1,142,764 results match your criteria muscle

Effects of partial substitution of NaCl on myofibrillar protein properties from pearl mussel Hyriopsis cumingii muscle: Structural characteristics and aggregation behaviors.

Food Chem 2021 Mar 31;356:129734. Epub 2021 Mar 31.

College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 30045, China. Electronic address:

The effects of NaCl and its partial substitutes (KCl, MgCl and CaCl) on solubility, structural characteristics and aggregation behaviors of myofibrillar protein (MP) from pearl mussel muscle were investigated and compared. MP at 0.6 M NaCl was beneficial to protein unfolding and showed excellent potential functional properties. Read More

View Article and Full-Text PDF

Effects of acetylation on dissociation and phosphorylation of actomyosin in postmortem ovine muscle during incubation at 4 °C in vitro.

Food Chem 2021 Mar 27;356:129696. Epub 2021 Mar 27.

Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, PR China.

This study aimed to assess the effects of acetylation levels on actomyosin disassociation and phosphorylation of lamb during incubation at 4 °C. Samples of whole proteins from lamb longissimus thoracis muscles were prepared and assigned into three treatments (high, middle and low acetylation groups). The results showed that deacetylation of myosin heavy chain and actin was inhibited by lysine deacetylase inhibitor trichostatin A and nicotinamide in this study. Read More

View Article and Full-Text PDF

Analysis of motor unit spike trains estimated from high-density surface electromyography is highly reliable across operators.

J Electromyogr Kinesiol 2021 Mar 30;58:102548. Epub 2021 Mar 30.

Department of Bioengineering, Faculty of Engineering, Imperial College London, UK.

There is a growing interest in decomposing high-density surface electromyography (HDsEMG) into motor unit spike trains to improve knowledge on the neural control of muscle contraction. However, the reliability of decomposition approaches is sometimes questioned, especially because they require manual editing of the outputs. We aimed to assess the inter-operator reliability of the identification of motor unit spike trains. Read More

View Article and Full-Text PDF

Active surveillance for non-muscle invasive bladder cancer: A systematic review and pooled-analysis.

Cancer Treat Res Commun 2021 Apr 3;27:100369. Epub 2021 Apr 3.

IRCCS Humanitas Research Hospital - Rozzano, Milan, Italy.

Introduction: One of the Non-Muscle Invasive Bladder Cancer (NMIBC) treatment options recently recommended by International Guidelines is represented by Active Surveillance (AS),. Herein we carried out a systematic review and pooled-analysis of currently available evidences in order to provide recommendations for daily urological practice.

Material And Methods: The PubMed, EMBASE, and Coch rane Library databases were searched with the terms "Non-Muscle Invasive" or "pTa/pT1" and "Bladder Cancer" or "Bladder Tumor". Read More

View Article and Full-Text PDF

Trunk kinematics and muscle activation patterns during stand-to-sit movement and the relationship with postural stability in aging.

Gait Posture 2021 Mar 24;86:292-298. Epub 2021 Mar 24.

University of Maryland School of Medicine, Department of Physical Therapy & Rehabilitation Science, Baltimore, MD, 21201, United States. Electronic address:

Background: Stand-to-sit (StandTS) movement is an important functional activity that can be challenging for older adults due to age-related changes in neuromotor control. Although trunk flexion, eccentric contraction of the rectus femoris (RF), and coordination of RF and biceps femoris (BF) muscles are important to the StandTS task, the effects of aging on these and related outcomes are not well studied.

Research Question: What are the age-related differences in trunk flexion, lower extremity muscle activation patterns, and postural stability during a StandTS task and what is the relationship between these variables?

Methods: Ten younger and ten older healthy adults performed three StandTS trials at self-selected speeds. Read More

View Article and Full-Text PDF

A rare case of a laryngeal leiomyosarcoma with a lymph node metastasis.

Int J Surg Case Rep 2021 Mar 23;82:105830. Epub 2021 Mar 23.

ENT and Head and Neck Surgery, Hospital August 20, 1953, Ibn Rochd Teaching Hospital, Casablanca, Morocco. Electronic address:

Introduction: Leiomyosarcoma is a rare mesenchymal tumor that originates from smooth muscle cells. Head and neck LMSs represent only 3% of all leiomyosarcomas with less than 50 cases of laryngeal LMS reported in the literature till now.

Case Presentation: We report a case of 50-year-old male presented at our ENT department for a chronic hoarseness. Read More

View Article and Full-Text PDF

Axially- and torsionally-polarized radially converging shear wave MRE in an anisotropic phantom made via Embedded Direct Ink Writing.

J Mech Behav Biomed Mater 2021 Mar 31;119:104483. Epub 2021 Mar 31.

University of Illinois at Chicago, Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.

Magnetic Resonance Elastography (MRE) is a non-invasive imaging method to quantitatively map the shear viscoelastic properties of soft tissues. In this study, Embedded Direct Ink Writing is used to fabricate a muscle mimicking anisotropic phantom that may serve as a standard for imaging studies of anisotropic materials. The technique allowed us to obtain a long shelf life silicone-based phantom expressing transverse isotropic mechanical properties. Read More

View Article and Full-Text PDF

Muscle Memory.

Maren Olson

Acad Pediatr 2021 Apr 7. Epub 2021 Apr 7.

Center for the Art of Medicine, University of Minnesota; Department of Pediatrics, University of Minnesota; Department of Medical Education, Children's Minnesota. Electronic address:

View Article and Full-Text PDF

Autophagy in the Diabetic Heart: A Potential Pharmacotherapeutic Target in Diabetic Cardiomyopathy.

Ageing Res Rev 2021 Apr 7:101338. Epub 2021 Apr 7.

Department of Biochemistry, Kakatiya Medical College, Warangal, 506007, Telangana, India; Applied Biology, CSIR-Indian Institute of Technology, Uppal Road, Tarnaka, Hyderabad, 50000, Telangana, India. Electronic address:

Association of diabetes with an elevated risk of cardiac failure has been clinically evident. Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction that produces the cardiac muscle-specific microvascular complication, clinically termed as diabetic cardiomyopathy. Elevated susceptibility of diabetic cardiomyopathy is primarily caused by the generation of free radicals in the hyperglycemic milieu, compromising the myocardial contractility and normal cardiac functions with increasing redox insult, impaired mitochondria, damaged organelles, apoptosis, and cardiomyocytes fibrosis. Read More

View Article and Full-Text PDF

The effect of age on mechanisms of exercise tolerance: Reduced arteriovenous oxygen difference causes lower oxygen consumption in older people.

Exp Gerontol 2021 Apr 7:111340. Epub 2021 Apr 7.

Cardiovascular Research Theme, Clinical and Translational Research Institute, Faculty of Medical Sciences, Newcastle University, UK; Department of Cardiology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Cardiovascular and Lifestyle Medicine Research Theme (CSELS), Faculty of Health and Life Sciences, Coventry University, UK. Electronic address:

Objective: To assess the effect of age on mechanisms of exercise tolerance.

Methods: Prospective observational study recruited 71 healthy individuals divided into two groups according to their age i.e. Read More

View Article and Full-Text PDF

Effect of muscle fatigue on brain activity in healthy individuals.

Brain Res 2021 Apr 7:147469. Epub 2021 Apr 7.

Department of Rehabilitation, Faculty of Health Science, Fukui Health Science University, Fukui-city, Fukui, Japan.

Fatigue is affected by both peripheral and central factors. However, the interrelationship between muscle fatigue and brain activity has not yet been clarified. This study aimed to clarify the effect of muscle fatigue due to sustained pinch movement on brain activity in healthy individuals using functional near-infrared spectroscopy (fNIRS). Read More

View Article and Full-Text PDF

The FacioScapuloHumeral muscular Dystrophy Rasch-built Overall Disability Scale (FSHD-RODS).

Eur J Neurol 2021 Apr 10. Epub 2021 Apr 10.

Department of Neurology, Curaçao Medical Center, Willemstad, Curaçao.

Background: Facioscapulohumeral muscular dystrophy is a debilitating inherited muscle disease for which various therapeutic strategies are being investigated. Thus far, little attention has been given in FSHD to the development of scientifically sound outcome measures fulfilling regulatory authorities' requirements. The aim of this study is to design a patient-reported Rasch-built interval scale on activity and participation for FSHD. Read More

View Article and Full-Text PDF

The relationship between fasting-induced torpor, sleep and waking in laboratory mice.

Sleep 2021 Apr 10. Epub 2021 Apr 10.

Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.

Study Objectives: Torpor is a regulated and reversible state of metabolic suppression used by many mammalian species to conserve energy. Whereas the relationship between torpor and sleep has been well-studied in seasonal hibernators, less is known about the effects of fasting-induced torpor on states of vigilance and brain activity in laboratory mice.

Methods: Continuous monitoring of electroencephalogram (EEG), electromyogram (EMG) and surface body temperature was undertaken in adult, male C57BL/6 mice over consecutive days of scheduled restricted feeding. Read More

View Article and Full-Text PDF

Hypokalemia-Induced Rhabdomyolysis Caused by Adrenal Tumor-Related Primary Aldosteronism: A Report of 2 Cases.

Am J Case Rep 2021 Apr 10;22:e929758. Epub 2021 Apr 10.

Division of Urology, Department of Surgery, Cathay General Hospital, Taipei, Taiwan.

BACKGROUND Primary aldosteronism, also known as Conn's syndrome, is a clinical condition caused by excessive production of aldosterone. The classic presenting signs of primary aldosteronism are hypertension and hypokalemia. However, rhabdomyolysis induced by severe hypokalemia is a rare manifestation of primary aldosteronism. Read More

View Article and Full-Text PDF

Combining chitin biological conduits with small autogenous nerves and platelet-rich plasma for the repair of sciatic nerve defects in rats.

CNS Neurosci Ther 2021 Apr 10. Epub 2021 Apr 10.

Department of Orthopedics and Trauma, Key Laboratory of Trauma and Neural Regeneration (Ministry of Education/Peking University, Peking University People's Hospital, Beijing, 100044, China.

Aims: Peripheral nerve defects are often difficult to recover from, and there is no optimal repair method. Therefore, it is important to explore new methods of repairing peripheral nerve defects. This study explored the efficacy of nerve grafts constructed from chitin biological conduits combined with small autogenous nerves (SANs) and platelet-rich plasma (PRP) for repairing 10-mm sciatic nerve defects in rats. Read More

View Article and Full-Text PDF

Bicarbonate ion transport by the electrogenic Na /HCO cotransporter, NBCe1, is required for normal electrical slow-wave activity in mouse small intestine.

Neurogastroenterol Motil 2021 Apr 10:e14149. Epub 2021 Apr 10.

Enteric Neuroscience Program, Division of Gastroenterology and Hepatology, Rochester, MN, USA.

Background: Normal gastrointestinal motility depends on electrical slow-wave activity generated by interstitial cells of Cajal (ICC) in the tunica muscularis of the gastrointestinal tract. A requirement for HCO in extracellular solutions used to record slow waves indicates a role for HCO transport in ICC pacemaking. The Slc4a4 gene transcript encoding the electrogenic Na /HCO cotransporter, NBCe1, is enriched in mouse small intestinal myenteric region ICC (ICC-MY) that generate slow waves. Read More

View Article and Full-Text PDF

Circular RNA circ-ARFIP2 regulates proliferation, migration and invasion in human vascular smooth muscle cells via miR-338-3p-dependent modulation of KDR.

Metab Brain Dis 2021 Apr 10. Epub 2021 Apr 10.

Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No.106 Zhongshan Second Road, Guangzhou, 510000, Guangdong, China.

Dysfunction of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of intracranial aneurysm (IA). Circular RNAs (circRNAs) have been implicated in the pathogenesis of IA by reducing microRNA (miRNA) activity. In this paper, we investigated the precise roles of circRNA ADP ribosylation factor interacting protein 2 (circ-ARFIP2, circ_0021001) in VSMC dysfunction. Read More

View Article and Full-Text PDF

Schwann-like cell conditioned medium promotes angiogenesis and nerve regeneration.

Cell Tissue Bank 2021 Apr 10. Epub 2021 Apr 10.

Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Jingkou District, Zhenjiang City, 212013, Jiangsu Province, China.

Vascular network reconstruction plays a pivotal role in the axonal regeneration and nerve function recovery after peripheral nerve injury. Increasing evidence indicates that Schwann cells (SCs) can promote nerve function repair, and the beneficial effects attributed to SCs therapy may exert their therapeutic effects through paracrine mechanisms. Recently, the previous research of our group demonstrated the promising neuroregenerative capacity of Schwann-like cells (SCLCs) derived from differentiated human embryonic stem cell-derived neural stem cells (hESC-NSCs) in vitro. Read More

View Article and Full-Text PDF

First time intravesically administered trifunctional antibody catumaxomab in patients with recurrent non-muscle invasive bladder cancer indicates high tolerability and local immunological activity.

Cancer Immunol Immunother 2021 Apr 10. Epub 2021 Apr 10.

Trion Research GmbH, Am Klopferspitz 19, 82152, Martinsried, Germany.

Transurethral resection of the tumor (TUR-B) followed by adjuvant intravesical treatment with cytostatic drugs or Bacillus Calmette-Guérin (BCG) as standard therapy of non-muscle-invasive bladder cancer (NMIBC) is associated with a high recurrence rate of about 60-70%, considerable side effects and requires close monitoring. Alternative treatment options are warranted. Two patients with epithelial cell adhesion molecule (EpCAM)-positive recurrent non-muscle invasive bladder cancer were treated the first time by an intravesical administration of the trifunctional bispecific EpCAM targeting antibody catumaxomab (total dosage of 470 and 1120 µg, respectively). Read More

View Article and Full-Text PDF

Signal intensity patterns in health and disease: basics of abdominal magnetic resonance imaging in children.

Pediatr Radiol 2021 Apr 10. Epub 2021 Apr 10.

Department of Radiology, Emory University and Children's Healthcare of Atlanta, 1405 Clifton Road, Atlanta, GA, 30322, USA.

Magnetic resonance imaging (MRI) is playing an increasing role in pediatric abdominal imaging, especially in the evaluation of diffuse parenchymal disease where other imaging modalities might be less sensitive. While quantitative imaging is slowly being incorporated into clinical imaging, qualitative assessment of visceral signal intensity should be part of the routine clinical workflow of all radiologists. Based on their T1 and T2 weighting, the liver, spleen, kidneys and pancreas have characteristic signal intensity patterns with respect to one another and to skeletal muscle. Read More

View Article and Full-Text PDF

Microablative radiofrequency versus pelvic floor muscle training for stress urinary incontinence: a randomized controlled trial.

Int Urogynecol J 2021 Apr 10. Epub 2021 Apr 10.

Department of Obstetrics and Gynecology, University of Campinas Faculty of Medical Sciences, Campinas, SP, Brazil.

Introduction And Hypothesis: The efficacy of radiofrequency (RF) in stress urinary incontinence (SUI) is as yet unknown. The aim was to compare the effect of fractional microablative RF and pelvic floor muscle training (PFMT) against the combination of both therapies (RF + PFMT) in the SUI and on genitourinary syndrome (GSM).

Methods: This was a three-arm randomized clinical trial including 117 climacteric women with SUI. Read More

View Article and Full-Text PDF

The interplay of membrane cholesterol and substrate on vascular smooth muscle biomechanics.

Curr Top Membr 2020 28;86:279-299. Epub 2020 Sep 28.

Department of Biomedical Engineering, University of South Dakota, Vermillion, SD, United States. Electronic address:

Cardiovascular disease (CVD) remains the primary cause of death worldwide. Specifically, atherosclerosis is a CVD characterized as a slow progressing chronic inflammatory disease. During atherosclerosis, vascular walls accumulate cholesterol and cause fatty streak formation. Read More

View Article and Full-Text PDF
September 2020

Vascular smooth muscle stiffness and its role in aging.

Curr Top Membr 2020 12;86:217-253. Epub 2020 Oct 12.

Department of Health and Kinesiology, Texas A&M University, College Station, TX, United States.

Vascular smooth muscle cells (VSMC) are now considered important contributors to the pathophysiological and biophysical mechanisms underlying arterial stiffening in aging. Here, we review mechanisms whereby VSMC stiffening alters vascular function and contributes to the changes in vascular stiffening observed in aging and cardiovascular disease. Vascular stiffening in arterial aging was historically associated with changes in the extracellular matrix; however, new evidence suggests that endothelial and vascular smooth muscle cell stiffness also contribute to overall blood vessel stiffness. Read More

View Article and Full-Text PDF
October 2020

Long non-coding RNA MFAT1 promotes skeletal muscle fibrosis by modulating the miR-135a-5p-Tgfbr2/Smad4 axis as a ceRNA.

J Cell Mol Med 2021 Apr 9. Epub 2021 Apr 9.

Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Fibrosis after skeletal muscle injury is common in sports and can cause irreversible damage to the biomechanical properties of skeletal muscle. Long non-coding RNAs (lncRNAs) have been validated to act as important modulators in the fibrosis of various organs. Here, we reported a novel lncRNA (the skeletal muscle fibrosis-associated transcript 1, lnc-MFAT1), which was highly expressed in skeletal muscle fibrosis. Read More

View Article and Full-Text PDF

Functional and Molecular Adaptations of Quadriceps and Hamstring Muscles to Blood Flow Restricted Training in Patients with ACL Rupture.

Scand J Med Sci Sports 2021 Apr 10. Epub 2021 Apr 10.

Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Slovenia, EU.

Effects of low-load blood flow restricted (LL-BFR) training remain unexplored in patients with ACL rupture. Our hypothesis was that LL-BFR training triggers augmented gains in knee muscle strength and size, which are paralleled with transcriptional responses of hypoxia-regulated genes and myokines. Eighteen volunteers (age 37. Read More

View Article and Full-Text PDF

Potential roles of Kruppel-like factors in mediating adverse vascular effects of nanomaterials: A review.

Yi Cao

J Appl Toxicol 2021 Apr 10. Epub 2021 Apr 10.

Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, University of South China, Hengyang, China.

The development of nanotechnology leads to the exposure of human beings to nanomaterials (NMs), and there is a health concern about the adverse vascular effects of NMs. Current data from epidemiology, controlled human exposure, and animal studies suggested that exposure to NMs could induce cardiopulmonary effects. In support of in vivo findings, in vitro studies showed that direct contact of vascular cells with NMs could induce endothelial cell (EC) activation and promote macrophage foam cell formation, although only limited studies showed that NMs could damage vascular smooth muscle cells and promote their phenotypic switch. Read More

View Article and Full-Text PDF

Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats.

Toxicol Sci 2021 Apr 9. Epub 2021 Apr 9.

Safety Assessment and Laboratory Animal Resources, Merck & Co., Inc., West Point, PA, 19486, USA.

A new safety testing paradigm that relies on gene expression biomarker panels was developed to easily and quickly identify drug-induced injuries across tissues in rats prior to drug candidate selection. Here we describe the development, qualification, and implementation of gene expression signatures that diagnose tissue degeneration/necrosis for use in early rat safety studies. Approximately 400 differentially expressed genes were first identified that were consistently regulated across 4 prioritized tissues (liver, kidney, heart, skeletal muscle), following injuries induced by known toxicants. Read More

View Article and Full-Text PDF

Gender-specific analysis for the association between trunk muscle mass and spinal pathologies.

Sci Rep 2021 Apr 9;11(1):7816. Epub 2021 Apr 9.

Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan.

We investigated the relationship between trunk muscle mass and spinal pathologies by gender. This multicenter cross-sectional study included patients aged ≥ 30 years who visited a spinal outpatient clinic. Trunk and appendicular muscle mass were measured using bioelectrical impedance analysis. Read More

View Article and Full-Text PDF

Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis.

Cell Death Dis 2021 Apr 9;12(4):385. Epub 2021 Apr 9.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Human antigen R (HuR) is a widespread RNA-binding protein involved in homeostatic regulation and pathological processes in many diseases. Atherosclerosis is the leading cause of cardiovascular disease and acute cardiovascular events. However, the role of HuR in atherosclerosis remains unknown. Read More

View Article and Full-Text PDF

LncRNA-FKBP1C regulates muscle fiber type switching by affecting the stability of MYH1B.

Cell Death Discov 2021 Apr 9;7(1):73. Epub 2021 Apr 9.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources & Lingnan Guangdong Laboratory of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.

Long non-coding RNAs (lncRNAs) are well-known to participate in a variety of important regulatory processes in myogenesis. In our previous RNA-seq study (accession number GSE58755), we found that lncRNA-FKBP1C was differentially expressed between White Recessive Rock (WRR) and Xinghua (XH) chicken. Here, we have further demonstrated that lncRNA-FKBP1C interacted directly with MYH1B by biotinylated RNA pull-down assay and RNA immunoprecipitation (RIP). Read More

View Article and Full-Text PDF