43,330 results match your criteria myc


Molecular Subtypes of Primary Small Cell Lung Cancer Tumors and Their Associations with Neuroendocrine and Therapeutic Markers.

J Thorac Oncol 2021 Sep 14. Epub 2021 Sep 14.

Thoracic Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health. Electronic address:

Introduction: A new molecular subtype classification was recently proposed for small cell lung cancer (SCLC). It is necessary to validate it in primary SCLC tumors by immunohistochemical (IHC) staining and define its clinical relevance.

Methods: We used IHC to assess four subtype markers (ASCL1, NEUROD1, POU2F3, and YAP1) in 194 cores from 146 primary SCLC tumors. Read More

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September 2021

CircVCAN/SUB1 Up-regulates MYC/HSP90β to Enhance the Proliferation and Migration of Glioma Cells.

Brain Res Bull 2021 Sep 14. Epub 2021 Sep 14.

Department of Neurosurgery, Shanxi Bethune Hospital Shanxi Academy of Medical Sciences, No.99 Longcheng Street, Xiaodian District, Taiyuan, 030000, Shanxi, China.

Background: Gliomas are the most malignant and aggressive form of brain tumors, and account for the majority of brain cancer related deaths. Previous studies have reported that SUB1 serves as a novel RBP, which is highly expressed in tumors.

Aim: In our research, we aimed at exploring the regulatory mechanism of SUB1 in glioma cells. Read More

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September 2021

MUC5AC serves as the nexus for β-catenin/c-Myc interplay to promote glutamine dependency during pancreatic cancer chemoresistance.

Gastroenterology 2021 Sep 14. Epub 2021 Sep 14.

Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center; Fred and Pamela Buffett Cancer Center, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.. Electronic address:

Background And Aims: A major clinical challenge for pancreatic cancer (PC) patients is metabolic adaptation. Neoplastic cells harboring molecular perturbations suffice for their increased anabolic demand and nucleotide biosynthesis to acquire chemoresistance. The mucin 5AC expressed de novo in malignant pancreas promotes cancer cell stemness and is significantly associated with poor patient survival. Read More

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September 2021

7-[[(4-methyl-2-pyridinyl)amino](2-pyridinyl)methyl]-8-quinolinol (compound 30666) inhibits enhancer activity and reduces B-cell lymphoma growth - A question of specificity.

Eur J Pharmacol 2021 Sep 14:174505. Epub 2021 Sep 14.

Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland. Electronic address:

B-cell non-Hodgkin lymphoma (NHL) is among the ten most common malignancies. Survival rates range from very poor to over 90% and highly depend on the stage and subtype. Characteristic features of NHL are recurrent translocations juxtaposing an oncogene (e. Read More

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September 2021

CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell.

Stem Cell Reports 2021 Sep 8. Epub 2021 Sep 8.

Department of Orthopaedics and Traumatology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Skeletal muscle satellite cells (SCs) are stem cells responsible for muscle development and regeneration. Although CRISPR/Cas9 has been widely used, its application in endogenous SCs remains elusive. Here, we generate mice expressing Cas9 in SCs and achieve robust editing in juvenile SCs at the postnatal stage through AAV9-mediated short guide RNA (sgRNA) delivery. Read More

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September 2021

LncRNA BASP1-AS1 interact with YBX1 to regulate Notch transcription and drives the malignancy of melanoma.

Cancer Sci 2021 Sep 17. Epub 2021 Sep 17.

Department of Dermatology, The First Hospital of China Medical University and National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, The First Hospital of China Medical University and Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, 110001, China.

Melanoma is a fatal skin malignant tumor with a poor prognosis, we found that LncRNA BASP1-AS1 is essential for the development and prognosis of melanoma. Firstly, the methylation, RNA-Seq, CNV, mutation data, and sample follow-up information of melanoma from TCGA were analyzed using WGCNA and selected 366 samples common to the three omics for multi-group clustering analysis. Then a 4-gene prognostic model (BASP1-AS1, LOC100506098, ARHGAP27P1, and LINC01532) was constructed in the TCGA cohort and validated using the GSE65904 series. Read More

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September 2021

Overexpression of BMP9 promotes ovarian cancer progression via Notch1 signaling.

Neoplasma 2021 Sep 17. Epub 2021 Sep 17.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Lanzhou University, Key Laboratory of Gynecological Oncology of Gansu Province, Lanzhou, Gansu, China.

Cell proliferation and migration play important parts in ovarian cancer progression. BMP9, as one of the members of the TGF-β superfamily and BMP family, plays a diverse and significant array of biological roles, including cell differentiation, proliferation, apoptosis, tumorigenesis, and metabolism. However, the role and mechanism of BMP9 in ovarian cancer progression remains uncertain. Read More

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September 2021

lncRNA FEZF1-AS1 regulates biological behaviors of cervical cancer by targeting miRNA-1254.

Food Sci Nutr 2021 Sep 14;9(9):4722-4737. Epub 2021 Jul 14.

Department of gynaecology and obstetrics Chongqing General Hospital University of Chinese Academy of Sciences Chongqing China.

Aim: The purpose of this research was to evaluate lncRNA FEZF1-AS1 in cervical cancer development and clinical significance.

Materials And Methods: Collecting cervical cancer tissues, measuring FEZF1-AS1 expression, and analysis correlation between FEZF1-AS1 and prognosis. In cell vitro study, using MTT assay to measure cell proliferation, evaluating cell apoptosis by flow cytometry, measuring cell invasion and migration by Transwell and wound healing assay; lncRNA FEZF1-AS1 and miR-1254 gene expressions were evaluated by RT-qPCR assay; relative protein (Smurf1, E-cadherin, Vimentin, N-cadherin, AKT, p-AKT, c-Myc, and ZEB1) expressions were measured by Western blot assay. Read More

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September 2021

Muscone suppresses gastric cancer via regulation of miRNA-145.

Food Sci Nutr 2021 Sep 26;9(9):4711-4721. Epub 2021 Jul 26.

Department of Clinical Laboratory Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China.

This study aims to determine the effects and mechanism of action of muscone on the biological activity of the gastric cancer cell lines SGC-7901 and MGC-803 (proliferation, apoptosis, invasion, and migration) in vitro. An optimal muscone concentration was determined using MTT and cell apoptosis tests. The SGC-7901 and MGC-803 cells were divided into five groups: normal control, muscone, miRNA, muscone + miRNA, and muscone + miRNA inhibitor. Read More

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September 2021

Standardized Bunge- Salisb. Extract Efficiently Suppresses Colon Cancer Progression Through Gut Microbiota Modification in CT26-Bearing Mice.

Front Pharmacol 2021 31;12:714322. Epub 2021 Aug 31.

School of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.

Altered gut microbiota and a damaged colon mucosal barrier have been implicated in the development of colon cancer. Bunge- Salisb. (ACE) is a common herbal drug pair that widely used clinically to treat cancer. Read More

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METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors.

Clin Epigenetics 2021 Sep 16;13(1):173. Epub 2021 Sep 16.

Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Via A. Scarpa, 14-16, 00161, Rome, Italy.

Background: Thymic epithelial tumors (TETs) are rare neoplasms, originating from epithelial thymic cells. The oncogenic potential of these rare neoplasms is still largely undefined, and a deeper molecular characterization could result in a relevant advance in their management, greatly improving diagnosis, prognosis and treatment choice. Deregulation of N6-methyladenosine (mA) RNA modification, catalyzed by the METTL3/METTL14 methyltransferase complex, is emerging as a relevant event in cell differentiation and carcinogenesis. Read More

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September 2021

MicroRNA-214 promotes alveolarization in neonatal rat models of bronchopulmonary dysplasia via the PlGF-dependent STAT3 pathway.

Mol Med 2021 Sep 16;27(1):109. Epub 2021 Sep 16.

Department of Neonatology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, No. 261, Huansha Road, Hangzhou, 310000, Zhejiang Province, People's Republic of China.

Background: Recently, the role of several microRNAs (miRNAs or miRs) in pulmonary diseases has been described. The molecular mechanisms by which miR-214 is possibly implicated in bronchopulmonary dysplasia (BPD) have not yet been addressed. Hence, this study aimed to investigate a putative role of miR-214 in alveolarization among preterm neonates with BPD. Read More

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September 2021

Prostate tumors of native men from West Africa show biologically distinct pathways-A comparative genomic study.

Prostate 2021 Sep 16. Epub 2021 Sep 16.

National Center for Radiotherapy, Oncology and Nuclear Medicine, Korle Bu Teaching Hospital Accra, Accra, Ghana.

Background: Native African men (NAM) experience a disproportionate burden of prostate cancer (PCa) and have higher mortality rates compared to European American men (EAM). While socioeconomic status has been implicated as a driver of this disparity, little is known about the genomic mechanisms and distinct biological pathways that are associated with PCa of native men of African origin.

Methods: To understand biological factors that contribute to this disparity we utilized a total of 406 multi-institutional localized PCa samples, collected by Men of African Descent and Carcinoma of the Prostate biospecimen network and Moffitt Cancer Center/University of Pennsylvania Health science system. Read More

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September 2021

MYC Expression Is Associated With p53 Expression and TP53 Aberration and Predicts Poor Overall Survival in Acute Lymphoblastic Leukemia/Lymphoma.

Am J Clin Pathol 2021 Sep 16. Epub 2021 Sep 16.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, MO, USA.

Objectives: We evaluated MYC and p53 expression, TP53 aberration, their relationship, and their impact on overall survival (OS) in acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL).

Methods: We identified 173 patients with ALL and LBL, including 12 cases of mixed-phenotype acute leukemia, 8 cases of therapy-related B-cell ALL (B-ALL), 119 cases of B-ALL, and 34 cases of T-cell ALL/LBL diagnosed from 2003 to 2019. We retrospectively assessed p53 and MYC expression by immunohistochemistry of bone marrow and correlated MYC expression with p53 expression and TP53 aberration. Read More

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September 2021

Quadruple-hit pleomorphic mantle cell lymphoma with MYC, BCL2, BCL6, and CCND1 gene rearrangements.

Br J Haematol 2021 Sep 16. Epub 2021 Sep 16.

National Clinical Research Center for Hematologic Diseases, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P.R. China.

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September 2021

Case Report and Literature Review: Primary Pulmonary NUT-Midline Carcinoma.

Front Oncol 2021 30;11:700781. Epub 2021 Aug 30.

Thoracic Surgery Department, Weifang People's Hospital, Weifang, China.

Nuclear protein of the testis (NUT) carcinoma is a very rare and aggressive carcinoma characterized by chromosomal rearrangement. NUT-midline carcinoma (NMC) can occur anywhere in the body, but most of the tumors are found in the midline anatomic structure or mediastinum. Pulmonary-originated NMC is extremely rare and often difficult to be distinguished from other poorly differentiated tumors, making the diagnosis awfully challenged in clinical practice. Read More

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Effect of regular and irregular stimulation cycles of dexamethasone on circadian clock in NIH3T3 cells.

Chronobiol Int 2021 Sep 15:1-9. Epub 2021 Sep 15.

Laboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

Animal studies have shown that irregular light-dark cycles cause circadian desynchronization, while few studies have addressed the effect of regular/irregular stimulation cycles of signaling hormones on the cellular clock . Here, we examined how cellular clocks respond to regular and irregular stimulation cycles of dexamethasone, using NIH3T3 cells transfected with the promoter-driven luciferase () reporter gene. Cyclic stimulation with dexamethasone at different time intervals (18-28 h, 3 times regularly) revealed that bioluminescence rhythms can be entrained to 22 and 24 h cycles during the stimulation period, but not to other cycles. Read More

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September 2021

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.

Cell Chem Biol 2021 Sep 8. Epub 2021 Sep 8.

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address:

Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest clinical outcome. The PIM family of kinases has emerged as a factor that is both overexpressed in TNBC and associated with poor outcomes. Preclinical data suggest that TNBC with an elevated MYC expression is sensitive to PIM inhibition. Read More

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September 2021

The STAT3-MYC Axis Promotes Survival of Leukemia Stem Cells by Regulating SLC1A5 and Oxidative Phosphorylation.

Blood 2021 Sep 15. Epub 2021 Sep 15.

University of Colorado, Aurora, Colorado, United States.

AML is characterized by the presence of leukemia stem cells (LSCs), and failure to fully eradicate this population contributes to disease persistence/relapse. Prior studies have characterized metabolic vulnerabilities of LSCs, which demonstrate preferential reliance on oxidative phosphorylation (OXPHOS) for energy metabolism and survival. In the present study, using both genetic and pharmacologic strategies in primary human AML specimens, we show that signal transducer and activator of transcription 3 (STAT3) mediates OXPHOS in LSCs. Read More

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September 2021

Defining and Treating High-grade B-cell lymphoma, NOS.

Blood 2021 Sep 15. Epub 2021 Sep 15.

Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, United States.

High-grade B-cell lymphoma, not otherwise specified (HGBL, NOS) is a recently introduced diagnostic category for aggressive B-cell lymphomas. It includes tumors with Burkitt-like or blastoid morphology that do not have double-hit cytogenetics and that cannot be classified as other well-defined lymphoma subtypes. HBCL, NOS are rare and heterogeneous; most have germinal center B-cell phenotype, and up to 45% carry a single-hit MYC rearrangement, but otherwise they have no unifying immunophenotypic or cytogenetic characteristics. Read More

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September 2021

IGFBP-2 as a biomarker in NAFLD improves hepatic steatosis:an integrated bioinformatics and experimental study.

Endocr Connect 2021 Sep 1. Epub 2021 Sep 1.

Q Wang, Department of Toxicology, Sun Yat-Sen University, Guangzhou, 510275, China.

Background And Aims: Non-alcoholic fatty liver disease (NAFLD) has become a common chronic liver disease in the world. Simple steatosis is the early phase of NAFLD. However, the molecular mechanisms underlying the development of steatosis have not yet been fully elucidated. Read More

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September 2021

Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of malignant tumors.

Biomater Sci 2021 Sep 15. Epub 2021 Sep 15.

Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.

Bromodomain and extra-terminal (BET) proteins are attractive targets for treating various malignancies including melanoma. The inhibition of BET bromodomains, with JQ1, is found to downregulate the expression of both c-MYC oncoprotein and programmed cell death ligand 1 (PD-L1), which play a crucial role in tumor growth and the immunosuppressive tumor microenvironment, respectively. The BET bromodomain inhibitors like JQ1 though exhibiting high selectivity and affinity show usually low bioavailability and efficacy due to fast clearance and inferior uptake by tumor cells. Read More

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September 2021

N-Myc promotes angiogenesis and therapeutic resistance of prostate cancer by TEM8.

Med Oncol 2021 Sep 14;38(10):127. Epub 2021 Sep 14.

Department of Pathology, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People's Republic of China.

Although patients with early localized prostate cancer can survive longer, castration-resistant prostate cancer (CRPC) has gradually emerged with the use of androgen deprivation therapy (ADT). N-Myc and TEM8 play a vital role in the progression of several cancer types. However, the underlying mechanism of how N-Myc and TEM8 promote the progression of prostate cancer remains unclear. Read More

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September 2021

PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis.

Genes Dis 2021 Nov 25;8(6):838-848. Epub 2020 Aug 25.

Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei Province, 430072, PR China.

Protein tyrosine phosphatase non-receptor type 18 (PTPN18) is often highly expressed in colorectal cancer (CRC), but its role in this disease remains unclear. We demonstrated that PTPN18 overexpression promotes growth and tumorigenesis in CRC cells and that PTPN18 deficiency yields the opposite results . Moreover, a xenograft assay showed that PTPN18 deficiency significantly inhibited tumorigenesis . Read More

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November 2021

Comprehensive identification of alterations in 5 557 Chinese patients with solid tumors by next-generation sequencing.

Am J Cancer Res 2021 15;11(8):3893-3906. Epub 2021 Aug 15.

Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences Guangzhou 510080, Guandong, China.

Deregulation of fibroblast growth factor receptor (FGFR) network is common in cancer due to activating mutations, gene amplifications and chromosomal translocations. Currently, various FGFR inhibitors are being developed. In order to optimize their clinical applications, understanding the frequencies and types of alterations in multiple cancer types appears to be extremely important. Read More

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Cystin genetic variants cause autosomal recessive polycystic kidney disease associated with altered Myc expression.

Sci Rep 2021 Sep 14;11(1):18274. Epub 2021 Sep 14.

Center for Translational Research, Children's National Research Institute, 111 Michigan Ave NW, Washington, DC, 20010, USA.

Mutation of the Cys1 gene underlies the renal cystic disease in the Cys1 (cpk) mouse that phenocopies human autosomal recessive polycystic kidney disease (ARPKD). Cystin, the protein product of Cys1, is expressed in the primary apical cilia of renal ductal epithelial cells. In previous studies, we showed that cystin regulates Myc expression via interaction with the tumor suppressor, necdin. Read More

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September 2021

DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.

Proc Natl Acad Sci U S A 2021 Sep;118(38)

Institute for Cancer Genetics, Vagelos College for Physicians and Surgeons, Columbia University, New York City, NY 10032;

CtIP is a DNA end resection factor widely implicated in alternative end-joining (A-EJ)-mediated translocations in cell-based reporter systems. To address the physiological role of CtIP, an essential gene, in translocation-mediated lymphomagenesis, we introduced the T855A mutation at murine CtIP to nonhomologous end-joining and Tp53 double-deficient mice that routinely succumbed to lymphomas carrying A-EJ-mediated IgH-Myc translocations. T855 of CtIP is phosphorylated by ATM or ATR kinases upon DNA damage to promote end resection. Read More

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September 2021

Expanding control of the tumor cell cycle with a CDK2/4/6 inhibitor.

Cancer Cell 2021 Sep 11. Epub 2021 Sep 11.

Pfizer Global Research and Development La Jolla, 10770 Science Center Drive, San Diego, CA 92121, USA.

The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free survival in HR/HER2 breast cancer when combined with anti-hormonals. We sought to discover PAL resistance mechanisms in preclinical models and through analysis of clinical transcriptome specimens, which coalesced on induction of MYC oncogene and Cyclin E/CDK2 activity. We propose that targeting the G kinases CDK2, CDK4, and CDK6 with a small-molecule overcomes resistance to CDK4/6 inhibition. Read More

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September 2021

Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38.

Bioengineered 2021 Dec;12(1):6529-6537

Department of Hepatobiliary and Pancreatic Surgery, People's Hospital of DeYang City, Deyang City, Sichuan Province, China.

Hepatocellular carcinoma (HCC) is a serious malignant tumor of the liver. It has been reported that serine/threonine kinase 39 (STK39) participates in tumorigenesis. However, the role of STK39 in HCC remains unknown. Read More

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December 2021

Inhibition of BRD4 Suppresses the Growth of Esophageal Squamous Cell Carcinoma.

Cancer Invest 2021 Sep 14:1-16. Epub 2021 Sep 14.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Background: Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on histones to facilitate the epigenetic regulation of many genes, and it plays a key role in many cancer types. Despite many prior reports that have explored the importance of BRD4 in oncogenesis and the regulation of epigenetic memory, its role in esophageal squamous cell carcinoma (ESCC) progression is poorly understood. Here, we investigated expression in human ESCC tissues to understand how it regulates the biology of these tumor cells. Read More

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September 2021