74,290 results match your criteria muscle strength

Burosumab treatment for fibrous dysplasia.

Bone 2021 May 10:116004. Epub 2021 May 10.

Metabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Background: Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare mosaic disorder of Gα activation. Fibroblast Growth Factor 23 (FGF23)-mediated hypophosphatemia is a feature of FD/MAS that has been associated with poor skeletal outcomes. Standard therapy includes oral phosphorus and vitamin D analogs; however, treatment is limited by potential adverse renal and gastrointestinal effects. Read More

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Sarcopenia is independently associated with parietal atrophy in older adults.

Exp Gerontol 2021 May 10:111402. Epub 2021 May 10.

Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Division of Neurology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; Department of Pharmacy, Tajen University, Pingtung, Taiwan. Electronic address:

Introduction: As populations age, sarcopenia becomes a major health problem among adults aged 65 years and older. However, little information is available about the relationship between sarcopenia and brain structure abnormalities. The objective of this study was to investigate associations between sarcopenia and brain atrophy in older adults and relationships with regional brain areas. Read More

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Effects of resistance training at different intensities of load on cross-education of muscle strength.

Appl Physiol Nutr Metab 2021 May 13. Epub 2021 May 13.

Federal University of Triangulo Mineiro , Department of Sport Sciences, Uberaba, Brazil;

The objectives of this study were 1) to compare the extent of cross-transfer of high- versus low-load unilateral resistance training performed with external pacing of the movement (URTEP) and 2) to compare the time course of the two approaches. Fifty subjects were randomized to one of the following three groups: G80 [two sets at 80% and two sets at 40% of one maximum repetition (1RM), 1 concentric second and 3 eccentric seconds controlled by a metronome]; G40 (four sets at 40% of 1 RM, 1s and 3s controlled by a metronome); or CG (control group). At week 1, the G80 increased the elbow flexion 1RM (P<0. Read More

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The efficacy of Schroth exercises combined with the Chêneau brace for the treatment of adolescent idiopathic scoliosis: a retrospective controlled study.

Disabil Rehabil 2021 May 13:1-9. Epub 2021 May 13.

Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Purpose: We aimed to determine the global effects of the Chêneau brace combined with Schroth exercises on adolescent idiopathic scoliosis (AIS).

Methods: We analyzed 192 patients with AIS who underwent the Chêneau brace treatment alone or combined with Schroth best practice (SBP) from June 2013 to October 2019. There were 138 patients in the Brace group and 54 patients in the Brace + SBP group. Read More

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Improving the diagnostic recognition of thoracic endometriosis: Spotlight on a new histo-morphological indicator.

PLoS One 2021 13;16(5):e0251385. Epub 2021 May 13.

Department of Anatomic Pathology and Forensic Medicine, College of Health Sciences, Nile University of Nigeria, Abuja, Nigeria.

The diagnosis of thoracic endometriosis (TE) is challenging, hence resulting in under-diagnosis as well as long delays before arriving at a correct definitive diagnosis. Our aim is to review the histopathological findings in TE, summarise the diagnostic features, identify any major histo-morphological indicator(s) hitherto unrecognised as such, suggest diagnostic criteria; all with the aim of improving the diagnostic capacity and reducing observer error even where the clinical suspicion is low. A case-control study in which a search in the pathology archives of a referral hospital over a 10-year period was conducted. Read More

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Exercise Only Works If You Do It! The Holy Grail of Adherence.

Am J Gastroenterol 2021 Apr;116(4):673-674

1Division of Gastroenterology (Liver Unit), University of Alberta, Edmonton, Canada; 2Department of Physical Therapy, University of Alberta, Edmonton, Canada.

Exercise interventions in patients with cirrhosis have been shown to improve muscle mass and strength, aerobic capacity, fatigue, and quality of life. There are gaps, however, including limited data on patients with decompensated cirrhosis and home-based routines. This editorial comments on the randomized controlled trial by Lai et al. Read More

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Frequency and type of adverse analytical findings in athletics: differences among disciplines.

Drug Test Anal 2021 May 13. Epub 2021 May 13.

Rey Juan Carlos University. Centre for Sport Studies, Madrid, Spain.

Athletics is a highly diverse sport that contains a set of disciplines grouped into jumps, throws, races of varying distances, and combined events. From a physiological standpoint, the physical capabilities linked to success are quite different among disciplines, with varying involvements of muscle strength, muscle power, and endurance. Thus, the use of banned substances in athletics might be dictated by physical dimensions of each discipline. Read More

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Contralateral training effects of low-intensity blood-flow restricted and high-intensity unilateral resistance training.

Eur J Appl Physiol 2021 May 12. Epub 2021 May 12.

Neuromuscular Research Lab, Faculdade de Motricidade Humana, Universidade de Lisboa, Estrada da Costa, Cruz Quebrada, Dafundo, 1499-002, Lisbon, Portugal.

Purpose: Determine whether unilateral low-intensity blood-flow restricted (LIBFR) exercise is as effective as high-intensity (HI) resistance training for improving contralateral muscle strength.

Methods: Thirty healthy adults (20-30 years) were randomly allocated to the following dynamic plantar-flexion training interventions: HI [75% of one-repetition maximum (1RM), 4 sets, 10 reps] and LIBFR [20% of 1RM, 4 sets, 30 + 15 + 15 + 15 reps]. Evoked V-wave and H-reflex recruitment curves, as well as maximal voluntary contraction (MVC) and panoramic ultrasound assessments of the trained and untrained soleus muscles were obtained pre-training, post-4 weeks of training and post-4 weeks of detraining. Read More

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Estimation of minimal clinically important difference for quadriceps and inspiratory muscle strength in older outpatients with chronic obstructive pulmonary disease: a prospective cohort study.

Phys Ther Res 2021 12;24(1):35-42. Epub 2020 Oct 12.

Department of Physical Therapy, Akita University Graduate School of Health Sciences, Japan.

Objective: To estimate the minimal clinically important difference (MCID) of quadriceps and inspiratory muscle strength after a home-based pulmonary rehabilitation program (PRP) in chronic obstructive pulmonary disease (COPD).

Method: Eighty-five COPD patients were included. Quadriceps maximal voluntary contraction (QMVC) was measured. Read More

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October 2020

Effects of Physical Agents on Muscle Healing with a Focus on Animal Model Research.

Miki Sakamoto

Phys Ther Res 2021 24;24(1):1-8. Epub 2021 Feb 24.

Department of Physical Therapy, School of Allied Health Sciences, Kitasato University, Japan.

Skeletal muscle injury is caused by a variety of events, such as muscle laceration, contusions, or strain. Muscle fibers respond to minor damage with immediate repair mechanisms that reseal the cell membrane. On the other hand, repair of irreversibly damaged fibers is achieved by activation of muscle precursor cells. Read More

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February 2021

Exercise training in chronic kidney disease-effects, expectations and adherence.

Clin Kidney J 2021 Apr 6;14(Suppl 2):ii3-ii14. Epub 2021 May 6.

KfH Kidney Center, Bischofswerda, Germany.

There is increasing evidence showing the health benefits of physical activity, such as better survival and possibly even a slower decline in kidney function, in people with chronic kidney disease (CKD). There is convincing evidence that exercise training improves physical function measured as aerobic capacity, muscle endurance strength and balance at all ages and all stages of CKD. In fact, long-term adherence to well-designed and adequately monitored exercise training programmes is high. Read More

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Oxidative Stress, Inflammation, and Activators of Mitochondrial Biogenesis: Tempol Targets in the Diaphragm Muscle of Exercise Trained- Mice.

Front Physiol 2021 26;12:649793. Epub 2021 Apr 26.

Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, Brazil.

The mouse phenotype aggravated by chronic exercise on a treadmill makes this murine model more reliable for the study of muscular dystrophy. Thus, to better assess the Tempol effect on dystrophic pathways, the analyses in this study were performed in the blood samples and diaphragm muscle from treadmill trained adult (7-11-weeks old) animals. The m mice were divided into three groups: , sedentary controls ( = 28); Ex, exercise-trained animals ( = 28); and Ex+T, exercise-trained animals with the Tempol treatment ( = 28). Read More

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Short-Term Immobilization Promotes a Rapid Loss of Motor Evoked Potentials and Strength That Is Not Rescued by rTMS Treatment.

Front Hum Neurosci 2021 26;15:640642. Epub 2021 Apr 26.

Department of Psychology, Faculty of Science & Technology, Lancaster University, Lancaster, United Kingdom.

Short-term limb immobilization results in skeletal muscle decline, but the underlying mechanisms are incompletely understood. This study aimed to determine the neurophysiologic basis of immobilization-induced skeletal muscle decline, and whether repetitive Transcranial Magnetic Stimulation (rTMS) could prevent any decline. Twenty-four healthy young males (20 ± 0. Read More

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[Function-based tests to determine the return-to-activity state in patients with non-specific low back pain].

Sportverletz Sportschaden 2021 May 12. Epub 2021 May 12.

Hochschule Furtwangen, Germany.

Background:  Most people with back pain suffer from non-specific low back pain, for which no specific reasons can be found. Two out of three have recurrent pain episodes. To reduce the likelihood of recurrence and long-lasting pain, functional tests are increasingly used to determine the current functional status. Read More

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The influence of the trunk muscle activation on occlusion pressure and respiratory muscle strength in healthy participants: randomized controlled trial.

Respir Physiol Neurobiol 2021 May 9:103682. Epub 2021 May 9.

Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland. Electronic address:

Objectives: The purpose of the study was to check if the trunk muscle activation done in accordance with rules of the Bobath concept affects the occlusion pressure and respiratory muscle efficacy in forced breathing manoeuvres in healthy participants.

Design: Randomized controlled trial. Between-subjects design. Read More

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High-Quality Supplemental Protein Enhances Acute Muscle Protein Synthesis and Long-Term Strength Adaptations to Resistance Training in Young and Old Adults.

J Nutr 2021 May 12. Epub 2021 May 12.

Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA.

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The Associations of Handgrip Strength and Leg Extension Power Asymmetry on Incident Recurrent Falls and Fractures in Older Men.

J Gerontol A Biol Sci Med Sci 2021 May 12. Epub 2021 May 12.

California Pacific Medical Center Research Institute, San Francisco Coordinating Center, San Francisco, CA, USA.

Background: Evaluating asymmetries in muscle function could provide important insights for fall risk assessments. We sought to determine the associations of 1) handgrip strength (HGS) asymmetry, and 2) leg extension power (LEP) asymmetry on risk of incident recurrent falls and fractures in older men.

Methods: There were 5,730 men with HGS asymmetry data and 5,347 men with LEP asymmetry data from the Osteoporotic Fractures in Men (MrOS) study. Read More

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Can physical activity levels and relationships with energy expenditure change the clinical aspects of sarcopenia and perceptions of falls among elderly women? Observational cross-sectional study.

Sao Paulo Med J 2021 May 10. Epub 2021 May 10.

MD, PhD. Professor and Coordinator of the Biomechanics and Musculoskeletal Rehabilitation Laboratory, Postgraduate Health Science Department, Medical School, Universidade Santo Amaro (UNISA), São Paulo (SP), Brazil; and Postdoctoral Student, Medical School, Universidade de São Paulo (USP), São Paulo (SP), Brazil.

Background: Physical activity (PA) is an effective strategy for managing sarcopenia in the elderly, but few studies have addressed PA levels regarding age-related changes.

Objective: To ascertain the effects of elderly women's PA levels on sarcopenia, physical performance, handgrip strength and perception of the risk of falling, and their relationship with energy expenditure.

Design And Setting: Observational cross-sectional study conducted in the southern region of the city of São Paulo, Brazil. Read More

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Moderators of strength gains and hypertrophy in resistance training: A systematic review and meta-analysis.

J Sports Sci 2021 May 12:1-10. Epub 2021 May 12.

Laboratory of Physical Activity and Health Promotion, University of Rio de Janeiro State, Rio de Janeiro, Brazil.

This meta-analysis investigated the role of resistance training (RT) moderators on strength and muscle mass gains in untrained young (YG) and older (OG) adults. Electronic databases were searched for randomised controlled trials simultaneously assessing muscle strength and mass. Effect sizes (ES) reflecting improvements in strength and muscle mass were found for all moderators in YG and OG (ES 0. Read More

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Partial range of motion training elicits favorable improvements in muscular adaptations when carried out at long muscle lengths.

Eur J Sport Sci 2021 May 12:1-24. Epub 2021 May 12.

Weight Training Laboratory, School of Physical Education, Physiotherapy and Occupational Therapy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

The study compared changes in strength and regional muscle hypertrophy between different ranges of motion (ROM) in the knee extension exercise. Forty-five untrained women were randomized to either a control group or to perform the exercise in one of the following 4 groups (0°=extended knee): Full ROM (FULL: 100°-30° of knee flexion); Initial Partial ROM (INITIAL: 100°-65°); Final Partial ROM (FINAL: 65°-30°); Varied ROM (VAR: daily alternation between the ROM of INITIAL and FINAL). Pre- and post-training assessments included one repetition maximum (1RM) testing in the ROM corresponding to the initial, final and full ROM, and measurement of cross-sectional areas of the rectus femoris and vastus lateralis muscles at 40%, 50%, 60% and 70% of femur length in regard to regional muscle hypertrophy. Read More

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Protocol for a randomised controlled trial of a primary care intervention to Reverse Frailty and Enhance Resilience through Exercise and dietary protein Education (REFEREE) in community-dwelling adults aged 65 and over.

HRB Open Res 2020 21;3:91. Epub 2021 Apr 21.

School of Medicine, University College Dublin, Dublin, Ireland.

Resistance exercises and dietary protein have been shown to reverse frailty, yet they are not commonly offered in clinical practice. We aim to measure changes in health outcomes, including physical frailty status (SHARE-FI), clinical frailty status (CFS) and muscle mass, as a result of an optimised exercise and dietary intervention versus usual care in a primary care (PC) setting. The intervention has been derived from our systematic review and meta-analysis findings and optimised through patient and public involvement and multidisciplinary team input. Read More

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Higher Hand Grip Strength Is Associated With Greater Radius Bone Size and Strength in Older Men and Women: The Framingham Osteoporosis Study.

JBMR Plus 2021 May 30;5(5):e10485. Epub 2021 Mar 30.

Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife Boston Massachusetts USA.

Mechanical loading by muscles elicits anabolic responses from bone, thus age-related declines in muscle strength may contribute to bone fragility in older adults. We used high-resolution peripheral quantitative computed tomography (HR-pQCT) to determine the association between grip strength and distal radius bone density, size, morphology, and microarchitecture, as well as bone strength estimated by micro-finite element analysis (μFEA), among older men and women. Participants included 508 men and 651 women participating in the Framingham Offspring Study with grip strength measured in 2011-2014 and HR-pQCT scanning in 2012-2015. Read More

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Effects of different resistance training frequencies on body composition and muscular performance adaptations in men.

PeerJ 2021 21;9:e10537. Epub 2021 Apr 21.

M2S (Laboratoire Mouvement, Sport, Santé) - EA 1274, Univ Rennes, Rennes, France.

Background: The aim of this study was to compare the effects of 8 weeks resistance training (RT) with two sessions versus four sessions per week under volume load-equated conditions on body composition, maximal strength, and explosive actions performance in recreationally trained men.

Methods: Thirty-five healthy young men participated in the study and were randomly divided into a two sessions per-week RT (RT2, = 12), four sessions per-week RT (RT4, = 13) or a control group (CG, = 10). All subjects were evaluated for thigh, chest and arm circumference, countermovement jump (CMJ), medicine ball throw (MBT), 1-repetition maximum (1RM) leg press, bench press, arm curl, muscular endurance (i. Read More

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High-intensity interval training can improve hand grip strength, inspiratory muscle, and quality of life in systemic sclerosis subjects.

Reumatologia 2021 27;59(2):98-103. Epub 2021 Apr 27.

Faculty of Medicine, Maranatha Christian University, Bandung, Indonesia.

Introduction: Systemic sclerosis/scleroderma (SSc) is a chronic autoimmune disease with connective tissue, multi-organ, and multisystem involvement. The disease has three main characteristics, namely vasculopathy, fibrosis, and autoimmunity. The effect of high-intensity interval training (HIIT) in aerobic exercise on other rheumatic diseases has been studied, for example in patients with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA). Read More

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Comparing Outcomes of Flap-Based Salvage Reconstructions in the Radiated Breast.

Ann Plast Surg 2021 May;86(5S Suppl 3):S403-S408

Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University Medical Center, Stanford, CA.

Introduction: Chest wall irradiation significantly decreases the strength and quality of breast tissue supporting prostheses, increasing the risk of skin breakdown and implant or tissue expander extrusion. Autologous tissue, including the latissimus dorsi (LD) or abdominal-based flaps, including the muscle-sparing transverse rectus abdominis myocutaneous or deep inferior epigastric perforator flaps, may be used to salvage reconstructions. However, data comparing outcomes of the two flap options remains limited. Read More

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Evolution of mechanical cooperativity among myosin II motors.

Proc Natl Acad Sci U S A 2021 May;118(20)

Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY 11794;

Myosin II is a biomolecular machine that is responsible for muscle contraction. Myosin II motors act cooperatively: during muscle contraction, multiple motors bind to a single actin filament and pull it against an external load, like people pulling on a rope in a tug-of-war. We model the dynamics of actomyosin filaments in order to study the evolution of motor-motor cooperativity. Read More

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Impact of Protein Intake during Weight Loss on Preservation of Fat-Free Mass, Resting Energy Expenditure, and Physical Function in Overweight Postmenopausal Women: A Randomized Controlled Trial.

Obes Facts 2021 May 11:1-12. Epub 2021 May 11.

Fulda University of Applied Sciences, Fulda, Germany.

Introduction: Weight loss in old age increases the risk of sarcopenia caused by the age-related reduction of fat-free mass (FFM). Due to the strong correlation between FFM and resting energy expenditure (REE), the maintenance of this must also be considered. Besides, the physical function (PF) must be maintained. Read More

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Voluntary and magnetically evoked muscle contraction protocol in males with Duchenne muscular dystrophy: safety, feasibility, reliability, and validity.

Muscle Nerve 2021 May 11. Epub 2021 May 11.

Division of Rehabilitation Science, Department of Rehabilitation Medicine, Medical School-University of Minnesota, Minneapolis, MN.

Introduction: Clinical trials addressing treatments for Duchenne muscular dystrophy (DMD) require reliable and valid measurement of muscle contractile function across all disease severity levels. This work aimed to evaluate a protocol combining voluntary and evoked contractions to measure strength and excitability of wrist extensor muscles, for safety, feasibility, reliability, and discriminant validity between males with DMD and controls.

Methods: Wrist extensor muscle strength and excitability were assessed in males with DMD (N=10; mean 15. Read More

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Clinically Important Reductions in Physical Function and Quality of Life in Adults with Tumor Prostheses in the Hip and Knee: A Cross-sectional Study.

Clin Orthop Relat Res 2021 05 10. Epub 2021 May 10.

C. E. Holm, A. Villadsen, M. S. Sørensen, M. M. Petersen, Musculoskeletal Tumor Section, Department of Orthopedic Surgery, University Hospital Rigshospitalet, Copenhagen, Denmark.

Background: Patients with a bone sarcoma who undergo limb-sparing surgery and reconstruction with a tumor prosthesis in the lower extremity have been shown to have reduced self-reported physical function and quality of life (QoL). To provide patients facing these operations with better expectations of future physical function and to better evaluate and improve upon postoperative interventions, data from objectively measured physical function have been suggested.

Questions/purposes: We sought to explore different aspects of physical function, using the International Classification of Functioning, Disability, and Health (ICF) as a framework, by asking: (1) What are the differences between patients 2 to 12 years after a bone resection and reconstruction surgery of the hip and knee following resection of a bone sarcoma or giant cell tumor of bone and age-matched controls without walking limitations in ICF body functions (ROM, muscle strength, pain), ICF activity and participation (walking, getting up from a chair, daily tasks), and QoL? (2) Within the patient group, do ICF body functions and ICF activity and participation outcome scores correlate with QoL?

Methods: Between 2006 and 2016, we treated 72 patients for bone sarcoma or giant cell tumor of bone resulting in bone resection and reconstruction with a tumor prosthesis of the hip or knee. Read More

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CYK-1/Formin activation in cortical RhoA signaling centers promotes organismal left-right symmetry breaking.

Proc Natl Acad Sci U S A 2021 May;118(20)

Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany;

Proper left-right symmetry breaking is essential for animal development, and in many cases, this process is actomyosin-dependent. In embryos active torque generation in the actomyosin layer promotes left-right symmetry breaking by driving chiral counterrotating cortical flows. While both Formins and Myosins have been implicated in left-right symmetry breaking and both can rotate actin filaments in vitro, it remains unclear whether active torques in the actomyosin cortex are generated by Formins, Myosins, or both. Read More

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