57,465 results match your criteria multiple antibiotic

Comparative Biofilm Assays Using Enterococcus faecalis OG1RF Identify New Determinants of Biofilm Formation.

mBio 2021 Jun 15:e0101121. Epub 2021 Jun 15.

Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.

Enterococcus faecalis is a common commensal organism and a prolific nosocomial pathogen that causes biofilm-associated infections. Numerous E. faecalis OG1RF genes required for biofilm formation have been identified, but few studies have compared genetic determinants of biofilm formation and biofilm morphology across multiple conditions. Read More

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Effects of Synbiotics on the Fecal Microbiome and Metabolomic Profiles of Healthy Research Dogs Administered Antibiotics: A Randomized, Controlled Trial.

Front Vet Sci 2021 26;8:665713. Epub 2021 May 26.

The Gastrointestinal Laboratory, Small Animal Clinical Sciences, Texas A&M University, College Station, TX, United States.

Antibiotic-associated gastrointestinal signs occurred in 100% of dogs administered enrofloxacin with metronidazole in a previous study, and signs partially were mitigated by synbiotics. The objective of this randomized, double-blinded, placebo-controlled trial was to compare the fecal microbiome and metabolome of dogs administered enrofloxacin and metronidazole, followed by either a placebo or a bacterial/yeast synbiotic combination. Twenty-two healthy research dogs were randomized to two treatment groups. Read More

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Isolation and Characterization of Potential Phages Targeting Multidrug-Resistant and Major Serovars of Derived From Broiler Production Chain in Thailand.

Front Microbiol 2021 28;12:662461. Epub 2021 May 28.

Faculty of Agro-Industry, Prince of Songkla University, Songkhla, Thailand.

is a major foodborne pathogen that causes foodborne disease in humans through consumption of contaminated foods, especially those of animal origin. Multiple strains are antibiotic-resistant due to the common use of antibiotics in farm animals, including broiler farms. In this study, an alternative strategy using phage-based treatment was evaluated against isolated from the broiler production. Read More

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Genotyping Helicobacter pylori antibiotic resistance - and virulence-associated genes in patients with gastric cancer in Wenzhou, China.

Arab J Gastroenterol 2021 Jun 10. Epub 2021 Jun 10.

Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address:

Background And Study Aims: Helicobacter pylori infection affects approximately 50% of the global population and has become a serious health concern related to gastric cancer, gastritis, and peptic ulcers. This organism acquires drug resistance through gene mutations, and its increasing resistance to antibiotics has severely influenced the effectiveness of eradication efforts. Therefore, we designed this study to determine the prevalence of H. Read More

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Multiple model triangulation to identify factors associated with lameness in British sheep flocks.

Prev Vet Med 2021 Jun 1;193:105395. Epub 2021 Jun 1.

Institute of Microbiology and Infection, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom.

Identification of factors associated with an outcome can be challenging when the number of explanatory variables is large in relation to the number of observations. Multiple model triangulation, where results from several model types are combined, improves the likelihood of identifying true predictor variables. The aim of this study was to use triangulation to identify covariates likely to be truly associated with the prevalence of lameness in sheep flocks in Great Britain. Read More

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Increased risk of short-term depressive disorder after Helicobacter pylori eradication: A population-based nested cohort study.

Helicobacter 2021 Jun 11:e12824. Epub 2021 Jun 11.

Institute of Brain Science, National Yang Ming Chiao Tung University School of Medicine, Taipei, Taiwan.

Background: Depressive disorder is a major psychiatric illness, and a disturbed brain-gut-microbiome axis may contribute to its pathophysiology. Chronic Helicobacter pylori (H. pylori) infections are common in the general population and using multiple antibiotics is required for its eradication, which is associated with gut dysbiosis and may lead to depression. Read More

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Recent strategies for inhibiting multidrug-resistant and β-lactamase producing bacteria: A review.

Colloids Surf B Biointerfaces 2021 Jun 6;205:111901. Epub 2021 Jun 6.

Enzyme and Microbial Biochemistry Laboratory, Department of Chemistry, Indian Institute of Technology Delhi, India. Electronic address:

β-lactam antibiotics are one of the most commonly used drugs for treating bacterial infections, but their clinical effectiveness has been severely affected with bacteria developing resistance against their action. Production of β-lactamase enzymes by bacteria that can degrade β-lactams is the most common mechanism of acquiring such resistance, leading to the emergence of multiple-drug resistance in them. Therefore, the development of efficient approaches to combat infections caused by β-lactamase producing and multidrug-resistant bacteria is the need of the hour. Read More

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Ozone nanobubble treatments improve survivability of Nile tilapia (Oreochromis niloticus) challenged with a pathogenic multi-drug-resistant Aeromonas hydrophila.

J Fish Dis 2021 Jun 10. Epub 2021 Jun 10.

Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok, Thailand.

A rapid increase in multi-drug-resistant (MDR) bacteria in aquaculture highlights the risk of production losses due to diseases and potential public health concerns. Previously, we reported that ozone nanobubbles (NB-O ) were effective at reducing concentrations of pathogenic bacteria in water and modulating fish immunity against pathogens; however, multiple treatments with direct NB-O exposures caused alterations to the gills of exposed fish. Here, we set up a modified recirculation system (MRS) assembled with an NB-O device (MRS-NB-O ) to investigate whether MRS-NB-O (a) were safe for tilapia (Oreochromis niloticus), (b) were effective at reducing bacterial load in rearing water and (c) improved survivability of Nile tilapia following an immersion challenge with a lethal dose of MDR Aeromonas hydrophila. Read More

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Survey on general practitioners' and pharmacists' opinions regarding patient-initiated treatment of recurring urinary tract infections.

Int J Clin Pharm 2021 Jun 10. Epub 2021 Jun 10.

Department of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

Background The Dutch general practitioners (GP) guideline for urinary tract infections (UTI) recommends patient-initiated treatment for women with recurring UTI. In countries other than the Netherlands, community pharmacists play a role in dispensing antibiotics for recurring UTI without preceding GP consultation. Objective To study GP and pharmacist opinions regarding the desirability of patient-initiated treatment, including potential pharmacist support for, and consequences of, facilitated access to antibiotics. Read More

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Risk factors in total hip arthroplasty and hemiarthroplasty: Infection and mortality.

Rev Esp Cir Ortop Traumatol 2021 Jul-Aug;65(4):239-247

Medicina Preventiva y Salud Pública, Hospital Universitario de La Princesa, Madrid, Spain.

Background: Surveillance systems make it possible to analyze the trends of infections associated with hip arthroplasty. The aim of this study is to determine risk factors associated with surgical site infection (SSI) and mortality following total hip arthroplasty (THA) or hemiarthroplasty (HHA).

Methods: Observational study including individuals ≥18 years who underwent THA or HHA between January 2007 and December 2017. Read More

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[Visual analysis of research on multidrug-resistant bacteria in intensive care unit in China].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):587-592

Department of Intensive Care Unit, Taian City Central Hospital, Taian 271000, Shandong, China.

Objective: To identify the distribution of research hotspots and frontiers of multidrug-resistant bacteria in intensive care units in China through the method of visualization, and to predict future research directions, analyze the research development process, so as to provide reference basis for further research in this field.

Methods: Studies related to multidrug-resistant bacteria in intensive care units published in China from 2000 to 2019 by CNKI were reviewed. According to the keywords by CiteSpace 5. Read More

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Multiple facial candidal abscesses after self-administered acupuncture in a patient with undiagnosed diabetes mellitus: a case report.

BMC Complement Med Ther 2021 Jun 10;21(1):170. Epub 2021 Jun 10.

Department of Ophthalmology, Chungnam National University College of Medicine, Chungnam National University Hospital, #282 Munhwa-ro, Jung-gu, Daejeon, 35015, Republic of Korea.

Background: Facial abscess caused by Candida albicans infection is a rare condition even in immunocompromised patients, and only a few cases have been reported. To our knowledge, this is the first case of multiple facial candidal abscesses caused by self-administered acupuncture in an undiagnosed diabetes mellitus patient.

Case Presentation: A 57-year-old woman who had self-acupuncture treatment 2 weeks previously, presented with a 1-week history of progressive left eyelid swelling, erythema, and pain. Read More

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Are Oral Antibiotics an Effective Alternative to Intravenous Antibiotics in Treatment of Osteomyelitis of The Jaw?

J Oral Maxillofac Surg 2021 Apr 22. Epub 2021 Apr 22.

Clinical Associate Professor, Program Director, Chief of Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, University of Washington, Harborview Medical Center, Seattle, WA. Electronic address:

Purpose: To review treatment of osteomyelitis of the jaw (OMJ) and determine whether antibiotic route and/or length of administration impacts resolution of infection postsurgically.

Methods: The investigators designed a retrospective cohort study enrolling a sample of patients treated at Harborview Medical Center from January 1st 2009 to December 31st 2019. The primary predictor variable was antibiotic administration route: oral (PO) only, intravenous (IV) only, IV transitioned to PO (IV + PO), or none. Read More

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Antibiotic resistance in mucosal bacteria from high Arctic migratory salmonids.

Environ Microbiol Rep 2021 Jun 9. Epub 2021 Jun 9.

College of the Sciences and Mathematics, West Chester University, West Chester, Pennsylvania, USA.

Two related salmonids, Arctic char (Salvelinus alpinus) and lake whitefish (Coregonus clupeaformis) sampled from the high Arctic region of Nunavut, Canada are anadromous fish, migrating annually from the same ice-covered freshwater waterbodies to spend summers in the marine waters of the Arctic Ocean. Microbiota associated with the skin-associated mucus undergo community change coincident with migration, and irrespective of this turnover, antibiotic resistance was detected in mixed bacterial cultures initiated with mucus samples. Although as expected most bacteria were unculturable, however, 5/7 isolates showed susceptibility to a panel of five common antibiotics. Read More

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Oral antibiotics for chronic blepharitis.

Cochrane Database Syst Rev 2021 Jun 9;6:CD013697. Epub 2021 Jun 9.

Byers Eye Institute, Stanford University, Palo Alto, California, USA.

Background: Posterior blepharitis is common and causes ocular surface and lid damage as well as discomfort. It affects 37% to 47% of all ophthalmology patients; its incidence increasing with age. It is a multifactorial disease associated with multiple other pathologies, such as rosacea, meibomianitis, and infections. Read More

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Pulmonary nodule in pediatrics: Beyond the infection.

Andes Pediatr 2021 Feb 22;92(1):110-116. Epub 2021 Feb 22.

División de Neumología Pediátrica, Fundación Hospital Pediátrico la Misericordia, Bogotá D.C., Colombia.

Introduction: The study of a pulmonary nodule in pediatrics is a diagnostic challenge where multiple pathologies must be taken into account, especially infections. In developing countries, where tuberculosis infec tion is endemic, it is one of the most likely diagnoses; however, the diagnostic possibility of malig nancy should never be overlooked.

Objective: To describe a case report of a patient with a pulmonary nodule, that after ruling out the most frequent causes, a primary malignant tumor was diagnosed. Read More

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February 2021

Systematic Literature Review on Burden of difficile Infection in India.

Clin Pathol 2021 Jan-Dec;14:2632010X211013816. Epub 2021 May 31.

Medical and Scientific Affairs, Pfizer Limited, Mumbai, India.

Background: Owing to limited diagnostic facilities and surveillance protocols, there is a paucity on the prevalence data of infections (CDIs) in developing countries such as India.

Objective: The aims of these studies are (1) to determine the prevalence of CDI in India, (2) to understand the risk factors of CDI, and (3) to determine the impact of different diagnostic methods on reported CDI rates.

Method: A systematic literature search was conducted using PubMed and Google Scholar database to identify Indian studies reporting the prevalence of CDI. Read More

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Addressing the global surge of COVID-19 cases: Insights from diagnostics, improved treatment strategies, vaccine development and application.

J Clin Transl Res 2021 Apr 12;7(2):127-139. Epub 2021 Mar 12.

Department of Medical Laboratory Sciences, College of Health Sciences, Ladoke Akintola University, Ogbomoso, Oyo State, Nigeria.

Background And Aim: As the rage of coronavirus disease 2019 (COVID-19) pandemic continues to spread globally, much effort is being directed to contain it through various efforts - genomic studies, drug discoveries, clinical trials, vaccine development, and the innovation of diagnostic techniques. However, some pertinent areas involving accurate and sensitive diagnostics, immunoglobulin specificity, evolution of mutant strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the drug combination strategy to combat it still require more attention.

Methods: This review critically examines the COVID-19 response and containment operations. Read More

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Drug- and Multidrug-Resistance Pattern of Enterobacteriaceae Isolated from Droppings of Healthy Chickens on a Poultry Farm in Southwest Ethiopia.

Infect Drug Resist 2021 2;14:2051-2058. Epub 2021 Jun 2.

Department of Medical Laboratory Sciences, Mizan-Tepi Universities, Mizan-Aman, SNNPR, Ethiopia.

Background: In Ethiopia, the precise attribution of animals and their food products as the sources of resistant strains and the consequences of it on human health have not yet been seriously evaluated. Therefore, the aim of this study was to assess the drug- and multidrug-resistance pattern of Enterobacteriaceae isolated from chicken droppings at Jimma University poultry farm, College of Agriculture and Veterinary Medicine, southwest of Ethiopia.

Methods: A cross-sectional descriptive study was conducted from April, 2018 to June, 2018. Read More

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Bacterial and fungal bloodstream infections in pediatric liver and kidney transplant recipients.

BMC Infect Dis 2021 Jun 8;21(1):541. Epub 2021 Jun 8.

Viro-immunology Research Unit, Department of Infectious Diseases 8632, Rigshospitalet, University of Copenhagen, Blegdamsvej 9B, DK-2100, Copenhagen Ø, Denmark.

Background: Bacterial and fungal bloodstream infections (BSI) are common after pediatric liver and kidney transplantations and associated with morbidity and mortality. However, knowledge about incidence rates, pathogen composition, and resistance patterns is limited. We aimed to describe the pattern of bacterial and fungal BSI in a cohort of pediatric liver and kidney transplant recipients. Read More

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Exploring care of hospital inpatients with substance involvement.

Soc Sci Med 2021 May 24;281:114071. Epub 2021 May 24.

St. Joseph's Care Group, Canada. Electronic address:

Introduction: This article presents demographic and care factors related to persons who are substance-involved and require inpatient administration of intravenous antibiotics.

Purpose: This study was conducted to explore healthcare responses to support substance-involved inpatients, through exploration of documented client outcomes, healthcare provider accounts, and representation of clients through documentation.

Method(s): A patient-oriented research team undertook this multiple methods, exploratory study. Read More

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WeFaceNano: a user-friendly pipeline for complete ONT sequence assembly and detection of antibiotic resistance in multi-plasmid bacterial isolates.

BMC Microbiol 2021 Jun 7;21(1):171. Epub 2021 Jun 7.

Department of Pathology, Clinical Bioinformatics Unit, Erasmus University Medical Center (Erasmus MC), Rotterdam, The Netherlands.

Background: Bacterial plasmids often carry antibiotic resistance genes and are a significant factor in the spread of antibiotic resistance. The ability to completely assemble plasmid sequences would facilitate the localization of antibiotic resistance genes, the identification of genes that promote plasmid transmission and the accurate tracking of plasmid mobility. However, the complete assembly of plasmid sequences using the currently most widely used sequencing platform (Illumina-based sequencing) is restricted due to the generation of short sequence lengths. Read More

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[Study on the effect of antibiotics application in perioperative period on carotid artery and serum interleukin-6 in periodontitis rats with hyperlipidemia or diabetes].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Jun;56(6):557-564

Department of Periodontology, Shanxi Medical University School and Hospital of Stomatology & Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001, China.

To investigate the effect of antibiotics application in perioperative period on carotid artery and serum interluekin-6 (IL-6) in chronic periodontitis (CP) rats with hyperlipidemia (HL) or diabetes mellitus (DM). The models of CP rats with HL or DM were established in different batches. The rats were divided into groups as follows: A and A' were normal control groups, =7 in each group; B(HL) and B'(DM) were groups of HL and DM, =7 in each; C(HL+CP) and C'(DM+CP) were groups of CP with HL and CP with DM, =21 in each. Read More

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Rate and characteristics of infection after transrectal prostate biopsy: a retrospective observational study.

Scand J Urol 2021 Jun 7:1-7. Epub 2021 Jun 7.

Division of Clinical Sciences,Department of Infection Medicine, Faculty of Medicine, Lund University, Lund, Sweden.

Objectives: The aim of this study was to assess the incidence of infection after transrectal prostate biopsy (TRbx). Secondary objectives were to describe infection characteristics, antibiotic resistance patterns, ICD-10 coding, and costs.

Methods: TRbx carried out at the hospitals of Ängelholm and Helsingborg, Scania, Sweden, between October 2017 and March 2019, were identified based on the NOMESCO Classification of Surgical Procedures code for TRbx, TKE00. Read More

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Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity.

Front Vet Sci 2021 21;8:676774. Epub 2021 May 21.

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Septic arthritis causes significant morbidity and mortality in veterinary and human clinical practice and is increasingly complicated by multidrug-resistant infections. Intra-articular (IA) antibiotic administration achieves high local drug concentrations but is considered off-label usage, and appropriate doses have not been defined. Using an equine joint model, we investigated the effects of amikacin injected at three different doses (500, 125, and 31. Read More

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Antimicrobial and Genetic Profiles of and Isolated From the Maryland Coastal Bays, United States.

Front Microbiol 2021 21;12:676249. Epub 2021 May 21.

Department of Natural Sciences, CREST Center for the Integrated Study of Coastal Ecosystem Processes and Dynamics in the Mid-Atlantic Region, NOAA Living Marine Resources Cooperative Science Center, University of Maryland Eastern Shore, Princess Anne, MD, United States.

, found naturally in marine and estuarine environments, are the leading cause of seafood associated gastrointestinal illness and death. Consumption of improperly cooked crabs and handling of live crabs are potential routes of exposure to pathogenic bacteria such as and Little information is available on serotype genetic and antimicrobial profiles of and recovered from Maryland estuaries. The aim of the present study was to determine the serotype of , evaluate antimicrobial susceptibility and genetic profiles of and isolated from water and blue crab () samples collected from the Maryland Coastal Bays. Read More

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Klebsiella spp. cause severe and fatal disease in Mozambican children: antimicrobial resistance profile and molecular characterization.

BMC Infect Dis 2021 Jun 5;21(1):526. Epub 2021 Jun 5.

Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.

Background: Klebsiella spp. are important pathogens associated with bacteremia among admitted children and is among the leading cause of death in children < 5 years in postmortem studies, supporting a larger role than previously considered in childhood mortality. Herein, we compared the antimicrobial susceptibility, mechanisms of resistance, and the virulence profile of Klebsiella spp. Read More

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Group B streptococcus neonatal umbilical colonization managed by dry cord care in nurseries: A retrospective cohort study.

Pediatr Neonatol 2021 May 18. Epub 2021 May 18.

Division of Neonatology, Department of Pediatrics, Saitama City Hospital, Saitama, Japan. Electronic address:

Background: Screening-based intrapartum antibiotic prophylaxis (IAP) has reduced the prevalence of early-onset group B Streptococcus (GBS) infection in newborns. Nevertheless, early-onset disease still occurs despite IAP, and IAP is not effective in preventing late-onset disease. This study aimed to determine the prevalence and risk factors of GBS neonatal umbilical colonization managed by dry cord care in Japan. Read More

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Environmental risk assessment and bioaccumulation of pharmaceuticals in a large urbanized estuary.

Sci Total Environ 2021 Aug 19;783:147021. Epub 2021 Apr 19.

Southern Seas Ecology Laboratories, School of Biological Sciences, The University of Adelaide, South Australia 5005, Australia.

We screened for the presence of 66 different pharmaceutical residues in surface waters and in multiple invertebrate and fish species of the Tejo estuary to produce an environmental risk assessment of individual pharmaceuticals and their mixtures, as well as evaluate the bioaccumulation of pharmaceuticals in one of Europe's largest estuarine systems. Sixteen pharmaceutical residues, from seven therapeutic classes, were detected in estuarine waters, with environmental mixture concentrations ranging from 42 to 1762 ng/L. Environmental risk assessment via the determination of risk quotients, demonstrated high ecological risk for the antibiotic amoxicillin and angiotensin II receptor blockers irbesartan and losartan. Read More

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