14,309 results match your criteria multisystem


Multisystem Inflammatory Syndrome in Children (MIS-C): Experiences With a New Disease Process.

J Neurosurg Anesthesiol 2022 Jan;34(1):127-131

Division of Pediatric Anesthesiology, Department of Anesthesiology, Columbia University, New York, NY.

On March 20, 2021, the Columbia University Department of Anesthesiology hosted the Papper virtual event dedicated to an academic discussion of various aspects of coronavirus disease-2019. Dr. Eva Cheung, a pediatric intensivist and pediatric cardiologist, spoke about the clinical challenges associated with tackling multisystem inflammatory syndrome in children, a novel clinical entity in pediatric patients related to coronavirus disease-2019, and the experience with confronting multisystem inflammatory syndrome in children in New York. Read More

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January 2022

SARS-CoV-2 infection in children with rheumatic disease: Experience of a tertiary referral center.

Arch Rheumatol 2021 Sep 9;36(3):381-388. Epub 2021 Feb 9.

Department of Child Health and Diseases, Pediatric Infectious Disease, Ümraniye Training and Research Hospital, Istanbul, Turkey.

Objectives: In this study, we present our clinical severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) experience in patients with childhood rheumatic disease during novel coronavirus-2019 (COVID-19) pandemic.

Patients And Methods: A total of 87 patients (50 males, 37 females; median age: 12 years; range, 6.6 to 16 years) suspected of having COVID-19 at our pediatric rheumatology clinic between March 11th and October 15th 2020 were retrospectively analyzed. Read More

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September 2021

Comparison of Interleukin-6 Plasma Concentration in Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Pediatric Sepsis.

Front Pediatr 2021 15;9:756083. Epub 2021 Nov 15.

Unidad de Paciente Crítico Pediátrico, Hospital El Carmen de Maipú, Santiago, Chile.

Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection is thought to be driven by a post-viral dysregulated immune response, where interleukin 6 (IL-6) might have a central role. In this setting, IL-6 inhibitors are prescribed as immunomodulation in cases refractory to standard therapy. To compare plasma IL-6 concentration between critically ill children with MIS-C and sepsis. Read More

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November 2021

Intermittent Frontal Rhythmic Discharges as an Electroencephalogram Biomarker of Acute SARS-CoV-2 Infection-Associated Encephalopathy in Children.

Cureus 2021 Oct 30;13(10):e19149. Epub 2021 Oct 30.

Neurology, Nemours Children's Health, Thomas Jefferson University, Wilmington, USA.

Data on neurological sequelae of COVID-19 infection in children are sparse. Neurotropic and neuroinvasive potentials of the SARS-CoV-2 virus are a matter of ongoing scientific debate and not yet well understood. Most of the reported symptoms are nonspecific including headache, encephalopathy, weakness, and as a part of multisystem inflammatory response syndrome. Read More

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October 2021

Beware of the ambiguous enemy of multisystem inflammatory syndrome in adult (MIS-A) following Covid-19 infection or vaccination.

Clin Case Rep 2021 Nov 26;9(11):e05138. Epub 2021 Nov 26.

Infectious Diseases Division Department of Internal Medicine Communicable Diseases Centre Hamad Medical Corporation Doha Qatar.

Multisystem Inflammatory Syndrome is a rare and novel clinical presentation described during the evolving COVID-19 pandemic. The condition is usually presenting as a sepsis-like syndrome leading to secondary multi-organ dysfunction post-COVID-19 infection. Although the syndrome has been mainly described in children, rare adults' form has been similarly described. Read More

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November 2021

Case Report: Infantile Urticaria as a Herald of Neonatal Onset Multisystem Inflammatory Disease With a Novel Mutation in NLRP3.

Front Immunol 2021 18;12:775140. Epub 2021 Nov 18.

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.

Neonatal multisystem onset inflammatory disorder (NOMID) is a severe autoinflammatory syndrome that can have an initial presentation as infantile urticaria. Thus, an immediate recognition of the clinical symptoms is essential for obtaining a genetic diagnosis and initiation of early therapies to prevent morbidity and mortality. Herein, we describe a neonate presenting with urticaria and systemic inflammation within hours after birth who developed arthropathy and neurologic findings. Read More

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November 2021

Effects of Creative Movement Therapies on Social Communication, Behavioral-Affective, Sensorimotor, Cognitive, and Functional Participation Skills of Individuals With Autism Spectrum Disorder: A Systematic Review.

Front Psychiatry 2021 18;12:722874. Epub 2021 Nov 18.

Physical Therapy Program, Department of Kinesiology, University of Connecticut, Storrs, CT, United States.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder affecting multiple developmental domains including social communication, behavioral-affective, sensorimotor, and cognitive systems. There is growing evidence for the use of holistic, whole-body, Creative Movement Therapies (CMT) such as music, dance, yoga, theater, and martial arts in addressing the multisystem impairments in ASD. We conducted a comprehensive quantitative and qualitative review of the evidence to date on the effects of CMT on multiple systems in individuals with ASD. Read More

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November 2021

Multisystem Inflammatory Syndrome in Children-United States, February 2020-July 2021.

Clin Infect Dis 2021 Dec 5. Epub 2021 Dec 5.

CDC COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe hyperinflammatory condition in persons aged <21 years associated with antecedent SARS-CoV-2 infection. Our objective was to describe MIS-C cases reported to CDC's national surveillance since the COVID-19 pandemic began.

Methods: We included patients meeting the MIS-C case definition with onset date from February 19, 2020 through July 31, 2021, using CDC's MIS-C case report form, which collects information on demographics, clinical presentation, and laboratory results. Read More

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December 2021

Multisystem inflammatory syndrome (MIS-C): a systematic review and meta-analysis of clinical characteristics, treatment, and outcomes.

J Pediatr (Rio J) 2021 Dec 2. Epub 2021 Dec 2.

Universidade Federal de Goiás, Departamento de Pediatria, Goiânia, GO, Brazil.

Objective: The clinical cases of patients with multisystem inflammatory syndrome (MIS-C) were analyzed via a systematic review and meta-analysis of the clinical findings, treatments, and possible outcomes of articles retrieved via database searches.

Sources: The authors searched the PubMed, Scielo, Web of Science, Science Direct, EMBASA, EBSCO, and Scopus databases for articles containing the keywords "multisystem inflammatory syndrome in children" or "MIS-C" or "PIMS-TS" or "SIMP" and "COVID-19" or "SARS-CoV-2" published between December 1st, 2019 and July 10th, 2021. Patient characteristics, tissue and organ comorbidities, the incidence of symptoms after COVID-19 infection, treatment, and patient evolution in the articles found were evaluated. Read More

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December 2021

A novel mutation of SATB2 inhibits odontogenesis of human dental pulp stem cells through Wnt/β-catenin signaling pathway.

Stem Cell Res Ther 2021 Dec 4;12(1):595. Epub 2021 Dec 4.

Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials, No. 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, People's Republic of China.

Background: SATB2-associated syndrome (SAS) is a multisystem disorder caused by mutation of human SATB2 gene. Tooth agenesis is one of the most common phenotypes observed in SAS. Our study aimed at identifying novel variant of SATB2 in a patient with SAS, and to investigate the cellular and molecular mechanism of tooth agenesis caused by SATB2 mutation. Read More

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December 2021

Incidence of MIS-C and the Comorbidity Scores in Pediatric COVID-19 Cases.

Pediatr Int 2021 Dec 4. Epub 2021 Dec 4.

Department of Medical Microbiology, Marmara University, Faculty of Medicine, İstanbul, Turkey.

Background: We aimed to determine the incidence of multisystem ınflammatory syndrome in children (MIS-C) in pediatric coronavirus disease 2019 (COVID-19) cases and to define the relationships between the need for hospitalization, the development of MIS-C, and Charlson (CCI) and Pediatric comorbidity index (PCI) scores.

Methods: All pediatric COVID-19 cases between March 25, 2020, and December 28, 2020, in the Marmara University Pendik Training and Research Hospital were enrolled. Patients who needed hospitalization were determined. Read More

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December 2021

Acute kidney injury in paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is not associated with progression to chronic kidney disease.

Arch Dis Child 2021 Dec 3. Epub 2021 Dec 3.

Department of Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

Background: Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) is a rare complication of SARS-CoV-2 associated with single or multiorgan dysfunction.

Objective: We aimed to evaluate the incidence of acute kidney injury (AKI) and risk factors for kidney dysfunction in PIMS-TS, with reporting of 6-month renal follow-up data. We also evaluated renal involvement between first and second waves of the SARS-CoV-2 pandemic in the UK, the latter attributed to the Alpha variant. Read More

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December 2021

COVID-19 and abdominal pain: a pediatric case report and a point of view in pediatric emergency medicine.

Eur Rev Med Pharmacol Sci 2021 Nov;25(22):7115-7126

Pediatric Unit, San Giovanni Battista Hospital, Foligno, Italy.

COVID-19 is to date a global pandemic that can affect all age groups; gastrointestinal symptoms are quite common in patients with COVID-19 and a new clinical entity defined as Multisystem Inflammatory Syndrome in Children (MIS-C) has been described in children and adolescents previously affected by COVID-19. Presenting symptoms of this new disease include high fever and severe abdominal pain that can mimic more common causes of abdominal pain; patients can rapidly deteriorate presenting severe cardiac dysfunction and multiorgan failure. Some fatalities due to this serious illness have been reported. Read More

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November 2021

Spectrum of SARS-CoV-2-Related Clinical Syndromes in Children: A Year in the Life.

Clin Pediatr (Phila) 2021 Dec 3:99228211064655. Epub 2021 Dec 3.

SSM Health Cardinal Glennon Children's Hospital, Saint Louis, MO, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a wide pediatric clinical spectrum. Initial reports suggested that children had milder symptoms compared with adults; then diagnosis of multisystem inflammatory syndrome in children (MIS-C) emerged. We performed a retrospective cohort study of hospitalized patients at a children's hospital over 1 year. Read More

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December 2021

Impact of elexacaftor/tezacaftor/ivacaftor on vitamin D absorption in cystic fibrosis patients.

Pediatr Pulmonol 2021 Dec 3. Epub 2021 Dec 3.

University of Iowa Hospitals and Clinics, Iowa City, IA, 52242.

Background: Cystic fibrosis (CF) is a multisystem disorder that results in the buildup of mucus in various organs. Ninety percent of CF patients are classified as pancreatic insufficient, leading to malabsorption of nutrients and fat-soluble vitamins without the assistance of exogenous pancreatic enzymes. This study was designed to determine if serum 25-hydroxyvitamin D concentrations were impacted by initiation of elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA). Read More

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December 2021

Distinguishing Between Multisystem Inflammatory Syndrome, Associated With COVID-19 in Children and the Kawasaki Disease: Development of Preliminary Criteria Based on the Data of the Retrospective Multicenter Cohort Study.

Front Pediatr 2021 10;9:787353. Epub 2021 Nov 10.

Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia.

Diagnostic between multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C) and Kawasaki disease (KD) can make difficulties due to many similarities. Our study aimed to create a Kawasaki/MIS-C differentiation score (KMDscore) allowing discrimination of MIS-C and KD. The retrospective multicenter cohort study included clinical, laboratory, and instrumental information about MIS-C ( = 72) and KD ( = 147). Read More

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November 2021

Pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 symptoms in Iran.

Future Virol 2021 Nov 26. Epub 2021 Nov 26.

Department of Basic & Laboratory Sciences, School of Nursing, Khomein University of Medical Sciences, Khomein, 39186, Iran.

We report two cases of pediatric patients diagnosed and treated for pediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS) symptoms. Two previously healthy 3- and 4-year-old boys were referred to the hospital after 5 days of 39°C fever, with symptoms such as erythema multiform in the lower extremities, irritability, refusal to eat, restlessness, lymphadenopathy, conjunctivitis and abnormal echocardiography. After 8 days of hospitalization, the patients showed normal laboratory tests, improvement of clinical condition and were discharged from the hospital. Read More

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November 2021

Basic Predictive Risk Factors for Cytokine Storms in COVID-19 Patients.

Front Immunol 2021 10;12:745515. Epub 2021 Nov 10.

City Hospital №40, Saint Petersburg, Russia.

Objective: A critical role in coronavirus disease 2019 (COVID-19) pathogenesis is played by immune dysregulation that leads to a generalized uncontrolled multisystem inflammatory response, caused by overproduction of proinflammatory cytokines, known as "a cytokine storm" (CS), strongly associated with a severe course of disease. The aim of this study is to identify prognostic biomarkers for CS development in COVID-19 patients and integrate them into a prognostic score for CS-associated risk applicable to routine clinical practice.

Materials And Methods: The authors performed a review of 458 medical records from COVID-19 patients (241 men and 217 women aged 60. Read More

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November 2021

S-nitrosothiols signaling in cystic fibrosis airways.

J Biosci 2021 ;46

Department of Pediatrics and Biochemistry, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.

S-nitrosothiols (SNOs) are small naturally occurring thiol and nitric oxide adducts that participate in many cell signaling pathways in living organisms. SNOs receive widespread attention in cell biology, biochemistry and chemistry because they can donate nitric oxide and/or nitrosonium ions in S-nitrosylation reactions, which are comparable to phosphorylation, acetylation, glutathionylation, and palmitoylation reactions. SNOs have advantageous effects in respiratory diseases and other systems in the body. Read More

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January 2021

Classification of systemic lupus erythematosus in children and adults.

Clin Immunol 2021 Nov 29;234:108898. Epub 2021 Nov 29.

Department of Rheumatology, Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Germany. Electronic address:

Systemic Lupus Erythematosus (SLE) is an autoimmune multisystem disease with a variable clinical phenotype and no single clinical, laboratory or pathological feature that can be used as a gold standard for disease classification or diagnosis. Classification criteria have been developed in an attempt to define homogenous groups of SLE patients for clinical research. They have been mainly validated in adult cohorts, given the much lower prevalence of SLE before puberty. Read More

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November 2021

Dysfunction of cerebellar microglia in Ataxia-telangiectasia.

Glia 2021 Dec 2. Epub 2021 Dec 2.

Department of Neurobiology, George S. Wise, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.

Ataxia-telangiectasia (A-T) is a multisystem autosomal recessive disease caused by mutations in the ATM gene and characterized by cerebellar atrophy, progressive ataxia, immunodeficiency, male and female sterility, radiosensitivity, cancer predisposition, growth retardation, insulin-resistant diabetes, and premature aging. ATM phosphorylates more than 1500 target proteins, which are involved in cell cycle control, DNA repair, apoptosis, modulation of chromatin structure, and other cytoplasmic as well as mitochondrial processes. In our quest to better understand the mechanisms by which ATM deficiency causes cerebellar degeneration, we hypothesized that specific vulnerabilities of cerebellar microglia underlie the etiology of A-T. Read More

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December 2021

Prenatal exome sequencing and chromosomal microarray analysis in fetal structural anomalies in a highly consanguineous population reveals a propensity of ciliopathy genes causing multisystem phenotypes.

Hum Genet 2021 Dec 1. Epub 2021 Dec 1.

Saudi Diagnostics Laboratory, KFSHI, P.O.BOX 6802, Riyadh, 12311, Saudi Arabia.

Fetal abnormalities are detected in 3% of all pregnancies and are responsible for approximately 20% of all perinatal deaths. Chromosomal microarray analysis (CMA) and exome sequencing (ES) are widely used in prenatal settings for molecular genetic diagnostics with variable diagnostic yields. In this study, we aimed to determine the diagnostic yield of trio-ES in detecting the cause of fetal abnormalities within a highly consanguineous population. Read More

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December 2021

COVID-19 Legacy.

South Med J 2021 12;114(12):751-759

From the Department of Medicine, Division of Rheumatology, and the Department of Behavior Medicine and Psychiatry, West Virginia University, Morgantown, Baptist Health, Lexington, Kentucky, and the Department of Psychiatry, University of Louisville School of Medicine, Louisville, Kentucky.

Coronavirus disease 2019 (COVID-19) is an infection caused by the severe acute respiratory syndrome-coronavirus-2 virus that led to a pandemic. Acute manifestations of COVID-19 include fever, cough, dyspnea, respiratory failure, pneumonitis, anosmia, thromboembolic events, cardiogenic shock, renal injury, ischemic strokes, encephalitis, and cutaneous eruptions, especially of hands or feet. Prolonged symptoms, unpredictable recoveries, and chronic sequelae (long COVID) sometimes emerge even for some people who survive the initial illness. Read More

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December 2021

Acute Appendicitis Associated With Kawasaki Disease: Case Report and Review of the Literature.

Cureus 2021 Oct 23;13(10):e18997. Epub 2021 Oct 23.

Pediatrics, Washington University School of Medicine, St. Louis, USA.

Acute appendicitis is a rare complication of Kawasaki disease in the setting of the absence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We experienced a rare case of acute appendicitis associated with Kawasaki disease. The patient is a six-year-old male who was brought to the emergency department by his mother with a pruritic rash, nausea, vomiting, and abdominal pain. Read More

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October 2021

Para-aortic lymphadenopathy associated with adult COVID-19 multisystem inflammatory syndrome.

BMJ Case Rep 2021 Dec 1;14(12). Epub 2021 Dec 1.

Unidade de Terapia Intensiva, Hospital Niteroi D'Or, D'Or São Luiz Network, Niterói, Brazil.

A 21-year-old woman arrived at the emergency department with dyspnoea, arterial hypotension and abdominal pain after 5 days with a influenza-like syndrome. SARS-CoV-2 was detected by reverse transcription PCR in a nasopharyngeal swab specimen. CT of the chest and abdomen with contrast demonstrated a minimal amount of free intraperitoneal fluid, gallbladder with wall oedema, multiple para-aortic lymph node and interlobular septal thickening with ground glass opacities on the lungs. Read More

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December 2021

Moyamoya Syndrome in an Infant with Aicardi-Goutières and Williams Syndromes: A Case Report.

Neuropediatrics 2021 Dec 1. Epub 2021 Dec 1.

Department of Pediatrics, Division of Pediatric Critical Care Medicine, Children's Hospital, London Health Sciences Centre, London, Ontario, Canada.

Stroke in infancy is a rare phenomenon but can lead to significant long-term disability. We present the story of a 6-month-old Old Order Amish infant with underlying Williams syndrome, a rare neurodevelopmental disorder caused by a microdeletion, encompassing the elastin gene that produces abnormalities in elastic fibers of the lungs and vessels. This infant presented with lethargy, irritability, and a new-onset generalized tonic-clonic seizure. Read More

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December 2021

Head and Neck Langerhans Cell Histiocytosis in Children.

J Oral Maxillofac Surg 2021 Nov 5. Epub 2021 Nov 5.

Associate Professor in Oral and Maxillofacial Surgery and Pediatrics, Department of Surgery, Emory University School of Medicine, Chief of Oral and Maxillofacial Surgery, Children's Healthcare of Atlanta, Atlanta, Georgia. Electronic address:

Purpose: Controversy exists among head and neck surgical specialties regarding management of Langerhan's Cell Histiocytosis (LCH). The purpose of this study was to evaluate diagnosis, management, and treatment outcomes in children with LCH of the head and neck.

Methods: This is a retrospective cohort study of children with LCH of the head and neck who presented to Children's Healthcare of Atlanta hospital from 2009 to 2021. Read More

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November 2021

Postvaccination Multisystem Inflammatory Syndrome in Adult with No Evidence of Prior SARS-CoV-2 Infection.

Emerg Infect Dis 2021 Dec 1;28(2). Epub 2021 Dec 1.

Ten days after receiving the first dose of coronavirus disease vaccine, a 22-year-old woman in South Korea experienced myocarditis, myopathy, pericarditis, and gastroenteritis; rash subsequently developed. There was no evidence of prior infection with severe acute respiratory syndrome coronavirus 2. The diagnosis was multisystem inflammatory syndrome resulting from coronavirus disease vaccination. Read More

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December 2021

Investigating cognitive factors and diagnostic error in a presentation of complicated multisystem disease.

Diagnosis (Berl) 2021 Jan 1. Epub 2021 Jan 1.

School of Medicine, University of Nottingham, Nottingham, UK.

Objectives: To use a case review approach for investigating the types of cognitive error identifiable following a complicated patient admission with a multisystem disorder in an acute care setting where diagnosis was difficult and delayed.

Methods: A case notes review was undertaken to explore the cognitive factors associated with diagnostic error in the case of an 18-year-old male presenting acutely unwell with myalgia, anorexia and vomiting. Each clinical interaction was analysed and identified cognitive factors were categorised using a framework developed by Graber et al. Read More

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January 2021