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Dental and maxillofacial manifestations of Steinert's myotonic dystrophy: a retrospective case series and therapeutic investigation.

J Stomatol Oral Maxillofac Surg 2022 Jun 22. Epub 2022 Jun 22.

Department and Maxillo-Facial Surgery, CHU Salengro, Rue Emile Laisne, 59037 Lille, France.

This retrospective study was performed to analyse the facial features and occlusal anomalies in 18 patients with Steinert's myotonic dystrophy (MD1). Medical and surgical management issues noted in this study may contribute to clinical decision-making. This series included 18 patients with MD1 who presented for maxillofacial consultations. Read More

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Combined effect of lower muscle quality and quantity on incident falls and fall-related fractures in community-dwelling older adults: A 3-year follow-up study.

Bone 2022 Jun 22:116474. Epub 2022 Jun 22.

National Center for Geriatrics and Gerontology, 7-430, Morioka-cho, Obu, Aichi 474-8511, Japan. Electronic address:

Objective: Falls and fractures are serious geriatric adverse events worldwide, and skeletal muscle is considered to be a key factor in these incidents. The objective of this study was to investigate the combined effect of lower muscle quality and quantity on the incidence of falls and fall-related fractures in a 3-year follow-up period among community-dwelling older adults.

Methods: We recruited community-dwelling adults aged 65 years and older who were living independently in 2018. Read More

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Soluble epoxide hydrolase inhibitor, TPPU, attenuates progression of atherosclerotic lesions and vascular smooth muscle cell phenotypic switching.

Vascul Pharmacol 2022 Jun 22:107086. Epub 2022 Jun 22.

Research Group of Natural Materials and Metabolism, Food Functionality Research, Korea Food Research Institute, Jeollabuk-Do, Republic of Korea. Electronic address:

Atherosclerosis manifests as a chronic inflammation resulting from multiple interactions between circulating factors and various cell types in blood vessel walls. Growing evidence shows that phenotypic switching and proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the progression of atherosclerosis. Soluble epoxide hydrolase (sEH)/epoxyeicosatrienoic acids are mediated by vascular inflammation. Read More

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Functional in vitro characterization of SLCO1B1 variants and simulation of the clinical pharmacokinetic impact of impaired OATP1B1 function.

Eur J Pharm Sci 2022 Jun 22:106246. Epub 2022 Jun 22.

Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, 00014, Helsinki, Finland. Electronic address:

Organic Anion Transporting Polypeptide 1B1 is important to the hepatic elimination and distribution of many drugs. If OATP1B1 function is decreased, it can increase plasma exposure of e.g. Read More

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Effects of Elephantopus scaber extract on growth, proximate composition, immunity, intestinal microbiota and resistance of the GIFT strain of Nile tilapia Oreochromis niloticus to Streptococcus agalactiae.

Fish Shellfish Immunol 2022 Jun 22. Epub 2022 Jun 22.

Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Hainan Institute of Tropical Agricultural Resources, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China. Electronic address:

This study aimed to investigate the effects of Elephantopus scaber extract on the GIFT (genetic improvement of farmed tilapia) strain of Nile tilapia Oreochromis niloticus. A total of 800 tilapia with an initial body weight of 1.34 ± 0. Read More

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Comparative Analysis of Fat Composition in Marrow, Serum, and Muscle from Aging C57BL6 mice.

Mech Ageing Dev 2022 Jun 22:111690. Epub 2022 Jun 22.

Australian Institute for Musculoskeletal Science (AIMSS), Geroscience & Osteosarcopenia Research Program, The University of Melbourne and Western Health, St. Albans, VIC, Australia; Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St. Albans, VIC, Australia. Electronic address:

Osteosarcopenia is an age-related condition characterized by fragile bone and low muscle mass and function. Fat infiltration concomitantly contributes to age-related bone and muscle decline. Fat-secreted factors could be locally secreted in the muscle and bone marrow milieu affecting cell function and survival. Read More

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Genotypic and phenotypic spectrum of Myofibrillar Myopathy 7 as a result of Kyphoscoliosis Peptidase deficiency: The first description of a missense mutation in KY and literature review.

Eur J Med Genet 2022 Jun 22:104552. Epub 2022 Jun 22.

Department of Medical Genetics, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

KY is located on chromosome 3 and encodes a transglutaminase-like protein in the skeletal muscles, namely Kyphoscoliosis Peptidase. KY is primarily involved in the formation and stabilization of neuromuscular intersections making it essential for the development of the musculoskeletal system. Mutations in KY cause Myofibrillar Myopathy-7 (MFM-7) and Hereditary Spastic Paraplegia (HSP). Read More

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Downregulation of eNOS and preserved endothelial function in endothelial-specific arginase 1-deficient mice.

Nitric Oxide 2022 Jun 22. Epub 2022 Jun 22.

Myocardial Infarction Research Laboratory, Department of Cardiology, Pulmonology, and Angiology, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Arginase 1 (Arg1) is a ubiquitous enzyme belonging to the urea cycle that catalyzes the conversion of l-arginine into l-ornithine and urea. In endothelial cells (ECs), Arg1 was proposed to limit the availability of l-arginine for the endothelial nitric oxide synthase (eNOS) and thereby reduce nitric oxide (NO) production, thus promoting endothelial dysfunction and vascular disease. The role of EC Arg1 under homeostatic conditions is in vivo less understood. Read More

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The in vitro and in vivo antibacterial activities of uniflorous honey from a medical plant, Scrophularia ningpoensis Hemsl., and characterization of its chemical profile with UPLC-MS/MS.

J Ethnopharmacol 2022 Jun 22:115499. Epub 2022 Jun 22.

College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, 350002, China; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address:

Ethnopharmacological Relevance: According to the Compendium of Materia Medica, honey has been used as a traditional medicine in treatment against mucositis, tinea, hemorrhoids and psoriasis. In complementary medicine, due to its significant antimicrobial activity, honey has been widely used as a remedy for skin wounds and gastrohelcosis for thousands of years.

Aim Of The Study: This study is aimed at exploring the antimicrobial activity and mechanisms of honey sourced from medical plants, and revealing the composition-activity relationship, to facilitate their complementary and alternative application in the therapy of bacterial infectious diseases. Read More

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The road to physiological maturation of stem cell-derived cardiac muscle runs through the sarcomere.

Authors:
Joseph M Metzger

J Mol Cell Cardiol 2022 Jun 22. Epub 2022 Jun 22.

Department of Integrative Biology and Physiology, University of Minnesota Medical School, 6-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA. Electronic address:

Recent advances the cardiac biomedical sciences have been propelled forward by the development and implementation of human iPSC-derived cardiac muscle. These notable successes notwithstanding, it is well recognized in the field that a major roadblock persists in the lack of full "adult cardiac muscle-like" maturation of hiPSC-CMs. This Perspective centers focus on maturation roadblocks in the essential physiological unit of muscle, the sarcomere. Read More

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Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1.

Mol Cell 2022 Jun 16. Epub 2022 Jun 16.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

Protein import into mitochondria is a highly regulated process, yet how cells clear mitochondria undergoing dysfunctional protein import remains poorly characterized. Here we showed that mitochondrial protein import stress (MPIS) triggers localized LC3 lipidation. This arm of the mitophagy pathway occurs through the Nod-like receptor (NLR) protein NLRX1 while, surprisingly, without the engagement of the canonical mitophagy protein PINK1. Read More

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Polycyclic aromatic hydrocarbons (PAHs) and antibiotics in oil-contaminated aquaculture areas: Bioaccumulation, influencing factors, and human health risks.

J Hazard Mater 2022 Jun 13;437:129365. Epub 2022 Jun 13.

Shandong Key Laboratory of Environmental Processes and Health, School of Environmental Science and Engineering, Shandong University, Qingdao 266237, China. Electronic address:

Polycyclic aromatic hydrocarbon (PAH) pollution caused by marine oil spills and antibiotic pollution caused by aquaculture industries were common environmental problems in the Yellow River Estuary, China. But few data are reported on the bioaccumulation and influencing factors of these two types of contaminants in aquaculture simultaneously. This study investigated the occurrence and bioaccumulation of PAHs and antibiotics in aquaculture areas of the Yellow River Estuary, and explored the factors affecting the bioaccumulation. Read More

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Acute patellar tendon rupture with tibial tubercle avulsion repair using suture anchors: Tiny avulsed fragment which affects the strength of construction-a case report.

Int J Surg Case Rep 2022 Jun 10;96:107283. Epub 2022 Jun 10.

Department of Orthopaedics and Traumatology, dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.

Introduction And Importance: Patellar tendon is one of the most important components of the knee extensor mechanism, which consisted of quadriceps femoris muscle, quadriceps tendon, patellar bone and patellar tendon. The total disruption of patellar tendon will lead to disability and significant morbidity of the patient, or even worse, the patient is disabled to walk. The incidence of patellar tendon rupture is uncommon and most commonly found in the third to fourth decade of life. Read More

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Liraglutide Attenuates Restenosis After Vascular Injury in Rabbits With Diabetes Via the TGF-β/Smad3 Signaling Pathway.

Altern Ther Health Med 2022 Jun 24. Epub 2022 Jun 24.

Background: Lower limb ischemia due to arterial stenosis is a major complication in patients with diabetes mellitus (DM). Liraglutide is a long-acting analogue of a glucagon-like peptide 1 (GLP-1) receptor agonist used for lowering blood glucose in patients with DM, and is believed to possess cardiovascular protective effects. The aim of this study was to investigate whether liraglutide has a protective effect on blood vessels and alleviates vascular intimal hyperplasia in streptozotocin (STZ)-induced rabbits with DM and its molecular mechanism. Read More

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Exosomes from human adipose-derived mesenchymal stromal/stem cells accelerate angiogenesis in wound healing: implication of the EGR-1/lncRNA-SENCR/DKC1/VEGF-A axis.

Hum Cell 2022 Jun 25. Epub 2022 Jun 25.

Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital, Central South University, No. 139, Mid Renmin Road, Furong District, Changsha, Hunan, 410011, People's Republic of China.

Exosomes (Exos) extracted from human adipose mesenchymal stromal/stem cells (hAD-MSCs) have been reported as therapeutic tools for tissue repair, but how they regulate angiogenesis of endothelial cells remains unknown. In this study, hAD-MSCs were isolated, and early growth response factor-1, Smooth muscle and endothelial cell enriched migration/differentiation-associated long-noncoding RNA (lncRNA-SENCR), and vascular endothelial growth factor-A (VEGF-A) overexpression or knockdown was achieved. Exos extracted from hAD-MSCs (hADSC-Exos) were co-cultured with human umbilical vein endothelial cells (HUVECs) to detect the effects of EGR-1, lncRNA-SENCR, and VEGF-A on angiogenesis and the relationships between EGR-1, lncRNA-SENCR, Dyskerin pseudouridine synthase 1 (DKC1), and VEGF-A. Read More

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Subacute groin complications related to ECMO cannulation are associated with longer hospitalizations.

J Artif Organs 2022 Jun 25. Epub 2022 Jun 25.

Division of Cardiovascular Surgery, Department of Surgery, The Hospital of the University of Pennsylvania, 3400 Spruce Street, 6 Silverstein, Philadelphia, PA, 19104, USA.

Subacute groin complications associated with extracorporeal membrane oxygenation (ECMO) cannulation are well recognized, yet their effects on clinical outcomes remain unknown. This single-center, retrospective study reviewed all patients receiving venoarterial ECMO from 01/2017 to 02/2020. Cohorts analyzed included transplanted patients (TPs) and non-transplanted patients (N-TPs) who did or did not develop ECMO-related subacute groin complications. Read More

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MRI evaluation of soft tissue tumors: comparison of a fast, isotropic, 3D T2-weighted fat-saturated sequence with a conventional 2D T2-weighted fat-saturated sequence for tumor characteristics, resolution, and acquisition time.

Eur Radiol 2022 Jun 25. Epub 2022 Jun 25.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital/The Johns Hopkins Medical Institutions, 600 North Wolfe Street, Baltimore, MD, 21287, USA.

Objectives: To test whether a 4-fold accelerated 3D T2-weighted (T2) CAIPIRINHA SPACE TSE sequence with isotropic voxel size is equivalent to conventional 2DT2 TSE for the evaluation of intrinsic and perilesional soft tissue tumors (STT) characteristics.

Methods: For 108 patients with histologically-proven STTs, MRI, including 3DT2 (CAIPIRINHA SPACE TSE) and 2DT2 (TSE) sequences, was performed. Two radiologists evaluated each sequence for quality (diagnostic, non-diagnostic), tumor characteristics (heterogeneity, signal intensity, margin), and the presence or absence of cortical involvement, marrow edema, and perilesional edema (PLE); tumor size and PLE extent were measured. Read More

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Deep learning-based acceleration of Compressed Sense MR imaging of the ankle.

Eur Radiol 2022 Jun 25. Epub 2022 Jun 25.

Department of Radiology, Klinikum Rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, Munich, Germany.

Objectives: To evaluate a compressed sensing artificial intelligence framework (CSAI) to accelerate MRI acquisition of the ankle.

Methods: Thirty patients were scanned at 3T. Axial T2-w, coronal T1-w, and coronal/sagittal intermediate-w scans with fat saturation were acquired using compressed sensing only (12:44 min, CS), CSAI with an acceleration factor of 4. Read More

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Pelvic floor symptoms in cisgender women with Ehlers-Danlos syndrome: an international survey study.

Int Urogynecol J 2022 Jun 25. Epub 2022 Jun 25.

Division of Female Pelvic Medicine and Reconstructive Pelvic Surgery, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Introduction And Hypothesis: Ehlers-Danlos Syndrome (EDS) is a group of inherited connective tissue disorders associated with abnormal collagen, and is more prevalent in women than in men. The aim of this cross-sectional study was to characterize pelvic floor symptoms in cisgender women with EDS and to describe their impact on quality of life.

Methods: An online questionnaire on obstetric and gynecological experiences of cisgender women with EDS was disseminated through EDS patient societies and social media. Read More

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Resistance exercise training and the motor unit.

Authors:
Trent J Herda

Eur J Appl Physiol 2022 Jun 25. Epub 2022 Jun 25.

Neuromechanics Laboratory, Department of Health, Sport and Exercise Sciences, University of Kansas, 1301 Sunnyside Avenue, Room 101BE, Lawrence, KS, 66045, USA.

Resistance exercise training (RET) is a key modality to enhance sports performance, injury prevention and rehabilitation, and improving overall health via increases in muscular strength. Yet, the contribution of neural mechanisms to increases in muscular strength are highly debated. This is particularly true for the involvement of the motor unit, which is the link between neural (activation) and mechanical (muscle fiber twitch forces) mechanisms. Read More

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Beneficial effects of denosumab on muscle performance in patients with low BMD: a retrospective, propensity score-matched study.

Osteoporos Int 2022 Jun 25. Epub 2022 Jun 25.

Department of Trauma and Orthopaedic Surgery, Division of Orthopaedics, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

This study examined the effects of denosumab compared to bisphosphonates and vitamin D alone on muscle performance in patients with low BMD. While grip force improved in both the denosumab and bisphosphonate group, a superior increase in chair rising test force was observed in the denosumab group.

Introduction: The aim of this study was to investigate the effect of the anti-resorptive agent denosumab (Dmab) on upper and lower limb muscle performance compared to bisphosphonate (BP) treatment and vitamin D supplementation alone (i. Read More

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Development of ribs and intercostal muscles in the chicken embryo.

J Anat 2022 Jun 25. Epub 2022 Jun 25.

Faculty of Medicine and University Hospital Cologne, Center of Anatomy, University of Cologne, Cologne, Germany.

In the thorax of higher vertebrates, ribs and intercostal muscles play a decisive role in stability and respiratory movements of the body wall. They are derivatives of the somites, the ribs originating in the sclerotome and the intercostal muscles originating in the myotome. During thorax development, ribs and intercostal muscles extend into the lateral plate mesoderm and eventually contact the sternum during ventral closure. Read More

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Exercise-induced metabolites and fatigue: can an inorganic phosphate breakpoint predict the rapid onset of peripheral fatigue?

Authors:
Nick Dobson

J Physiol 2022 Jun 25. Epub 2022 Jun 25.

Department of Health and Exercise Science, University of Oklahoma, 8409 NW 107th St, Oklahoma City, Oklahoma, 73162, United States.

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Prognostic values of muscle mass assessed by dual-energy X-ray absorptiometry and bioelectrical impedance analysis in older patients with heart failure.

Geriatr Gerontol Int 2022 Jun 25. Epub 2022 Jun 25.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Aim: This study aimed to compare bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA) in measuring skeletal muscle mass (MM), and its prognostic implications in old patients with heart failure.

Methods: We prospectively evaluated MM measured by both BIA and DEXA in 226 hospitalized elderly (≥65 years) patients with heart failure. The cut-off values proposed by the Asian Working Group in Sarcopenia were used to define low MM. Read More

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Necrotizing Fasciitis In A Patient with Metastatic Clear Cell Ovarian Carcinoma Treated with Bevacizumab.

Am J Case Rep 2022 Jun 25;23:e935584. Epub 2022 Jun 25.

Department of Internal Medicine, BronxCare Hospital, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

BACKGROUND Necrotizing fasciitis is a life-threatening infection of the deep soft tissues that leads to progressive destruction of the fascia and subcutaneous fat. It typically spreads along the muscle fascia planes because of the relatively poor blood supply. Muscle tissue is usually spared because of its better blood supply. Read More

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Effects of aerobic exercise and progressive muscle relaxation on migraine.

J Pak Med Assoc 2022 Jun;72(6):1153-1157

Department of Neurosurgery, Combined Military Hospital, Muzaffarabad, Pakistan.

Objective: To determine the effect of aerobic exercises and progressive muscle relaxation in migraine patients.

Methods: The quasi-experimental study was conducted at the Sheikh Khalifa Bin Zayed Al Nayhan Hospital / Combined Military Hospital, Muzaffarabad, Azad Jammu and Kashmir, from February to July 2017, and comprised migraine patients of either gender aged 20-50 years. They were divided into experimental and control group. Read More

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Formulation and exploration of novel, intramuscular pressure based, muscle activation strategies in a spine model.

Comput Biol Med 2022 Jul 20;146:105646. Epub 2022 May 20.

Musculoskeletal Biomechanics Research Lab, Department of Mechanical Engineering, McGill University, Montréal, Quebec, Canada; Orthopaedic Research Lab, Montreal General Hospital, McGill University Hospital Center Research Institute, Montréal, Quebec, Canada. Electronic address:

Optimization models are often devised to assess spinal stability via estimating individual muscle forces. However, neglecting muscles' fluidic behavior remains an approximation due to the role of muscle pressure in force transmission. The purpose of this study was to leverage a validated Finite Element (FE) model of the spine, inclusive of Intra-Muscular Pressure (IMP), to explore muscle activation strategies towards maintaining equilibrium spinal stability. Read More

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Correction: Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells.

Skelet Muscle 2022 Jun 24;12(1):15. Epub 2022 Jun 24.

Guangdong Provincial Key Laboratory of Medical Biomechanics, Department of Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.

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Feasibility and acceptability of a remotely delivered, home-based, pragmatic resistance 'exercise snacking' intervention in community-dwelling older adults: a pilot randomised controlled trial.

BMC Geriatr 2022 Jun 25;22(1):521. Epub 2022 Jun 25.

Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia.

Background: Very few older adults meet current muscle strengthening exercise guidelines, and several barriers exist to supervised, community-based resistance exercise programs. Older adults therefore require access to feasible resistance exercise modalities that may be performed remotely. This pilot study assessed the feasibility and acceptability of undertaking a four-week home-based resistance 'exercise snacking' intervention (performed either once, twice, or thrice daily) when delivered and monitored remotely in older adults. Read More

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