enzyme against substrates is poorly understood at the molecular level. Herein, the study aimed to examine interactions between a mutant T1 lipase (Mut-T1 lipase) and selected fatty acids (caprylic, myristic, stearic, oleic, linoleic and linolenic acids) by performing molecular docking and molecular dynamics (MD) simulation. Read More

J Exp Zool A Ecol Integr Physiol 2021 Aug 29;335(7):595-601. Epub 2021 Jun 29.

Division of Entomology, ICAR-Indian Agricultural Research Institute, New Delhi, India.

The Chilo partellus (Crambidae: Lepidoptera) larvae undergoes both hibernation and estivation in India. Although, much has been done on reproductive physiological aspects, little is known about biochemical changes happening during hibernation and estivation in C. partellus. Read More

Anim Sci J 2021 Dec;92(1):e13576

Postgraduate Program in Animal Science, Federal University of Pará (UFPA), Belém, Brazil.

The objective was to evaluate the effect of concentrate supplementation using by-products of the Amazonian industry on milk production, milk composition, and milk fatty acid profile of dairy buffaloes. Twelve lactating buffaloes (544.5 ± 35. Read More

Sci Justice 2021 Jul 26;61(4):378-383. Epub 2021 Mar 26.

Rio Grande do Sul Technical and Scientific Division, Bioforensic Research Group, Brazilian Federal Police, Ipiranga Av., 1365, 90160-093 Porto Alegre, RS, Brazil.

Latent fingermarks are important trace evidence found in crime scenes mainly used for identification purposes. Once deposited, the composition of samples changes over time influencing the efficacy of latent fingermark development methods. In this sense, the aims of this work were to characterize the fatty acid (FA) profile of sebaceous latent fingermarks by GC-FID and to preliminarily evaluate the development efficiency of enhancement methods (powder dusting, iodine fuming and silver nitrate method) in a 30-day period of aging under controlled parameters of temperature, photoperiod and humidity. Read More

Nutrition 2021 May 1;90:111306. Epub 2021 May 1.

Department of Physiology, Faculty of Medicine, University of Alexandria, Alexandria, Egypt; Department of Pharmacology, University of Oxford, Oxford, UK.

Objective: The aim of this study was to examine the time scale of plasma fatty acid changes during transition to an exclusively plant- and fish-based diet in healthy individuals and determine whether there are associated alterations in arachidonic acid (ARA)-derived inflammatory mediators, estimated stearoyl coenzyme A desaturase (SCD) activity, and blood pressure.

Methods: In pursuit of a religious fast, 36 adults abstained  from eating poultry, meat, dairy products, and eggs, while increasing fish intake for 6 wk. Participants were assessed 1 wk before (W0) and 1 (W1) and 6 (W6) weeks after the diet change. Read More

Microb Biotechnol 2021 Jun 22. Epub 2021 Jun 22.

School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Korea.

Biofilms are communities of bacteria, fungi or yeasts that form on diverse biotic or abiotic surfaces, and play important roles in pathogenesis and drug resistance. A generic saw palmetto oil inhibited biofilm formation by Staphylococcus aureus, Escherichia coli O157:H7 and fungal Candida albicans without affecting their planktonic cell growth. Two main components of the oil, lauric acid and myristic acid, are responsible for this antibiofilm activity. Read More

Theriogenology 2021 Jun 8;172:88-94. Epub 2021 Jun 8.

Faculty of Bioscience and Technology for Food Agriculture and Environment, University of Teramo, Teramo, Italy. Electronic address:

Sperm cryopreservation represents a powerful tool for horse breeding. To improve the efficiency of artificial insemination in the horse using cryopreserved spermatozoa, an adequate understanding of the underlying biophysical properties that affect sperm cryosurvival needs to be reached yet. In this pilot study, we described isolation and analysis of the main fatty acids from sperms of stallions classified as good and poor freezers (7 GF and 5 PF, according to sperm motility and viability, before and after cryopreservation). Read More

Am J Clin Nutr 2021 Jun 16. Epub 2021 Jun 16.

The Fatty Acid Research Institute, Sioux Falls, SD, USA.

Background: RBC long-chain omega-3 (n-3) fatty acid (FA) percentages (of total fatty acids) are associated with lower risk for total mortality, but it is unknown if a suite of FAs could improve risk prediction.

Objectives: The objective of this study was to compare a combination of RBC FA levels with standard risk factors for cardiovascular disease (CVD) in predicting risk of all-cause mortality.

Methods: Framingham Offspring Cohort participants without prevalent CVD having RBC FA measurements and relevant baseline clinical covariates (n = 2240) were evaluated during 11 y of follow-up. Read More

J Nutr 2021 Jun 10. Epub 2021 Jun 10.

Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Background: Metabolic flexibility is the responsiveness to heterogeneous physiological conditions, such as food ingestion. A key unresolved question is how inflammation affects metabolic flexibility.

Objectives: Our study objective was to compare metabolic flexibility, specifically the metabolomic response to a standardized meal, by fasting inflammation status. Read More

Nat Commun 2021 06 8;12(1):3443. Epub 2021 Jun 8.

Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, St Lucia, QLD, Australia.

Polyunsaturated free fatty acids (FFAs) such as arachidonic acid, released by phospholipase activity on membrane phospholipids, have long been considered beneficial for learning and memory and are known modulators of neurotransmission and synaptic plasticity. However, the precise nature of other FFA and phospholipid changes in specific areas of the brain during learning is unknown. Here, using a targeted lipidomics approach to characterise FFAs and phospholipids across the rat brain, we demonstrated that the highest concentrations of these analytes were found in areas of the brain classically involved in fear learning and memory, such as the amygdala. Read More

Cancer Immunol Immunother 2021 Jun 5. Epub 2021 Jun 5.

Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.

Background: Lipids have immunomodulatory functions and the potential to affect cancer immunity.

Methods: The associations of pretreatment serum cholesterol and long-chain fatty acids with the objective response rate (ORR), progression-free survival (PFS), and overall survival (OS) were evaluated in 148 patients with non-small cell lung cancer who received nivolumab.

Results: When each lipid was separately evaluated, increased low-density lipoprotein (LDL)-cholesterol (P < 0. Read More

Food Technol Biotechnol 2021 Mar;59(1):44-55

University of East Sarajevo, Faculty of Technology, Karakaj 34A, 75400 Zvornik, Bosnia and Herzegovina.

Research Background: Numerous factors affect the ripening of reduced-fat white cheese. The aim of this study is to investigate the influence of ripening environment (brine or vacuum plastic bags without brine) on the chemical composition, protein, fatty acid profile and mineral content as well as antioxidant properties of industrially produced reduced-fat white cheese.

Experimental Approach: A low-fat white cheese was manufactured on an industrial scale from milk that remained after the production of kajmak and ripened for 60 days at 4 °C after packaging in a polystyrene container with brine containing 6% salt or in vacuum-sealed polyethylene bags. Read More

Langmuir 2021 Jun 3;37(23):7043-7054. Epub 2021 Jun 3.

College of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.

Frequent leakage and pollution of oily wastewater seriously affect the world's ecosystem safety and economic development, which prompts us to urgently develop a highly effective, low-cost, wear-resistant, chemically stable, and environmentally friendly new functional material for oil/water separation. In this paper, a robust superhydrophobic material was successfully electrodeposited on the porous copper foam substrates in myristic acid (CH(CH)COOH) and lanthanum chloride (LaCl·6HO) electrodeposition solution under a continuous pumping circulation and rotation condition. Moreover, SEM, EDS, XRD, FTIR, and XPS technologies were utilized to characterize the surface morphology and chemical composition information. Read More

Int J Mol Sci 2021 May 31;22(11). Epub 2021 May 31.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Bacterial symbionts associated with insects are often involved in host development and ecological adaptation. , a common facultative endosymbiont harbored in pea aphids, improves host fitness and heat tolerance, but studies concerning the nutritional metabolism and impact on the aphid host associated with carrying are limited. In the current study, we showed that -infected aphids had a shorter nymphal developmental time and higher body weight than -free aphids when fed on detached leaves. Read More

Ultrason Sonochem 2021 Jul 24;75:105606. Epub 2021 May 24.

Departamento de Bioquímica y Biología Molecular B e Inmunología. Facultad de Química, Campus de Excelencia Internacional Regional "Campus Mare Nostrum", Universidad de Murcia, E-30100 Murcia, Spain. Electronic address:

A commercial immobilized lipase was successfully used for the synthesis of five xylityl acyl esters by means of the esterification of free fatty acids (caprylic, capric, lauric and myristic, respectively) with xylitol under solvent-free conditions. Ultrasound-assistance was shown to be a key tool to overcome the handicap imposed by both the mutual immiscibility of fatty acids and xylitol substrates, and the semisolid character of the initial reaction mixtures. In such semisolid systems, ultrasonic irradiation may enable the transport of substrate molecules to the enzyme catalytic-site, leading to the efficient synthesis of xylityl fatty ester (e. Read More

Front Cell Infect Microbiol 2021 13;11:592826. Epub 2021 May 13.

The Biology Department and South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, United States.

is a soil-borne fungal pathogen and causative agent of a human respiratory disease (coccidioidomycosis) endemic to semi-desert regions of southwestern United States, Mexico, Central and South America. Aerosolized arthroconidia inhaled by the mammalian host first undergo conversion to large parasitic cells (spherules, 80-100 μm diameter) followed by endosporulation, a process by which the contents of spherules give rise to multiple endospores. The latter are released upon rupture of the maternal spherules and establish new foci of lung infection. Read More

Nutr Cancer 2021 May 21:1-16. Epub 2021 May 21.

Pharmacology Division, CSIR-National Botanical Research Institute, Lucknow, India.

Hepatocellular Carcinoma is one of the most frequently diagnosed cancer and highly refractory for chemotherapeutics agents. Therefore, the study aims to explore the new therapeutic agents for HCC. Phenolics rich fraction of leaves of was studied against hepatic cancer cell lines (HepG2) and NDEA-induced HCC rat model system. Read More

J Agric Food Chem 2021 May 19. Epub 2021 May 19.

College of Food Science and Engineering, Northwest A&F University, 22 Xinong Road, Yangling 712100 Xianyang, Shaanxi, P. R. China.

The effects of fatty acid type (myristic, palmitic, stearic, oleic, linoleic, and linolenic acid) on the characteristics of starch-lipid complexes under high temperature were investigated. Fatty acids with a shorter carbon chain or a greater number of double bonds contributed to the formation of V-type starch-lipid complexes. The thermostability of starch-unsaturated fatty acid (UFA) complexes prepared at high temperature was increased compared with those obtained at lower temperature. Read More

Meat Sci 2021 Sep 10;179:108554. Epub 2021 May 10.

Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand; Center of Excellence on Agricultural Biotechnology: (AG-BIO/PERDO-CHE), Bangkok 10900, Thailand; Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, Thailand; Innovative Agriculture Research Center, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:

Several adipocytokines are involved in inflammatory and immune responses as well as regulated fat deposition and lipid metabolism in mammals. This study aimed to verify the polymorphisms of the porcine interleukin 1A (IL-1A) and interleukin 6 (IL-6) genes and to assess their association with intramuscular fat (IMF) content and fatty acid (FA) composition in commercial crossbred pigs. Two single nucleotide polymorphisms (SNPs) of the porcine IL-1A g. Read More

Front Nutr 2021 30;8:643350. Epub 2021 Apr 30.

AgResearch Ltd., Grasslands Research Centre, Palmerston North, New Zealand.

Most milk consumed by humans undergoes heat treatment to ensure microbiological safety and extend shelf life. Although heat treatment impacts the structure and physiochemical properties of milk, effects on nutrient absorption in humans are unclear. Therefore, a rapid review was performed to identify studies conducted on healthy human adult subjects that have assessed the impacts of heat treatment of milk on protein and fat digestion and metabolism in the postprandial period (up to 24 h). Read More

Appl Microbiol Biotechnol 2021 May 15;105(10):4285-4295. Epub 2021 May 15.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Postbox 309#, 130 Meilong Road, Shanghai, 200237, People's Republic of China.

Natural killer-92 cells (NK-92 cells) need to be efficiently expanded by serum-free culture in vitro to meet clinical requirements. Fatty acids mainly provide substrates for energy production, which is of crucial importance to meet the energy demands of highly proliferating cells. This study optimized the medium (EM) for NK-92 cells by designing an experiment to expand cells efficiently. Read More

Life Sci 2021 Aug 11;278:119605. Epub 2021 May 11.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Diabetes mellitus (DM) may lead to testicular-related infertility while Myristic acid (MA) is beneficial to lower hyperglycaemia. Thus, we hypothesized that MA could protect testes against hyperglycaemia-induced damage in DM. DM was induced in adult male rats by high-fat diet consumption for 12 weeks, accompanied by a single dose streptozotocin injection. Read More

J Anim Sci Technol 2021 Mar 31;63(2):380-393. Epub 2021 Mar 31.

Department of Animal Science, Chungbuk National University, Cheongju 28644, Korea.

This study aimed to determine the blood lipid profiles, fatty acid composition, and lipogenic enzyme activities in rat adipose tissues as affected by the Angus beef fat (ABF) and Hanwoo beef fat (HBF) containing high oleic acid (OA) content. We assigned 60 Sprague Dawley rats with a mean bodyweight of 249 ± 3.04 g to three groups (n = 20 each) to receive diets containing 7% coconut oil (CON), 7% ABF, or 7% HBF. Read More

J Insect Sci 2021 May;21(3)

Department of Animal Science, Faculty of Sciences and Technology, Tel-Hai College, Upper Galilee, Israel.

Fatty acids are important compounds for insects, but the requirements for essential fatty acids may differ between insect species. Most of the fatty acids are acquired through the insect's diet; therefore, supplementing the diet with baker's yeast (Saccharomyces cerevisiae Meyen ex E.C. Read More

J Oleo Sci 2021 Jun 7;70(6):787-797. Epub 2021 May 7.

Department of Biochemical Engineering, Graduate School of Science and Engineering, Yamagata University.

1,2-Alkanediols are characteristic cosmetic ingredients because these moisturizers exhibit the antibacterial activity against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis). Read More