78,897 results match your criteria multiple measures

Improving river hydromorphological assessment through better integration of riparian vegetation: Scientific evidence and guidelines.

J Environ Manage 2021 May 12;292:112730. Epub 2021 May 12.

Centro de Estudos Florestais, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017, Lisboa, Portugal.

River hydromorphology has long been subjected to huge anthropogenic pressures with severe negative impacts on related ecosystems' functioning and water quality. Therefore, improving river hydromorphological conditions represents a priority task in sustainable river management and requires proper assessment tools. It is well known that riparian vegetation plays a crucial role in sustaining river hydromorphological conditions. Read More

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Quality of life in multiple sclerosis is dominated by fatigue, disability and self-efficacy.

J Neurol Sci 2021 Apr 9;426:117437. Epub 2021 Apr 9.

Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK. Electronic address:

Background And Objective: Quality of life in multiple sclerosis (MS) reflects complex relationships between symptoms (fatigue, spasticity pain, and bladder or vision dysfunction), disability, health perceptions, and self-efficacy.

Methods: In this cross-sectional study, a self-report questionnaire pack of patient reported outcome measures was collected from 5695 people with MS (pwMS) alongside clinical data from their neurologists. Each patient reported outcome measure was converted to interval-scaled estimates following fit to the Rasch model. Read More

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Improvements in sleep-disordered breathing during acclimatization to 3800 m and the impact on cognitive function.

Physiol Rep 2021 May;9(9):e14827

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, USA.

Sojourners to high altitude often experience poor sleep quality due to sleep-disordered breathing. Additionally, multiple aspects of cognitive function are impaired at high altitude. However, the impact of acclimatization on sleep-disordered breathing and whether poor sleep is a major contributor to cognitive impairments at high altitude remains uncertain. Read More

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The use of statistical modelling to identify important parameters for the shape of the torso following surgery for adolescent idiopathic scoliosis.

J Anat 2021 May 15. Epub 2021 May 15.

Institute of Clinical Science, University of Birmingham, Birmingham, UK.

The surgical strategy in adolescent idiopathic scoliosis (AIS) aims to recreate the symmetry of the torso. This requires the minimisation of both the size of the scoliosis and the angulation between the sides of the torso, along with the recreation of a normal thoracic kyphosis. This study uses predictive modelling to identify the significance of the value of the pre-operative parameters, and the change in the magnitude of the parameters as a result of an operation on the shape of the torso using the 'most prominent points'; two areas of maximum prominence on either side of the spine with x, y and z coordinates. Read More

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Greater daily glucose variability and lower time in range assessed with continuous glucose monitoring are associated with greater aortic stiffness: The Maastricht Study.

Diabetologia 2021 May 15. Epub 2021 May 15.

CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, the Netherlands.

Aims: CVD is the main cause of morbidity and mortality in individuals with diabetes. It is currently unclear whether daily glucose variability contributes to CVD. Therefore, we investigated whether glucose variability is associated with arterial measures that are considered important in CVD pathogenesis. Read More

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Schizophrenia outcomes in the 21st century: A systematic review.

Brain Behav 2021 May 15:e02172. Epub 2021 May 15.

Clinical Professor of Psychiatry and Adjunct Professor of Anthropology, University of Colorado, Denver, CO, USA.

Objective: We report a review of outcomes in schizophrenia in the twenty-first century, replicating and extending work undertaken by the late Richard Warner in his seminal book, "Recovery from Schizophrenia: Psychiatry and Political Economy" (1985;2004).

Method: Warner's methods were followed as closely as possible. Only observational/naturalistic studies were included. Read More

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Restlessness in Generalized Anxiety Disorder: Using Actigraphy to Measure Physiological Reactions to Threat.

Behav Ther 2021 May 18;52(3):734-744. Epub 2020 Sep 18.

University of Pennsylvania.

Generalized anxiety disorder (GAD) is characterized by excessive, uncontrollable worry accompanied by symptoms of physiological arousal. Although individuals with GAD report greater subjective arousal than healthy individuals, they show equivalent or even attenuated physiological reactions to threat. This may result from using physiological measures better suited to fear than anxiety. Read More

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Development and validation of a patient-centered, meningioma-specific quality-of-life questionnaire.

J Neurosurg 2021 May 14:1-10. Epub 2021 May 14.

1Division of Neurosurgery, Department of Surgery and.

Objective: Meningiomas can have significant impact on health-related quality of life (HRQOL). Patient-centered, disease-specific instruments for assessing HRQOL in these patients are lacking. To this end, the authors sought to develop and validate a meningioma-specific HRQOL questionnaire through a standardized, patient-centered questionnaire development methodology. Read More

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P-wave signal averaged ECG: reference values, clinical correlates, and heritability in the Framingham Heart Study.

Heart Rhythm 2021 May 11. Epub 2021 May 11.

National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, MA, USA; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA.

Background: P-wave signal-averaged electrocardiography (P-SAECG) quantifies atrial electrical activity. P-SAECG measures and their clinical correlates and heritability have had limited characterization in community-based cohorts.

Objectives: To 1) Establish reference values; 2) Identify clinical risk factors associated with P-SAECG; and 3) Estimate genetic heritability for P-SAECG traits. Read More

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Social Needs, Chronic Conditions, and Health Care Utilization among Medicaid Beneficiaries.

Popul Health Manag 2021 May 14. Epub 2021 May 14.

Brown School of Social Work, Washington University in St. Louis, St. Louis, Missouri, USA.

Health care organizations are increasingly assessing patients' social needs (eg, food, utilities, transportation) using various measures and methods. Prior studies have assessed social needs at the point of care and many studies have focused on correlates of 1 specific need (eg, food). This comprehensive study examined multiple social needs and medical and pharmacy claims data. Read More

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Press Ganey Surveys in Patients Undergoing Upper-Extremity Surgical Procedures: Response Rate and Evidence of Nonresponse Bias.

J Bone Joint Surg Am 2021 May 14. Epub 2021 May 14.

Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, Maryland.

Background: Patient satisfaction surveys are important measures of the patient experience that provide data for quality improvement. The purpose of this study was to establish the response rate and the factors associated with the completion of the Press Ganey (PG) Ambulatory Surgery Survey (PGAS) in patients who underwent ambulatory upper-extremity surgical procedures.

Methods: A prospective orthopaedic registry at a single academic ambulatory surgical center was retrospectively reviewed for patients who underwent an upper-extremity surgical procedure from 2015 to 2019. Read More

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A Primer on RECIST 1.1 for Oncologic Imaging in Clinical Drug Trials.

Radiol Imaging Cancer 2021 May;3(3):e210008

From the Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Suite 1621, Los Angeles, CA 90095-1721 (K.R., M.D., V.S., A.G., R.D., J.G.); and Department of Radiology, Beth Israel Lahey Health, Burlington, Mass (M.B.A.).

Drug discovery and approval in oncology is mediated by the use of imaging to evaluate drug efficacy in clinical trials. Imaging is performed while patients receive therapy to evaluate their response to treatment. Response criteria, specifically Response Evaluation Criteria in Solid Tumors version 1. Read More

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The clinical and cognitive spectrum of locked-in syndrome: 1-year follow-up of 100 patients.

Acta Neurol Belg 2021 May 13. Epub 2021 May 13.

Neurology Department, Acibadem Hospital, Bursa, Türkiye.

In patients with locked-in syndrome (LIS), it is not known exactly to what extent cognitive functions are preserved and it is not known exactly how much it has improved. We aimed to examine the clinical and cognitive features of LIS 1 year after stroke. One hundred patients with locked-in syndrome (LIS) were recruited between January 2008 and May 2019 among 8200 patients with ischemic stroke. Read More

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Associations of cognitive performance with cardiovascular magnetic resonance phenotypes in the UK Biobank.

Eur Heart J Cardiovasc Imaging 2021 May 14. Epub 2021 May 14.

Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford, OX3 9DU, UK.

Aims: Existing evidence suggests links between brain and cardiovascular health. We investigated associations between cognitive performance and cardiovascular magnetic resonance (CMR) phenotypes in the UK Biobank, considering a range of potential confounders.

Methods And Results: We studied 29 763 participants with CMR and cognitive testing, specifically, fluid intelligence (FI, 13 verbal-numeric reasoning questions), and reaction time (RT, a timed pairs matching exercise); both were considered continuous variables for modelling. Read More

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Two-stage S sleeve resection of the right lower lobe and S and S segmentectomy of the left upper lobe: a case report.

Ann Transl Med 2021 Apr;9(8):723

Department of Thoracic Surgery, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.

Synchronous multiple nodules in the lungs, such as peripheral ground-glass opacities (GGOs) and solid small nodules, are common, but only lesions suspected of being malignant should be surgically removed. The surgical strategy is anatomical sub-lobectomy in early stage of non-small cell lung cancer synchronously or asynchronously to decrease the impact of lung resection on the lung function. Here, we report a case of a 56-year-old man, who was a pack-a-day smoker, with endobronchial hamartomas the medial basal bronchus (B7). Read More

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Pupillary Response to Postural Demand in Parkinson's Disease.

Front Bioeng Biotechnol 2021 27;9:617028. Epub 2021 Apr 27.

Department of Physical Therapy and Rehabilitation Science, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, United States.

Individuals with Parkinson's disease (PD) may need to spend more mental and physical effort (i.e., cognitive workload) to maintain postural control. Read More

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Antimicrobial Efficacy of Propolis-Containing Varnish in Children: A Randomized and Double-Blind Clinical Trial.

Evid Based Complement Alternat Med 2021 26;2021:5547081. Epub 2021 Apr 26.

Postgraduate Program in Pharmacology, School of Medicine, Federal University of Ceara, Alexandre Baraúna 949, 60430-160, Fortaleza, Brazil.

Dental caries is a sugar-dependent condition common in childhood, which causes microbiological imbalance in dental biofilm. The present study evaluated the antimicrobial efficacy of a 2.5% Brazilian Red Propolis (BRP) dental varnish to prevent caries in children. Read More

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The landscape and driver potential of site-specific hotspots across cancer genomes.

NPJ Genom Med 2021 May 13;6(1):33. Epub 2021 May 13.

Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.

Large sets of whole cancer genomes make it possible to study mutation hotspots genome-wide. Here we detect, categorize, and characterize site-specific hotspots using 2279 whole cancer genomes from the Pan-Cancer Analysis of Whole Genomes project and provide a resource of annotated hotspots genome-wide. We investigate the excess of hotspots in both protein-coding and gene regulatory regions and develop measures of positive selection and functional impact for individual hotspots. Read More

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Effect of post-stroke spasticity on voluntary movement of the upper limb.

J Neuroeng Rehabil 2021 May 13;18(1):81. Epub 2021 May 13.

Department of Industrial Engineering and Management, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Background: Hemiparesis following stroke is often accompanied by spasticity. Spasticity is one factor among the multiple components of the upper motor neuron syndrome that contributes to movement impairment. However, the specific contribution of spasticity is difficult to isolate and quantify. Read More

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Team-work, Team-brain: Exploring synchrony and team interdependence in a nine-person drumming task via multiparticipant hyperscanning and inter-brain network topology with fNIRS.

Neuroimage 2021 May 10:118147. Epub 2021 May 10.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University; IDG/McGovern Institute for Brain Research, Beijing Normal University. Electronic address:

Teamwork is indispensable in human societies. However, due to the complexity of studying ecologically valid synchronous team actions, requiring multiple members and a range of subjective and objective measures, the mechanism underlying the impact of synchrony on team performance is still unclear. In this paper, we simultaneously measured groups of nine-participants' (total N = 180) fronto-temporal activations during a drum beating task using functional near infrared spectroscopy (fNIRS)-based hyperscanning and multi-brain network modeling, which can assess patterns of shared neural synchrony and attention/information sharing across entire teams. Read More

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Prevalence, predictors and correlates of religious and spiritual struggles in palliative cancer patients.

J Pain Symptom Manage 2021 May 10. Epub 2021 May 10.

Department of Religion, Health and Human Values, Rush University Medical Center, Chicago, Illinois.

Context: Religion and spirituality (r/s) are important resources in coping with cancer. However, there are aspects of r/s, such as religious and spiritual struggles, found to be associated with poorer outcomes. A new measure has been adapted from the Religious and Spiritual Struggles Scale (RSS) to assess r/s struggles: the RSS-14. Read More

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Articulatory Correlates of Stress Pattern Disturbances in Talkers With Dysarthria.

J Speech Lang Hear Res 2021 May 13:1-14. Epub 2021 May 13.

Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN.

Purpose Reduced stress commonly occurs in talkers with Parkinson's disease (PD), whereas excessive and equal stress is frequently associated with dysarthria of talkers with amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). This study sought to identify articulatory impairment patterns that underlie these two impaired stress patterns. We further aimed to determine if talkers with the same stress pattern disturbance but different diseases (ALS and MS) exhibit disease-specific articulatory deficits. Read More

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Are extracapsular and intracapsular hip-fracture patients two distinct rehabilitation subpopulations?

Disabil Rehabil 2021 May 13:1-6. Epub 2021 May 13.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To assess whether intracapsular and extracapsular hip fracture patients in a post-acute rehabilitation setting differ in their background characteristics and whether fracture type affects rehabilitation outcome.

Methods: A retrospective cohort study.

Outcome Measures: Functional Independence Measure (FIM), motor FIM (mFIM), mFIM effectiveness, length of stay (LOS), and discharge destination. Read More

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An integrated multicomponent care model for men affected by prostate cancer: A feasibility study of TrueNTH Australia.

Psychooncology 2021 May 13. Epub 2021 May 13.

Queensland University of Technology, Cancer and Palliative Care Outcomes Centre, Kelvin Grove, QLD, Australia.

Objective: To evaluate the feasibility of implementing an integrated multicomponent survivorship care model for men affected by prostate cancer.

Methods: Using a single arm prospective cohort study design, men with prostate cancer were recruited from two regional public hospitals in Australia for a 6-month program that provided information and decision support, exercise and nutrition management, specialised clinical support, and practical support through localised and central care coordination. Carers of the men were also invited to the program. Read More

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Implementation of the Uniformed Services University Pain Registry Biobank: A Military and Veteran Population Focused Biobank and Registry.

Pain Med 2021 May 13. Epub 2021 May 13.

Defense and Veterans Center for Integrative Pain Management, Uniformed Services University, 11300 Rockville Pike, Rockville, MD.

Objective: The objective of this overview is to discuss the development, implementation, data content, and structure of the Uniformed Services University Pain Registry Biobank. Additionally, procedures and policies for accessing samples for pain-related research purposes are detailed.

Design: Cross-sectional overview. Read More

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Relevance of Anthropometric Measurements in a Multiethnic Obesity Cohort: Observational Study.

Interact J Med Res 2021 May 13;10(2):e27784. Epub 2021 May 13.

Mohammad Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Background: The prevalence of obesity is increasing worldwide, and the Middle East is not an exception to this increasing trend. Obesity increases the risk of multiple metabolic complications, such as diabetes mellitus. Measurement of obesity has primarily relied on the BMI to identify risk; however, both bedside and office-based anthropometric measures of obesity can provide more detailed information on risk. Read More

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Corroboration of Height Velocity Prediction Markers for rhGH With an Oral GH Secretagogue Treatment in Children With GHD.

J Endocr Soc 2021 Jun 25;5(6):bvab029. Epub 2021 Feb 25.

Lumos Pharma, Inc., Austin, TX, USA.

Context: Recombinant human growth hormone (rhGH) is approved for treatment of pediatric growth hormone deficiency (GHD), with greatest growth responses observed in those with severe GHD. Orally administered GH secretagogues (GHS) may be useful treatment in patients with moderate GHD. Distinguishing children with severe moderate GHD could identify children who would be better treated with rhGH or GHS. Read More

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