906 results match your criteria multifocal osteomyelitis


Chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO).

J Transl Autoimmun 2021 20;4:100095. Epub 2021 Mar 20.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, UK.

Chronic nonbacterial osteomyelitis (CNO) is an inflammatory bone disorder that most frequently affects children and adolescents. Chronic recurrent multifocal osteomyelitis (CRMO) is a severe form of CNO, usually characterized by symmetrical inflammatory bone lesions and its waxing and waning character. Sometimes severe and chronic pain can significantly affect the quality of life and psychosocial development of individuals affected. Read More

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Rare presentation of chronic recurrent multifocal osteomyelitis of the Iliac wing mimicking Ewing's sarcoma.

SA J Radiol 2021 18;25(1):2030. Epub 2021 Feb 18.

Department of Radiology, University of Texas Health, San Antonio, Texas, United States of America.

This report describes a case of chronic recurrent multifocal osteomyelitis (CRMO) in an 11-year-old girl, involving the iliac bone as an initial, solitary site. Atypical imaging features were suspicious of a bone tumour, such as Ewing's sarcoma. Chronic recurrent multifocal osteomyelitis is a great masquerader and can present atypically. Read More

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February 2021

Variability in phenotype and response to treatment in chronic nonbacterial osteomyelitis; the Irish experience of a national cohort.

Pediatr Rheumatol Online J 2021 Mar 25;19(1):45. Epub 2021 Mar 25.

UCD Centre for Arthritis Research, School of Medicine, University College Dublin, Dublin, Ireland.

Background: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory disease affecting bone with considerable phenotypic heterogeneity and variable association with other autoinflammatory conditions. Disease pathogenesis is incompletely understood, and treatment protocols vary between physicians with no clinical treatment guidelines available prior to 2017. Although CNO was previously considered benign, it is now clear that long-term sequelae do occur. Read More

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Chronic Regional Multifocal Osteomyelitis RE: SAPHO syndrome: A Radiological Case Report.

Indian J Radiol Imaging 2020 Oct-Dec;30(4):533-534. Epub 2021 Jan 13.

Consultant Radiologist, Apollo Hospital, Indore, Madhya Pradesh, India.

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January 2021

Genetics of chronic nonbacterial osteomyelitis in the irish population: no significant association with rare FBLIM1 variants.

Pediatr Rheumatol Online J 2021 Mar 17;19(1):32. Epub 2021 Mar 17.

UCD Centre for Arthritis Research, School of Medicine, University College Dublin, Dublin, Ireland.

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Bone sporotrichosis: 41 cases from a reference hospital in Rio de Janeiro, Brazil.

PLoS Negl Trop Dis 2021 Mar 17;15(3):e0009250. Epub 2021 Mar 17.

Pós-Graduação em Medicina Tropical, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Background: Bone sporotrichosis is rare. The metropolitan region of Rio de Janeiro is hyperendemic for zoonotic sporotrichosis and the bone presentations are increasing.

Methods: We studied a retrospective cohort of 41 cases of bone sporotrichosis, diagnosed from 1999-2016. Read More

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[SAPHO syndrome : An overview and nosological differentiation of 35 disease cases].

Z Rheumatol 2021 Mar 16. Epub 2021 Mar 16.

Abt. für Rheumatologie, klinische Immunologie, Osteologie und Physikalische Medizin, Kerckhoff-Klinik GmbH, Campus Kerckhoff der Justus-Liebig-Universität Gießen, Benekestr. 2-8, 61231, Bad Nauheim, Deutschland.

The SAPHO syndrome is not a single entity but an inhomogeneous, nosologically heterogeneous complex of symptoms with unknown etiology and heterogeneous pathogenesis. Clinically subacute, recurrent or chronic disease processes and a common skin-bone association (skibo disease) can be found. Under the acronym SAPHO, chronically recurrent multifocal osteomyelitis (CRMO) is the most common disease that can occur in youth as well as adolescence. Read More

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Majeed Syndrome: A Review of the Clinical, Genetic and Immunologic Features.

Biomolecules 2021 Feb 28;11(3). Epub 2021 Feb 28.

Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Majeed syndrome is a multi-system inflammatory disorder affecting humans that presents with chronic multifocal osteomyelitis, congenital dyserythropoietic anemia, with or without a neutrophilic dermatosis. The disease is an autosomal recessive disorder caused by mutations in , the gene encoding the phosphatidic acid phosphatase LIPIN2. It is exceedingly rare. Read More

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February 2021

Multifocal skeletal tuberculosis with mycobacteremia after kidney transplantation: A case report.

Transpl Infect Dis 2021 Mar 2:e13591. Epub 2021 Mar 2.

Internal Medicine Department, Universidad de Antioquia Medical School, Medellín, Colombia.

Solid organ transplant recipients have a higher risk of active Mycobacterium tuberculosis infection (TB) compared to the general population. Recognized risk factors are immunosuppressant use, graft dysfunction, diabetes mellitus, liver disease caused by the hepatitis C virus, and co-infections by other opportunists. Most of the active TB cases reported in solid organ transplant recipients occur in kidney transplant patients, especially if they come from M tuberculosis-endemic areas. Read More

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Whole-body MRI Imaging Is an Essential Tool in Diagnosing and Monitoring Patients With Sterile Osteomyelitis.

J Rheumatol 2021 Mar 1. Epub 2021 Mar 1.

TSS was supported by the University of Iowa's Department of Radiology and Divisions of Pediatric Radiology and Neuroradiology. PJF was supported by NIH/NIAMS R01AR059703 and The Marjorie K. Lamb Professorship at the University of Iowa Carver College of Medicine. T.S. Sato, Clinical Assistant Professor, Divisions of Pediatric Radiology and Neuroradiology, Department of Radiology, Carver College of Medicine, University of Iowa; P.J. Ferguson, Professor, Division of Pediatric Rheumatology, Allergy and Immunology, Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. Address correspondence to Dr. P. Ferguson, University of Iowa, 200 Hawkins Dr., Iowa City, IA 52240, USA. Email:

From the first description in 1972 as "subacute and chronic recurrent osteomyelitis" to the currently recognized chronic recurrent multifocal osteomyelitis (CRMO) or chronic nonbacterial osteitis (CNO), diagnosis and monitoring of patients with this disease has been and continues to be a challenge While the most common presenting symptom is focal bone pain, its waxing and waning nature tends to contribute to the diagnostic odyssey that many patients must endure. Read More

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Genomic Expression Profiling and Bioinformatics Analysis of Chronic Recurrent Multifocal Osteomyelitis.

Biomed Res Int 2021 9;2021:6898093. Epub 2021 Feb 9.

Department of Orthopaedics, Tongde Hospital of Zhejiang Province, Hangzhou, China.

Objective: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder. Its most severe form is referred to as chronic recurrent multifocal osteomyelitis (CRMO). Currently, the exact molecular pathophysiology of CNO/CRMO remains unknown. Read More

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February 2021

Assessing Knowledge and Promoting Awareness of Chronic Recurrent Multifocal Osteomyelitis Among Oral and Maxillofacial Surgeons.

J Oral Maxillofac Surg 2021 Jan 28. Epub 2021 Jan 28.

Professor of Oral and Maxillofacial Surgery, Harvard School of Dental Medicine, Leonard B. Kaban, DMD, MD Chair in Oral and Maxillofacial Surgery, Oral Surgeon-in-Chief, Department of Plastic and Oral Surgery, Boston Children's Hospital, Boston, MA. Electronic address:

Purpose: Chronic recurrent multifocal osteomyelitis (CRMO) is underdiagnosed and underreported because of a lack of awareness among providers. While patients with undiagnosed CRMO often present to oral and maxillofacial surgeons (OMSs) with a chief complaint of mandibular pain, to our knowledge, there is no literature regarding how well informed these providers are about this disease. Survey studies and educational efforts have been carried out among other specialists with the aim of raising awareness. Read More

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January 2021

Haematogenous osteoarticular infections in paediatric sickle cell trait patients: A reality in a tertiary centre in West Africa.

Afr J Paediatr Surg 2021 Jan-Mar;18(1):62-66

Department of Pediatric Surgery, CHU Yopougon, Abidjan, Côte d'Ivoire.

Background: Sickle cell trait (SCT) affects at least 5.2% of the world population, and it is considered asymptomatic by medical practitioners. There is a paucity of data regarding SCT paediatric patients and haematogenous osteoarticular infections (HOAIs). Read More

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February 2021

[Acute haematogenous osteomyelitis of the pelvis with multifocal pyogenic abscesses in an adult].

Khirurgiia (Mosk) 2021 (2):84-87

Sechenov First Moscow State Medical University, Moscow, Russia.

Acute hematogenous osteomyelitis (AHO) in adults is a rare disease complicating timely diagnosis. Even greater difficulties are observed in case of pelvic bone lesion. The authors report AHO of the pelvis an adult. Read More

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February 2021

Whole-body MRI in paediatric undefined inflammatory conditions.

Pediatr Int 2021 Feb 10. Epub 2021 Feb 10.

Department of Clinical Sciences and Community Health, University of Milan, Italy, Milano.

Background: Whole Body Magnetic Resonance Imaging (WBMRI) is a multiregional imaging technique suitable to investigate the extent of multisystemic diseases without exposure to radiation, with a high sensitivity to bone alterations. The aim of our study was to evaluate the role of WBMRI in the workup of children with non-specific musculoskeletal features, and non-indicative laboratory and instrumental data, suspected to have a rheumatologic disease.

Methods: We retrospectively analysed medical records, including laboratory tests and radiological data of 34 children who have been evaluated due to non-specific musculoskeletal manifestations, for which a WBMRI was prescribed. Read More

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February 2021

Osteomyelitis and pyomyositis due to in an osteomalacic adult with multiple fractures.

J Community Hosp Intern Med Perspect 2021 Jan 26;11(1):85-88. Epub 2021 Jan 26.

Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.

Multifocal osteomyelitis and pyomyositis usually arise from hematogenous dissemination, especially in patients with immunodeficiency, trauma, or injection drug abuse. We report the case of a 75-year-old man with multifocal pyomyositis and osteomyelitis, which were due to and were presumably related to multiple fractures. The patient had no risk factors for these hematogenous infections. Read More

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January 2021

The multi-kinase inhibitor dasatinib suppresses autoinflammation and increases bone density in a mouse model for chronic recurrent multifocal osteomyelitis.

Cell Biochem Funct 2021 Feb 1. Epub 2021 Feb 1.

Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan.

Chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory bone disease that presents with bone destruction and pain. Although genetic studies have identified signalling pathways involving CRMO, molecularly targeted drugs remain unavailable. We used an animal model of CRMO as an in vivo screening system for candidate therapeutic agents. Read More

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February 2021

Whole-body magnetic resonance imaging in inflammatory diseases: Where are we now? Results of an International Survey by the European Society of Musculoskeletal Radiology.

Eur J Radiol 2021 Mar 9;136:109533. Epub 2021 Jan 9.

Department of Radiology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Purpose: To investigate the current role of WB-MRI for rheumatic inflammatory diseases in clinical practice using a survey addressed to musculoskeletal radiologists.

Methods: A survey composed of 61 questions, subdivided in three sections, demographics (five questions), application of WB-MRI for inflammatory musculoskeletal diseases in adults and children (28 questions: 7 open and 21 multiple choice for each subgroup) was distributed via the European Society of Musculoskeletal Radiology (ESSR) from July 2 to December 31, 2018 to radiologists working in academic, private, and public workplaces. Comparisons among the different workplaces were performed using the Chi-squared and the Kruskal-Wallis test for nominal and ordinal data, respectively (p < 0. Read More

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Crohn's disease and chronic recurrent multifocal osteomyelitis in a Japanese boy.

Pediatr Int 2021 Jan 27;63(1):115-117. Epub 2020 Dec 27.

Departments of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Japan.

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January 2021

Imaging of Joints and Bones in Autoinflammation.

J Clin Med 2020 Dec 17;9(12). Epub 2020 Dec 17.

Department of Radiology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

Autoinflammatory disorders are commonly characterized by seemingly unprovoked systemic inflammation mainly driven by cells and cytokines of the innate immune system. In many disorders on this spectrum, joint and bone involvement may be observed and imaging of these manifestations can provide essential diagnostic information. This review aimed to provide a comprehensive overview of the imaging characteristics for major diseases and disease groups on the autoinflammatory spectrum, including familial Mediterranean fever (FMF), Behçet disease (BD), crystal deposition diseases (including gout), adult-onset Still's disease (AoSD), and syndromatic synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO)/chronic recurrent multifocal osteomyelitis (CRMO). Read More

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December 2020

Biological therapy in refractory chronic nonbacterial osteomyelitis: A case series of 19 patients.

Joint Bone Spine 2021 Mar 17;88(2):105120. Epub 2020 Dec 17.

Department of Pediatric Rheumatology, University Hospital 12 de Octubre, Av Cordoba s/n, 28041 Madrid, Spain; Department of Public Health & Maternal and Child Health, Complutense University of Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.

Introduction: Chronic non-bacterial osteomyelitis (CNO) represents an autoinflammatory bone disorder. Currently there are no standardized diagnostic or treatment guidelines. The objective of the study is to describe our experience with biological therapy in children with the disease. Read More

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[Chronic multifocal osteomyelitis: A case report and literature review].

Authors:
Y W Hu R Liu L Luo

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Dec;52(6):1140-1145

Department of Rheumatology, the First Affiliated Hospital of Xinjiang Medical University, Urumchi 8300542, China.

A case of chronic multifocal osteomyelitis was described in terms of its clinical manifestations, serological and imaging examinations, diagnostic criteria, treatment options, and follow-up evaluation after discharge. The pathogenesis, diagnosis, differential diagnosis and treatment of chronic multifocal osteomyelitis were reviewed, and the characteristics of autoinflammatory osteopathy were reviewed. The patient with onset from youth had developed severe skin lesions, progressive arthralgia and rachialgia. Read More

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December 2020

Chronic recurrent multifocal osteomyelitis: diagnosis and treatment.

Curr Opin Pediatr 2021 Feb;33(1):90-96

Division of Pediatric Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA.

Purpose Of Review: The aim of this article is to review recent findings regarding the diagnosis and treatment of chronic recurrent multifocal osteomyelitis (CRMO).

Recent Findings: An adequate understanding of pathophysiology along with the new advances in MRI imaging make it possible to determine the extent of disease and establish early treatment. TNF-α inhibitors and bisphosphonates have shown to be a well-tolerated and efficient treatment for CRMO providing both symptomatic relief and normalization of bone morphology. Read More

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February 2021

A case of bone destruction caused by chronic non-bacterial osteomyelitis (CNO) successfully repaired with a tumour necrosis factor-α (TNF-α) inhibitor, adalimumab.

Mod Rheumatol Case Rep 2020 07 20;4(2):196-201. Epub 2020 Apr 20.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

Chronic Non-bacterial Osteomyelitis (CNO) is an autoinflammatory bone disorder that causes non-bacterial and non-neoplastic osteomyelitis. CNO appeared to the long bone, clavicle, pelvis, and spine on children commonly. This time, we report a case with osteomyelitis of the mandible for the adult-onset. Read More

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[Extranodal B-cell lymphoma in the distal femur with pre-existing CRMO].

Z Rheumatol 2021 Feb 15;80(1):78-84. Epub 2020 Oct 15.

Abt. Rheumatologie und klinische Immunologie, Medizinische Klinik II, Universitätsklinikum Würzburg, Würzburg, Deutschland.

CRMO is a rare form of nonbacterial osteomyelitis, which is mainly found in children. The diagnosis is complex because bone tumors or lymphoma must also be excluded. The case report describes the development of a solitary femoral lymphoma on the basis of a known CRMO disease as well as the differential diagnostic pitfalls. Read More

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February 2021

A rare case of salmonellosis with multifocal osteomyelitis and pulmonary involvement.

J Infect Public Health 2020 Nov 11;13(11):1787-1790. Epub 2020 Oct 11.

Alanya Alaaddin Keykubat University, Education and Research Hospital, Antalya, Turkey.

Salmonellosis is characterized by gastroenteritis and enteric fever in humans and affects various organs, particularly in endemic regions and in immunocompromised patients. Here, we report on a 45-year-old male patient with multifocal osteomyelitis, pneumonia and colonic ulcers caused by Salmonella typhi infection. The patient was admitted to our outpatient department with dysuria, fever and hip pain and had been treated with prednisolone and methotrexate for pemphigus vulgaris for two months. Read More

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November 2020

Chronic nonbacterial osteomyelitis - clinical and magnetic resonance imaging features.

Pediatr Radiol 2021 Feb 9;51(2):282-288. Epub 2020 Oct 9.

Section of Pediatric Radiology, University Hospital of North Norway, 9019, Tromsø, Norway.

Background: Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory bone disorder. Little information exists on the use of imaging techniques in CNO.

Materials And Methods: We retrospectively reviewed clinical and MRI findings in children diagnosed with CNO between 2012 and 2018. Read More

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February 2021

Multifocal primary musculoskeletal tuberculosis in nonimmunocompromised patient from nonendemic area.

BJR Case Rep 2020 Sep 29;6(2):20190077. Epub 2020 Sep 29.

Department of Pathology, Benha University, City, Egypt.

Iliopsoas primary tuberculous abscess is a rare clinical and imaging entity. Most reported imaging literature cases are secondary to tuberculous spondylodiscitis. Iliopsoas tuberculous inflammation and abscess constitutes a diagnostic challenge owing to its insidious onset and subtle non-specific symptoms. Read More

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September 2020

Contribution of radiobiphosphonates bone scan in multifocal tuberculous osteomyelitis.

World J Nucl Med 2020 Apr-Jun;19(2):184-186. Epub 2020 Jun 11.

Department of Nuclear Medicine, Mohammed V Military Teaching Hospital, Rabat, Morocco.

We share the case of a 86-year-old male patient, followed up for recent left hip pain. Interrogation revealed a fever, nocturnal shivering, and bone pains. Standard radiographs and computed tomography centered on both shoulders and pelvis showed osteoarthritis of the left hip and multiple lytic lesions in both humeral heads and clavicles, suggestive of chronic infectious, metabolic, or secondary disease. Read More

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