4,611 results match your criteria multiparametric mri

Multiparametric MRI for the improved diagnostic accuracy of Alzheimer's disease and mild cognitive impairment: Research protocol of a case-control study design.

PLoS One 2021 21;16(9):e0252883. Epub 2021 Sep 21.

Gerontology Unit, Department of Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Background: Alzheimer's disease (AD) is a major neurocognitive disorder identified by memory loss and a significant cognitive decline based on previous level of performance in one or more cognitive domains that interferes in the independence of everyday activities. The accuracy of imaging helps to identify the neuropathological features that differentiate AD from its common precursor, mild cognitive impairment (MCI). Identification of early signs will aid in risk stratification of disease and ensures proper management is instituted to reduce the morbidity and mortality associated with AD. Read More

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September 2021

Characterizing Fibrosis and Inflammation in a Partial Bile Duct Ligation Mouse Model by Multiparametric Magnetic Resonance Imaging.

J Magn Reson Imaging 2021 Sep 21. Epub 2021 Sep 21.

Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, China.

Background: Partial bile duct ligation (PBDL) model is a reliable cholestatic fibrosis experimental model that showed complex histopathological changes. Magnetic resonance imaging (MRI) features of PBDL have not been well characterized.

Purpose: To investigate the potential of MRI parameters in assessing fibrosis in PBDL and explore the relationships between MRI and pathological features. Read More

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September 2021

Combination MRI-targeted and systematic prostate biopsy may overestimate gleason grade on final surgical pathology and impact risk stratification.

Urol Oncol 2021 Sep 17. Epub 2021 Sep 17.

Department of Urology, Massachusetts General Hospital, Boston, MA. Electronic address:

Purpose: Gleason grade (GG) on prostate biopsy is important for risk stratification and clinical decision making. Multiparametric MRI (mpMRI) improved detection of clinically significant disease and some studies suggest that MRI-fusion biopsy combined with systematic biopsy results in fewer upgrades on final surgical pathology. However, the downgrade rate is unclear and there is controversy in the literature. Read More

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September 2021

A Radiomics Model for Predicting Early Recurrence in Grade II Gliomas Based on Preoperative Multiparametric Magnetic Resonance Imaging.

Front Oncol 2021 2;11:684996. Epub 2021 Sep 2.

Department of Radiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Objective: This study aimed to develop a radiomics model to predict early recurrence (<1 year) in grade II glioma after the first resection.

Methods: The pathological, clinical, and magnetic resonance imaging (MRI) data of patients diagnosed with grade II glioma who underwent surgery and had a recurrence between 2017 and 2020 in our hospital were retrospectively analyzed. After a rigorous selection, 64 patients were eligible and enrolled in the study. Read More

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September 2021

Comparison of intrahepatic progression patterns of hepatocellular carcinoma and colorectal liver metastases following CT-guided high dose-rate brachytherapy.

Ther Adv Med Oncol 2021 8;13:17588359211042304. Epub 2021 Sep 8.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Radiology, Augustenburger Platz 1, 13353 Berlin, Germany.

Introduction: Given the metachronous and multifocal occurrence of hepatocellular carcinoma (HCC) and colorectal cancer metastases in the liver (CRLM), this study aimed to compare intrahepatic progression patterns after computed tomography (CT)-guided high dose-rate brachytherapy.

Patients And Methods: This retrospective analysis included 164 patients (114 HCC, 50 CRLM) treated with brachytherapy between January 2016 and January 2018. Patients received multiparametric magnetic resonance imaging (MRI) before, and about 8 weeks after brachytherapy, then every 3 months for the first, and every 6 months for the following years, until progression or death. Read More

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September 2021

The Role of Prostate-specific Membrane Antigen Positron Emission Tomography/Magnetic Resonance Imaging in Primary and Recurrent Prostate Cancer: A Systematic Review of the Literature.

Eur Urol Focus 2021 Sep 15. Epub 2021 Sep 15.

LYX Institute of Urology, Universidad Francisco de Vitoria, Madrid, Spain; Department of Urology, Hospital Universitario Puerta De Hierro-Majadahonda, Madrid, Spain. Electronic address:

Context: Prostate-specific membrane antigen (PSMA) positron emission tomography/magnetic resonance imaging (PET/MRI) is a novel imaging technique with several potential applications in the prostate cancer (PCa) setting.

Objective: To perform a systematic review of the current evidence regarding the diagnostic performance of PSMA PET/MRI in patients with primary and recurrent PCa.

Evidence Acquisition: A comprehensive bibliographic search on the MEDLINE and Cochrane Library databases was performed in October 2020. Read More

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September 2021

Impact of prostate-specific antigen screening on tumor size in patients with prostate cancer in a super-aging district in Kyoto, Japan.

Int J Clin Oncol 2021 Sep 19. Epub 2021 Sep 19.

Department of Urology, Kyoto Prefectural University of Medicine, 465, Kajiicho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: Population-based prostate-specific antigen (PSA) screening is effective for reducing prostate cancer (PCa)-related mortality rates. In this study, we assessed biopsy-proven maximum cancer core length (MCCL) and maximum cancer diameter on magnetic resonance imaging (MRI; MCDM) in prostate biopsy and multiparametric MRI (mp-MRI) by PCa detection.

Methods: We retrospectively assessed 214 male PCa patients and 187 PCa patients with Prostate Imaging Reporting and Data System version 2 (PI-RADS) category 3-5 lesions in pre-biopsy mp-MRI and targeted biopsy characteristics. Read More

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September 2021

Comparison and prediction of artefact severity due to total hip replacement in 1.5 T versus 3 T MRI of the prostate.

Eur J Radiol 2021 Sep 11;144:109949. Epub 2021 Sep 11.

University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, D-40225 Dusseldorf, Germany. Electronic address:

Purpose: To evaluate image quality and diagnostic value of multiparametric prostate MRI (mpMRI) in patients with total hip replacement (THR) at 1.5 and 3 Tesla.

Methods: In this retrospective multicenter cohort study patients with uni- or bilateral THR and 1. Read More

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September 2021

Magnetic resonance imaging radiomics signatures for predicting endocrine resistance in hormone receptor-positive non-metastatic breast cancer.

Breast 2021 Sep 11;60:90-97. Epub 2021 Sep 11.

Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China; Department of Medical Oncology, Phase I Clinical Trial Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou, China. Electronic address:

Background: One-third of patients with hormone receptor (HR)-positive breast cancers fail to respond to hormone therapy, and some patients even progress within two years of adjuvant endocrine therapy (ET) toward primary endocrine resistance. However, there is no effective way to predict endocrine resistance.

Objective: To build a model that incorporates the radiomic signature of pretreatment magnetic resonance imaging (MRI) with clinical information to predict endocrine resistance. Read More

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September 2021

Prostate Cancer Diffusion-Weighted Magnetic Resonance Imaging: Does the Choice of Diffusion-Weighting Level Matter?

J Magn Reson Imaging 2021 Sep 18. Epub 2021 Sep 18.

Department of Radiology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Diffusion-weighted magnetic resonance imaging plays an important role in multiparametric assessment of prostate lesions. The derived apparent diffusion coefficient (ADC) could be a useful quantitative biomarker for malignant growth, but lacks acceptance because of low reproducibility.

Purpose: To investigate the impact of the choice of diffusion-weighting levels (b-values) on contrast-to-noise ratio and quantitative measures in prostate diffusion-weighted MRI. Read More

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September 2021

3-T MRI and clinical validation of ultrasound-guided transperineal laser ablation of benign prostatic hyperplasia.

Eur Radiol Exp 2021 Sep 17;5(1):41. Epub 2021 Sep 17.

Department of Biomedicine and Prevention, University of Rome "Tor Vergata", 00133, Rome, Italy.

Background: Transperineal laser ablation (TPLA) of the prostate is a novel, mini-invasive option for men with lower urinary tract symptoms (LUTS) due to benign prostate hyperplasia (BPH). Our aim was to assess the impact of ultrasound-guided TPLA regarding urodynamic improvement and sexual function, monitoring clinical data, postprocedural complications and imaging findings at 3-T multiparametric magnetic resonance imaging.

Methods: Forty-four patients aged ≥ 50 affected with moderate to severe LUTS (International Prostate Symptoms score ≥ 12) due to benign prostatic obstruction and refractoriness, intolerance or poor compliance to medical therapies underwent US-guided TPLA between May 2018 and February 2020. Read More

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September 2021

Incremental Impact of [ Ga]Ga-PSMA-11 PET/CT in Primary N and M Staging of Prostate Cancer Prior to Curative-Intent Surgery: a Prospective Clinical Trial in Comparison with mpMRI.

Mol Imaging Biol 2021 Sep 14. Epub 2021 Sep 14.

Division of Molecular Imaging and Theranostics, Department of Nuclear Medicine and Endocrinology, University Hospital, Paracelsus Medical University, Müllner Hauptstraße 48, 5020, Salzburg, Austria.

Purpose: The main objective of this prospective study was to assess the value of gallium-68 prostate-specific membrane antigen ([ Ga]Ga-PSMA-11) positron emission tomography/computed tomography (PET/CT) in primary N and M staging of intermediate- and high-risk prostate cancer (PCa) patients before planned curative-intent radical prostatectomy (RPE) and extended pelvic lymph node dissection (ePLND). The second objective was to compare the [ Ga]Ga-PSMA-11 PET/CT findings with standard of care pelvic multi-parametric magnetic resonance imaging (mpMRI) in the detection of locoregional lymph node metastases and intraprostatic prostate cancer.

Procedures: A total of 81 patients (mean age: 64. Read More

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September 2021

3D Isotropic Super-resolution Prostate MRI Using Generative Adversarial Networks and Unpaired Multiplane Slices.

J Digit Imaging 2021 Sep 10. Epub 2021 Sep 10.

Department of Radiology, Columbia University Irving Medical Center, 622 W 168 11th St, New York, NY, USA.

We developed a deep learning-based super-resolution model for prostate MRI. 2D T2-weighted turbo spin echo (T2w-TSE) images are the core anatomical sequences in a multiparametric MRI (mpMRI) protocol. These images have coarse through-plane resolution, are non-isotropic, and have long acquisition times (approximately 10-15 min). Read More

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September 2021

Functional analysis of peripheral and intratumoral neoantigen-specific TCRs identified in a patient with melanoma.

J Immunother Cancer 2021 Sep;9(9)

Klinik und Poliklinik für Innere Medizin III, Klinikum rechts der Isar der Technischen Universität München, München, Germany

Background: Neoantigens derived from somatic mutations correlate with therapeutic responses mediated by treatment with immune checkpoint inhibitors. Neoantigens are therefore highly attractive targets for the development of therapeutic approaches in personalized medicine, although many aspects of their quality and associated immune responses are not yet well understood. In a case study of metastatic malignant melanoma, we aimed to perform an in-depth characterization of neoantigens and respective T-cell responses in the context of immune checkpoint modulation. Read More

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September 2021

Bioelectric Impedance Analysis Test Improves the Detection of Prostate Cancer in Biopsy Candidates: A Multifeature Decision Support System.

Front Oncol 2021 27;11:555277. Epub 2021 Aug 27.

Department of Information Engineering & Research Center "E. Piaggio", University of Pisa, Pisa, Italy.

Prostate cancer (PCa) gold-standard diagnosis relies on prostate biopsy, which is currently overly recommended since other available noninvasive tools such as prostate-specific antigen (PSA) multiparametric MRI (mMRI) showed low diagnostic accuracy or high costs, respectively. The aim of the study was to determine the accuracy of a novel Bioelectric Impedance Analysis (BIA) test endorectal probe for the selection of patients candidate to prostate biopsy and in particular the clinical value of three different parameters such as resistance (R), reactance (Xc), and phase angle (PA) degree. One-hundred twenty-three consecutive candidates to prostate biopsy and 40 healthy volunteers were enrolled. Read More

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MRI DTI and PDFF as Biomarkers for Lower Motor Neuron Degeneration in ALS.

Front Neurosci 2021 26;15:682126. Epub 2021 Aug 26.

Department of Neuroradiology, Center Hospital Luxembourg, Luxembourg City, Luxembourg.

Objective: To evaluate the utility of nerve magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and muscle MRI multi-echo Dixon for assessing lower motor neuron (LMN) degeneration in amyotrophic lateral sclerosis (ALS).

Methods: In this prospective observational cohort study, 14 patients with ALS and 13 healthy controls underwent a multiparametric MRI protocol, including DTI of the sciatic nerve and assessment of muscle proton density fat fraction of the biceps femoris and the quadriceps femoris muscles by a multi-echo Dixon sequence.

Results: In ALS patients, mean fractional anisotropy values of the sciatic nerve were significantly lower than those of healthy controls. Read More

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Quantitative biomarkers allow the diagnosis of head and neck paraganglioma on multiparametric MRI.

Eur J Radiol 2021 Aug 16;143:109911. Epub 2021 Aug 16.

Department of Medical Imaging, Conception University Hospital, Aix-Marseille Univ, France; Center for Magnetic Resonance in Biology and Medicine, UMR 7339, La Timone University Hospital, Aix-Marseille Univ, France. Electronic address:

Purpose: The aim of this study is to identify quantitative MR biomarkers in head and neck paragangliomas.

Methods: The study was approved by an institutional review board. A retrospective review of patients with head and neck paragangliomas (HNPGL) evaluated by time-resolved MRA sequences between 2009 and 2019 was performed. Read More

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Patient understanding and experience of non-invasive imaging diagnostic techniques and the liver patient pathway.

J Patient Rep Outcomes 2021 Sep 10;5(1):89. Epub 2021 Sep 10.

Perspectum Ltd, Oxford, UK.

Background: Clinical and patient-reported outcomes are positively affected when efforts to increase patient understanding of underlying diseases and foster patient participation are part of care pathways. The prevalence of liver diseases is increasing globally, and successful communication of results from liver diagnostic tests will be important for physicians to ensure patient engagement and encourage adherence to lifestyle changes and therapy. Here, we aimed to explore the impact of non-invasive liver tests on patient experience and patient comprehension of liver disease in chronic liver disease diagnostic pathways typically managed with liver biopsies. Read More

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September 2021

Multiparametric MRI Evaluation of Oropharyngeal Squamous Cell Carcinoma. A Mono-Institutional Study.

J Clin Med 2021 Aug 28;10(17). Epub 2021 Aug 28.

Department of Radiology and Diagnostic Imaging, IRCCS Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy.

The aim of this paper is to define the pre-treatment radiological characteristics of oropharyngeal squamous cell carcinoma (OPSCC) using morphological and non-morphological magnetic resonance imaging (MRI), based on HPV status, in a single-institution cohort. In total, 100 patients affected by OPSCC were prospectively enrolled in the present study. All patients underwent 1. Read More

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The Relationship between PI-RADS Categories and Incidental Findings in Multiparametric Prostate MRI.

J Coll Physicians Surg Pak 2021 Sep;31(9):1030-1034

Department of Radiology, Faculty of Medicine, Medeniyet University, Goztepe Education and Research Hospital, Istanbul, Turkey.

Objective: To find the frequency and significance of extraprostatic incidental findings (ep-IFs) during multiparametric-magnetic prostate resonance imaging (mp-MRI), and compare them with prostate imaging reporting and data system (PI-RADS) outcomes.

Study Design: Analytical study. Place & Duration of Study: Goztepe Education and Research Hospital, Istanbul, Turkey, from June 2019 to January 2020. Read More

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September 2021

Combined Transfer Learning and Test-Time Augmentation Improves Convolutional Neural Network-Based Semantic Segmentation of Prostate Cancer from Multi-Parametric MR Images.

Comput Methods Programs Biomed 2021 Aug 28;210:106375. Epub 2021 Aug 28.

Biomedical Translational Imaging Centre, Nova Scotia Health Authority and IWK Health Centre, Halifax, NS, Canada; Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada. Electronic address:

Purpose: Multiparametric MRI (mp-MRI) is a widely used tool for diagnosing and staging prostate cancer. The purpose of this study was to evaluate whether transfer learning, unsupervised pre-training and test-time augmentation significantly improved the performance of a convolutional neural network (CNN) for pixel-by-pixel prediction of cancer vs. non-cancer using mp-MRI datasets. Read More

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Focal Cryoablation of Image-Localized Prostate Cancer.

J Endourol 2021 Sep;35(S2):S17-S23

Department of Urologic Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Focal cryoablation of localized prostate cancer can offer patients superior genitourinary functional outcomes in terms of preservation of urinary continence and potency compared with radical whole-gland therapy, while maintaining intermediate-term oncologic control. We present a step-by-step guide to focal cryoablation of localized prostate cancer. A patient with elevated prostate specific antigen (PSA) underwent multiparametric MRI (mpMRI) of the prostate that revealed a prostate imaging-reporting and data system (PI-RADS) four lesion. Read More

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September 2021

Diffusion-weighted imaging in prostate cancer.

MAGMA 2021 Sep 7. Epub 2021 Sep 7.

Department of Radiology, Kawasaki Medical School, 577 Matsushima, Kurashiki city, Okayama, 701-0192, Japan.

Diffusion-weighted imaging (DWI), a key component in multiparametric MRI (mpMRI), is useful for tumor detection and localization in clinically significant prostate cancer (csPCa). The Prostate Imaging Reporting and Data System versions 2 and 2.1 (PI-RADS v2 and PI-RADS v2. Read More

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September 2021

An interpretable multiparametric radiomics model for the diagnosis of schizophrenia using magnetic resonance imaging of the corpus callosum.

Transl Psychiatry 2021 Sep 6;11(1):462. Epub 2021 Sep 6.

Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.

There is a growing need to develop novel strategies for the diagnosis of schizophrenia using neuroimaging biomarkers. We investigated the robustness of the diagnostic model for schizophrenia using radiomic features from T1-weighted and diffusion tensor images of the corpus callosum (CC). A total of 165 participants [86 schizophrenia and 79 healthy controls (HCs)] were allocated to training (N = 115) and test (N = 50) sets. Read More

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September 2021

Toward magnetic resonance fingerprinting for low-field MR-guided radiation therapy.

Med Phys 2021 Sep 6. Epub 2021 Sep 6.

Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Purpose: The acquisition of multiparametric quantitative magnetic resonance imaging (qMRI) is becoming increasingly important for functional characterization of cancer prior to- and throughout the course of radiation therapy. The feasibility of a qMRI method known as magnetic resonance fingerprinting (MRF) for rapid T and T mapping was assessed on a low-field MR-linac system.

Methods: A three-dimensional MRF sequence was implemented on a 0. Read More

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September 2021

The role of MRI in the management of a prostate cancer patient with bone and lymph nodes metastases. A case report.

Acta Biomed 2021 09 2;92(4):e2021214. Epub 2021 Sep 2.

Department of Oncology and Hemato-Oncology, University of Milan, 20122 Milan, Italy. Precision Imaging and Research Unit, Department of Medical Imaging and Radiation Sciences, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy.

The use of multiparametric prostate magnetic resonance imaging (mpMRI) is recommended, in the European Association of Urology (EAU) guidelines, for local staging of patients with prostate cancer (PCa). Systemic staging is recommended only for patients with unfavourable intermediate and high-risk disease; with bone and lymph node assessments usually being performed using bone scan (BS) and computed tomography (CT), respectively. Magnetic resonance imaging (MRI) is the imaging technique with the highest sensitivity for the detection of bone metastases and has shown promising results also for lymph node assessments. Read More

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September 2021

Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol-associated liver disease.

Alcohol Clin Exp Res 2021 Sep 5. Epub 2021 Sep 5.

Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Background: Magnetic resonance imaging (MRI) and MRI-based elastography (MRE) are the most promising noninvasive techniques in assessing liver diseases. The purpose of this study was to evaluate an advanced multiparametric imaging method for staging disease and assessing treatment response in realistic preclinical ALD models.

Methods: We utilized four different preclinical mouse models in our study: Model 1-mice were fed a fast-food diet and fructose water for 48 weeks to induce nonalcoholic fatty liver disease; Model 2-mice were fed chronic-binge ethanol (EtOH) for 10 days or 8 weeks to induce liver steatosis/inflammation. Read More

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September 2021


Harefuah 2021 Sep;160(9):576-581

Urology Department, Shaare Zedek Medical Center.

Introduction: Transrectal ultrasound is utilized as an auxiliary tool when performing a prostate biopsy, but its sensitivity and specificity are low. Performing prostate multiparametric magnetic resonance imaging (mp-MRI) before prostate biopsy can increase the probability to detect aggressive prostate cancer while decreasing the probability to detect indolent prostate cancer, thereby assisting in the selection of patients before the biopsy. The Israel Basket of Health Services does not include prostate mpMRI prior to the first prostate biopsy. Read More

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September 2021

Dov Engelstein

Harefuah 2021 Sep;160(9):556-558

The Israeli Urological Association.

Introduction: In this special issue dedicated to surgical urology we discuss several aspects of our profession with 8 original articles and 4 reviews. Calculi in the urinary tract are a major topic in day-to-day practice. A comparison between stone fragmentation and dusting using laser technology is discussed. Read More

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September 2021

Multiparameter MRI-based radiomics for preoperative prediction of extramural venous invasion in rectal cancer.

Eur Radiol 2021 Sep 4. Epub 2021 Sep 4.

Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.

Objectives: To compare multiparameter MRI-based radiomics for preoperative prediction of extramural venous invasion (EMVI) in rectal cancer using different machine learning algorithms and to develop and validate the best diagnostic model.

Methods: We retrospectively analyzed 317 patients with rectal cancer. Of these, 114 were EMVI positive and 203 were EMVI negative. Read More

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September 2021