884 results match your criteria mycobacterium phlei

[Rare infectious complication after intramuscular self-injections].

Rev Esp Quimioter 2021 Aug 29;34(4):393-395. Epub 2021 May 29.

Javier Colomina Rodríguez. Servicio de Microbiología Clínica, Hospital Clínico Universitario de Valencia. Avda. Blasco Ibáñez, 17. 46010, Valencia, Spain.

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New Application of 1,2,4-Triazole Derivatives as Antitubercular Agents. Structure, In Vitro Screening and Docking Studies.

Molecules 2020 Dec 19;25(24). Epub 2020 Dec 19.

Independent Radiopharmacy Unit, Faculty of Pharmacy, Medical University of Lublin, 20-093 Lublin, Poland.

A series of 1,2,4-triazole derivatives were synthesized and assigned as potential anti-tuberculosis substances. The molecular and crystal structures for the model compounds C1, C12, and C13 were determined using X-ray analysis. The X-ray investigation confirmed the synthesis pathway and the assumed molecular structures for analyzed 1,2,4-triazol-5-thione derivatives. Read More

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December 2020

Isolation and Histopathological Changes Associated with Non-Tuberculous Mycobacteria in Lymph Nodes Condemned at a Bovine Slaughterhouse.

Vet Sci 2020 Nov 10;7(4). Epub 2020 Nov 10.

Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tamaulipas. Cd. Victoria, Tamaulipas C.P. 87000, Mexico.

: non-tuberculous mycobacteria (NTM) infect humans and animals and have a critical confounding effect on the diagnosis of bovine tuberculosis. The Official Mexican Standard (Norma Oficial Mexicana, NOM-ZOO-031-1995) for food safety regulates in cattle, but not the NTM species. The study's objective was to isolate and identify the NTM present in condemned bovine lymph nodes in a slaughterhouse, characterize the histological lesions, and correlate bacteriological and microscopic findings with the antemortem tuberculin skin test. Read More

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November 2020

Antibacterial Cyclic Tripeptides from Antarctica-Sponge-Derived Fungus HDN151418.

Mar Drugs 2020 Oct 26;18(11). Epub 2020 Oct 26.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Three new aspochracin-type cyclic tripeptides, sclerotiotides M-O (-), together with three known analogues, sclerotiotide L (), sclerotiotide F (), and sclerotiotide B (), were obtained from the ethyl acetate extract of the fungus HDN151418, which was isolated from an unidentified Antarctica sponge. Spectroscopic and chemical approaches were used to elucidate their structures. The absolute configuration of the side chain in compound was elucidated for the first time. Read More

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October 2020

Evaluation of Locally Injected Mycobacterium Cell Wall Fraction in Horses with Sarcoids.

J Equine Vet Sci 2020 07 22;90:103102. Epub 2020 Apr 22.

Veterinary Pathology, Iowa State University, Ames, IA.

A reformulation of Mycobacterium cell wall fraction immunotherapeutic can be used to successfully treat sarcoids in horses. Sarcoids are reported to be the most common equine skin tumors with tumor type and location influencing the choice of treatment. Wide surgical excision is curative for many tumors, but may not always be feasible. Read More

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Preparation and in vivo evaluation of glyco-gold nanoparticles carrying synthetic mycobacterial hexaarabinofuranoside.

Beilstein J Nanotechnol 2020 19;11:480-493. Epub 2020 Mar 19.

Laboratory of Immunochemistry, Institute of Biochemistry and Physiology of Plants and Microorganisms, Russian Academy of Sciences, Prospekt Entuziastov 13, Saratov, 410049, Russia.

A number of bacterial glycans are specific markers for the detection and the serological identification of microorganisms and are also widely used as antigenic components of vaccines. The use of gold nanoparticles as carriers for glyco-epitopes is becoming an important alternative to the traditional conjugation with proteins and synthetic polymers. In this study, we aimed to prepare and evaluate in vivo glyco-gold nanoparticles (glyco-GNPs) bearing the terminal-branched hexaarabinofuranoside fragment (Ara) of arabinan domains of lipoarabinomannan and arabinogalactan, which are principal polysaccharides of the cell wall of , the causative agent of tuberculosis. Read More

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Systematic Review of the Therapeutic Efficacy of Bladder-preserving Treatments for Non-muscle-invasive Bladder Cancer Following Intravesical Bacillus Calmette-Guérin.

Eur Urol 2020 09 4;78(3):387-399. Epub 2020 Mar 4.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center, Tampa, FL, USA.

Context: There is a critical need for effective bladder-sparing therapies for bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC). Owing to the current lack of effective agents that can be used as a control, the US Food and Drug Administration began to accept single-arm trials for patients with carcinoma in situ (CIS), using complete response rate (CRR) and duration of response as the primary endpoints to support marketing applications. Despite the ensuing growth of clinical trials in this space, no consensus exists on a clinically relevant benchmark for CRR. Read More

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September 2020

Vertebral Osteomyelitis.

J Am Acad Orthop Surg Glob Res Rev 2019 Dec 5;3(12). Epub 2019 Dec 5.

Department of Orthopaedic Surgery (Dr. McGee, Dr. Dean, and Dr. Kleck), The University of Colorado, Aurora, CO; the Division Plastics and Reconstructive (Dr. Ignatiuk), Department of Surgery, Rutgers New Jersey Medical School, Newark, NJ; and the Department of Infectious Diseases (Dr. Savelli), The University of Colorado School of Medicine, Aurora, CO.

A report of an instance of vertebral osteomyelitis secondary to an uncommon pathogen, .

Summary: is a rapidly growing nontuberculous osteomyelitis which is typically nonpathogenic with only four reported cases of human infection. Diagnosing infections related to nontuberculous mycobacteria (NTM) is difficult and can often be delayed as conventional microbiologic tests are inadequate. Read More

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December 2019

Antibacterial Polyketides from Antarctica Sponge-Derived Fungus sp. HDN151272.

Mar Drugs 2020 Jan 23;18(2). Epub 2020 Jan 23.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Three new polyketides, ketidocillinones A-C (-), were discovered from the extract of an Antarctica sponge-derived fungus sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. Read More

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January 2020

Identification of mycobacteria species by molecular methods.

Int Wound J 2020 Apr 20;17(2):245-250. Epub 2019 Dec 20.

Health Services Vocational School, Trakya University, Edirne, Turkey.

In this study, mycobacteria, which were previously identified as Mycobacterium tuberculosis complex (MTC), and mycobacteria other than tuberculosis (MOTT) with cord factor and the p-nitro-alpha-acetyl-amino-beta-hydroxypropiophenone (NAP) test were reanalysed using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis method in order to confirm the identification, and at the same time, species accepted as MOTT were identified. Although the results of the NAP test were obtained within 3-5 days, the PCR-RFLP results were obtained in 1 day. Ten species identified as MTC with the NAP test and cord factor were confirmed with the PCR-RFLP method. Read More

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Secondary Metabolites Produced by Combined Culture of and a sp.

J Nat Prod 2019 07 2;82(7):2013-2017. Epub 2019 Jul 2.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy , Ocean University of China , Qingdao 266003 , People's Republic of China.

Four new alkyl aromatics, penixylarins A-D (-), along with the known biogenetically related 1,3-dihydroxy-5-(12-hydroxyheptadecyl)benzene () and 1,3-dihydroxy-5-(12-sulfoxyheptadecyl)benzene (), were isolated from a mixed culture of the Antarctic deep-sea-derived fungus PRB-2 and the mangrove-derived fungus sp. HDN13-249. UPLC-MS data and an analysis of structural features showed that compounds and were produced by collaboration of the two fungi, while compounds - could be produced by sp. Read More

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Design, Synthesis and Biological Evaluation of Anti-tuberculosis Agents based on Bedaquiline Structure.

Med Chem 2020 ;16(5):703-714

Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China.

Background: Bedaquiline is a novel anti-tuberculosis drug that inhibits Mycobacterial ATP synthase. However, studies have found that bedaquiline has serious side effects due to high lipophilicity. Recently, the complete structure of ATP synthase was first reported in the Journal of Science. Read More

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Pathogenicity of Mycolicibacterium phlei, a non-pathogenic nontuberculous mycobacterium in an immunocompetent host carrying anti-interferon gamma autoantibodies: a case report.

BMC Infect Dis 2019 May 22;19(1):454. Epub 2019 May 22.

Otsu City Hospital, 2-9-9, Motomiya, Otsu-city, Shiga Prefecture, Japan.

Background: Mycolicibacterium phlei (M. phlei) is known to be a non-pathogenic nontuberculous mycobacterium (NTM) which rarely causes diseases in humans. A disseminated NTM infection is mostly caused by the Mycobacterium avium complex (MAC) and is known to develop in immunocompromised hosts, like those with acquired immune deficiency syndrome (AIDS). Read More

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Mycobacterium avium subspecies paratuberculosis is able to manipulate host lipid metabolism and accumulate cholesterol within macrophages.

Microb Pathog 2019 May 1;130:44-53. Epub 2019 Mar 1.

Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camden, NSW, Australia. Electronic address:

Johne's disease is a chronic wasting disease of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). Closely related pathogenic mycobacteria such as M. tuberculosis are capable of altering host lipid metabolism, highlighting the need to explore the role of lipid metabolism contributing to intracellular survival. Read More

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Synthesis, In Vitro Screening and Docking Studies of New Thiosemicarbazide Derivatives as Antitubercular Agents.

Molecules 2019 Jan 11;24(2). Epub 2019 Jan 11.

Institute of General and Ecological Chemistry, Technical University, 90-924 Łódź, Poland.

A series of thiosemicarbazide derivatives was designed and synthesized by reaction of carboxylic acid hydrazide with isothiocyanates. The molecular structures of the investigated thiosemicarbazides were confirmed and characterized by spectroscopic analysis. The conformational preference of carbonylthiosemicarbazide chain and intra- and intermolecular interactions in the crystalline state were characterized using X-ray analysis. Read More

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January 2019

Synthesis, antimicrobial activity and molecular modeling study of 3-(5-amino-(2H)-1,2,4-triazol-3-yl]-naphthyridinones as potential DNA-gyrase inhibitors.

Bioorg Chem 2018 12 6;81:599-611. Epub 2018 Sep 6.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, October 6 University, 6 October City 12585, Giza, Egypt. Electronic address:

Four series of triazolylnaphthyridinone derivatives were synthesized as structural surrogates of nalidixic acid. The targeted derivatives involve: 3-(5-acylamino-2H-1,2,4-triazol-3-yl)-naphtyridin-4-ones 6(a-e); 3-(5-benzylidineamino-2H-1,2,4-triazol-3-yl)-naphthyridin-4-ones 8(a-g) and their 6-bromonaphthyridin-4-one analogs 7(a-e); 9(a-g). The synthesized compounds were evaluated In vitro for their antimicrobial activity against selected resistant strains of G+ve, G-ve, and Mycobacterium phlei. Read More

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December 2018

Cytotoxic Tetrahydroxanthone Dimers from the Mangrove-Associated Fungus HDN1009.

Mar Drugs 2018 Sep 14;16(9). Epub 2018 Sep 14.

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.

Three new tetrahydroxanthone dimers, 5--asperdichrome (), versixanthones N (), and O (), were isolated from the mangrove-derived fungus HDN1009. Their structures, including the absolute configurations, were elucidated by NMR, HRMS, and circular dichroism (CD) experiments. Among them, compound was the second example of tetrahydroxanthone dimers, which dimerized by a rare diaryl ether linkage and showed promising antibacterial activities against , , , and , with MIC values ranging from 100 μM to 200 μM; whilst compounds and exhibited extensive cytotoxicities against five cancer cell lines (HL-60, K562, H1975, MGC803, and HO-8910), with IC values ranging from 1. Read More

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September 2018

The assessment of changes to the nontuberculous mycobacterial metabolome in response to anti-TB drugs.

FEMS Microbiol Lett 2018 08;365(15)

School of Biological Sciences, Royal Holloway University of London, Egham Hill, Egham TW20 0EX, UK.

Mycobacterium species can cause a range of nontuberculous infections of healthy and immunocompromised people as well as infected people during and after surgical procedures. The similarity of nontuberculous mycobacteria (NTM) to the tuberculosis bacilli (TB) could ultimately enable the use of anti-TB drugs for the genus. Hence, three NTM (Mycobacterium smegmatis, Mycobacterium phlei and Mycobacterium avium) were cultured under different lab conditions, causing two mycobacterial phenotypes (active and dormant), and treated with isoniazid (INH) and ethambutol (EMB) independently or in combination. Read More

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Mutacin 1140 Lantibiotic Variants Are Efficacious Against Infection.

Front Microbiol 2018 16;9:415. Epub 2018 Mar 16.

Oragenics, Inc., Tampa, FL, United States.

Lantibiotics offer an untapped pipeline for the development of novel antibiotics to treat serious Gram-positive (+) infections including . Mutacin 1140 (MU1140) is a lantibiotic produced by and acts via a novel mechanism of action, which may limit the development of resistance. This study sought to identify a lead compound for the treatment of associated diarrhea (CDAD). Read More

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Effects of an immune stimulant, inactivated Mycobacterium phlei, on the growth performance as well as meat quality of fattening pigs.

Anim Sci J 2018 Apr 3;89(4):703-712. Epub 2018 Jan 3.

College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.

Inactivated mycobacterium phlei (M. phlei) is well known for its immune-stimulatory functions in humans and livestock, but less information is available about the influence on meat quality of pigs when used as a feed additive. This study was designed to evaluate the effects of inactivated M. Read More

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Non-tuberculous Mycobacteria isolated from lymph nodes and faecal samples of healthy slaughtered cattle and the abattoir environment.

Transbound Emerg Dis 2018 Jun 17;65(3):711-718. Epub 2017 Dec 17.

Institute for Food Safety and Hygiene, Vetsuisse Faculty University of Zurich, Zurich, Switzerland.

Infections caused by non-tuberculous mycobacteria (NTM) are reported as emerging disease in many countries worldwide. The occurrence of NTM in different hosts and their implication as obligate or opportunistic pathogen remain largely unclear. Lymph nodes and faecal samples of clinically healthy Swiss cattle at slaughter were analysed for the presence of NTM. Read More

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Bioprospecting of Novel and Bioactive Compounds from Marine Actinomycetes Isolated from South China Sea Sediments.

Na Yang Fuhang Song

Curr Microbiol 2018 Feb 16;75(2):142-149. Epub 2017 Sep 16.

Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100190, People's Republic of China.

Marine actinomycetes are less investigated compared to terrestrial strains as potential sources of natural products. To date, few investigations have been performed on culturable actinomycetes associated with South China Sea sediments. In the present study, twenty-eight actinomycetes were recovered from South China Sea sediments after dereplication by traditional culture-dependent method. Read More

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February 2018

Metabolic activity of mature biofilms of Mycobacterium tuberculosis and other non-tuberculous mycobacteria.

Sci Rep 2017 08 23;7(1):9225. Epub 2017 Aug 23.

Center of Biomechanics & Biocalorimetry, University Basel, Gewerbestr. 14, CH-4123, Allschwil, Switzerland.

Mycobacteria are classified into two groups, fast- and slow-growing. Often, fast-growing mycobacteria are assumed to have a higher metabolic activity than their slower counterparts, but in mature biofilms this assumption might not be correct. Indeed, when measuring the metabolic activity of mycobacterial biofilms with two independent non-invasive techniques (isothermal microcalorimetry and tunable diode laser absorption spectrometry), mature biofilms of slow- and fast-growing species appeared more alike than expected. Read More

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Enzymatic phosphorylation of mannose by glucomannokinase from Mycobacterium phlei using inorganic polyphosphate.

Enzyme Microb Technol 2017 Sep 29;104:16-21. Epub 2017 May 29.

Beijing Bioprocess Key Laboratory, Beijing University of Chemical Technology, Beijing, 100029, PR China.

Mannose-6-phosphate is an important phosphor-sugar, which is involved in many physiological functions and it is used to treat many diseases. Its production is however expensive since it requires costly substrate ATP as phosphorylation agent. This study has focused upon the direct synthesis of M6P by glucomannokinase using inorganic polyphosphate without involvement of ATP. Read More

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September 2017

Immunogenicity and therapeutic effects of recombinant Ag85AB fusion protein vaccines in mice infected with Mycobacterium tuberculosis.

Vaccine 2017 07;35(32):3995-4001

Army Tuberculosis Prevention and Control Key Laboratory, Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment, Institute of Tuberculosis Research, The 309th Hospital of Chinese PLA, Beijing 100091, China. Electronic address:

The immune function of tuberculosis (TB) patients is disordered. By using immune regulators to assist chemotherapy for TB the curative effect might be improved. In this study, a vaccine containing Mycobacterium tuberculosis (M. Read More

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[Distribution and drug resistance of nontuberculous in Beijing].

Zhonghua Jie He He Hu Xi Za Zhi 2017 Mar;40(3):210-214

Central Laboratory of Beijing Research Institute for Tuberculosis Control, Beijing 100035, China.

To analyze the distribution and drug resistance of nontuberculous mycobacteria(NTM) in Beijing. Using PCR-fluorescence probe method we identified 1 552 mycobacterial isolates in 2009 and 1 553 mycobacterial isolates in 2013, which were stored by Beijing Research Institute for Tuberculosis Control.All identified NTM strains were confirmed by 16S rRNA gene sequencing, and drug sensitivity testing was performed by using 1% ratio method. Read More

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The Antituberculosis Drug Ethambutol Selectively Blocks Apical Growth in CMN Group Bacteria.

mBio 2017 02 7;8(1). Epub 2017 Feb 7.

Ludwig-Maximilians-Universität, Fakultät Biologie, Planegg-Martinsried, Germany

Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved among all CMN group bacteria. The arabinogalactan and mycolic acid synthesis pathways constitute effective drug targets for tuberculosis treatment. Read More

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February 2017

Efficacy of Mycobacterium Phlei Cell Wall-Nucleic Acid Complex (MCNA) in BCG-Unresponsive Patients.

Bladder Cancer 2017 Jan 27;3(1):65-71. Epub 2017 Jan 27.

Department of Urology, The University of Texas MD Anderson Cancer Center , Houston, TX, USA.

We have previously reported the results of a prospective multi-institutional study on the efficacy of MCNA in patients who recurred after intravesical BCG treatment [1]. Since that publication, a new standardized definition for BCG-unresponsiveness has been established [2]. We re-analyzed the oncologic outcomes following intravesical MCNA in patients classified as BCG-unresponsive according to the new definition. Read More

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January 2017

"Mycobacterium massilipolynesiensis" sp. nov., a rapidly-growing mycobacterium of medical interest related to Mycobacterium phlei.

Sci Rep 2017 01 11;7:40443. Epub 2017 Jan 11.

Aix-Marseille Université, URMITE, UMR CNRS 7278, IRD 198, Inserm 1095, Marseille, France.

In French Polynesia, respiratory tract clinical isolate M26, displayed unusual phenotype and contradictory phylogenetic affiliations, suggesting a hitherto unidentified rapidly-growing Mycobacterium species. The phenotype of strain M26 was further characterized and its genome sequenced. Strain M26 genome consists in a 5,732,017-bp circular chromosome with a G + C% of 67. Read More

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January 2017

Detection of Mycobacterium avium subsp. Paratuberculosis in Cattle by using Indirect Absorbed ELISA (enzyme-linked immunosorbent assay) system and culture in Alborz Province, Iran.

Int J Mycobacteriol 2016 Dec 27;5 Suppl 1:S220-S221. Epub 2016 Oct 27.

Department of Veterinary and Medicine, School of Veterinary, Karaj Azad University, Alborz, Iran.

Objective/background: Mycobacterium avium subsp. paratuberculosis is a slow growing, Gram-positive, and acid-fast bacillus. It is the causative agent of the chronic enteritis disease of ruminants called Johne's disease. Read More

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December 2016