12,795 results match your criteria mycobacterium avium

Mycobacterium avium complex peritonitis in a pediatric patient on peritoneal dialysis: A case report.

Medicine (Baltimore) 2021 Jun;100(24):e26321

Division of Nephrology and Rheumatology.

Introduction: Peritonitis due to Mycobacterium avium complex (MAC) is a rare but life-threatening complication in patients on peritoneal dialysis (PD). However, optimal therapeutic regimen, treatment duration, and appropriate timing of kidney transplantation (KT) after treatment are unknown.

Symptoms: We herein report a 4-year-old boy on PD due to end-stage kidney disease resulting from bilateral hypoplastic kidneys. Read More

View Article and Full-Text PDF

Genome-Wide Essentiality Analysis of by Saturated Transposon Mutagenesis and Deep Sequencing.

mBio 2021 Jun 15:e0104921. Epub 2021 Jun 15.

The Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Mycobacterium abscessus is an emerging opportunistic human pathogen that naturally resists most major classes of antibiotics, making infections difficult to treat. Thus far, little is known about physiology, pathogenesis, and drug resistance. Genome-wide analyses have comprehensively catalogued genes with essential functions in Mycobacterium tuberculosis and Mycobacterium avium subsp. Read More

View Article and Full-Text PDF

Is vaccination a viable method to control Johne's disease caused by Mycobacterium avium subsp. paratuberculosis? Data from 12 million ovine vaccinations and 7.6 million carcass examinations in New South Wales, Australia from 1999-2009.

PLoS One 2021 14;16(6):e0246411. Epub 2021 Jun 14.

James J. Peters VAMC, Bronx, New York, United States of America.

Background: Mycobacterium avium subsp. paratuberculosis (MAP) causes Johne's disease (or paratuberculosis), a chronic wasting disease of ruminants and other animals resulting from granulomatous enteritis. There are increasing concerns that MAP is zoonotic. Read More

View Article and Full-Text PDF

A Solitary Necrotizing Sarcoid Granulomatosis-like Pulmonary Lesion Possibly Associated with Propionibacterium Acnes and Mycobacterium Avium.

Intern Med 2021 Jun 12. Epub 2021 Jun 12.

Division of Pathology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Japan.

We report a case of a pulmonary necrotizing sarcoid granulomatosis (NSG)-like lesion possibly associated with coinfection of Mycobacterium avium and Propionibacterium acnes. A solitary nodule in the right middle lobe of the lung was notable for coagulative necrosis with aggregates of sarcoid-like epithelioid granulomas. Small arteries were damaged by granulomas. Read More

View Article and Full-Text PDF

Factors influencing the effectiveness of the Gudair vaccine for controlling Johne's disease in sheep flocks in Australia.

Prev Vet Med 2021 May 31;193:105394. Epub 2021 May 31.

Sydney School of Veterinary Science, The University of Sydney, Australia.

Ovine Johne's disease is a chronic debilitating disease of sheep caused by Mycobacterium avium subsp. paratuberculosis (Mptb) which results in diarrhoea, emaciation and mortalities in infected animals. Vaccination with Gudair® has been a key strategy for controlling the disease in Australia since its approval in 2002. Read More

View Article and Full-Text PDF

Oesophageal Obstruction in a Donkey Due to Mediastinal Lymphadenitis Caused by Mycobacterium avium Complex.

J Comp Pathol 2021 May 25;185:66-71. Epub 2021 May 25.

Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, Hertfordshire, UK.

Mycobacterial infections are rare in horses, donkeys and mules. Although there are a few reports in horses, mycobacterial disease is poorly documented in the donkey. Mycobacterial infection of equine species typically affects the alimentary tract, causing granulomatous enterocolitis resulting in diarrhoea and chronic weight loss, while lymph nodes and liver may also be affected. Read More

View Article and Full-Text PDF

Application of Volatilome Analysis to the Diagnosis of Mycobacteria Infection in Livestock.

Front Vet Sci 2021 24;8:635155. Epub 2021 May 24.

Department of Anatomy and Comparative Pathology and Toxicology, International Agrifood Campus of Excellence (ceiA3), University of Córdoba, Córdoba, Spain.

Volatile organic compounds (VOCs) are small molecular mass metabolites which compose the volatilome, whose analysis has been widely employed in different areas. This innovative approach has emerged in research as a diagnostic alternative to different diseases in human and veterinary medicine, which still present constraints regarding analytical and diagnostic sensitivity. Such is the case of the infection by mycobacteria responsible for tuberculosis and paratuberculosis in livestock. Read More

View Article and Full-Text PDF

Social network analysis and whole-genome sequencing to evaluate disease transmission in a large, dynamic population: A study of avian mycobacteriosis in zoo birds.

PLoS One 2021 9;16(6):e0252152. Epub 2021 Jun 9.

Disease Investigations, San Diego Zoo Wildlife Alliance, San Diego, California, United States of America.

This study combined a social network analysis and whole-genome sequencing (WGS) to test for general patterns of contagious spread of a mycobacterial infection for which pathways of disease acquisition are not well understood. Our population included 275 cases diagnosed with avian mycobacteriosis that were nested in a source population of 16,430 birds at San Diego Zoo Wildlife Alliance facilities from 1992 through mid-2014. Mycobacteria species were determined using conventional methods and whole genome sequencing (WGS). Read More

View Article and Full-Text PDF

Immunoadjunctive Therapy against Bacterial Infections Using Herbal Medicines Based on Th17 Cell-mediated Protective Immunity.

Curr Pharm Des 2021 Jun 8. Epub 2021 Jun 8.

Department of Community Medicine Management, Shimane University School of Medicine, Izumo, Japan.

One of the major health concerns in the world is the global increase in intractable bacterial infectious diseases due to the emergence of multi- and extensively drug-resistant bacterial pathogens as well as an increase in compromised hosts around the world. Particularly, in the case of mycobacteriosis, the high incidence of tuberculosis in developing countries, resurgence of tuberculosis in industrialized countries, and increase in the prevalence of Mycobacterium avium complex infections are important worldwide health concerns. However, the development of novel antimycobacterial drugs is currently making slow progress. Read More

View Article and Full-Text PDF

R-CHOP Chemotherapy for Disseminated Complex Disease due to Anti-Interferon-Gamma Autoantibodies: A Case Report.

Open Forum Infect Dis 2021 Jun 10;8(6):ofab181. Epub 2021 Apr 10.

Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.

A 77-year-old Japanese man with disseminated complex (MAC) disease due to anti-interferon-gamma autoantibodies received rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP) chemotherapy because of non-Hodgkin lymphoma complication. The hepatobiliary nodules due to MAC resolved with R-CHOP and multidrug antimycobacterial treatment. R-CHOP could serve as an alternative adjunctive therapy for patients with anti-interferon-gamma autoantibodies. Read More

View Article and Full-Text PDF

Effect of the deletion of lprG and p55 genes in the K10 strain of Mycobacterium avium subspecies paratuberculosis.

Res Vet Sci 2021 May 28;138:1-10. Epub 2021 May 28.

Instituto de Agrobiotecnología y Biología Molecular (IABIMO), INTA-CONICET, Hurlingham, Buenos Aires 1686, Argentina.

The lprG-p55 operon of Mycobacterium tuberculosis, M. bovis and M. avium strain D4ER has been identified as a virulence factor involved in the transport of toxic compounds. Read More

View Article and Full-Text PDF

Robustness of Aerosol Delivery of Amikacin Liposome Inhalation Suspension using the eFlow® Technology.

Eur J Pharm Biopharm 2021 May 31. Epub 2021 May 31.

Insmed Incorporated, 700 US 206 North, Bridgewater, NJ, USA 08807. Electronic address:

The purpose of these studies was to understand the effect on product performance of batch-to-batch variability in both the amikacin liposome inhalation suspension (ALIS) formulation and its delivery device, the Lamira® nebulizer system, designed and manufactured by PARI (PARI Pharma GmbH, Munich, Germany). Three batches of ALIS spanning a range of lipid concentrations (43, 48 and 54 mg/mL) were tested with nine PARI inhalation devices that varied within the production process of the vibrating membrane with respect to hole geometry. Three clusters were built including a geometry close to the mean geometry (median) and two geometries deviating from the mean geometry with smaller (smaller) and larger (larger) holes. Read More

View Article and Full-Text PDF

Development of a reference standard for the detection and quantification of Mycobacterium avium subsp. paratuberculosis by quantitative PCR.

Sci Rep 2021 Jun 2;11(1):11622. Epub 2021 Jun 2.

Department of Microbiology and Antimicrobial Resistance, Veterinary Research Institute, Brno, Czech Republic.

Quantitative PCR (qPCR) has become a frequently employed direct method for the detection and quantification of Mycobacterium avium subsp. paratuberculosis (MAP). The quantity of MAP determined by qPCR, however, may be affected by the type of qPCR quantification standard used (PCR product, plasmid, genomic DNA) and the way in which standard DNA quantity is determined (absorbance, fluorescence). Read More

View Article and Full-Text PDF

Mycobacterium Avium Complex Genitourinary Infections: Case Report and Literature Review.

Infect Dis Rep 2021 May 24;13(2):454-464. Epub 2021 May 24.

School of Medicine, Creighton University, Omaha, NE 68124, USA.

Nontuberculous mycobacterial (NTM) genitourinary (GU) infections are relatively rare, and there is frequently a delay in diagnosis. Mycobacterium avium-intracellulare complex (MAC) cases seem to be less frequent than other NTM as a cause of these infections. In addition, there are no set treatment guidelines for these organisms in the GU tract. Read More

View Article and Full-Text PDF

Detection of Subspecies in Pooled Fecal Samples by Fecal Culture and Real-Time PCR in Relation to Bacterial Density.

Animals (Basel) 2021 May 29;11(6). Epub 2021 May 29.

Animal Health Service, Thuringian Animal Diseases Fund, Victor-Goerttler-Straße 4, 07745 Jena, Germany.

Within paratuberculosis control programs subsp. (MAP)-infected herds have to be detected with minimum effort but with sufficient reliability. We aimed to evaluate a combination of random sampling (RS) and pooling for the detection of MAP-infected herds, simulating repeated RS in imitated dairy herds (within-herd prevalence 1. Read More

View Article and Full-Text PDF

Nicotine Increases Macrophage Survival through α7nAChR/NF-κB Pathway in    Infection.

Microorganisms 2021 May 18;9(5). Epub 2021 May 18.

Division of Molecular Microbiology, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, USA.

Recently, we reported that nicotine plays a role in the failure of the macrophage in the clearance of subspecies (MAP) during infection in Crohn's disease smokers. We also demonstrated that nicotine enhances macrophages cellular survival during MAP infection. Blocking α7 nicotinic acetylcholine receptor (α7nAChR) with the pharmacological antagonist-mecamylamine-subverted the anti-inflammatory effect of nicotine in macrophages. Read More

View Article and Full-Text PDF

Bovine Intelectin 2 Expression as a Biomarker of Paratuberculosis Disease Progression.

Animals (Basel) 2021 May 12;11(5). Epub 2021 May 12.

Center for Animal Biotechnology, Servicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), 33394 Deva, Spain.

Paratuberculosis (PTB), a chronic granulomatous enteritis caused by   subsp. (MAP), is responsible for important economic losses in the dairy industry. Our previous RNA-sequencing (RNA-Seq) analysis showed that bovine intelectin 2 (ITLN2) precursor gene was overexpressed in ileocecal valve (ICV) samples of animals with focal (log2 fold-change = 10. Read More

View Article and Full-Text PDF

Detection of Paratuberculosis in Dairy Herds by Analyzing the Scent of Feces, Alveolar Gas, and Stable Air.

Molecules 2021 May 11;26(10). Epub 2021 May 11.

Institute of Molecular Pathogenesis at 'Friedrich-Loeffler-Institut' (Federal Research Institute for Animal Health), Naumburgerstr. 96a, 07743 Jena, Germany.

Paratuberculosis is an important disease of ruminants caused by ssp. (MAP). Early detection is crucial for successful infection control, but available diagnostic tests are still dissatisfying. Read More

View Article and Full-Text PDF

Successful Cord Blood Transplantation for Idiopathic CD4+ Lymphocytopenia.

Acta Haematol 2021 Jun 1:1-7. Epub 2021 Jun 1.

Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan.

Idiopathic CD4+ lymphocytopenia (ICL) is the depletion of CD4+ lymphocytes to <300 cells/mm3 without human immunodeficiency virus infection or other causes of lymphocytopenia. ICL causes fatal infections; its etiology remains unclear and it lacks consensus regarding therapeutic options. We report the first patient with ICL who had a successful clinical course following a cord blood transplant (CBT). Read More

View Article and Full-Text PDF

Seroprevalence of selected endemic infectious diseases in large-scale Estonian dairy herds and their associations with cow longevity and culling rates.

Prev Vet Med 2021 Jul 27;192:105389. Epub 2021 May 27.

Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 62, Tartu, 51006, Estonia.

Herd culling rates and longevity represent herd health and welfare status as well as farm economic performance. The contribution of endemic circulation of the main cattle pathogens to herd performance has not been previously analysed. The aim of this study was to estimate the herd prevalence of selected endemic bovine pathogens among large commercial dairy herds and to analyse their associations with herd culling rates and longevity. Read More

View Article and Full-Text PDF

[Effective Treatment of Secondary Spontaneous Pneumothorax due to Pulmonary Mycobacterium Avium Complex by Thoracoscopic Intra-fistula Filling with Suture Closure].

Kyobu Geka 2021 Jun;74(6):434-437

Department of Thoracic Surgery, Japanese Red Cross Society Himeji Hospital, Himeji, Japan.

Secondary spontaneous pneumothorax associated with pulmonary Mycobacterium avium complex (MAC) infection is often difficult to treat. Pneumothorax associated with pulmonary MAC is characterized by a large fistula with a cavity or bronchodilation, and pleural thickening due to pleurisy. Herein, we report two cases of pneumothorax with pulmonary MAC successfully treated by minimally invasive thoracoscopic intra-fistula filling with a suture closure method. Read More

View Article and Full-Text PDF

Early Detection of subsp. Infected Cattle: Use of Experimental Johnins and Innovative Interferon-Gamma Test Interpretative Criteria.

Front Vet Sci 2021 14;8:638890. Epub 2021 May 14.

Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche "Togo Rosati", Perugia, Italy.

Paratuberculosis (PTB), also known as Johne's disease, is a chronic proliferative enteritis of ruminants caused by subsp. (MAP). To date, PTB diagnosis, based on serology, fecal culture, and real-time polymerase chain reaction, has identified animals in advanced stages of infection. Read More

View Article and Full-Text PDF

Disseminated nontuberculous mycobacteriosis and fungemia after second delivery in a patient with MonoMAC syndrome/GATA2 mutation: a case report.

BMC Infect Dis 2021 May 29;21(1):502. Epub 2021 May 29.

Department of Respiratory Medicine, Juntendo University Faculty of Medicine and Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.

Background: Heterozygous mutations in the transcription factor GATA2 result in a wide spectrum of clinical phenotypes, including monocytopenia and Mycobacterium avium complex (MAC) infection (MonoMAC) syndrome. Patients with MonoMAC syndrome typically are infected by disseminated nontuberculous mycobacteria, fungi, and human papillomavirus, exhibit pulmonary alveolar proteinosis during late adolescence or early adulthood, and manifest with decreased content of dendritic cells (DCs), monocytes, and B and natural killer (NK) cells.

Case Presentation: A 39-year-old woman was diagnosed with MonoMAC syndrome postmortem. Read More

View Article and Full-Text PDF

Disseminated and infection causing an immune reconstitution inflammatory syndrome in a female patient with HIV infection.

BMJ Case Rep 2021 May 28;14(5). Epub 2021 May 28.

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.

This case study discusses the management of a disseminated and infection causing an immune reconstitution inflammatory syndrome in a 52-year-old woman with HIV infection. Disseminated infections have extensively been described in HIV patients; however, reports of infections with are rare. Treatment of infections is challenging due to its high rates of natural drug resistances, and thus far, no standard treatment regimen exists. Read More

View Article and Full-Text PDF

Hematologic values in domestic pigeons naturally infected with Mycobacterium avium subsp. avium.

Vet Clin Pathol 2021 May 27. Epub 2021 May 27.

Razi Vaccine and Serum Research Institute, Karaj, Iran.

Avian mycobacteriosis is an important disease of birds and is most often caused by Mycobacterium avium or Mycobacterium genavense. However, little information on the hematologic changes associated with this infectious disease in pigeons has been published. The aim of this investigation was to compare the hematologic parameters of domestic pigeons (Columba livia var. Read More

View Article and Full-Text PDF

Bronchial Brushing and Diagnosis of Pulmonary Nontuberculous Mycobacteria Infection.

Respiration 2021 May 27:1-9. Epub 2021 May 27.

Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan.

Background: The optimal bronchoscopy procedure for diagnosis of pulmonary nontuberculous mycobacteria (NTM) infection is unclear.

Objective: This study investigated the usefulness of bronchial brushing in bronchoscopy for diagnosis of pulmonary NTM infection in patients with suspected NTM lung disease and nodular bronchiectasis on chest computed tomography (CT) images.

Methods: Bronchoscopy was prospectively performed for 69 patients with clinically suspected pulmonary NTM infection on chest CT from December 2017 through December 2019. Read More

View Article and Full-Text PDF

[Association between early peripheral lung cancer and nontuberculous mycobacterial lung disease].

Arkh Patol 2021 ;83(3):52-55

Novosibirsk Tuberculosis Research Institute, Novosibirsk, Russia.

Mycobacteriosis is an infectious disease caused by nontuberculous mycobacteria, with granulomatous inflammation in the affected organs and tissues. The association of mycobacteriosis and lung cancer in one patient is quite rarely observed and is of interest to the medical community. A 63-year-old male patient was admitted to the hospital with a diagnosis of infiltrative tuberculosis in SI-SII of both lungs in the lung cavitation phase on the right, peripheral mass in SIII on the right in order to make a decision about a surgical intervention. Read More

View Article and Full-Text PDF

Whole-Genome Analysis of subsp. IS-.

Front Microbiol 2021 10;12:660002. Epub 2021 May 10.

INRAE, ISP, Université de Tours, Nouzilly, France.

subsp. () is the etiological agent of Johne's disease in ruminants. The IS insertion sequence (IS) has been used widely as an epidemiological marker and target for PCR diagnosis. Read More

View Article and Full-Text PDF

Extracellular DNA of slow growers of mycobacteria and its contribution to biofilm formation and drug tolerance.

Sci Rep 2021 May 26;11(1):10953. Epub 2021 May 26.

Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.

DNA is basically an intracellular molecule that stores genetic information and carries instructions for growth and reproduction in all cellular organisms. However, in some bacteria, DNA has additional roles outside the cells as extracellular DNA (eDNA), which is an essential component of biofilm formation and hence antibiotic tolerance. Mycobacteria include life-threating human pathogens, most of which are slow growers. Read More

View Article and Full-Text PDF

Association of serum antibodies against the Mycobacterium avium complex and hemoptysis: a cross-sectional study.

BMC Infect Dis 2021 May 26;21(1):480. Epub 2021 May 26.

Department of Respiratory Medicine, National Hospital Organization Fukuoka National Hospital, 4-39-1 Yakatabaru, Minami-ku, Fukuoka, 811-1394, Japan.

Background: Hemoptysis is very common and can be life threatening in clinical practice for nontuberculous mycobacteria. The serum antibody against the Mycobacterium avium complex (MAC-Ab), the majority of nontuberculous mycobacteria species, is well known to reflect the activity of MAC lung disease; however, there is no study investigating the association between the MAC-Ab and hemoptysis in MAC patients. Therefore, we assessed whether the MAC-Ab is a good biomarker for hemoptysis among subjects with MAC lung disease. Read More

View Article and Full-Text PDF