83,506 results match your criteria multivariable analysis


Postoperative Neutrophil to Lymphocyte Ratio as an Overall Mortality Midterm Prognostic Factor following OPCAB Procedures.

Clin Pract 2021 Sep 3;11(3):587-597. Epub 2021 Sep 3.

Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Poznan, Poland.

Background: Off-pump coronary artery bypass grafting (OPCAB) is believed to limit inflammatory reaction. Neutrophil to lymphocyte ratio (NLR) is one of the more common and easily accessible markers of inflammatory response. The aim of the study was to compare postoperative results of NLR with mid-term OPCAB results. Read More

View Article and Full-Text PDF
September 2021

Variables Associated with Coronavirus Disease 2019 Vaccine Hesitancy Amongst Patients with Neurological Disorders.

Infect Dis Rep 2021 Aug 30;13(3):763-810. Epub 2021 Aug 30.

John A. Burns School of Medicine, University of Hawai'i at Mānoa, Honolulu, HI 96813, USA.

Introduction: Given that the success of vaccines against coronavirus disease 2019 (COVID-19) relies on herd immunity, identifying patients at risk for vaccine hesitancy is imperative-particularly for those at high risk for severe COVID-19 (i.e., minorities and patients with neurological disorders). Read More

View Article and Full-Text PDF

The Use of Patient Reported Outcome Measures (PROMs) 6 Months Post-Stroke and Their Association with the National Institute of Health Stroke Scale (NIHSS) on Admission to Hospital.

Geriatrics (Basel) 2021 Sep 7;6(3). Epub 2021 Sep 7.

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London WC2R 2LS, UK.

Patient Reported Outcome Measures (PROMs) assess clinical outcomes from the perspective of the patient. The stroke community recommended fifteen questions for use in stroke survivors, based on the established PROMIS10 with five additional stroke-specific questions. This study aimed to determine its association with the National Institute of Health Stroke Scale (NIHSS) on admission. Read More

View Article and Full-Text PDF
September 2021

Association between osteosarcopenia and cognitive frailty in older outpatients visiting a frailty clinic.

Arch Gerontol Geriatr 2021 Sep 17;98:104530. Epub 2021 Sep 17.

Department of Geriatric Medicine, Hospital, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi 474-8511, Japan. Electronic address:

Purpose: Osteosarcopenia and cognitive frailty are both risk factors for falls and fractures. The purpose of this study was to determine the association between osteosarcopenia and cognitive frailty.

Materials And Methods: This was a cross-sectional secondary data analysis of the Frailty Registry Study with outpatients aged ≥65 years who visited a frailty clinic at a geriatric hospital. Read More

View Article and Full-Text PDF
September 2021

Predicting if lung cancer will relapse-The role of neutrophil/lymphocyte ratio.

Hematol Oncol Stem Cell Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Hematology and Medical Oncology, Sinai Hospital of Baltimore, Baltimore, MD 21215, USA.

Objective/background: Baseline neutrophil/lymphocyte ratio (NLR), a surrogate marker for systemic inflammation and immunosuppression, is a well-studied prognostic marker in non-small cell lung cancer (NSCLC). This study tests if interim NLR is prognostic in NSCLC patients in remission.

Methods: This single-center, retrospective cohort study analyzed 131 NSCLC patients treated from 2010 to 2015 who achieved complete remission. Read More

View Article and Full-Text PDF
September 2021

Risk factors for Immune-related Adverse Events from anti-PD-1 or anti PD-L1 treatment in an Asian cohort of non-small cell lung cancer patients.

Int J Cancer 2021 Sep 25. Epub 2021 Sep 25.

Dept of Haematology-Oncology, National University Cancer Institute, Singapore.

Immune-related adverse events (IrAEs) of immune checkpoint inhibitors (ICIs) can be serious and unpredictable. We examine the incidence rate and risk factors for IrAEs in an Asian cohort of non-small cell lung cancer (NSCLC) patients treated with immunotherapy. Between June 2014 to August 2020, we retrospectively analyzed IrAEs in NSCLC patients treated with Anti-PD-1 or Anti-PD-L1 inhibitors at the National University Cancer Institute Singapore. Read More

View Article and Full-Text PDF
September 2021

Retrospective review of confluent and reticulated papillomatosis in pediatric patients.

Pediatr Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Section of Dermatology, Department of Medicine and Pediatrics, University of Chicago Medical Center, Chicago, IL, USA.

Background/objectives: Confluent and reticulated papillomatosis is a skin condition with unclear etiology and limited understanding of risk factors, comorbidities, and treatment strategies in the pediatric population. This study aims to describe the varied presentations and outcomes of confluent and reticulated papillomatosis and report associated comorbidities in pediatric patients.

Methods: In this retrospective single-institution case-control study, pediatric patients with a diagnosis of confluent and reticulated papillomatosis seen between 2012 and 2020 were matched approximately 1:5 with an acne vulgaris cohort based on diagnosis, setting, and time period when seen. Read More

View Article and Full-Text PDF
September 2021

Prediction of vaginal birth after cesarean for labor dystocia by sonographic estimated fetal weight.

Int J Gynaecol Obstet 2021 Sep 24. Epub 2021 Sep 24.

Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat-Gan, Israel.

Objective: To estimate the association of the weight difference between the index TOLAC sonographic estimated fetal weight (sEFW) and prior delivery birthweight with TOLAC success rate, among women with previous labor dystocia and no prior vaginal delivery.

Methods: A retrospective cohort study including all women with prior cesarean for labor dystocia and no prior vaginal delivery undergoing TOLAC during 3/2011-6/2020 with a sonographic estimated fetal weight within one week from delivery.

Results: Overall 168 women were included, of those 107 (63. Read More

View Article and Full-Text PDF
September 2021

Clinical significance of part-solid lung cancer in the eighth edition TNM staging system.

Interact Cardiovasc Thorac Surg 2021 Sep 25. Epub 2021 Sep 25.

Department of Thoracic and Breast Surgery, Oita University Faculty of Medicine, Oita, Japan.

Objectives: The ground-glass component of part-solid tumour (PST) was eliminated as a clinical T (cT) descriptor in the eighth edition of the tumour, node and metastasis (TNM) staging system. We aimed to validate the new cT descriptor and investigate the prognostic impact of PST in the new staging system.

Methods: Non-small-cell lung cancer (NSCLC) patients (n = 1061) who underwent lung resection and were available for the assessment of thin-section computed tomography images were retrospectively reviewed. Read More

View Article and Full-Text PDF
September 2021

The blood pressure control and arteriosclerotic cardiovascular risk among Chinese community hypertensive patients.

Sci Rep 2021 Sep 24;11(1):19066. Epub 2021 Sep 24.

Department of Chronic and Non-Infection Disease Control and Prevention, Hangzhou Center for Disease Control and Prevention, Mingshi Road No.568, Hangzhou, 310021, China.

The present study aimed to describe the blood pressure (BP) control rate and 10-years arteriosclerotic cardiovascular disease (ASCVD) risk estimation among community hypertensive patients. A total of 196,803 subjects were enrolled. The control rates calculated as the intensive (SBP < 130 mmHg and DBP < 80 mmHg) and standard (SBP < 140 mmHg and DBP < 90 mmHg) threshold. Read More

View Article and Full-Text PDF
September 2021

Risk of serious infection with low-dose glucocorticoids in patients with rheumatoid arthritis: an instrumental variable analysis.

Epidemiology 2021 Sep 20. Epub 2021 Sep 20.

University of Pennsylvania, Division of Rheumatology, Philadelphia, Pennsylvania, UA University of Pennsylvania, Department of Biostatistics, Epidemiology, and Informatics, Philadelphia, Pennsylvania, UA University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology, Birmingham, Alabama, UA.

Background: Low-dose glucocorticoids are commonly used in the treatment of rheumatoid arthritis (RA). Observational studies have found increased risk of serious infection associated with low-dose glucocorticoids, but concerns about residual confounding remain.

Methods: We identified adults with RA on stable immunomodulatory therapy for >6 months receiving no glucocorticoids or ≤5mg/day using Medicare data from 2006-2015. Read More

View Article and Full-Text PDF
September 2021

Knowledge, attitude and practice of antibiotics and their determinants in Eritrea: an urban population-based survey.

BMJ Open 2021 Sep 24;11(9):e046432. Epub 2021 Sep 24.

Department of Statistics, Eritrean Institute Technology, Asmara, Eritrea.

Objective: To measure knowledge, attitude and practice of antibiotics and antibiotic resistance (ABR) and their determinants in the Eritrean urban population.

Design: A population-based, nation-wide, cross-sectional study.

Setting: Urban settings of Eritrea. Read More

View Article and Full-Text PDF
September 2021

A Nomogram for the Prediction of Intermediate Significant Renal Function Loss After Robot-assisted Partial Nephrectomy for Localized Renal Tumors: A Prospective Multicenter Observational Study (RECORd2 Project).

Eur Urol Focus 2021 Sep 21. Epub 2021 Sep 21.

Department of Urology, Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, University of Florence, Florence, Italy. Electronic address:

Background: Robot-assisted partial nephrectomy (RAPN) is increasingly adopted for the treatment of localized renal tumors; however, rates and predictors of significant renal function (RF) loss after RAPN are still poorly investigated, especially at a long-term evaluation.

Objective: To analyze the predictive factors and develop a clinical nomogram for predicting the likelihood of ultimate RF loss after RAPN.

Design, Setting, And Participants: We prospectively evaluated all patients treated with RAPN in a multicenter series (RECORd2 project). Read More

View Article and Full-Text PDF
September 2021

A first trimester prediction model for large for gestational age infants: a preliminary study.

BMC Pregnancy Childbirth 2021 Sep 24;21(1):654. Epub 2021 Sep 24.

Obstetrics Unit, Mother Infant Department, University Hospital Policlinico of Modena, Modena, Italy.

Background: Large for gestational age infants (LGA) have increased risk of adverse short-term perinatal outcomes. This study aims to develop a multivariable prediction model for the risk of giving birth to a LGA baby, by using biochemical, biophysical, anamnestic, and clinical maternal characteristics available at first trimester.

Methods: Prospective study that included all singleton pregnancies attending the first trimester aneuploidy screening at the Obstetric Unit of the University Hospital of Modena, in Northern Italy, between June 2018 and December 2019. Read More

View Article and Full-Text PDF
September 2021

Systemic Immune-Inflammation Index Predicts Delayed Cerebral Vasospasm After Aneurysmal Subarachnoid Hemorrhage.

Neurosurgery 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurology and Rehabilitation, University of Illinois College of Medicine, Chicago, Illinois, USA.

Background: Delayed cerebral vasospasm is a feared complication of aneurysmal subarachnoid hemorrhage (SAH).

Objective: To investigate the relationship of systemic inflammation, measured using the systemic immune-inflammation (SII) index, with delayed angiographic or sonographic vasospasm. We hypothesize that early elevations in SII index serve as an independent predictor of vasospasm. Read More

View Article and Full-Text PDF
September 2021

Association Between Hyperoxemia and Increased Cell-Free Plasma Hemoglobin During Cardiopulmonary Bypass in Infants and Children.

Pediatr Crit Care Med 2021 Sep 24. Epub 2021 Sep 24.

Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA. Department of Pediatrics, Division of Critical Care Medicine, Ochsner Hospital for Children, New Orleans, LA. Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA. UPMC Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA. Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA.

Objectives: To determine potential risk factors for severe hemolysis during pediatric cardiopulmonary bypass and examine whether supraphysiologic levels of oxygen and cardiopulmonary bypass duration are associated with hemolysis.

Design: Prospective observational study.

Setting: Cardiac ICU in a university-affiliated children's hospital. Read More

View Article and Full-Text PDF
September 2021

Pediatric Sepsis Biomarker Risk Model Biomarkers and Estimation of Myocardial Dysfunction in Pediatric Septic Shock.

Pediatr Crit Care Med 2021 Sep 27. Epub 2021 Sep 27.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH. Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Objectives: Sepsis-associated myocardial dysfunction is common in pediatric septic shock and negatively impacts outcomes. Early estimation of sepsis-associated myocardial dysfunction risk has the potential to inform clinical care and improve clinical trial design. The Pediatric Sepsis Biomarker Risk Model II is validated as a biomarker-based enrichment algorithm to discriminate children with septic shock with high baseline mortality probability. Read More

View Article and Full-Text PDF
September 2021

HIV is Associated with Impaired Pulmonary Diffusing Capacity Independent of Emphysema.

J Acquir Immune Defic Syndr 2021 Sep 24. Epub 2021 Sep 24.

Johns Hopkins University School of Medicine, Baltimore, MD Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC.

Background: HIV is associated with accelerated decline in lung function and increased risk for Chronic Obstructive Pulmonary Disease (COPD). Recently there has been growing attention towards the impairment in the diffusing capacity of the lungs for carbon monoxide (DLCO), a marker of pulmonary gas exchange, observed among persons living with HIV. While increased emphysema can contribute to the DLCO impairment observed, other factors may drive this association. Read More

View Article and Full-Text PDF
September 2021

Intra-operative ventilator mechanical power as a predictor of postoperative pulmonary complications in surgical patients: A secondary analysis of a randomised clinical trial.

Eur J Anaesthesiol 2021 Sep 22. Epub 2021 Sep 22.

From the Department of Anaesthesia (DK, LW, PP, LE, RH, BP, COT, DS, MOD, PH, CO, JG), Department of Intensive Care, Austin Hospital (DK, ASN, AW, GE, RB, DAJ), Department of Critical Care (DK, ASN, PP, LE, RH, BP, COT, DS, RB), Department of Surgery, University of Melbourne (LW, LE, RH, BP, COT), Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University (ASN, RB, DAJ), Data Analytics Research and Evaluation (DARE) Centre, University of Melbourne, Melbourne, Victoria, Australia (ASN, RB) and Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil (ASN).

Background: Studies in critically ill patients suggest a relationship between mechanical power (an index of the energy delivered by the ventilator, which includes driving pressure, respiratory rate, tidal volume and inspiratory pressure) and complications.

Objective: We aimed to assess the association between intra-operative mechanical power and postoperative pulmonary complications (PPCs).

Design: Post hoc analysis of a large randomised clinical trial. Read More

View Article and Full-Text PDF
September 2021

The diagnostic accuracy of MRI and nonenhanced CT for high-risk vertebral artery anatomy for subaxial anterior cervical spine surgery safety.

J Neurosurg Spine 2021 Sep 24:1-8. Epub 2021 Sep 24.

1Spine Care Institute, Hospital for Special Surgery, New York, New York.

Objective: Medial migration of the vertebral artery (VA) can be a risk factor for injury during anterior procedures. CT angiography (CTA) has been considered the gold standard for the evaluation of various areas of the arterial anatomy. MRI and nonenhanced CT are more commonly used as routine preoperative imaging studies, but it is unclear if these modalities can safely exclude the anomalous course of the VA. Read More

View Article and Full-Text PDF
September 2021

The safety and efficacy of dexamethasone in the perioperative management of glioma patients.

J Neurosurg 2021 Sep 24:1-8. Epub 2021 Sep 24.

1Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Objective: In this single-institution retrospective cohort study, the authors evaluated the effect of dexamethasone on postoperative complications and overall survival in patients with glioma undergoing resection.

Methods: A total of 435 patients who underwent resection of a primary glioma were included in this retrospective cohort study. The inclusion criterion was all patients who underwent resection of a primary glioma at a tertiary medical center between 2014 and 2019. Read More

View Article and Full-Text PDF
September 2021

Clinical and radiologic outcomes after stereotactic radiosurgery for meningiomas in direct contact with the optic apparatus: an international multicenter study.

J Neurosurg 2021 Sep 24:1-7. Epub 2021 Sep 24.

17Department of Radiation Oncology, University of Southern California, Los Angeles, California.

Objective: Resection of meningiomas in direct contact with the anterior optic apparatus carries risk of injury to the visual pathway. Stereotactic radiosurgery (SRS) offers a minimally invasive alternative. However, its use is limited owing to the risk of radiation-induced optic neuropathy. Read More

View Article and Full-Text PDF
September 2021

Time to return to work after elective lumbar spine surgery.

J Neurosurg Spine 2021 Sep 24:1-9. Epub 2021 Sep 24.

1Combined Neurosurgical and Orthopedic Spine Service, Department of Orthopedic Surgery, University of British Columbia, Vancouver, British Columbia.

Objective: Time to return to work (RTW) after elective lumbar spine surgery is variable and dependent on many factors including patient, work-related, and surgical factors. The primary objective of this study was to describe the time and rate of RTW after elective lumbar spine surgery. Secondary objectives were to determine predictors of early RTW (< 90 days) and no RTW in this population. Read More

View Article and Full-Text PDF
September 2021

Risk factors for unchanged ventricles during pediatric shunt malfunction.

J Neurosurg Pediatr 2021 Sep 24:1-7. Epub 2021 Sep 24.

1Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville.

Objective: Children whose ventricles do not change during shunt malfunction present a diagnostic dilemma. This study was performed to identify risk factors for unchanged ventricular size at shunt malfunction.

Methods: This retrospective 1:1 age-matched case-control study identified children with shunted hydrocephalus who underwent shunt revision with intraoperative evidence of malfunction at one of the three participating institutions from 1997 to 2019. Read More

View Article and Full-Text PDF
September 2021

Dietary patterns and risk of non-alcoholic fatty liver disease in adults: A prospective cohort study.

Clin Nutr 2021 Sep 4;40(10):5373-5382. Epub 2021 Sep 4.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China; Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China; Health Management Centre, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China; Center for International Collaborative Research on Environment, Nutrition and Public Health, Tianjin, China. Electronic address:

Background And Aims: Prospective cohort studies linking dietary patterns and non-alcoholic fatty liver disease (NAFLD) are limited, especially in Asian populations. This study aimed to prospectively investigate the association between dietary patterns and risk of NAFLD in a general Chinese adult population.

Methods: This study included a total of 17,360 participants free from NAFLD at baseline. Read More

View Article and Full-Text PDF
September 2021

Risk factor analysis for Salmonella contamination of broiler chicken (Gallus gallus) hatcheries in Great Britain.

Prev Vet Med 2021 Sep 13;196:105492. Epub 2021 Sep 13.

Department of Bacteriology, Animal and Plant Health Agency (APHA - Weybridge), Woodham Lane, New Haw, Addlestone, KT15 3NB, UK.

Salmonellosis is the second most commonly reported zoonosis in the European Union and contaminated meat from broiler chickens (Gallus gallus) is an important source of human infection. In Great Britain (GB), prevalence of Salmonella enterica in broiler flocks is low, having declined considerably since the introduction of the Salmonella National Control Programme in 2010. However, this decreasing trend has stabilised in recent years and serovars with known ability to persistently colonise hatcheries have been isolated from broiler flocks with increasing frequency, indicating that further controls on hatchery contamination are required. Read More

View Article and Full-Text PDF
September 2021

Food Acquisition and Shopping Patterns in the United States: Characteristics and Relation to BMI in FoodAPS.

J Acad Nutr Diet 2021 Sep 21. Epub 2021 Sep 21.

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina. Electronic address:

Background: Previous studies examined the association between shopping distance, frequency, and store type separately.

Objectives: The objective is to explore food acquisition and shopping habits using multi-dimensional measures and examine its association with body mass index (BMI).

Design: A cross-sectional study was conducted. Read More

View Article and Full-Text PDF
September 2021

In-hospital and one-year outcomes are similar for women and men following transcarotid artery revascularization in symptomatic and asymptomatic patients.

J Vasc Surg 2021 Sep 21. Epub 2021 Sep 21.

Division of Vascular Surgery and Endovascular Therapy, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:

Objectives: In randomized controlled trials and retrospective series, women have higher rates of periprocedural stroke and death following carotid endarterectomy and transfemoral carotid artery stenting compared to men. We sought to compare outcomes by sex following transcarotid artery revascularization (TCAR) among patients in the Vascular Quality Initiative (VQI).

Methods: We reviewed all patients in the VQI who underwent TCAR from 2017 to 2020. Read More

View Article and Full-Text PDF
September 2021

Prevalence and associated factors of needle stick and sharps injuries among healthcare workers in northwestern Ethiopia.

PLoS One 2021 24;16(9):e0252039. Epub 2021 Sep 24.

Department of Epidemiology and Biostatistics, School of Public Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

Background: Needle stick and sharp injuries (NSSIs) are a common problem among healthcare workers (HCWs). Although the factors related to NSSIs for HCWs are well documented by several studies in Ethiopia, no evidence has been reported about the magnitude of and factors related to NSSIs in hospitals in northwestern Ethiopia.

Methods: An institution-based cross-sectional study was carried out from January to March 2019 among 318 HCWs in three randomly-selected hospitals of the eight hospitals found in South Gondar Zone. Read More

View Article and Full-Text PDF
September 2021