43,802 results match your criteria muscles liver


Intramuscular Expression of Plasmid-Encoded FVII-Fc Immunoconjugate for Tumor Immunotherapy by Targeting Tumoral Blood Vessels and Cells.

Front Oncol 2021 24;11:638591. Epub 2021 May 24.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China.

Tissue factor (TF) has been confirmed to be specifically expressed by vascular endothelial cells (VECs) in solid tumors and certain types of malignant tumor cells. Coagulation factor VII (FVII) can specifically bind to TF with high affinity, so the FVII-TF interaction provides an ideal target for tumor therapy. Expression of proteins in skeletal muscles is a simple and economical avenue for continuous production of therapeutic molecules. Read More

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Evolution of viscera and muscle fractional protein synthesis rate in lean meat selected hybrids and castrated Duroc pigs fed under moderate crude protein restriction.

Animal 2021 Jun 4;15(6):100220. Epub 2021 Jun 4.

Departament de Ciència Animal, Universitat de Lleida- Agrotecnio-CERCA Centre, Av. Alcalde Rovira Roure 191, 25198 Lleida, Spain.

Differences in producing performance and organoleptic meat characteristics among pig genotypes and/or producing types are widely known. These parameters are also subjected to the animal's development, feeding and management. Detailed knowledge of the effects of production phase (PP), pig producing type (PT), dietary protein availability and their interactions on nutrient digestibility, nitrogen balance and protein metabolism is essential information to improve precision feeding techniques. Read More

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Moderate endurance training reduced hepatic tumourigenesis associated with lower lactate overload compared to high-intensity interval training.

Clin Exp Pharmacol Physiol 2021 Jun 6. Epub 2021 Jun 6.

Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, China.

The anti-tumour effects of exercise are still poorly understood. In recent years, high-intensity interval exercise has been recognised as one of the best choices for better health. However, high-intensity interval exercise induces lactate production in muscles and elevates blood lactic acid levels, and the resulting acidic microenvironment may promote tumour progression. Read More

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The Effect of CQPC02 on Fatigue and Biochemical Oxidation Levels in a Mouse Model of Physical Exhaustion.

Front Nutr 2021 20;8:641544. Epub 2021 May 20.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, China.

Chinese Sichuan pickle is a fermented food rich in microorganisms. Microorganisms have the potential to become an important new form of potent future therapeutic capable of treating human disease. Selecting vitamin C as a positive control, a lactic acid bacteria ( CQPC02, LP-CQPC02) isolated from Sichuan pickle was given to mice over 4 weeks to investigate the effect of CQPC02 on fatigue levels and biochemical oxidation phenomena in exercise-exhausted Institute of Cancer Research (ICR) mice. Read More

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Fat biology and metabolic balance: On the significance of sex.

Mol Cell Endocrinol 2021 Jun 4;533:111336. Epub 2021 Jun 4.

Department of Endocrinology, Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, PR China; Branch of National Clinical Research Center for Metabolic Diseases, Hubei, PR China. Electronic address:

Obesity and its related metabolic disorders have become prevalent and fatal, which are faced by the entire human beings since decades. An energy equilibrium is urgently important for human metabolic health, which requires the participation of multiple organs, such as adipose tissues, liver and skeletal muscles. It seems that both sex and age play a role in the above processes. Read More

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A 3-D virtual human thermoregulatory model to predict whole-body and organ-specific heat-stress responses.

Eur J Appl Physiol 2021 Jun 5. Epub 2021 Jun 5.

Department of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, United States Army Medical Research and Development Command, FCMR-TT, 504 Scott Street, Fort Detrick, MD, 21702-5012, USA.

Objective: This study aimed at assessing the risks associated with human exposure to heat-stress conditions by predicting organ- and tissue-level heat-stress responses under different exertional activities, environmental conditions, and clothing.

Methods: In this study, we developed an anatomically detailed three-dimensional thermoregulatory finite element model of a 50th percentile U.S. Read More

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A rare presentation of hydatid cyst, involvement of uncommon sites with sparing of typical locations.

J Res Med Sci 2021 28;26. Epub 2021 Jan 28.

Clinical Informationist Research Group, Health Information Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Hydatid cyst (HC) is a serious health problem in endemic areas. Liver and lung are the most common involved organs while the involvement of muscles, heart, kidney, brain, and spleen is rare. The involvement of these rare locations for HC is mostly in association with infestation of common sites. Read More

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January 2021

NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA.

Nat Commun 2021 06 2;12(1):3292. Epub 2021 Jun 2.

Department of Biochemistry and Molecular Biology, The University of Tokyo, Tokyo, Japan.

Autophagy regulates primary cilia formation, but the underlying mechanism is not fully understood. In this study, we identify NIMA-related kinase 9 (NEK9) as a GABARAPs-interacting protein and find that NEK9 and its LC3-interacting region (LIR) are required for primary cilia formation. Mutation in the LIR of NEK9 in mice also impairs in vivo cilia formation in the kidneys. Read More

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The Concentration of Selected Heavy Metals in Muscles, Liver and Kidneys of Pigs Fed Standard Diets and Diets Containing 60% of New Rye Varieties.

Animals (Basel) 2021 May 12;11(5). Epub 2021 May 12.

Department of Animal Genetics, Breeding and Ethology, Faculty of Animal Sciences, University of Agriculture in Kraków, 24/28 Mickiewicza Ave., 30-059 Cracow, Poland.

The carry-over of heavy metals from feed to muscles is generally low if animals are fed with a standard diet containing amounts below the maximum permissible levels. However, prolonged exposure to heavy metals can lead to their accumulation in some organs like muscles, liver, and kidneys. This paves the way for human health risks related to the consumption of products of animal-origin. Read More

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Cardiopulmonary values and organ blood flows before and during heat stress: data in nine subjects at rest in the upright position.

Can J Physiol Pharmacol 2021 Jun 1. Epub 2021 Jun 1.

Université de Montréal, 5622, Environmental and Occupational Health, School of Public Health, Montreal, Quebec, Canada.

Physiological changes associated with thermoregulation can influence the kinetics of chemicals in the human body, such as alveolar ventilation (VA) and redistribution of blood flow to organs. In this study, the influence of heat stress on various physiological parameters was evaluated in nine male volunteers during sessions of exposure to wet blub globe temperatures (WBGT) of 21, 25 and 30°C for four hours. Skin and core temperatures and more than twenty cardiopulmonary parameters were measured. Read More

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The role of lactate in sepsis and COVID-19: Perspective from contracting skeletal muscle metabolism.

Exp Physiol 2021 May 31. Epub 2021 May 31.

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

New Findings: What is the topic of this review? Lactate is considered an important substrate for mitochondria in muscles, heart, and brain during exercise, and is the main gluconeogenetic precursor in the liver and kidneys. In this light, we review the (patho)physiology of lactate metabolism in sepsis and coronavirus disease 2019 (COVID-19). What advances does it highlight? Elevated blood lactate is strongly associated with mortality in septic patients. Read More

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Vernonia amygdalina stimulates muscle glucose uptake and modulates redox activities and functional chemistry in oxidative hepatic injury.

J Food Biochem 2021 May 31:e13794. Epub 2021 May 31.

Department of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.

The ethyl acetate, ethanol, and aqueous extracts sequentially obtained from the leaves of Vernonia amygdalina were investigated for their antidiabetic and antioxidant protective effect in oxidative hepatic injury. The extracts showed significant (p < .05) free radical scavenging and reducing power activities. Read More

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Microscopic analysis of plant-mediated silver nanoparticle toxicity in rainbow trout fish (Oncorhynchus mykiss).

Microsc Res Tech 2021 May 28. Epub 2021 May 28.

College of Life Science, Northwest University, Xi'an, Shaanxi, China.

Over the years, nanoscience and the application of nanomaterials have gained the attention of researchers due to their enormous application history. Especially, the application of AgNPs providing innovative solutions to a wide range of environmental issues, for instance, wastewater treatment, bioremediations, and environmental sensing. Besides all these, the environmental application of silver nanomaterials causes severe problems in the terrestrial and aquatic ecosystems. Read More

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Potential health risk assessment of some bioaccumulated metals in Nile tilapia (Oreochromis niloticus) cultured in Kafr El-Shaikh farms, Egypt.

Environ Res 2021 May 25;200:111358. Epub 2021 May 25.

Oceanography Department, Faculty of Science, Alexandria University, Egypt.

In Egypt, using agricultural drainage water is a serious challenge for fish farming, due to water scaristy. Metals could be a potential threat to the quality of the cultured fish. Thus, this study aimed to assess the content of the metals in the cultured fish, their effect on the fish tissues, and the possible human health risk upon their consumption. Read More

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Cyto-histopathological and Protein Polymorphism Alterations in Five Populations of Nile Tilapia (Oreochromis niloticus) as biomonitor for water heavy metal pollution.

J Fish Biol 2021 May 27. Epub 2021 May 27.

Department of Genetics, Faculty of Agriculture, Minia University, Minia, Egypt.

Cytological, histopathological and (SDS-PAGE) analysis were carried out on five populations of common Nile Tilapia fish (Oreochromis niloticus) occurring in five sites: River Nile (reference site), Bahr Yusef canal, Ibrahimia canal, Irrigation drain and El Moheet drain of El-Minia Province, Egypt to evaluate the usability of Nile Tilapia as biomonitor for water heavy metals contaminants. Water surface samples were collected from the five sites and lead (Pb) concentration was shown to surpass the limits defined by WHO (1996). Ni and Cd were shown to be elevated in Ibrahimia canal samples. Read More

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Hepatic Presentation of Late-Onset Multiple Acyl-CoA Dehydrogenase Deficiency (MADD): Case Report and Systematic Review.

Front Pediatr 2021 10;9:672004. Epub 2021 May 10.

Postgraduate School of Pediatrics, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, Italy.

Diagnosis of pediatric steatohepatitis is a challenging issue due to a vast number of established and novel causes. Here, we report a child with Multiple Acyl-CoA Dehydrogenase Deficiency (MADD) presenting with an underrated muscle weakness, exercise intolerance and an atypically severe steatotic liver involvement. A systematic literature review of liver involvement in MADD was performed as well. Read More

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New clinical and pathophysiological perspectives defining the trajectory of cirrhosis.

J Hepatol 2021 Jul;75 Suppl 1:S14-S26

European Foundation for Study of Chronic Liver Failure, EF-Clif, Barcelona, Spain.

Traditionally, the complications of cirrhosis, namely variceal bleeding, ascites and hepatic encephalopathy, were thought to result predominantly from circulatory dysfunction and altered organ perfusion arising as a result of portal hypertension. Over the past 20 years, large, international prospective studies have indicated the importance of systemic inflammation and organ immunopathology as additional determinants of organ dysfunction in cirrhosis, which not only manifests in the liver, brain, circulation and the kidneys, but also the immune system, gut, muscles, adrenal glands, reproductive organs, heart and lungs. This review provides an overview of the traditional and emerging concepts around the initiation and maintenance of organ dysfunction in cirrhosis and proposes a new paradigm based upon a better understanding of acute decompensation of cirrhosis. Read More

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Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes.

Mol Genet Metab 2021 May 8. Epub 2021 May 8.

Division of Genomics Research, Life Science Research Center, Gifu University, Gifu, Japan; Institute for Glyco-core Research (iGCORE), Gifu University, Gifu, Japan; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.

In Zellweger syndrome (ZS), lack of peroxisome function causes physiological and developmental abnormalities in many organs such as the brain, liver, muscles, and kidneys, but little is known about the exact pathogenic mechanism. By disrupting the zebrafish pex2 gene, we established a disease model for ZS and found that it exhibits pathological features and metabolic changes similar to those observed in human patients. By comprehensive analysis of the fatty acid profile, we found organ-specific accumulation and reduction of distinct fatty acid species, such as an accumulation of ultra-very-long-chain polyunsaturated fatty acids (ultra-VLC-PUFAs) in the brains of pex2 mutant fish. Read More

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Metal Bioaccumulation in the Gill, Liver, and Muscle of Bluefish (Pomatomus saltatrix) From the Northeastern Mediterranean and Human Health Risk Assessment Associated with Their Seasonal Consumption.

Arch Environ Contam Toxicol 2021 Jul 20;81(1):58-66. Epub 2021 May 20.

Department of Fisheries Technology, Faculty of Fisheries, University of Cukurova, 01330, Adana, Turkey.

Heavy metals are continuously released into the oceans from both natural and anthropogenic sources. They are serious threats to both ecosystem and human health because of their toxicity, persistence, bioaccumulation, and biomagnification. We present metal concentrations in the economically important bluefish from Iskenderun Bay, providing valuable information on Northeastern Mediterranean aquatic ecosystem health, as well as the human health risk. Read More

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Insulin resistance in metabolic syndrome depending on the occurrence of its components.

Endokrynol Pol 2021 May 19. Epub 2021 May 19.

Department of Endocrinology and Diabetology of Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, ul. M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Poland.

Metabolic syndrome (MetS) is described as a cluster of several commonly occurring disorders including abdominal obesity, hypertension (HT) (≥130/85 mmHg), carbohydrates disorders: impaired fasting glucose or type 2 diabetes mellitus and lipids disorders such as hypertriglyceridemia (TG) and low level of high-density-lipoprotein cholesterol (HDL-C). Insulin resistance (IR) is defined as a glucose homoeostasis disorder involving a decreased sensitivity of muscles, adipose tissue, liver and other body tissues to insulin, despite its normal or increased concentration in blood. The study group included 424 subjects with MetS (260 females, 164 males). Read More

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Temporal and seasonal changes in mercury accumulation in Tatra chamois from West Carpathians.

Environ Sci Pollut Res Int 2021 May 17. Epub 2021 May 17.

State Forests of TANAP, 05960, Tatranská Lomnica, Slovakia.

The main aim of this study was to determine the concentration of total mercury (T-Hg) in different tissues, hair, and faeces from a long-lived animal that actively lives in the subalpine and alpine zone within temperate climate zone throughout the year. Levels of T-Hg in samples from naturally deceased Tatra chamois (n = 72) from the Tatra Mountains (Slovakia) were determined using direct mercury analyses on the basis of dry weight. The mercury concentrations in hair samples were compared over the last three decades. Read More

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Skeletal muscle metastases of hepatocellular carcinoma: A case report and literature review.

World J Clin Cases 2021 May;9(14):3334-3341

Department of Ultrasound, Bethune First Hospital of Jilin University, Changchun 130000, Jilin Province, China.

Background: The metastasis of liver cancer to skeletal muscle is extremely rare compared to other sites. We herein report a case of rapidly developing skeletal metastases following liver transplantation due to primary liver cancer.

Case Summary: A 70-year-old male with underlying chronic hepatitis B virus infection was diagnosed with hepatocellular carcinoma (HCC), for which he underwent liver transplantation in 2014. Read More

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Microfluidic platform accelerates tissue processing into single cells for molecular analysis and primary culture models.

Nat Commun 2021 05 17;12(1):2858. Epub 2021 May 17.

Department of Biomedical Engineering, University of California, Irvine, Irvine, CA, USA.

Tissues are complex mixtures of different cell subtypes, and this diversity is increasingly characterized using high-throughput single cell analysis methods. However, these efforts are hindered, as tissues must first be dissociated into single cell suspensions using methods that are often inefficient, labor-intensive, highly variable, and potentially biased towards certain cell subtypes. Here, we present a microfluidic platform consisting of three tissue processing technologies that combine tissue digestion, disaggregation, and filtration. Read More

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Different Parts of the Chicken Embryo Egg Improve D-Galactose-Induced Aging in a Mice Model.

Biomed Res Int 2021 27;2021:6654683. Epub 2021 Apr 27.

Department of Animal Science, National Chiayi University, Chiayi 600, Taiwan.

Chick (CE) or duck embryo eggs are known for nutritional supplement foods in traditional East countries for physical fitness enhancement and postpartum conditioning for many years. In this study, we evaluated the effects of different parts of the 10-day CE (embryo: CEr, yolk: CEw, and chorioallantoic membrane: CEp) on the antifatigue and antiaging activities in a D-galactose- (D-gal) induced aging mice model. The results showed CEp obviously increased the muscle weight and the liver and muscle glycogen content and enhanced exercise performance. Read More

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Role of Pharmacogenetics in Adverse Drug Reactions: An Update towards Personalized Medicine.

Front Pharmacol 2021 30;12:651720. Epub 2021 Apr 30.

Arrhythmology and Electrophysiology Department, IRCCS Policlinico San Donato, Milan, Italy.

Adverse drug reactions (ADRs) are an important and frequent cause of morbidity and mortality. ADR can be related to a variety of drugs, including anticonvulsants, anaesthetics, antibiotics, antiretroviral, anticancer, and antiarrhythmics, and can involve every organ or apparatus. The causes of ADRs are still poorly understood due to their clinical heterogeneity and complexity. Read More

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The association between myofascial trigger points and the incidence of chronic functional constipation.

J Bodyw Mov Ther 2021 Apr 3;26:201-206. Epub 2020 Dec 3.

Department of Physical Therapy, University of North Georgia, Dahlonega, GA, USA. Electronic address:

Introduction: Chronic functional constipation (CFC) is the most prevalent type of constipation. Considering the proven effect of pelvic floor muscles dysfunction in these patients' symptom and the fascial connection between pelvic floor and abdominal and lumbopelvic muscles, this study aimed to examine the possible relationship between this muscles and CFC.

Method: We conveniently selected 100 patients with CFC and 100 healthy participants based on the Rome IV criteria. Read More

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Genetic potential for residual feed intake and diet fed during early- to mid-gestation influences post-natal DNA methylation of imprinted genes in muscle and liver tissues in beef cattle.

J Anim Sci 2021 May;99(5)

Agriculture and Agri-Food Canada, Edmonton, AB T6G 2C8, Canada.

Discovery of epigenetic modifications associated with feed efficiency or other economically important traits would increase our understanding of the molecular mechanisms underlying these traits. In combination with known genetic markers, this would provide opportunity to improve genomic selection accuracy in cattle breeding programs. It would also allow cattle to be managed to improve favorable gene expression. Read More

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The role of skeletal muscle in the pathogenesis of altered concentrations of branched-chain amino acids (valine, leucine, and isoleucine) in liver cirrhosis, diabetes, and other diseases.

Authors:
M Holeček

Physiol Res 2021 May 12. Epub 2021 May 12.

Milan Holeček, Charles University, Faculty of Medicine in Hradec Králové, Hradec Králové, Czech Republic.

The article shows that skeletal muscle plays a dominant role in the catabolism of branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) and the pathogenesis of their decreased concentrations in liver cirrhosis, increased concentrations in diabetes, and nonspecific alterations in disorders with signs of systemic inflammatory response syndrome (SIRS), such as burn injury and sepsis. The main role of skeletal muscle in BCAA catabolism is due to its mass and high activity of BCAA aminotransferase, which is absent in the liver. Decreased BCAA levels in liver cirrhosis are due to increased use of the BCAA as a donor of amino group to alpha-ketoglutarate for synthesis of glutamate, which in muscles acts as a substrate for ammonia detoxification to glutamine. Read More

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Influence of Dietary Lipids and Environmental Salinity on the n-3 Long-Chain Polyunsaturated Fatty Acids Biosynthesis Capacity of the Marine Teleost .

Mar Drugs 2021 Apr 29;19(5). Epub 2021 Apr 29.

Departamento de Biología Animal, Edafología y Geología, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.

Fish vary in their ability to biosynthesise long-chain polyunsaturated fatty acids (LC-PUFA) depending upon the complement and function of key enzymes commonly known as fatty acyl desaturases and elongases. It has been reported in the existence of a Δ4 desaturase, enabling the biosynthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA), which can be modulated by the diet. The present study aims to evaluate the combined effects of the partial replacement of fish oil (FO) with vegetable oils and reduced environmental salinity in the fatty acid composition of relevant body compartments (muscle, hepatocytes and enterocytes), the enzymatic activity over α-linolenic acid (ALA) to form n-3 LC-PUFA through the incubation of isolated hepatocytes and enterocytes with [1-C] 18:3 n-3, and the regulation of the and in the liver and intestine. Read More

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Serum Creatinine-to-Cystatin C Ratio in the Progression Monitoring of Non-alcoholic Fatty Liver Disease.

Front Physiol 2021 7;12:664100. Epub 2021 Apr 7.

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.

Background: The simultaneous assessment of visceral adiposity and muscle mass might be useful to monitor the risk of non-alcoholic fatty liver disease (NAFLD) progression in large population. We aimed to investigate the value of serum creatinine-to-cystatin C ratio (CCR) in evaluating these two parameters and predicting liver steatosis and fibrosis.

Methods: 154 overweight/obese inpatients (49 males, 105 females) scheduled for bariatric surgery and 49 non-overweight/obese volunteers (18 males, 31 females) responded to the hospital advertisement were involved in the cross-sectional study. Read More

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