7,192 results match your criteria multiple nutrients

Upregulation of Nogo-B by HIF-1 and AP-1 in hepatocellular carcinoma.

Cancer Sci 2021 May 8. Epub 2021 May 8.

Department of Clinical Laboratory, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, 200062, China.

Nogo-B is an important regulator of tumor angiogenesis. Expression of Nogo-B is remarkably upregulated in multiple tumor types, especially hepatocellular carcinoma (HCC). Here, we show the transcriptional regulation mechanisms of Nogo-B in liver cancer. Read More

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Determinants of trophic cascade strength in freshwater ecosystems: a global analysis.

Ecology 2021 May 7:e03370. Epub 2021 May 7.

Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China.

Top-down cascade effects are among the most important mechanisms underlying community structure and abundance dynamics in aquatic and terrestrial ecosystems worldwide. A current challenge is understanding the factors controlling trophic cascade strength under global environmental changes. Here, we synthesized 161 global sites to analyze how multiple factors influence consumer-resource interactions with fish in freshwater ecosystems. Read More

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Repeated loss of variation in insect ovary morphology highlights the role of development in life-history evolution.

Proc Biol Sci 2021 May 5;288(1950):20210150. Epub 2021 May 5.

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.

The number of offspring an organism can produce is a key component of its evolutionary fitness and life history. Here we perform a test of the hypothesized trade-off between the number and size of offspring using thousands of descriptions of the number of egg-producing compartments in the insect ovary (ovarioles), a common proxy for potential offspring number in insects. We find evidence of a negative relationship between egg size and ovariole number when accounting for adult body size. Read More

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Adherence to the Mediterranean Diet in a School Population in the Principality of Asturias (Spain): Relationship with Physical Activity and Body Weight.

Nutrients 2021 Apr 29;13(5). Epub 2021 Apr 29.

Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n, 33001 Oviedo, Spain.

The Mediterranean diet (MD), despite its multiple benefits, presents low levels of adherence among children. Moreover, childhood is a key stage in the acquisition of healthy habits. The aim of this study was to describe adherence to MD in school-age children from Asturias, Spain, and to evaluate the association with weight status and several lifestyle behaviors. Read More

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Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management.

Nutrients 2021 Apr 29;13(5). Epub 2021 Apr 29.

Agroscope, Federal Department of Economic Affairs, Education and Research EAER, 3003 Bern, Switzerland.

Recent discoveries in the "omics" field and the growing focus on preventive health have opened new avenues for personalized nutrition (PN), which is becoming an important theme in the strategic plans of organizations that are active in healthcare, food, and nutrition research. PN holds great potential for individual health optimization, disease management, public health interventions, and product innovation. However, there are still multiple challenges to overcome before PN can be truly embraced by the public and healthcare stakeholders. Read More

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Association of Iron Supplementation Programs with Iron-Deficiency Anemia Outcomes among Children in Brazil.

Nutrients 2021 Apr 30;13(5). Epub 2021 Apr 30.

School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo 03828-000, Brazil.

Anemia remains a condition with high prevalence in populations worldwide, and the prevalence of anemia among children under five years old in Brazil is approximately 40%, being higher in communities marked by social inequities. Diverse government programs during recent decades targeted iron-deficiency anemia, considering its impacts throughout the lifetime. The objective of this study was to investigate the effects of two government iron supplementation programs on health outcomes related to iron-deficiency anemia among children up to 4 years old in Brazilian municipalities. Read More

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Dietary Micronutrients and Risk of Chronic Kidney Disease: A Cohort Study with 12 Year Follow-Up.

Nutrients 2021 Apr 30;13(5). Epub 2021 Apr 30.

Department of Preventive Medicine, College of Medicine, Seoul National University, 103 Daehakro, Jongnogu, Seoul 03080, Korea.

We investigated the association between dietary micronutrient intakes and the risk of chronic kidney disease (CKD) in the Ansan-Ansung study of the Korean Genome and Epidemiologic Study (KoGES), a population-based prospective cohort study. Of 9079 cohort participants with a baseline estimate glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m and a urine albumin to creatinine ratio (UACR) <300 mg/g and who were not diagnosed with CKD, we ascertained 1392 new CKD cases over 12 year follow-up periods. Read More

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Root Exudates Alter the Expression of Diverse Metabolic, Transport, Regulatory, and Stress Response Genes in Rhizosphere .

Front Microbiol 2021 14;12:651282. Epub 2021 Apr 14.

School of Biological, Environmental, and Earth Sciences, The University of Southern Mississippi, Hattiesburg, MS, United States.

Plants live in association with microorganisms that positively influence plant development, vigor, and fitness in response to pathogens and abiotic stressors. The bulk of the plant microbiome is concentrated belowground at the plant root-soil interface. Plant roots secrete carbon-rich rhizodeposits containing primary and secondary low molecular weight metabolites, lysates, and mucilages. Read More

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Microbial biomodification of clay minerals.

Adv Appl Microbiol 2021 26;114:111-139. Epub 2020 Sep 26.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, China; Jiangsu Provincial Key Lab for Organic Solid Waste Utilization, Nanjing Agricultural University, Nanjing, China. Electronic address:

Clay minerals are important reactive centers in the soil system. Their interactions with microorganisms are ubiquitous and wide-ranging, affecting growth and function, interactions with other organisms, including plants, biogeochemical processes and the fate of organic and inorganic pollutants. Clay minerals have a large specific surface area and cation exchange capacity (CEC) per unit mass, and are abundant in many soil systems, especially those of agricultural significance. Read More

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September 2020

Distinct interaction effects of warming and anthropogenic input on diatoms and dinoflagellates in an urbanized estuarine ecosystem.

Glob Chang Biol 2021 May 1. Epub 2021 May 1.

Department of Ocean Science, The Hong Kong University of Science and Technology, Hong Kong SAR, China.

Diatoms and dinoflagellates are two major bloom-forming phytoplankton groups in coastal ecosystems and their dominances will notably affect the marine ecosystem. By analyzing an 18-year monthly monitoring dataset (2000-2017) in the Pearl River Estuary (one of the most highly urbanized and populated estuarine in the world), we observe an increasing trend of the diatom to dinoflagellate ratio (Diatom/Dino). As revealed by multiple statistical models (generalized additive mixed model, random forests, and gradient boosting algorithms), both groups are positively correlated with temperature. Read More

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Aberrant Redox Biology and Epigenetic Reprogramming: Co-conspirators across Multiple Human Diseases.

Free Radic Biol Med 2021 Apr 28. Epub 2021 Apr 28.

Department of Radiation Oncology, Kaiser Permanente Los Angeles Medical Center 4950 Sunset Blvd. Los Angeles, CA 90027. Electronic address:

An epigenetic landscape encompasses a series of dynamic interconnected mechanisms working together to fashion a diverse set of phenotypes from a singular genotype. The epigenetic plasticity observed in disease and development is facilitated by enzymes that create and remove covalent modifications to DNA and histones. Several important discoveries within the past decade have revealed that epigenetic control mechanisms are subject to redox regulation and mitochondrial-to-nuclear retrograde signaling. Read More

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The consumption of wholegrain is related to depressive symptoms among Chinese adults: a cross-sectional study.

Eur J Clin Nutr 2021 Apr 30. Epub 2021 Apr 30.

Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, China.

Background: Wholegrains contribute a range of beneficial nutrients, such as dietary fiber and several minerals and vitamins, that are beneficial to depressive symptoms. However, there are a few studies aimed at exploring whether a wholegrain diet is related to depressive symptoms. We conducted this study to investigate the relationship between wholegrains consumption and depressive symptoms. Read More

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Association Between Dietary Intake and Serum Uric Acid Levels in Kidney Transplant Patients.

J Ren Nutr 2021 Apr 27. Epub 2021 Apr 27.

Laboratory of Nutrition, Exercise and Health (LaNES), School of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Minas Gerais, Brazil. Electronic address:

Objectives: The aim of this study was to evaluate the association between dietary intake and uric acid (UA) levels in kidney transplant patients (KTPs).

Methods: A cross-sectional study was performed with 113 KTPs. Dietary intake assessment was carried out thorough two 24-hour dietary recalls using the 5-step multiple pass method. Read More

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Feeding state greatly modulates the effect of xenobiotics on gut microbiome metabolism: A case study of tetracycline.

J Hazard Mater 2021 Jul 16;413:125441. Epub 2021 Feb 16.

School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798; Nanyang Environment and Water Research Institute, Nanyang Technological University, Singapore 637141; Singapore Phenome Center, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921. Electronic address:

The human gut microbiome is crucial in modulating host health mostly through bacterial metabolites. Chemical exposure is typical external stress which alters its composition and functionality. To date, very few studies have investigated the effect of feeding state on chemical-induced gut microbial metabolic dysregulations. Read More

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Variation, distribution, and diversity of canonical ammonia-oxidizing microorganisms and complete-nitrifying bacteria in highly contaminated ecological restoration regions in the Siding mine area.

Ecotoxicol Environ Saf 2021 Jul 27;217:112274. Epub 2021 Apr 27.

Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, China; College of Environment and Resources, Guangxi Normal University, 541004 Guilin, China; Innovation Institute of Sustainable Development, Guangxi Normal University, 541004 Guilin, China. Electronic address:

Canonical ammonia-oxidizing archaea (AOA), ammonia-oxidizing bacteria (AOB) and complete-nitrifying bacteria (comammox) exist in a variety of ecosystems. However, little is known about AOA, AOB and comammox or their contributions to nitrification in the soils of heavily degraded and acidic mine regions. In the present study, the activity, richness, diversity and distribution patterns of AOA, AOB and comammox in the Siding mine area were investigated. Read More

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Do taxes on unhealthy foods and beverages influence food purchases?

Curr Nutr Rep 2021 Apr 30. Epub 2021 Apr 30.

Global Obesity Centre, Institute for Health Transformation, Deakin University, 221 Burwood Highway, Burwood, Victoria, 3125, Australia.

Purpose Of Review: Interest in taxes on unhealthy foods and beverages as a public health tool has increased in recent years. This paper aimed to summarise recent evidence of the impact of taxes on unhealthy foods and beverages on food purchases, and discuss opportunities to advance knowledge and policy impact.

Recent Findings: Evaluations of taxes on unhealthy foods and beverages have shown reductions in purchases of targeted unhealthy products and nutrients. Read More

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Longitudinal Changes in the Concentration of Major Human Milk Proteins in the First Six Months of Lactation and Their Effects on Infant Growth.

Nutrients 2021 Apr 27;13(5). Epub 2021 Apr 27.

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.

Our knowledge related to human milk proteins is still limited. The present study determined the changes in multiple human milk proteins during the first six months of lactation, investigated the influencing factors of milk proteins, and explored the impact of milk proteins on infant growth. A total of 105 lactating women and their full-term infants from China were prospectively surveyed in this research. Read More

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Silicon Effects on the Root System of Diverse Crop Species Using Root Phenotyping Technology.

Plants (Basel) 2021 Apr 28;10(5). Epub 2021 Apr 28.

Department of Applied Biosciences, Kyungpook National University, Daegu 41566, Korea.

Roots play an essential function in the plant life cycle, as they utilize water and essential nutrients to promote growth and plant productivity. In particular, root morphology characteristics (such as length, diameter, hairs, and lateral growth) and the architecture of the root system (spatial configuration in soil, shape, and structure) are the key elements that ensure growth and a fine-tuned response to stressful conditions. Silicon (Si) is a ubiquitous element in soil, and it can affect a wide range of physiological processes occurring in the rhizosphere of various crop species. Read More

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Invited Review: Maintain or Improve Piglet Gut Health around Weanling: The Fundamental Effects of Dietary Amino Acids.

Shengfa F Liao

Animals (Basel) 2021 Apr 13;11(4). Epub 2021 Apr 13.

Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS 39762, USA.

Gut health has significant implications for swine nutrient utilization and overall health. The basic gut morphology and its luminal microbiota play determinant roles for maintaining gut health and functions. Amino acids (AA), a group of essential nutrients for pigs, are not only obligatory for maintaining gut mucosal mass and integrity, but also for supporting the growth of luminal microbiota. Read More

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Alcohol Consumption in Rheumatoid Arthritis: A Path through the Immune System.

Nutrients 2021 Apr 16;13(4). Epub 2021 Apr 16.

Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, 91054 Erlangen, Germany.

Benefits and harms of different components of human diet have been known for hundreds of years. Alcohol is one the highest consumed, abused, and addictive substances worldwide. Consequences of alcohol abuse are increased risks for diseases of the cardiovascular system, liver, and nervous system, as well as reduced immune system function. Read More

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The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases.

Nutrients 2021 Apr 16;13(4). Epub 2021 Apr 16.

Department of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy.

Chronic neuroinflammation is a pathological condition of numerous central nervous system (CNS) diseases such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis and many others. Neuroinflammation is characterized by the microglia activation and concomitant production of pro-inflammatory cytokines leading to an increasing neuronal cell death. The decreased neuroinflammation could be obtained by using natural compounds, including flavonoids known to modulate the inflammatory responses. Read More

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Enhancing the Nutritional Value of Red Meat through Genetic and Feeding Strategies.

Foods 2021 Apr 16;10(4). Epub 2021 Apr 16.

Lacombe Research and Development Centre, Agriculture and Agri-Food Canada, Lacombe, AB T4L 1W1, Canada.

Consumption of red meat contributes to the intake of many essential nutrients in the human diet including protein, essential fatty acids, and several vitamins and trace minerals, with high iron content, particularly in meats with high myoglobin content. Demand for red meat continues to increase worldwide, particularly in developing countries where food nutrient density is a concern. Dietary and genetic manipulation of livestock can influence the nutritional value of meat products, providing opportunities to enhance the nutritional value of meat. Read More

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Plasma Fatty Acids and Quantitative Ultrasound, DXA and pQCT Derived Parameters in Postmenopausal Spanish Women.

Nutrients 2021 Apr 25;13(5). Epub 2021 Apr 25.

Metabolic Bone Diseases Research Group, Nursing and Occupational Therapy College, University of Extremadura, 10003 Caceres, Spain.

Different factors may contribute to the development of osteopenia or osteoporosis. Fatty acids are key nutrients for health, and a number of studies have reported an association between bone mineral density (BMD) and fatty acid intake. We aimed to investigate the relationships between serum levels of different fatty acids and bone parameters determined by quantitative bone ultrasound (QUS), peripheral quantitative computed tomography (pQCT), and dual-energy X-ray absorptiometry (DXA) in a sample of Spanish postmenopausal women. Read More

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The Structure of Relationships between the Human Exposome and Cardiometabolic Health: The Million Veteran Program.

Nutrients 2021 Apr 19;13(4). Epub 2021 Apr 19.

Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC), Boston Veterans Affairs Healthcare System, Boston, MA 02130, USA.

The represents the array of dietary, lifestyle, and demographic factors to which an individual is exposed. Individual components of the exposome, or groups of components, are recognized as influencing many aspects of human physiology, including cardiometabolic health. However, the influence of the whole exposome on health outcomes is poorly understood and may differ substantially from the sum of its individual components. Read More

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Analysis of the Effects of Nutrient Intake and Dietary Habits on Depression in Korean Adults.

Nutrients 2021 Apr 19;13(4). Epub 2021 Apr 19.

School of Electronics and Computer Engineering, Chonnam National University, Gwangju 61186, Korea.

While several studies have explored nutrient intake and dietary habits associated with depression, few studies have reflected recent trends and demographic factors. Therefore, we examined how nutrient intake and eating habits are associated with depression, according to gender and age. We performed simple and multiple regressions using nationally representative samples of 10,106 subjects from the Korea National Health and Nutrition Examination Survey. Read More

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Non-Celiac Gluten/Wheat Sensitivity: Clinical Characteristics and Microbiota and Mycobiota Composition by Response to the Gluten Challenge Test.

Nutrients 2021 Apr 12;13(4). Epub 2021 Apr 12.

Department of Medical Sciences, University of Torino, 10126 Torino, Italy.

The aims of this observational "proof-of-concept" study were to analyze the clinical/psychological characteristics and gut microbiota/mycobiota composition of individuals with suspected non-celiac gluten/wheat sensitivity (NCGS/WS) according to responses to the double-blind-placebo-controlled (DBPC) crossover gluten challenge test. Fifty individuals with suspected NCGS/WS were subjected to the DBPC challenge test; anthropometric measurements, psychometric questionnaires, and fecal samples were collected. Twenty-seven (54%) participants were gluten responsive (NCGS), and 23 were placebo responsive, with an order effect. Read More

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Association between Malnutrition and Quality of Life in Elderly Patients with Rheumatoid Arthritis.

Nutrients 2021 Apr 12;13(4). Epub 2021 Apr 12.

Department of Clinical Nursing, Wroclaw Medical University, 51-618 Wrocław, Poland.

Rheumatoid arthritis (RA) is a progressive articular disease. In addition to damaging the joints, it may cause multiple organ complications, and considerably impair the patient's functioning. Elderly patients with RA report pain, fatigue, mood disorders, sleep disorders and insomnia, accompanied by weakness, poor appetite, and weight loss. Read More

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Diet-Cognition Associations Differ in Mild Cognitive Impairment Subtypes.

Nutrients 2021 Apr 17;13(4). Epub 2021 Apr 17.

National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 29 Nanwei Road, Beijing 100050, China.

Cognitive function is not generally associated with diet, and there is debate over that association. Moreover, little is known about such associations with the specific cognitive domains and subtypes of mild cognitive impairment (MCI). We analyzed data of 4309 Chinese adults aged 55 and over from the Community-based Cohort Study on Nervous System Diseases from 2018-2019. Read More

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The Unique Phenotype of Lipid-Laden Macrophages.

Int J Mol Sci 2021 Apr 14;22(8). Epub 2021 Apr 14.

Leiden Institute of Chemistry, Leiden University, 2333 CC Leiden, The Netherlands.

Macrophages are key multi-talented cells of the innate immune system and are equipped with receptors involved in damage and pathogen recognition with connected immune response guiding signaling systems. In addition, macrophages have various systems that are involved in the uptake of extracellular and intracellular cargo. The lysosomes in macrophages play a central role in the digestion of all sorts of macromolecules and the entry of nutrients to the cytosol, and, thus, the regulation of endocytic processes and autophagy. Read More

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Measuring Dietary Botanical Diversity as a Proxy for Phytochemical Exposure.

Nutrients 2021 Apr 14;13(4). Epub 2021 Apr 14.

Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.

The study of natural plant molecules and their medicinal properties, pharmacognosy, provides a taxonomy for botanical families that represent diverse chemical groupings with potentially distinct functions in relation to human health. Yet, this reservoir of knowledge has not been systematically applied to elucidating the role of patterns of plant food consumption on gut microbial ecology and function. All chemical classes of dietary phytochemicals can affect the composition of the microbes that colonize the gut and their function. Read More

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