8,799 results match your criteria multivariate approaches


Digital Twin of Low Dosage Continuous Powder Blending - Artificial Neural Networks and Residence Time Distribution Models.

Eur J Pharm Biopharm 2021 Sep 22. Epub 2021 Sep 22.

Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rakpart 3, Budapest H-1111, Hungary. Electronic address:

In this paper we present a thorough description of the digital twin development for a continuous pharmaceutical powder blending process in accordance with the Process Analytical Technologies (PAT) and Quality by Design (QbD) guidelines. A low-dosage system of caffeine active pharmaceutical ingredient (API) and dextrose excipient was examined via continuous blending experiments. Near infrared (NIR) spectroscopy-based process analytics were applied; quantitative evaluation of spectra was achieved using multivariate data analysis. Read More

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September 2021

A case-control study of Dietary Approaches to Stop Hypertension (DASH) diets, colorectal cancer and adenomas among Iranian population.

BMC Cancer 2021 Sep 25;21(1):1050. Epub 2021 Sep 25.

Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology, Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Aims: Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on colorectal adenomas (CRAs) as its precursor are scarce. Thus, the purpose of this case-control study was to investigate the association of DASH score with the risk of CRC and CRA in Iranian adults. Read More

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September 2021

Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

Neuroimage 2021 Sep 21:118603. Epub 2021 Sep 21.

NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Neurosciences, University of California San Diego, La Jolla, CA 92037, USA; Department of Radiology, University of California San Diego, La Jolla, CA 92037, USA; Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA 92037, USA. Electronic address:

Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by the genetic variants discovered so far. Here we extended the Multivariate Omnibus Statistical Test (MOSTest) and applied it to genome-wide association studies (GWAS) of vertex-wise structural magnetic resonance imaging (MRI) cortical measures from N=35,657 participants in the UK Biobank. We identified 695 loci for cortical surface area and 539 for cortical thickness, in total 780 unique genetic loci associated with cortical morphology robustly replicated in 8,060 children of mixed ethnicity from the Adolescent Brain Cognitive Development (ABCD) Study. Read More

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September 2021

National disparities in use of minimally invasive surgery for rectal cancer in older adults.

J Am Geriatr Soc 2021 Sep 24. Epub 2021 Sep 24.

Division of Colorectal Surgery, Department of Surgery, The University of California at Davis Medical Center, Sacramento, California, USA.

Background: Minimally invasive surgery (MIS) is safe and improves outcomes in older persons with rectal cancer but may be underutilized. As older persons are the largest surgical population, investigation of the current use and factors impacting MIS use is warranted. Our goal is to investigate the trends and disparities that affect utilization of MIS in older persons with rectal cancer. Read More

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September 2021

Mental heartbeat tracking and rating of emotional pictures are not related.

Psychol Res 2021 Sep 23. Epub 2021 Sep 23.

Institute of Health Promotion and Sport Sciences, ELTE Eötvös Loránd University, Budapest, Hungary.

Our aim was to conceptually replicate the findings of previous empirical studies showing that people with higher cardiac interoceptive accuracy experience more intense emotions. Apart of the mental heartbeat tracking task of Schandry, Hungarian (n = 46, 76.0% female, mean age 22. Read More

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September 2021

Individual Differences in Different Measures of Opioid Self-Administration in Rats Are Accounted for by a Single Latent Variable.

Front Psychiatry 2021 7;12:712163. Epub 2021 Sep 7.

Hennepin Healthcare Research Institute, Minneapolis, MN, United States.

Individual differences in vulnerability to addiction have been widely studied through factor analysis (FA) in humans, a statistical method that identifies "latent" variables (variables that are not measured directly) that reflect the common variance among a larger number of observed measures. Despite its widespread application in behavioral genetics, FA has not been used in preclinical opioid addiction research. The current study used FA to examine the latent factor structure of four measures of i. Read More

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September 2021

Incorporation of causality structures to complex network analysis of time-varying behaviour of multivariate time series.

Sci Rep 2021 Sep 23;11(1):18880. Epub 2021 Sep 23.

University College London, Computer Science, London, WC1E 6EA, UK.

This paper presents a new methodology for characterising the evolving behaviour of the time-varying causality between multivariate time series, from the perspective of change in the structure of the causality pattern. We propose that such evolutionary behaviour should be tracked by means of a complex network whose nodes are causality patterns and edges are transitions between those patterns of causality. In our new methodology each edge has a weight that includes the frequency of the given transition and two metrics relating to the gross and net structural change in causality pattern, which we call [Formula: see text] and [Formula: see text]. Read More

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September 2021

Air quality prediction using CNN+LSTM-based hybrid deep learning architecture.

Environ Sci Pollut Res Int 2021 Sep 23. Epub 2021 Sep 23.

Electrical & Electronics Engineering Department, Kadir Has University, Fatih, Istanbul, Turkey.

Air pollution prediction based on variables in environmental monitoring data gains further importance with increasing concerns about climate change and the sustainability of cities. Modeling of the complex relationships between these variables by sophisticated methods in machine learning is a promising field. The objectives of this work are to develop a supervised model for the prediction of air pollution by using real sensor data and to transfer the model between cities. Read More

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September 2021

Haploidentical vs. sibling, unrelated, or cord blood hematopoietic cell transplantation for acute lymphoblastic leukemia.

Blood Adv 2021 Sep 21. Epub 2021 Sep 21.

University of Virginia, Charlottesville, Virginia, United States.

The role of haploidentical hematopoietic cell transplantation (HCT) using post-transplant cyclophosphamide (PTCy) for acute lymphoblastic leukemia (ALL) is being defined. We performed a retrospective, multivariate analysis comparing outcomes of HCT approaches by donor for adults with ALL in remission. The primary objective was to compare overall survival (OS) between haploidentical HCT using PTCy and HLA-matched sibling donor (MSD), 8/8 HLA-matched unrelated donor (MUD) , 7/8 HLA-matched UD, or umbilical cord blood (UCB) HCT. Read More

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September 2021

A tool for evaluating novel osteoarthritis therapies using multivariate analyses of human cartilage-synovium explant co-culture.

Osteoarthritis Cartilage 2021 Sep 18. Epub 2021 Sep 18.

Osteoarthritis Research Program, Division of Orthopedic Surgery, Schroeder Arthritis Institute, University Health Network, Canada; Krembil Research Institute, University Health Network, Canada; Institute of Biomedical Engineering, University of Toronto, Canada; Division of Hematology, Department of Medicine, University of Toronto, Canada. Electronic address:

Objective: There is a need to incorporate multiple tissues into in vitro OA models to evaluate novel therapeutics. This approach is limited by inherent donor variability. We present an optimized research tool: a human OA cartilage-synovium explant co-culture model (OA-EXM) that employs donor-matched lower and upper limit response controls combined with statistical approaches to address variability. Read More

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September 2021

Multi-level multi-modality (PET and CT) fusion radiomics: Prognostic modeling for non-small cell lung carcinoma.

Phys Med Biol 2021 Sep 20. Epub 2021 Sep 20.

Division of Nuclear Medicine, University Hospital of Geneva, 24 Rue Micheli-du-Crest, 1211 Geneva 4, Geneva, SWITZERLAND.

We developed multi-modality radiomic models by integrating information extracted from 18F-FDG PET and CT images using feature- and image-level fusions, toward improved prognosis for non-small cell lung carcinoma (NSCLC) patients. Two independent cohorts of NSCLC patients from two institutions (87 and 95 patients) were cycled as training and testing datasets. Fusion approaches were applied at two levels, namely feature- and image-levels. Read More

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September 2021

Metabolomics profile responses to changing environments in a common bean (Phaseolus vulgaris L.) germplasm collection.

Food Chem 2021 Aug 31;370:131003. Epub 2021 Aug 31.

Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República, 2780-157 Oeiras, Portugal; iBET, Instituto de Biologia Experimental e Tecnológica, Av. da República, Apartado 12, 2781-901 Oeiras, Portugal; Faculdade de Farmácia, Universidade de Lisboa, Av. das Forças Armadas, 1649-019 Lisboa, Portugal. Electronic address:

Metabolomics is one of the most powerful -omics to assist plant breeding. Despite the recognized genetic diversity in Portuguese common bean germplasm, details on its metabolomics profiles are still missing. Aiming to promote their use and to understand the environment's effect in bean metabolomics profiles, 107 Portuguese common bean accessions, cropped under contrasting environments, were analyzed using spectrophotometric, untargeted and targeted mass spectrometry approaches. Read More

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Exploring the Pleiotropic Genes and Therapeutic Targets Associated with Heart Failure and Chronic Kidney Disease by Integrating metaCCA and SGLT2 Inhibitors' Target Prediction.

Biomed Res Int 2021 8;2021:4229194. Epub 2021 Sep 8.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.

Background: Previous studies have shown that heart failure (HF) and chronic kidney disease (CKD) have common genetic mechanisms, overlapping pathophysiological pathways, and therapeutic drug-sodium-glucose cotransporter 2 (SGLT2) inhibitors.

Methods: The genetic pleiotropy metaCCA method was applied on summary statistics data from two independent meta-analyses of GWAS comprising more than 1 million people to identify shared variants and pleiotropic effects between HF and CKD. Targets of SGLT2 inhibitors were predicted by SwissTargetPrediction and DrugBank databases. Read More

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September 2021

The "DOLPHINS" Project: A Low-Cost Real-Time Multivariate Process Control From Large Sensor Arrays Providing Sparse Binary Data.

Front Chem 2021 3;9:734132. Epub 2021 Sep 3.

Dipartimento di Chimica, Università Degli Studi di Torino, Torino, Italy.

The "DOLPHINS" project started in 2018 under a collaboration between three partners: CNH Industrial Iveco (CHNi), RADA (an informatics company), and the Chemistry Department of the University of Turin. The project's main aim was to establish a predictive maintenance method in real-time at a pilot plant (CNHi Iveco, Brescia, Italy). This project currently allows maintenance technicians to intervene on machinery preventively, avoiding breakdowns or stops in the production process. Read More

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September 2021

Analysis of multivariate longitudinal immuno-epidemiological data using a pairwise joint modelling approach.

BMC Immunol 2021 Sep 17;22(1):63. Epub 2021 Sep 17.

MRC International Statistics and Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Background: Immuno-epidemiologists are often faced with multivariate outcomes, measured repeatedly over time. Such data are characterised by complex inter- and intra-outcome relationships which must be accounted for during analysis. Scientific questions of interest might include determining the effect of a treatment on the evolution of all outcomes together, or grouping outcomes that change in the same way. Read More

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September 2021

Initial therapy of chronic graft vs. host disease: Analysis of practice variation and failure-free survival.

Blood Adv 2021 Sep 17. Epub 2021 Sep 17.

Fred Hutchinson Cancer Research Center, SEATTLE, Washington, United States.

Prior clinical trials largely considered prednisone 1mg/kg/day with or without calcineurin inhibitor as standard initial therapy for chronic graft vs. host disease (cGVHD) but uncertainty remains regarding the extent of practice variation and whether this affects subsequent outcomes. We assembled a cohort of 745 cGVHD patients treated with initial systemic immune suppressive (IS) therapy from three prior Chronic GVHD Consortium observational studies. Read More

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September 2021

Alcohol and Cannabis Cross Motives, Class Analysis, and Substance Use among Concurrent Users.

Subst Use Misuse 2021 Sep 17:1-11. Epub 2021 Sep 17.

Department of Psychological Sciences, Texas Tech University, Lubbock, Texas, USA.

Substance use motives refer to an individual's reasons for engaging in substance use. Although the respective alcohol and cannabis literatures have linked specific substance-use motives to indices of use, less is known about motives in concurrent users, particularly examination of cross-motives (e.g. Read More

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September 2021

Application of the experimental design in the optimization of a procedure for antimony (Sb) remediation in environmental samples employing mesoporous array.

Environ Sci Pollut Res Int 2021 Sep 16. Epub 2021 Sep 16.

CDMF, Polymer Laboratory, Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, 13565-905, Brazil.

This study describes the sustainable and eco-friendly synthesis of the silica-based mesoporous structure from the use of alternative amorphous silica extracted from rice husk ash (RHA). The mesoporous material was called MCM-48 (RHA), and its application as adsorbent to the antimony (Sb) remediation in environmental samples was tested. The adsorbent was prepared by an efficient and sustainable hydrothermal method, which exhibited an amorphous framework with type IV isotherms and type H1 hysteresis, and surface area, total pore volume, and pore diameter values of 820. Read More

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September 2021

Milk metabolome reveals variations on enteric methane emissions from dairy cows fed a specific inhibitor of the methanogenesis pathway.

J Dairy Sci 2021 Sep 13. Epub 2021 Sep 13.

INRAE, Université Clermont Auvergne, Vetagro Sup, UMRH, 63122, Saint-Genès-Champanelle, France. Electronic address:

Metabolome profiling in biological fluids is an interesting approach for exploring markers of methane emissions in ruminants. In this study, a multiplatform metabolomics approach was used for investigating changes in milk metabolic profiles related to methanogenesis in dairy cows. For this purpose, 25 primiparous Holstein cows at similar lactation stage were fed the same diet supplemented with (treated, n = 12) or without (control, n = 13) a specific antimethanogenic additive that reduced enteric methane production by 23% with no changes in intake, milk production, and health status. Read More

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September 2021

Biomarkers for autism spectrum disorder: opportunities for magnetoencephalography (MEG).

J Neurodev Disord 2021 Sep 15;13(1):34. Epub 2021 Sep 15.

Dept. of Radiology, Lurie Family Foundations MEG Imaging Center, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

This paper reviews a candidate biomarker for ASD, the M50 auditory evoked response component, detected by magnetoencephalography (MEG) and presents a position on the roles and opportunities for such a biomarker, as well as converging evidence from allied imaging techniques (magnetic resonance imaging, MRI and spectroscopy, MRS). Data is presented on prolonged M50 latencies in ASD as well as extension to include children with ASD with significant language and cognitive impairments in whom M50 latency delays are exacerbated. Modeling of the M50 latency by consideration of the properties of auditory pathway white matter is shown to be successful in typical development but challenged by heterogeneity in ASD; this, however, is capitalized upon to identify a distinct subpopulation of children with ASD whose M50 latencies lie well outside the range of values predictable from the typically developing model. Read More

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September 2021

Alternative Approaches to Ensuring Adequate Nurse Staffing: The Effect of State Legislation on Hospital Nurse Staffing.

Med Care 2021 Oct;59(Suppl 5):S463-S470

Trachtenberg School of Public Policy and Public Administration, The George Washington University, Washington, DC.

Objective: The objective of this study was to addresses the basic question of whether alternative legislative approaches are effective in encouraging hospitals to increase nurse staffing.

Methods: Using 16 years of nationally representative hospital-level data from the American Hospital Association (AHA) annual survey, we employed a difference-in-difference design to compare changes in productive hours per patient day for registered nurses (RNs), licensed practical/vocational nurses (LPNs), and nursing assistive personnel (NAP) in the state that mandated staffing ratios, states that legislated staffing committees, and states that legislated public reporting, to changes in states that did not implement any nurse staffing legislation before and after the legislation was implemented. We constructed multivariate linear regression models to assess the effects with hospital and year fixed effects, controlling for hospital-level characteristics and state-level factors. Read More

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October 2021

Using structure-function relationships to understand the mechanism of phenazine-mediated extracellular electron transfer in .

iScience 2021 Sep 25;24(9):103033. Epub 2021 Aug 25.

Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA.

Phenazines are redox-active nitrogen-containing heterocyclic compounds that can be produced by either bacteria or synthetic approaches. As an electron shuttles (mediators), phenazines are involved in several biological processes facilitating extracellular electron transfer (EET). Therefore, it is of great importance to understand the structural and electronic properties of phenazines that promote EET in microbial electrochemical systems. Read More

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September 2021

Prenatal exposure to neurotoxic metals and micronutrients and neurodevelopmental outcomes in early school age children from Poland.

Environ Res 2021 Sep 11:112049. Epub 2021 Sep 11.

Department of Environmental and Occupational Health Hazards, Nofer Institute of Occupational Medicine, 91-348, Lodz, Poland; Department of Hygiene and Epidemiology, Medical University of Lodz, 90-752, Lodz, Poland. Electronic address:

Exposure to environmental factors, such as neurotoxic metals and micronutrients, during critical periods of development can contribute to long-term consequences in offspring's health, including neurodevelopmental outcomes. The aim of this study was to evaluate the association between simultaneous prenatal exposure to metals [lead (Pb), cadmium (Cd), mercury (Hg)] and micronutrients [selenium (Se), zinc (Zn), copper (Cu)] and neurodevelopmental outcomes in school-age children from the Polish Mother and Child Cohort (REPRO_PL). Metals and micronutrients concentrations were measured in cord blood (Pb, Cd, Se, Zn, Cu) and in maternal hair (Hg) collected during the 3rd trimester of pregnancy. Read More

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September 2021

TUBA1C expression promotes proliferation by regulating the cell cycle and indicates poor prognosis in glioma.

Biochem Biophys Res Commun 2021 Sep 8;577:130-138. Epub 2021 Sep 8.

Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330000, China; Nanchang University, Nanchang, Jiangxi Province, 330000, China. Electronic address:

Gliomas are the major type of primary brain tumors. Accumulating research has demonstrated that tubulin is connected with the development and malignant progression of tumors. TUBA1C is a subtype of α-tubulin and is linked to prognosis in multiple cancers. Read More

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September 2021

Gender Disparities in Anti-dementia Medication Use among Older Adults: Health Equity Considerations and Management of Alzheimer's Disease and Related Dementias.

Front Pharmacol 2021 25;12:706762. Epub 2021 Aug 25.

Department of Pharmaceutical and Administrative Sciences, Presbyterian College School of Pharmacy, Clinton, SC, United States.

The prevalence of Alzheimer's disease and related dementias (ADRD) in women is higher than men. However, the knowledge of gender disparity in ADRD treatment is limited. Therefore, this study aimed to determine the gender disparities in the receipt of anti-dementia medications among Medicare beneficiaries with ADRD in the U. Read More

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Increased Angiogenin Expression Correlates With Radiation Resistance and Predicts Poor Survival for Patients With Nasopharyngeal Carcinoma.

Front Pharmacol 2021 26;12:627935. Epub 2021 Aug 26.

State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

Despite the development of such multiple therapeutic approaches, approximately 20% patients experience recurrence. Identification of molecular markers for stratifying the different risks of tumour recurrence and progression is considered imperative. We used a RayBio Human Cytokine Antibody Array that simultaneously detected the levels of 297 proteins and profiled the conditioned medium of HONE1 cells and the radioresistant NPC cells HONE1-IR. Read More

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Chemometric quality assessment of Paracetamol and Phenylephrine Hydrochloride with Paracetamol impurities; comparative UV-spectrophotometric implementation of four predictive models.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Sep 2;265:120308. Epub 2021 Sep 2.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr-El-Aini, 11562 Cairo, Egypt.

Spectrophotometric data analysis using multivariate approaches has many useful applications. One of these applications is the analysis of active ingredients in presence of impurities. Four chemometric-assisted spectrophotometric methods, namely, principal component regression (PCR), partial least-squares (PLS), artificial neural networks (ANN) and multivariate curve resolution-alternating least squares (MCR-ALS) were proposed and validated. Read More

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September 2021

Bayesian Uncertainty Estimation of Learned Variational MRI Reconstruction.

IEEE Trans Med Imaging 2021 Sep 10;PP. Epub 2021 Sep 10.

Recent deep learning approaches focus on improving quantitative scores of dedicated benchmarks, and therefore only reduce the observation-related (aleatoric) uncertainty. However, the model-immanent (epistemic) uncertainty is less frequently systematically analyzed. In this work, we introduce a Bayesian variational framework to quantify the epistemic uncertainty. Read More

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September 2021

Arthroscopic distal clavicle excision is associated with fewer postoperative complications than open.

JSES Int 2021 Sep 14;5(5):856-862. Epub 2021 Jul 14.

Hospital for Special Surgery, Shoulder Service, New York, NY, USA.

Background: The rate of complications of open compared to arthroscopic distal clavicle excision remain poorly studied. Therefore, the purpose of this investigation was to (1) Identify most recent national trends in the usage of open vs. arthroscopic approaches for distal clavicle excision (DCE) from 2007 to 2017; (2) to identify and compare the complication rates for both approaches, and to identify patient-specific risk factors for complications; (3) to identify and compare the revision rate for both approaches; and (4) to identify and compare the reimbursement of each approach. Read More

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September 2021

The Use of Computational Methods for the Development of Molecularly Imprinted Polymers.

Polymers (Basel) 2021 Aug 24;13(17). Epub 2021 Aug 24.

Bioorganic & Biophysical Chemistry Laboratory, Linnaeus University Centre for Biomaterials Chemistry, Department of Chemistry & Biomedical Sciences, Linnaeus University, SE-391 82 Kalmar, Sweden.

Recent years have witnessed a dramatic increase in the use of theoretical and computational approaches in the study and development of molecular imprinting systems. These tools are being used to either improve understanding of the mechanisms underlying the function of molecular imprinting systems or for the design of new systems. Here, we present an overview of the literature describing the application of theoretical and computational techniques to the different stages of the molecular imprinting process (pre-polymerization mixture, polymerization process and ligand-molecularly imprinted polymer rebinding), along with an analysis of trends within and the current status of this aspect of the molecular imprinting field. Read More

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