2,951 results match your criteria multisystem inflammatory


Multisystem Inflammatory Syndrome in Children (MIS-C): Experiences With a New Disease Process.

J Neurosurg Anesthesiol 2022 Jan;34(1):127-131

Division of Pediatric Anesthesiology, Department of Anesthesiology, Columbia University, New York, NY.

On March 20, 2021, the Columbia University Department of Anesthesiology hosted the Papper virtual event dedicated to an academic discussion of various aspects of coronavirus disease-2019. Dr. Eva Cheung, a pediatric intensivist and pediatric cardiologist, spoke about the clinical challenges associated with tackling multisystem inflammatory syndrome in children, a novel clinical entity in pediatric patients related to coronavirus disease-2019, and the experience with confronting multisystem inflammatory syndrome in children in New York. Read More

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January 2022

SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center.

Arch Rheumatol 2021 Sep 9;36(3):381-388. Epub 2021 Feb 9.

Department of Child Health and Diseases, Pediatric Infectious Disease, Ümraniye Training and Research Hospital, Istanbul, Turkey.

Objectives: In this study, we present our clinical severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) experience in patients with childhood rheumatic disease during novel coronavirus-2019 (COVID-19) pandemic.

Patients And Methods: A total of 87 patients (50 males, 37 females; median age: 12 years; range, 6.6 to 16 years) suspected of having COVID-19 at our pediatric rheumatology clinic between March 11th and October 15th 2020 were retrospectively analyzed. Read More

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September 2021

Comparison of Interleukin-6 Plasma Concentration in Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Pediatric Sepsis.

Front Pediatr 2021 15;9:756083. Epub 2021 Nov 15.

Unidad de Paciente Crítico Pediátrico, Hospital El Carmen de Maipú, Santiago, Chile.

Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection is thought to be driven by a post-viral dysregulated immune response, where interleukin 6 (IL-6) might have a central role. In this setting, IL-6 inhibitors are prescribed as immunomodulation in cases refractory to standard therapy. To compare plasma IL-6 concentration between critically ill children with MIS-C and sepsis. Read More

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November 2021

Intermittent Frontal Rhythmic Discharges as an Electroencephalogram Biomarker of Acute SARS-CoV-2 Infection-Associated Encephalopathy in Children.

Cureus 2021 Oct 30;13(10):e19149. Epub 2021 Oct 30.

Neurology, Nemours Children's Health, Thomas Jefferson University, Wilmington, USA.

Data on neurological sequelae of COVID-19 infection in children are sparse. Neurotropic and neuroinvasive potentials of the SARS-CoV-2 virus are a matter of ongoing scientific debate and not yet well understood. Most of the reported symptoms are nonspecific including headache, encephalopathy, weakness, and as a part of multisystem inflammatory response syndrome. Read More

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October 2021

Beware of the ambiguous enemy of multisystem inflammatory syndrome in adult (MIS-A) following Covid-19 infection or vaccination.

Clin Case Rep 2021 Nov 26;9(11):e05138. Epub 2021 Nov 26.

Infectious Diseases Division Department of Internal Medicine Communicable Diseases Centre Hamad Medical Corporation Doha Qatar.

Multisystem Inflammatory Syndrome is a rare and novel clinical presentation described during the evolving COVID-19 pandemic. The condition is usually presenting as a sepsis-like syndrome leading to secondary multi-organ dysfunction post-COVID-19 infection. Although the syndrome has been mainly described in children, rare adults' form has been similarly described. Read More

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November 2021

Case Report: Infantile Urticaria as a Herald of Neonatal Onset Multisystem Inflammatory Disease With a Novel Mutation in NLRP3.

Front Immunol 2021 18;12:775140. Epub 2021 Nov 18.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.

Neonatal multisystem onset inflammatory disorder (NOMID) is a severe autoinflammatory syndrome that can have an initial presentation as infantile urticaria. Thus, an immediate recognition of the clinical symptoms is essential for obtaining a genetic diagnosis and initiation of early therapies to prevent morbidity and mortality. Herein, we describe a neonate presenting with urticaria and systemic inflammation within hours after birth who developed arthropathy and neurologic findings. Read More

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November 2021

Multisystem Inflammatory Syndrome in Children-United States, February 2020-July 2021.

Clin Infect Dis 2021 Dec 5. Epub 2021 Dec 5.

CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory condition in persons aged <21 years associated with antecedent SARS-CoV-2 infection. Our objective was to describe MIS-C cases reported to CDC's national surveillance since the COVID-19 pandemic began.

Methods: We included patients meeting the MIS-C case definition with onset date from February 19, 2020 through July 31, 2021, using CDC's MIS-C case report form, which collects information on demographics, clinical presentation, and laboratory results. Read More

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December 2021

Multisystem inflammatory syndrome (MIS-C): a systematic review and meta-analysis of clinical characteristics, treatment, and outcomes.

J Pediatr (Rio J) 2021 Dec 2. Epub 2021 Dec 2.

Universidade Federal de Goiás, Departamento de Pediatria, Goiânia, GO, Brazil.

Objective: The clinical cases of patients with multisystem inflammatory syndrome (MIS-C) were analyzed via a systematic review and meta-analysis of the clinical findings, treatments, and possible outcomes of articles retrieved via database searches.

Sources: The authors searched the PubMed, Scielo, Web of Science, Science Direct, EMBASA, EBSCO, and Scopus databases for articles containing the keywords "multisystem inflammatory syndrome in children" or "MIS-C" or "PIMS-TS" or "SIMP" and "COVID-19" or "SARS-CoV-2" published between December 1st, 2019 and July 10th, 2021. Patient characteristics, tissue and organ comorbidities, the incidence of symptoms after COVID-19 infection, treatment, and patient evolution in the articles found were evaluated. Read More

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December 2021

Incidence of MIS-C and the Comorbidity Scores in Pediatric COVID-19 Cases.

Pediatr Int 2021 Dec 4. Epub 2021 Dec 4.

Department of Medical Microbiology, Marmara University, Faculty of Medicine, İstanbul, Turkey.

Background: We aimed to determine the incidence of multisystem ınflammatory syndrome in children (MIS-C) in pediatric coronavirus disease 2019 (COVID-19) cases and to define the relationships between the need for hospitalization, the development of MIS-C, and Charlson (CCI) and Pediatric comorbidity index (PCI) scores.

Methods: All pediatric COVID-19 cases between March 25, 2020, and December 28, 2020, in the Marmara University Pendik Training and Research Hospital were enrolled. Patients who needed hospitalization were determined. Read More

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December 2021

Acute kidney injury in paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is not associated with progression to chronic kidney disease.

Arch Dis Child 2021 Dec 3. Epub 2021 Dec 3.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

Background: Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is a rare complication of SARS-CoV-2 associated with single or multiorgan dysfunction.

Objective: We aimed to evaluate the incidence of acute kidney injury (AKI) and risk factors for kidney dysfunction in PIMS-TS, with reporting of 6-month renal follow-up data. We also evaluated renal involvement between first and second waves of the SARS-CoV-2 pandemic in the UK, the latter attributed to the Alpha variant. Read More

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December 2021

COVID-19 and abdominal pain: a pediatric case report and a point of view in pediatric emergency medicine.

Eur Rev Med Pharmacol Sci 2021 Nov;25(22):7115-7126

Pediatric Unit, San Giovanni Battista Hospital, Foligno, Italy.

COVID-19 is to date a global pandemic that can affect all age groups; gastrointestinal symptoms are quite common in patients with COVID-19 and a new clinical entity defined as Multisystem Inflammatory Syndrome in Children (MIS-C) has been described in children and adolescents previously affected by COVID-19. Presenting symptoms of this new disease include high fever and severe abdominal pain that can mimic more common causes of abdominal pain; patients can rapidly deteriorate presenting severe cardiac dysfunction and multiorgan failure. Some fatalities due to this serious illness have been reported. Read More

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November 2021

Spectrum of SARS-CoV-2-Related Clinical Syndromes in Children: A Year in the Life.

Clin Pediatr (Phila) 2021 Dec 3:99228211064655. Epub 2021 Dec 3.

SSM Health Cardinal Glennon Children's Hospital, Saint Louis, MO, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a wide pediatric clinical spectrum. Initial reports suggested that children had milder symptoms compared with adults; then diagnosis of multisystem inflammatory syndrome in children (MIS-C) emerged. We performed a retrospective cohort study of hospitalized patients at a children's hospital over 1 year. Read More

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December 2021

Distinguishing Between Multisystem Inflammatory Syndrome, Associated With COVID-19 in Children and the Kawasaki Disease: Development of Preliminary Criteria Based on the Data of the Retrospective Multicenter Cohort Study.

Front Pediatr 2021 10;9:787353. Epub 2021 Nov 10.

Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia.

Diagnostic between multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C) and Kawasaki disease (KD) can make difficulties due to many similarities. Our study aimed to create a Kawasaki/MIS-C differentiation score (KMDscore) allowing discrimination of MIS-C and KD. The retrospective multicenter cohort study included clinical, laboratory, and instrumental information about MIS-C ( = 72) and KD ( = 147). Read More

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November 2021

Pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 symptoms in Iran.

Future Virol 2021 Nov 26. Epub 2021 Nov 26.

Department of Basic & Laboratory Sciences, School of Nursing, Khomein University of Medical Sciences, Khomein, 39186, Iran.

We report two cases of pediatric patients diagnosed and treated for pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) symptoms. Two previously healthy 3- and 4-year-old boys were referred to the hospital after 5 days of 39°C fever, with symptoms such as erythema multiform in the lower extremities, irritability, refusal to eat, restlessness, lymphadenopathy, conjunctivitis and abnormal echocardiography. After 8 days of hospitalization, the patients showed normal laboratory tests, improvement of clinical condition and were discharged from the hospital. Read More

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November 2021

Basic Predictive Risk Factors for Cytokine Storms in COVID-19 Patients.

Front Immunol 2021 10;12:745515. Epub 2021 Nov 10.

City Hospital №40, Saint Petersburg, Russia.

Objective: A critical role in coronavirus disease 2019 (COVID-19) pathogenesis is played by immune dysregulation that leads to a generalized uncontrolled multisystem inflammatory response, caused by overproduction of proinflammatory cytokines, known as "a cytokine storm" (CS), strongly associated with a severe course of disease. The aim of this study is to identify prognostic biomarkers for CS development in COVID-19 patients and integrate them into a prognostic score for CS-associated risk applicable to routine clinical practice.

Materials And Methods: The authors performed a review of 458 medical records from COVID-19 patients (241 men and 217 women aged 60. Read More

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November 2021

COVID-19 Legacy.

South Med J 2021 12;114(12):751-759

From the Department of Medicine, Division of Rheumatology, and the Department of Behavior Medicine and Psychiatry, West Virginia University, Morgantown, Baptist Health, Lexington, Kentucky, and the Department of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky.

Coronavirus disease 2019 (COVID-19) is an infection caused by the severe acute respiratory syndrome-coronavirus-2 virus that led to a pandemic. Acute manifestations of COVID-19 include fever, cough, dyspnea, respiratory failure, pneumonitis, anosmia, thromboembolic events, cardiogenic shock, renal injury, ischemic strokes, encephalitis, and cutaneous eruptions, especially of hands or feet. Prolonged symptoms, unpredictable recoveries, and chronic sequelae (long COVID) sometimes emerge even for some people who survive the initial illness. Read More

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December 2021

Acute Appendicitis Associated With Kawasaki Disease: Case Report and Review of the Literature.

Cureus 2021 Oct 23;13(10):e18997. Epub 2021 Oct 23.

Pediatrics, Washington University School of Medicine, St. Louis, USA.

Acute appendicitis is a rare complication of Kawasaki disease in the setting of the absence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We experienced a rare case of acute appendicitis associated with Kawasaki disease. The patient is a six-year-old male who was brought to the emergency department by his mother with a pruritic rash, nausea, vomiting, and abdominal pain. Read More

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October 2021

Para-aortic lymphadenopathy associated with adult COVID-19 multisystem inflammatory syndrome.

BMJ Case Rep 2021 Dec 1;14(12). Epub 2021 Dec 1.

Unidade de Terapia Intensiva, Hospital Niteroi D'Or, D'Or São Luiz Network, Niterói, Brazil.

A 21-year-old woman arrived at the emergency department with dyspnoea, arterial hypotension and abdominal pain after 5 days with a influenza-like syndrome. SARS-CoV-2 was detected by reverse transcription PCR in a nasopharyngeal swab specimen. CT of the chest and abdomen with contrast demonstrated a minimal amount of free intraperitoneal fluid, gallbladder with wall oedema, multiple para-aortic lymph node and interlobular septal thickening with ground glass opacities on the lungs. Read More

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December 2021

Postvaccination Multisystem Inflammatory Syndrome in Adult with No Evidence of Prior SARS-CoV-2 Infection.

Emerg Infect Dis 2021 Dec 1;28(2). Epub 2021 Dec 1.

Ten days after receiving the first dose of coronavirus disease vaccine, a 22-year-old woman in South Korea experienced myocarditis, myopathy, pericarditis, and gastroenteritis; rash subsequently developed. There was no evidence of prior infection with severe acute respiratory syndrome coronavirus 2. The diagnosis was multisystem inflammatory syndrome resulting from coronavirus disease vaccination. Read More

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December 2021

Challenges in Diagnosing COVID-19 Related Disease in Pediatric Patients With Rheumatic Disease.

Mod Rheumatol 2021 Nov 30. Epub 2021 Nov 30.

Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe University, Ankara, Ankara, Turkey.

Objectives: Multisystem inflammatory syndrome in children (MIS-C) is a rare but severe condition associated with coronavirus disease 2019 (COVID-19). Here we aimed to raise awareness for the symptoms of MIS-C in patients with rheumatic diseases, emphasizing the challenges of the differential features.

Methods: We retrospectively evaluated the demographic and clinical characteristics, laboratory and imaging findings, treatments, and outcomes of six MIS-C patients with previous rheumatic disease. Read More

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November 2021

Multisystem Inflammatory Syndrome in Adults after SARS-CoV-2 infection and COVID-19 vaccination.

Clin Infect Dis 2021 Nov 28. Epub 2021 Nov 28.

COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Multisystem inflammatory syndrome in adults (MIS-A) was reported in association with the COVID-19 pandemic. MIS-A was included in the list of adverse events to be monitored as part of the emergency use authorizations issued for COVID-19 vaccines.

Methods: Reports of MIS-A patients received by the Centers for Disease Control and Prevention (CDC) after COVID-19 vaccines became available were assessed. Read More

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November 2021

SARS-CoV-2 SPIKE PROTEIN IN INTESTINAL CELLS OF A PATIENT WITH COVID-19 MULTISYSTEM INFLAMMATORY SYNDROME.

J Pediatr 2021 Nov 26. Epub 2021 Nov 26.

Department of Pediatrics. Hospital Universitario Central de Asturias, Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain; Department of Pediatrics. University of Oviedo, Oviedo, Spain; Maternal and Child Health and Development Research Network (REDSAMID), Institute of Health Carlos III, Madrid, Spain.

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November 2021

Cutaneous manifestations of PIMS-TS: a single centre experience.

Br J Dermatol 2021 Nov 29. Epub 2021 Nov 29.

Guy's and St Thomas' Hospitals NHS Trust, St John's Institute of Dermatology, London, London, United Kingdom of Great Britain and Northern Ireland.

Paediatric inflammatory multisystem syndrome associated with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection (PIMS-TS) is defined as 'a child presenting with persistent fever, inflammation and evidence of single or multi-organ dysfunction with additional features which include a rash'. The World Health Organisation's (WHO) definition further includes a 'rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs'. Previously reported mucocutaneous manifestations (MCM) in PIMS-TS have been vague. Read More

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November 2021

Bacillus Calmette-Guerin scar reactivation in multisystem inflammatory syndrome in children.

Trop Doct 2021 Nov 29:494755211051194. Epub 2021 Nov 29.

Consultant and Head of the department, Paediatric intensive care unit, 435708NMC Royal hospital, Abu Dhabi, UAE.

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November 2021

Detection of faecal SARS-CoV-2 RNA in a prospective cohort of children with multisystem inflammatory syndrome (MIS-C).

Epidemiol Prev 2021 ;45:In press

Department of Public Health and Paediatrics, University of Torino, Turin (Italy);

Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe illness associated with SARS-CoV-2 infection. A dysregulated immune response is recognized as the main pathogenic mechanism. Previous studies demonstrated the presence of SARS-CoV-2 RNA in faeces of almost one-third of patients with COVID-19, while data are currently missing about MIS-C. Read More

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November 2021

Asymmetric septal edema masking as hypertrophy in an infant with COVID-19 myocarditis.

Prog Pediatr Cardiol 2021 Nov 22:101464. Epub 2021 Nov 22.

Division of Cardiology, Cardiac Center, the Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States of America.

Cardiac disease in pediatric patients due to coronavirus SARS-CoV-2 disease (COVID-19) include myocarditis and multisystem inflammatory syndrome, both of which can present with a broad range in severity. Here we describe an infant with COVID-19 causing fulminant myocarditis with inotrope-resistant acute heart failure requiring extracorporeal membrane oxygenation. The patient demonstrated an atypical finding of localized septal thickening suggestive of hypertrophic cardiomyopathy, but the diagnosis of myocarditis was confirmed by cardiac MRI. Read More

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November 2021

FATAL STAPHYLOCOCCUS AUREUS ENDOCARDITIS MISDIAGNOSED AS MULTISYSTEM INFLAMMATORY SYNDROME IN CHILDREN.

Pediatr Infect Dis J 2021 Nov 29. Epub 2021 Nov 29.

From the Pediatrics Department Pediatric Cardiology Department Pediatric Intensive Care Department, Gregorio Marañón University Hospital. Madrid, Spain.

We present a case of a 10-year-old male with Staphylococcus aureus mitral endocarditis who was initially misdiagnosed with multisystem inflammatory syndrome associated with coronavirus disease 2019, with eventual fatal outcome due to brain hemorrhage after cardiac intervention. Our case differs from recent studies, in which microbleeds did not increase the risk of hemorrhagic stroke or global mortality risk. Read More

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November 2021

Multisystem inflammatory syndrome in adults (MIS-A): a new addition to COVID-19 puzzle.

J Eur Acad Dermatol Venereol 2021 Nov 27. Epub 2021 Nov 27.

Department of Dermatology and Venereal Disease, School of Tropical Medicine, Kolkata, India.

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November 2021

Autoantibody Release in Children after Corona Virus mRNA Vaccination: A Risk Factor of Multisystem Inflammatory Syndrome?

Vaccines (Basel) 2021 Nov 18;9(11). Epub 2021 Nov 18.

CellTrend GmbH, 14943 Luckenwalde, Germany.

Multisystem inflammatory syndrome (MIS) is a new systemic inflammatory acute onset disease that mainly affects children (MIS-C) and, at a lesser frequency, adults (MIS-A); it typically occurs 3-6 weeks after acute SARS-CoV infection. It has been postulated and shown in adults that MIS may occur after SARS-CoV-2 vaccination (MIS-V). Our current case is one of the first published cases with a multisystem inflammatory syndrome in an 18-year-old adolescent after the SARS-CoV-2 vaccine from Pfizer/BionTech (BNT162b2), who fulfills the published level 1 criteria for a definitive disease: age < 21 years, fever > 3 consecutive days, pericardial effusion, elevated CRP/NT-BNP/Troponin T/D-dimeres, cardiac involvement, and positive SARS-CoV-2 antibodies. Read More

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November 2021