Pharmacogenet Genomics 2021 Sep 20. Epub 2021 Sep 20.
Department of Endocrinology Department of Infection Control Department of Neurology, Meizhou People's Hospital, Meizhou, Guangdong Province Department of Endocrinology, Central Hospital of Shenzhen Guangming New District, Shenzhen Department of Endocrinology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, People's Republic of China.
Metformin is the first-choice oral anti-hyperglycemic drug for type 2 diabetes mellitus (T2DM) patients. There are controversies about the association of SLC22A1 rs622342, which was not reported in the Chinese population, and ataxia-telangiectasia mutated (ATM) rs11212617 polymorphisms with metformin efficacy in T2DM. Our study was to investigate the effects of the two single nucleotide polymorphisms on the efficacy of metformin in T2DM of Han nationality in Chaoshan China. Read More