103 results match your criteria myelomatous pleural

Pomalidomide and dexamethasone in myelomatous pleural effusion.

BMJ Case Rep 2020 Dec 10;13(12). Epub 2020 Dec 10.

Division of Hematology and Oncology, Orlando VA Medical Center, Orlando, Florida, USA.

Myelomatous pleural effusion (MPE) is an uncommon clinical entity and occurs in less than 1% of all patients with multiple myeloma. MPE indicates a progression of disease, therefore is associated with a poor prognosis and estimated median survival of <3 months. Treatment of MPE is challenging, and the data regarding the role of novel agents lack in the literature. Read More

View Article and Full-Text PDF
December 2020

[Successful treatment of myelomatous pleural effusion with daratumumab administration before autologous peripheral stem cell transplantation].

Rinsho Ketsueki 2020 ;61(8):879-884

Department of Hematology, Toyama University Hospital.

A 50-year-old woman diagnosed with surgically resected plasmacytoma of the ovaries and uterus presented with another plasmacytoma in the pancreas with positive uptake on positron emission tomography (PET) and massive right pleural effusion with plasma cell infiltration (myelomatous pleural effusion). After four courses of the bortezomib, lenalidomide, and dexamethasone regimen as induction therapy, partial response was achieved with reduced myelomatous pleural effusion and negative uptake on PET in the pancreatic plasmacytoma. However, soon after she received bortezomib and high-dose cyclophosphamide for peripheral blood stem cell harvesting, right myelomatous pleural effusion increased without signs of heart failure or infection. Read More

View Article and Full-Text PDF
October 2020

Transient Pleural Fluid Infiltration by Clonal Plasma Cells Associated with Pulmonary Tuberculosis.

Case Rep Oncol 2020 May-Aug;13(2):883-891. Epub 2020 Jul 29.

Department of Medical Education, Hamad Medical Corporation, Doha, Qatar.

Pleural effusion is a rare presentation of plasma cell myeloma, occurring in around 6% of patients during the course of their disease, most commonly as a consequence of a concurrent disease process like heart failure secondary to amyloid deposition. Direct infiltration of the pleural fluid by malignant cells leading to myelomatous pleural effusion is a rare mechanism occurring in less than 1% of patients with plasma cell myeloma, and it is associated with a worse prognosis. There are few case reports of myelomatous pleural effusion as an initial presentation of multiple myeloma. Read More

View Article and Full-Text PDF

Myelomatous pleural effusion with plasmablastic morphology and high genetic complexity as isolated extramedullary relapse.

Ann Hematol 2020 Nov 27;99(11):2705-2706. Epub 2020 May 27.

Department of Haematology, Ramón y Cajal University Hospital, M-607, km. 9, 100, Madrid, 28034, Spain.

View Article and Full-Text PDF
November 2020

Massive pleural effusion due to IgG-Kappa subtype multiple myeloma: A case report.

Respir Med Case Rep 2020 12;29:100984. Epub 2019 Dec 12.

Division of Pulmonary, Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand.

Multiple myeloma (MM) is a hematologic malignancy of plasma cell origin. Incidence of pleural effusion in multiple myeloma patients is approximately 6%. Myelomatous pleural effusions (MPE) are rare and occur in less than 1% of all MM cases. Read More

View Article and Full-Text PDF
December 2019

Alterations in the Transcriptional Programs of Myeloma Cells and the Microenvironment during Extramedullary Progression Affect Proliferation and Immune Evasion.

Clin Cancer Res 2020 02 26;26(4):935-944. Epub 2019 Sep 26.

Samsung Genome Institute, Samsung Medical Center, Seoul, Korea.

Purpose: In multiple myeloma, extramedullary progression is associated with treatment resistance and a high mortality rate. To understand the molecular mechanisms controlling the devastating progression of myeloma, we applied single-cell RNA-sequencing (RNA-seq) to myeloma in the bone marrow and myelomatous pleural effusions or ascites.

Experimental Design: Bone marrow or extramedullary myeloma samples were collected from 15 patients and subjected to single-cell RNA-seq. Read More

View Article and Full-Text PDF
February 2020

Myelomatous Pleural Effusion as a Presenting Symptom: A Case Report.

Cureus 2019 Jul 16;11(7):e5153. Epub 2019 Jul 16.

Medical Oncology / Hematology, Houston Methodist Hospital, Houston, USA.

Myelomatous pleural effusion (MPE) is a rare complication in patients suffering from multiple myeloma (MM). Dyspnea is the predominant symptom in the clinical presentation. Poor prognosis and aggressive MM behavior have been linked to this condition. Read More

View Article and Full-Text PDF

Myelomatous pleural effusion and extensive extraskeletal soft tissue involvement: a rare presentation of clonal plasma cell disorders.

BMJ Case Rep 2019 Sep 12;12(9). Epub 2019 Sep 12.

Department of Medicine, Unit-3, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.

A 65-year-old woman presented with a history of progressive dyspnoea, left pleuritic pain, loss of weight and appetite. Previous history was significant for pulmonary tuberculosis diagnosed 10 years before. Physical examination revealed a left supraclavicular soft tissue mass with absent breath sounds over the left hemithorax. Read More

View Article and Full-Text PDF
September 2019

[Transudative myelomatous pleurisy revealing pleural localization of primary plasma cell leukemia].

Ann Biol Clin (Paris) 2019 04;77(2):187-190

Laboratoire d'hématologie, CHU Mohammed VI, Oujda, Maroc, Faculté de médecine et de pharmacie, Université Mohammed Premier, Oujda, Maroc.

Primary plasma cell leukemia (PPCL) is an aggressive and rare variant of multiple myeloma (MM), with frequent extramedullary involvement, mainly liver and splenic lesions. Pleuropulmonary involvement has rarely been described in the literature. We report a case of primary plasma cell leukemia in a 46-year-old patient, whose first symptom was pleural effusion with mediastinal adenopathies simulating a pleural localization of a lymphomatous process. Read More

View Article and Full-Text PDF

Clinicopathological Profile of Myelomatous Pleural Effusion: Single-center Real-world Experience and Review of Literature.

Clin Lymphoma Myeloma Leuk 2019 03 3;19(3):183-189.e1. Epub 2019 Jan 3.

Clinical Hematology Division, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

Background: Multiple myeloma (MM) is a hematologic malignancy of plasma cell origin. MM primarily affects bone marrow, but extramedullary sites can also be involved. Myelomatous pleural effusion (MPE) is an atypical and rare complication of MM. Read More

View Article and Full-Text PDF

Hematolymphoid neoplasms in effusion cytology.

Cytojournal 2018 14;15:15. Epub 2018 Jun 14.

Address: Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Background: Hematolymphoid neoplasms (HLNs) presenting as body cavity effusions are not a common finding. They may be the first manifestation of the disease. A diagnosis on effusion cytology may provide an early breakthrough for effective clinical management. Read More

View Article and Full-Text PDF

Pleural effusion in 11:14 translocation q1 multiple myeloma in the setting of proteasome inhibitor presents therapeutic complexity.

Memo 2018 21;11(1):71-76. Epub 2018 Feb 21.

1Neurology Department, University of Minnesota, Minneapolis, MN USA.

Background: Primary malignant pleural effusion has been reported in about 134 cases of multiple myeloma (MM). Associated pleural effusions in cases of MM portend a poor prognosis and identifying them is highly relevant. Reported is the case of a man diagnosed with MM who developed primary myelomatous pleural effusion in the setting of multiple relapses and subsequent mortality within 2 months of the pleural effusion diagnosis. Read More

View Article and Full-Text PDF
February 2018

Cytology and clinical features of myelomatous pleural effusion: Three case reports and a review of the literature.

Diagn Cytopathol 2018 Jul 5;46(7):604-609. Epub 2018 Feb 5.

Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.

The purpose of this study was to report the clinical features, laboratory findings, and cytomorphology, and prognosis of three patients with myelomatous pleural effusion (MPE). The literature pertaining to MPE was reviewed. The three cases and literature review suggest that MPE is rare and often associated with a poor prognosis. Read More

View Article and Full-Text PDF

Characteristics of patients with myelomatous pleural effusion. A systematic review.

Rev Clin Esp 2018 Mar 29;218(2):89-97. Epub 2017 Nov 29.

Servicio de Neumología, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, La Coruña, España; Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago de Compostela (IDIS), Santiago de Compostela, La Coruña, España.

Background: Myelomatous pleural effusion (MPE) is rare in multiple myeloma, and therefore its characteristics are not well defined.

Methods: A systematic review (4 online databases) was conducted of articles describing the clinical characteristics of patients with MPE, pleural effusion's biochemical characteristics and treatment efficacy. We analysed isolated cases and small retrospective series. Read More

View Article and Full-Text PDF

Catch me if you can-How to make the best use of pleural effusion.

J Thorac Dis 2017 Aug;9(8):E664-E668

The Geriatrics Department, Peking University First Hospital, Beijing 100034, China.

Etiology diagnosis of pleural effusion is a commonly encountered yet challenging problem. How to make the best use of pleural effusion evokes thinking. Myelomatous pleural effusion (MPE) is a rare condition and has been reported sporadically. Read More

View Article and Full-Text PDF

Pleural Effusion in Multiple Myeloma: Characteristics and Practice Patterns.

Acta Haematol 2017 11;138(2):69-76. Epub 2017 Aug 11.

Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.

In many Asian countries battling with the double burden of increasing noninfectious diseases on top of infectious diseases, multiple myeloma (MM) patients presenting with pleural effusion (PE) pose a great diagnostic challenge. Thus, we aimed to analyze the clinical features and practice patterns of such patients. This is a multicenter retrospective study of newly diagnosed MM patients between January 2011 and December 2015. Read More

View Article and Full-Text PDF
September 2017

Bilateral Myelomatous Pleural Effusion in a Patient with IgA Kappa Multiple Myeloma.

Cureus 2017 May 10;9(5):e1238. Epub 2017 May 10.

Internal Medicine/Hematology and Oncology, Roger Williams Medical Center.

Multiple myelomas is a neoplastic plasma cell disorder that accounts for one percent of all cancers and 13% of hematologic malignancies. Although primarily known to be a bone marrow disorder, it can metastasize to extramedullary sites or it can present as a solitary extramedullary plasmacytoma. Primary pleural effusion from myeloma is rare, occurring in less than one percent of the patients. Read More

View Article and Full-Text PDF

Myelomatous pleural effusion: A rare case entity reported from a tertiary care cancer center in South India.

Lung India 2017 Mar-Apr;34(2):176-178

Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Multiple myeloma (MM) is a plasma cell neoplasm and constitutes 10% of hematologic malignancies. Malignant myelomatous pleural effusions are very rare and occur in <1% of cases of MM. In this article, we report a rare case of a patient who initially presented with pleural effusion and was subsequently found to be secondary to MM with an underlying raised IgG paraprotein. Read More

View Article and Full-Text PDF

Solitary pleural myeloma diagnosed by semi-rigid thoracoscopy: A case report and literature review.

Mol Clin Oncol 2016 Nov 23;5(5):532-536. Epub 2016 Aug 23.

Department of Respiratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

Multiple myeloma (MM) is characterized by abnormal proliferation of neoplastic plasma cells. Pleural effusion as an initial presentation of this disease is rare, as is true pleural myeloma. We herein present a case of solitary pleural myelomatous lesion in a 70-year-old male patient diagnosed by pleural biopsy via semi-rigid thoracoscopy followed by histopathological examination. Read More

View Article and Full-Text PDF
November 2016

Primary malignant myelomatous pleural effusion.

Clin Case Rep 2016 Aug 15;4(8):803-6. Epub 2016 Jul 15.

Division of Hematology / Oncology Department of Internal Medicine John H. Stroger Jr. Hospital of Cook County 1901 West Harrison Street Chicago Illinois 60612 USA.

Primary malignant myelomatous pleural effusion (PMMPE) occurs in less than 1% of patients with multiple myeloma and is diagnosed either by visualization of plasma cells on cytology or by positive flow cytometry. The presence of immature plasma cells characterized by high nucleus to cytoplasm ratio, visible nucleolus and presence of Mott cells and Russell bodies are independent poor prognostic factors. The clinician should differentiate PMMPE from secondary pleural effusion as it is associated with a significantly worse prognosis and poor overall survival. Read More

View Article and Full-Text PDF

Cytomorphology, clinicopathologic, and cytogenetics correlation of myelomatous effusion of serous cavities: A retrospective review.

Diagn Cytopathol 2016 Sep 19;44(9):742-7. Epub 2016 Jul 19.

Department of Pathology, Rush University Medical Center, Chicago, Illinois.

Background: Myelomatous effusions (ME) of the serous cavities are rare. Identification of the atypical plasma cells in the body fluids may be critical for prognostic considerations.

Methods: We retrospectively reviewed clinicopathologic findings of 21 serous effusion specimens from 13 cases of ME including 10 pleural, two concurrent pleural and pericardial, and one peritoneal from 1994 to 2014. Read More

View Article and Full-Text PDF
September 2016

Flow Cytometry in Diagnosis of Myelomatous Pleural Effusion: A Case Report.

Indian J Hematol Blood Transfus 2016 Jun 3;32(Suppl 1):138-42. Epub 2015 Sep 3.

Department of Medical Oncology, Dr BRA IRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

Plasma cell myeloma is a multifocal plasma cell neoplasm associated with increased monoclonal protein in serum and/or urine. Pleural effusions in patients with myeloma are uncommon (6 %). However, effusions due to direct infiltration of the pleura by plasma cells (myelomatous pleural effusion) are extremely rare (<1 %) and usually seen with IgA myeloma. Read More

View Article and Full-Text PDF

Concurrent Myelomatous Pleural Effusion and Extramedullary Mediastinal Involvement as an Initial Manifestation of Multiple Myeloma.

Am J Case Rep 2016 Jul 11;17:472-5. Epub 2016 Jul 11.

Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center at Memphis, Memphis, TN, USA.

BACKGROUND Myelomatous pleural effusion (MPE) is a rare occurrence in patients with multiple myeloma (MM). Fewer than 20 cases of MPE have been reported as an initial manifestation of MM. Extramedullary plasmacytoma (EMP) occurs in fewer than 5% patients with MM, and mediastinal EMP is even rarer, with only about 80 cases reported in the literature. Read More

View Article and Full-Text PDF

Bilateral myelomatous pleural effusion: presentation of two cases.

Blood Res 2016 Jun 23;51(2):142-4. Epub 2016 Jun 23.

Division of Hematology and Oncology, West Michigan Cancer Center, Kalamazoo, MI, USA.

View Article and Full-Text PDF

Validation and Utility of the Free Light Chain Assay in Pleural Effusions of Patients With Multiple Myeloma.

Clin Lymphoma Myeloma Leuk 2016 07 5;16(7):e113-7. Epub 2016 May 5.

Division of Hematology and Oncology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

View Article and Full-Text PDF

Pleural Effusion in Multiple Myeloma.

Intern Med 2016 15;55(4):339-45. Epub 2016 Feb 15.

Department of Respiratory Medicine, Beijing Jishuitan Hospital, China.

Objective: Pleural effusion is rarely observed in patients with multiple myeloma (MM). Myeloma cell infiltration or invasion to the pleura is very rare. This study aimed to investigate the clinical characteristics of pleural effusion in patients with MM. Read More

View Article and Full-Text PDF

Disseminated plasma cell myeloma presenting as massive pleural effusion.

Eur Clin Respir J 2015 24;2. Epub 2015 Nov 24.

Department of Pathology, Apollo Hospital, Chennai, India.

Plasma cell myeloma (PCM) is a hematologic malignancy of plasma cell origin and usually associated with the presence of lytic bone lesions. Pleural effusions are rarely associated with PCM and most often signify a concurrent disease process. Malignant myelomatous pleural effusions are even more unusual and carry a poor prognosis. Read More

View Article and Full-Text PDF
December 2015

Myelomatous pleural effusion - Thoracoscopic evaluation of a rare entity.

Lung India 2015 Sep-Oct;32(5):505-7

Department of Pathology, J.L.N Medical College, Ajmer, Rajasthan, India.

Multiple myeloma is a malignant neoplasm of plasma cell origin that mainly affects bone marrow and skeletal system, producing large amount of light chain immunoglobulins. Pleural involvement in multiple myeloma is a rare complication which carries very poor prognosis. We report a case of multiple myeloma who presented with recurrent pleural effusion that was evaluated by means of thoracoscopy. Read More

View Article and Full-Text PDF
December 2015