J Biomech Eng 2021 May 11. Epub 2021 May 11.
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, The Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, 473 West 12th Avenue Columbus, OH 43210; Department of Biomedical Engineering, The Ohio State University, 140 West 19th Avenue Columbus, OH 43210.
Cells within the lung microenvironment are continuously subjected to dynamic mechanical stimuli which is converted into biochemical signaling events in a process known as mechanotransduction. In pulmonary diseases, the abrogated mechanical conditions modify the homeostatic signaling which influences cellular phenotype and disease progression. The use of in vitro models has significantly expanded our understanding of lung mechanotransduction mechanisms. Read More