51,758 results match your criteria multivariate normal


Risk factors for inadvertent intraoperative hypothermia in patients undergoing laparoscopic surgery: A prospective cohort study.

PLoS One 2021 23;16(9):e0257816. Epub 2021 Sep 23.

Department of Anesthesiology, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.

Background: Inadvertent intraoperative hypothermia is frequent during open surgeries; however, few studies on hypothermia during laparoscopic abdominal surgery have been reported. We aimed to investigate the incidence and risk factors for hypothermia in patients undergoing laparoscopic abdominal surgery.

Methods: This single-center prospective cohort observational study involved patients undergoing laparoscopic surgery between October 2018 and June 2019. Read More

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September 2021

Impact of Mobile Technologies on Cervical Cancer Screening Practices in Lagos, Nigeria (mHealth-Cervix): A Randomized Controlled Trial.

JCO Glob Oncol 2021 Aug;7:1418-1425

Department of Obstetrics and Gynaecology, Stanford University School of Medicine, Stanford, CA.

Purpose: We assessed the impact of mHealth on Pap test screening uptake and also determined the factors that affect screening uptake among women in Lagos, Nigeria.

Materials And Methods: A randomized controlled trial was carried out among women in two tertiary health institutions in Lagos, Nigeria, between July 2020 and March 2021. Participants were randomly assigned to either a text message (mHealth) intervention or usual care arm. Read More

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Downregulation of GNA15 Inhibits Cell Proliferation P38 MAPK Pathway and Correlates with Prognosis of Adult Acute Myeloid Leukemia With Normal Karyotype.

Front Oncol 2021 6;11:724435. Epub 2021 Sep 6.

Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: The prognosis of acute myeloid leukemia (AML) with a normal karyotype is highly heterogonous, and the current risk stratification is still insufficient to differentiate patients from high-risk to standard-risk. Changes in some genetic profiles may contribute to the poor prognosis of AML. Although the prognostic value of G protein subunit alpha 15 () in AML has been reported based on the GEO (Gene Expression Omnibus) database, the prognostic significance of has not been verified in clinical samples. Read More

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September 2021

Establishment of an Endocytosis-Related Prognostic Signature for Patients With Low-Grade Glioma.

Front Genet 2021 6;12:709666. Epub 2021 Sep 6.

Research Center of Translational Medicine, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Low-grade glioma (LGG) is a heterogeneous tumor that might develop into high-grade malignant glioma, which markedly reduces patient survival time. Endocytosis is a cellular process responsible for the internalization of cell surface proteins or external materials into the cytosol. Dysregulated endocytic pathways have been linked to all steps of oncogenesis, from initial transformation to late invasion and metastasis. Read More

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September 2021

High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer.

Recent Pat Anticancer Drug Discov 2021 Jul 6. Epub 2021 Jul 6.

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630. China.

Background: The prognosis of Epithelial Ovarian Cancer (EOC) is poor, but the prognostic biomarkers are neither sensitive nor specific. Therefore, it is very important to search novel prognostic biomarkers for EOC.

Objectives: The present study aimed to investigate Myosin Light Chain 9(MYL9) expression in Epithelial Ovarian Cancer (EOC) tissues (including paraffin-embedded and fresh tissue samples) and its relationship with clinicopathological characteristics, as well as its potential prognostic value in patients with EOC. Read More

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Right ventricular dysfunction and tricuspid regurgitation in functional mitral regurgitation.

ESC Heart Fail 2021 Sep 22. Epub 2021 Sep 22.

The Christ Hospital Health Network, 2139 Auburn Ave, Cincinnati, OH, 45219, USA.

Aim: The objective of this study was to investigate the prognostic importance of right ventricular dysfunction (RVD) and tricuspid regurgitation (TR) in patients with moderate-severe functional mitral regurgitation (FMR) receiving MitraClip procedure. RVD and TR grade are associated with cardiovascular mortality in the general population and other cardiovascular diseases. However, there are limited data from observational studies on the prognostic significance of RVD and TR in FMR receiving MitraClip procedure. Read More

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September 2021

Increased serum exosomal long non-coding RNA SNHG15 expression predicts poor prognosis in non-small cell lung cancer.

J Clin Lab Anal 2021 Sep 22:e23979. Epub 2021 Sep 22.

Department of Respiratory and Critical Care Medicine, the First Hospital of Yulin City, Yulin City, Shaanxi Province, China.

Background: Circulating long non-coding RNAs (lncRNAs) are emerging as promising biomarkers for non-small cell lung cancer (NSCLC). This study aimed to detect serum exosomal lncRNA SNHG15 expression in NSCLC and evaluate its potential clinical value.

Methods: A total of 238 serum samples were collected from 118 patients with NSCLC, 40 patients with benign pulmonary lesions and 80 healthy volunteers. Read More

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September 2021

Identification and clinical validation of gene signatures with grade and survival in head and neck carcinomas.

Braz J Med Biol Res 2021 20;54(11):e11069. Epub 2021 Sep 20.

Department of Otolaryngology - Head and Neck Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China.

This study aimed to explore gene expression profiles that drive malignancy from low- to high-grade head and neck carcinomas (HNC), as well as to analyze their correlations with survival. Gene expressions and clinical data of HNC were downloaded from the Gene Expression Omnibus (GEO) repository. The significantly differential genes (SDGs) between low- and high-grade HNC were screened. Read More

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September 2021

Impact of BMI on Left Atrial Strain and Abnormal Atrioventricular Interaction in Patients With Type 2 Diabetes Mellitus: A Cardiac Magnetic Resonance Feature Tracking Study.

J Magn Reson Imaging 2021 Sep 22. Epub 2021 Sep 22.

Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Background: Type 2 diabetes mellitus (T2DM) and obesity often coexist and together contribute to left atrial (LA) functional abnormalities. However, little is known about the impact of body mass index (BMI) on LA strains measured using cardiac magnetic resonance feature tracking (MR-FT).

Purpose: To investigate the additive effect of BMI on LA functional remodeling using MR-FT as well as to explore abnormal atrioventricular interaction in T2DM patients. Read More

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September 2021

[Effects of neoadjuvant chemoradiotherapy on infiltrating immune cells in the tumor microenvironment of rectal cancer].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Aug;41(8):1270-1276

Department of Oncology, Xiangya Second Hospital of Central South University, Changsha 410011, China.

Objective: To detect the changes in the number and phenotype of tumor infiltrating immune cells in rectal cancer tissues before and after neoadjuvant concurrent chemoradiotherapy (CRT) and analyze their correlation with the clinicopathological parameters of the patients.

Methods: The protein expressions of CD3, CD4, CD8, CD56 and Foxp3 in biopsy specimens and postoperative pathological specimens collected from 20 rectal cancer patients before and after neoadjuvant CRT were detected using Elivision Plus immunohistochemistry, and the results were statistically analyzed.

Results: Compared with the measurements before the therapy, neoadjuvant CRT resulted in significant increments in CD3 (21. Read More

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Clinicopathological Analysis and Prognostic Assessment of TCN1 in Patients with Gastric Cancer.

Surg Innov 2021 Sep 22:15533506211045318. Epub 2021 Sep 22.

Department of General Surgery, 105860The Second Affiliated Hospital of Soochow University, Suzhou, China.

Background: Stomach cancer is the fourth most common type of cancer worldwide. TCN1 mainly encodes the vitamin B12 transporter, transcobalamin. TCN1 is a marker of gastrointestinal tumor progression, but the impact of TCN1 on survival is unclear. Read More

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September 2021

How to Use Model-Based Cluster Analysis Efficiently in Person-Oriented Research.

J Pers Oriented Res 2021 26;7(1):22-35. Epub 2021 Aug 26.

Károli Gáspár University, Budapest, Hungary.

Model-based cluster analysis (MBCA) was created to automatize the often subjective model-selection procedure of traditional explorative clustering methods. It is a type of finite mixture modelling, assuming that the data come from a mixture of different subpopulations following given distributions, typically multivariate normal. In that case cluster analysis is the exploration of the underlying mixture structure. Read More

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Expression and subcellular localization of Discoidin Domain Receptor 1 (DDR1) define prostate cancer aggressiveness.

Cancer Cell Int 2021 Sep 21;21(1):507. Epub 2021 Sep 21.

Department of Pathology, Wayne State University School of Medicine and Karmanos Cancer Institute, Scott Hall #8200, 540 E. Canfield St, Detroit, MI, 48201, USA.

Background: The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to collagen, which has been implicated in cancer progression. Here, we examined the expression of DDR1 in prostate cancer (PCa), and assessed its potential value as a prognostic marker, as a function of grade, stage and other clinicopathologic parameters.

Methods: We investigated the association between the expression level and subcellular localization of DDR1 protein and PCa aggressiveness by immunohistochemistry, using tissue microarrays (TMAs) encompassing 200 cases of PCa with various Gleason scores (GS) and pathologic stages with matched normal tissue, and a highly specific monoclonal antibody. Read More

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September 2021

Impact of Preoperative Nutritional Indicator on Poor Postoperative Outcomes in Geriatric Patients with Colorectal Cancer.

Nutr Cancer 2021 Sep 21:1-9. Epub 2021 Sep 21.

Department of Surgery, Kyoto Chubu Medical Center, Nantan, Japan.

The present study aimed to analyze the association between preoperative nutritional assessment and poor postoperative outcomes in geriatric patients with colorectal cancer. This retrospective study included 138 patients aged ≥80 years with colorectal cancer who underwent surgery from January 2013 to December 2018. Patients were classified into two groups according to outcomes, poor group and normal group. Read More

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September 2021

[Risk stratified management of cervical adenocarcinoma in situ based on cone margin state].

Zhonghua Fu Chan Ke Za Zhi 2021 Sep;56(9):622-629

Department of Pathology, Obstetrics and Gynecology Hospital, Fudan University, ShangHai 200011, China.

To investigate the hierarchical management scheme of cervical adenocarcinoma in situ (AIS) based on cervical conization margin state. All medical records of 249 patients diagnosed as AIS by loop electrosurgical excision procedure (LEEP) conization from Jan. 2010 to Dec. Read More

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September 2021

Meloxicam administration in the management of postoperative pain and inflammation associated with caesarean section in beef heifers: Evaluation of reproductive parameters.

Theriogenology 2021 Sep 11;175:148-154. Epub 2021 Sep 11.

Laboratoire National de Contrôle des Reproducteurs, 13 rue Jouet, 94700, Maisons-Alfort, France.

Post-operative pain and inflammation are normal physiological reactions to caesarean section. Their management in cattle have rarely been investigated. This surgical procedure negatively affects reproductive function with, for example, a reduction in fertility resulting in an increase in calving interval. Read More

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September 2021

A tool for evaluating novel osteoarthritis therapies using multivariate analyses of human cartilage-synovium explant co-culture.

Osteoarthritis Cartilage 2021 Sep 18. Epub 2021 Sep 18.

Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Canada; Krembil Research Institute, University Health Network, Canada; Institute of Biomedical Engineering, University of Toronto, Canada; Division of Hematology, Department of Medicine, University of Toronto, Canada. Electronic address:

Objective: There is a need to incorporate multiple tissues into in vitro OA models to evaluate novel therapeutics. This approach is limited by inherent donor variability. We present an optimized research tool: a human OA cartilage-synovium explant co-culture model (OA-EXM) that employs donor-matched lower and upper limit response controls combined with statistical approaches to address variability. Read More

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September 2021

Functional Deficit of Sense Organs as a risk factor for Cognitive Functional Disorder in Chinese Community Elderly People.

Int J Clin Pract 2021 Sep 21:e14905. Epub 2021 Sep 21.

Mental Health Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.

Objective: To explore the relationship between mild cognitive impairment (MCI) and sense organs functional deficit in community elderly people.

Methods: 3095 community elderly people above 60 years in Hebei Province were selected by cross-sectional random cluster sampling method, who were evaluated face-to-face for general demographic data, the condition of sense organs functional deficit (vision, hearing, gustation, olfactory sensation, taste) and cognitive function by Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).

Results: A total of 3075 valid questionnaires were obtained. Read More

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September 2021

Role of hepatosteatosis in HBsAg seroconversion in HBeAg-negative chronic hepatitis B patients.

Int J Clin Pract 2021 Sep 21:e14899. Epub 2021 Sep 21.

Ankara City Hospital, Department of Gastroenterology, Ankara, Turkey.

Background: In chronic HBV infection, certain individual and viral characteristics such as advanced age, presence of hepatic steatosis (HS), normal ALT levels, initially negative HBeAg and HBV DNA, and genotype of the virus are associated with HBsAg seroclearance and seroconversion. Herein, we report the results of our study evaluating the association between hepatosteatosis and HbsAg seroconversion.

Methods: The clinical and biochemical data of patients with CHB and hepatosteatosis (HS) (HBsAg seroconversion, n:52, and non-HbsAg seroconversion, n:352), and the rate of development HBsAg seroconversion were evaluated. Read More

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September 2021

Mechanism of Fuzheng Kang'ai Formula () Regulating Tumor Microenvironment in Non-Small Cell Lung Cancer.

Chin J Integr Med 2021 Sep 21. Epub 2021 Sep 21.

Evidence Based Medicine Center, School of Basic Medical Science of Lanzhou University, Lanzhou, 730000, China.

Objective: To study the mechanism of Chinese herbal medicine Fuzheng Kang'ai Formula (, FZKA) on tumor microenvironment (TME).

Methods: CIBERSORTx was used for analysis of TME. Traditional Chinese Medicine Systems Pharmacology and Analysis Platform was applied to identify compounds-targets network and the Cancer Genome Atlas (TCGA) was employed to identify the differential expression genes (DEGs) between tumor and paracancerous tissues in lung adenocarcinoma (LUAD) from TCGA-LUAD. Read More

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September 2021

Hepatic Steatosis is Associated with an Increased Risk of Postoperative Infections and Perioperative Transfusion Requirements in Patients Undergoing Hepatectomy.

World J Surg 2021 Sep 21. Epub 2021 Sep 21.

Department of Surgery - Transplant Division, College of Medicine, University of Kentucky, 740 South Limestone, K301, Lexington, KY, 40536-0293, USA.

Background: To determine the impact of hepatic steatosis on perioperative outcomes of patients undergoing hepatectomy.

Methods: We analyzed all hepatectomy patients with normal and fatty liver texture, between 2014 and 2018 using NSQIP. Main endpoints included perioperative transfusions (within 72 h) and infectious complications. Read More

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September 2021

Linear unmixing protocol for hyperspectral image fusion analysis applied to a case study of vegetal tissues.

Sci Rep 2021 Sep 20;11(1):18665. Epub 2021 Sep 20.

Department of Chemical Engineering and Analytical Chemistry, Universitat de Barcelona, 08028, Barcelona, Spain.

Hyperspectral imaging (HSI) is a useful non-invasive technique that offers spatial and chemical information of samples. Often, different HSI techniques are used to obtain complementary information from the sample by combining different image modalities (Image Fusion). However, issues related to the different spatial resolution, sample orientation or area scanned among platforms need to be properly addressed. Read More

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September 2021

A Bayesian latent class mixture model with censoring for correlation analysis in antimicrobial resistance across populations.

BMC Med Res Methodol 2021 Sep 20;21(1):186. Epub 2021 Sep 20.

Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, United States of America.

Background: The emergence of antimicrobial resistance across populations is a global threat to public health. Surveillance programs often monitor human and animal populations to evaluate trends of emergence in these populations. Many national level antibiotic resistance surveillance programs quantify the proportion of resistant bacteria as a means of monitoring emergence and control measures. Read More

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September 2021

Neural dynamics underlying the acquisition of distinct auditory category structures.

Neuroimage 2021 Sep 17:118565. Epub 2021 Sep 17.

Department of Communication Science and Disorders, School of Health and Rehabilitation Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA; Center for the Neural Basis of Cognition, Pittsburgh, PA, 15232, USA. Electronic address:

Despite the multidimensional and temporally fleeting nature of auditory signals we quickly learn to assign novel sounds to behaviorally relevant categories. The neural systems underlying the learning and representation of novel auditory categories are far from understood. Current models argue for a rigid specialization of hierarchically organized core regions that are fine-tuned to extracting and mapping relevant auditory dimensions to meaningful categories. Read More

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September 2021

Serial circulating tumor DNA to predict early recurrence in patients with hepatocellular carcinoma: a prospective study.

Mol Oncol 2021 Sep 20. Epub 2021 Sep 20.

Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China.

We studied the value of circulating tumor DNA (ctDNA) in predicting early postoperative tumor recurrence and monitoring tumor burden in patients with hepatocellular carcinoma (HCC). Plasma-free DNA, germline DNA and tissue DNA were isolated from 41 patients with HCC. Serial ctDNAs were analyzed by next-generation sequencing before and after operation. Read More

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September 2021

Identifying causal variants by fine mapping across multiple studies.

PLoS Genet 2021 Sep 20;17(9):e1009733. Epub 2021 Sep 20.

Department of Computer Science, University of California, Los Angeles, California, United States.

Increasingly large Genome-Wide Association Studies (GWAS) have yielded numerous variants associated with many complex traits, motivating the development of "fine mapping" methods to identify which of the associated variants are causal. Additionally, GWAS of the same trait for different populations are increasingly available, raising the possibility of refining fine mapping results further by leveraging different linkage disequilibrium (LD) structures across studies. Here, we introduce multiple study causal variants identification in associated regions (MsCAVIAR), a method that extends the popular CAVIAR fine mapping framework to a multiple study setting using a random effects model. Read More

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September 2021

Blood Triglyceride and High-Density Lipoprotein Levels Are Associated with Plasma Amyloid-β Transport: A Population-Based Cross-Sectional Study.

J Alzheimers Dis 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: Studies have found that blood lipids are associated with plasma amyloid-β (Aβ) levels, but the underlying mechanism is still unclear. Two Aβ transporters, soluble form of low-density lipoprotein receptor related protein-1 (sLRP1) and soluble receptor of advanced glycation end products (sRAGE), are crucial in peripheral Aβ transport.

Objective: The aim was to investigate the effects of lipids on the relationships between plasma Aβ and transporter levels. Read More

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September 2021

The utility of geriatric nutritional risk index to predict outcomes in chronic limb-threatening ischemia.

Catheter Cardiovasc Interv 2021 Sep 19. Epub 2021 Sep 19.

Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

Objectives: To assess geriatric nutritional risk index (GNRI) in patients with chronic limb-threatening ischemia (CLTI).

Background: The prevalence of CLTI continues to rise, with major amputation and mortality remaining prominent. Frailty is a vital risk factor for adverse outcomes in cardiovascular care. Read More

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September 2021

Prevalence of diabetic foot among adults with diabetes mellitus in northern Sudan: a cross-sectional study.

Int J Clin Pract 2021 Sep 19:e14892. Epub 2021 Sep 19.

Department of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia.

Objective: The aim of this study was to determine the prevalence and associated factors for diabetic foot (DF) among patients with diabetes Mellites (DM) in Nahr an Nil State (River Nile State), Sudan.

Methods: We conducted across-sectional study between May and August 2018. DM patients were examined for DF, and clinical data were collected through a questionnaire. Read More

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September 2021