453 results match your criteria multi-functional nanostructures


[Preparation of multi-functional magnetic nanoparticles for harvesting low-molecular-weight glycoproteins].

Se Pu 2021 Oct;39(10):1102-1110

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.

Low-molecular-weight glycoproteins (LMW-GPs) are considered promising candidates for disease biomarker discovery. Selective sorbents are essential for the extraction and enrichment of this class of compounds. Boronate affinity chromatography is a unique separation mode in liquid chromatography. Read More

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October 2021

Enhancement of Activity and Development of Low Pt Content Electrocatalysts for Oxygen Reduction Reaction in Acid Media.

Molecules 2021 Aug 25;26(17). Epub 2021 Aug 25.

Faculty of Chemistry, University of Warsaw, Pasteura 1, PL-02-093 Warsaw, Poland.

Platinum is a main catalyst for the electroreduction of oxygen, a reaction of primary importance to the technology of low-temperature fuel cells. Due to the high cost of platinum, there is a need to significantly lower its loadings at interfaces. However, then O-reduction often proceeds at a less positive potential, and produces higher amounts of undesirable HO-intermediate. Read More

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A potentially valuable nano graphene oxide/USPIO tumor diagnosis and treatment system.

Mater Sci Eng C Mater Biol Appl 2021 Sep 3;128:112293. Epub 2021 Jul 3.

School of Pharmaceutical Sciences, Guangxi Medical University, No. 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address:

Due to increased requirements for precision cancer treatment, cancer chemotherapy and combination therapies have gradually developed in the direction of diagnosis and treatment integration. In this study, a non-toxic nano carrier that demonstrates integrated MRI signal enhancing performance, as well as better chemotherapy and photothermal conversion performance, was prepared and characterized. Furthermore, the carrier was used to construct an integrated system of tumor diagnosis and treatment. Read More

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September 2021

Bio-inspired graphene-based nano-systems for biomedical applications.

Nanotechnology 2021 Aug 9. Epub 2021 Aug 9.

Department of Natural Sciences, Florida Polytechnic University, 4700 Research Way, IST#2018, Lakeland, Florida, 33805, UNITED STATES.

The increasing demands of environmentally sustainable, affordable, and scalable materials have inspired researchers to explore greener nanosystems of unique properties which can enhance the performance of existing systems. Such nanosystems, extracted from nature, are state-of-art high-performance nanostructures due to intrinsic hierarchical micro/nanoscale architecture and generous interfacial interactions in natural resources. Among several, bio-inspired graphene nanosystems have emerged as an essential nano-platform wherein a highly electroactive, scalable, functional, flexible, and adaptable to a living being is a key factor. Read More

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A Rational design of multi-functional nanoplatform: Fluorescent-based "off-on" theranostic gold nanoparticles modified with D-α-Tocopherol succinate.

J Photochem Photobiol B 2021 Sep 16;222:112261. Epub 2021 Jul 16.

Research Institute for Health Science and Technologies (SABITA), 34810 Istanbul, Turkey; International School of Medicine, Medical Biochemistry, Istanbul Medipol University, 34810 Istanbul, Turkey. Electronic address:

It is crucial to develop nanocarrier systems to detect and treat drug-resistant micro tumors to prevent recurrence and/or metastasis of cancer. Due to their exceptional features such as biocompatibility, easy surface modification, serving as imaging and therapeutic agent, gold nanoparticles (AuNPs) draw attention as theranostic agents. It is beneficial to combine AuNPs with a second imaging and/or treatment modality such as photodynamic therapy (PDT). Read More

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September 2021

Recent advances in near infrared light responsive multi-functional nanostructures for phototheranostic applications.

Biomater Sci 2021 Aug 16;9(16):5472-5483. Epub 2021 Jul 16.

Department of Bioscience and Bioengineering, Indian Institute of Technology Jodhpur, Karwar 342037, India.

Light-based theranostics have become indispensable tools in the field of cancer nanomedicine. Specifically, near infrared (NIR) light mediated imaging and therapy of deeply seated tumors using a single multi-functional nanoplatform have gained significant attention. To this end, several multi-functional nanomaterials have been utilized to tackle cancer and thereby achieve significant outcomes. Read More

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Hydroxyapatite/NELL-1 Nanoparticles Electrospun Fibers for Osteoinduction in Bone Tissue Engineering Application.

Int J Nanomedicine 2021 25;16:4321-4332. Epub 2021 Jun 25.

Department of Stomatology, Binzhou Medical University Hospital, Binzhou, 256603, People's Republic of China.

Background: As commonly bone defect is a disease of jaw that can seriously affect implant restoration, the bioactive scaffold can be used as potential systems to provide effective repair for bone defect.

Purpose: A osteoinductive bone tissue engineering scaffold has been prepared in order to explore the effect of bioactive materials on bone tissue engineering.

Methods: In this study, NELL-1 nanoparticles (Chi/NNP) and nano hydroxyapatite were incorporated in composite scaffolds by electrospinning and characterized using TEM, SEM, contact angle, tensile tests and in vitro drug release. Read More

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Co-immunization with L-Myc enhances CD8 or CD103 DCs mediated tumor-specific multi-functional CD8 T cell responses.

Cancer Sci 2021 Sep 10;112(9):3469-3483. Epub 2021 Jul 10.

Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, China.

Renal carcinoma shows a high risk of invasion and metastasis without effective treatment. Herein, we developed a chitosan (CS) nanoparticle-mediated DNA vaccine containing an activated factor L-Myc and a tumor-specific antigen CAIX for renal carcinoma treatment. The subcutaneous tumor models were intramuscularly immunized with CS-pL-Myc/pCAIX or control vaccine, respectively. Read More

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September 2021

Novel photosensitive dual-anisotropic conductive Janus film endued with magnetic-luminescent properties and derivative 3D structures.

J Colloid Interface Sci 2021 Nov 26;601:899-914. Epub 2021 May 26.

Key Laboratory of Applied Chemistry and Nanotechnology at Universities of Jilin Province, Changchun University of Science and Technology, Changchun 130022, China.

A new photosensitive dual-anisotropic conductive Janus film (PDCJF) is proposed for the first time. It is rationally designed and manufactured by facile electrospinning. PDCJF is firstly constructed using 2,7-dibromo-9-fluorenone (DBF) with photoconductive and luminescent properties. Read More

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November 2021

Fabrication of Chiral M13 Bacteriophage Film by Evaporation-Induced Self-Assembly.

Small 2021 07 3;17(26):e2008097. Epub 2021 Jun 3.

Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.

Biomacromolecules are likely to undergo self-assembly and show specific collective behavior concentrated in the medium. Although the assembly procedures have been studied for unraveling their mysteries, there are few cases to directly demonstrate the collective behavior and phase transition process in dynamic systems. In the contribution, the drying process of M13 droplet is investigated, and can be successfully simulated by a doctor blade coating method. Read More

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Nanoclay/Polymer-Based Hydrogels and Enzyme-Loaded Nanostructures for Wound Healing Applications.

Gels 2021 May 14;7(2). Epub 2021 May 14.

Tecnologico de Monterrey, School of Engineering and Sciences, Monterrey 64849, Mexico.

Multi-polymeric nanocomposite hydrogels with multi-functional characteristics have been engineered with high interest around the globe. The ease in fine tunability with maintained compliance makes an array of nanocomposite biomaterials outstanding candidates for the biomedical sector of the modern world. In this context, the present work intends to tackle the necessity of alternatives for the treatment of diabetic foot ulcers through the formulation of nanoclay and/or polymer-based nanocomposite hydrogels. Read More

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Self-assembling Peptide Hydrogels Facilitate Vascularization in Two-Component Scaffolds.

Chem Eng J 2021 Oct 4;422. Epub 2021 May 4.

Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.

One of the major constraints against using polymeric scaffolds as tissue-regenerative matrices is a lack of adequate implant vascularization. Self-assembling peptide hydrogels can sequester small molecules and biological macromolecules, and they can support infiltrating cells . Here we demonstrate the ability of self-assembling peptide hydrogels to facilitate angiogenic sprouting into polymeric scaffolds after subcutaneous implantation. Read More

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October 2021

High-performance antiviral nano-systems as a shield to inhibit viral infections: SARS-CoV-2 as a model case study.

J Mater Chem B 2021 06;9(23):4620-4642

Microfluidics & MEMS Centre, CSIR - Advanced Materials and Processes Research Institute (AMPRI), Hoshangabad Road, Bhopal 462026, India. and Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

Despite significant accomplishments in developing efficient rapid sensing systems and nano-therapeutics of higher efficacy, the recent coronavirus disease (COVID-19) pandemic is not under control successfully because the severe acute respiratory syndrome virus (SARS-CoV-2, original and mutated) transmits easily from human to -human and causes life-threatening respiratory disorders. Thus, it has become crucial to avoid this transmission through precautions and keep premises hygienic using high-performance anti-viral nanomaterials to trap and eradicate SARS-CoV-2. Such an antiviral nano-system has successfully demonstrated useful significant contribution in COVID-19 pandemic/endemic management effectively. Read More

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Programmably tiling rigidified DNA brick on gold nanoparticle as multi-functional shell for cancer-targeted delivery of siRNAs.

Nat Commun 2021 05 18;12(1):2928. Epub 2021 May 18.

Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350108, China.

Small interfering RNA (siRNA) is an effective therapeutic to regulate the expression of target genes in vitro and in vivo. Constructing a siRNA delivery system with high serum stability, especially responsive to endogenous stimuli, remains technically challenging. Herein we develop anti-degradation Y-shaped backbone-rigidified triangular DNA bricks with sticky ends (sticky-YTDBs) and tile them onto a siRNA-packaged gold nanoparticle in a programmed fashion, forming a multi-functional three-dimensional (3D) DNA shell. Read More

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Synthesis of a clustered carbon aerogel interconnected by carbon balls from the biomass of taros for construction of a multi-functional electrochemical sensor.

Anal Chim Acta 2021 Jun 14;1164:338514. Epub 2021 Apr 14.

Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education, National & Local United Engineering Laboratory for Power Batteries, Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Analysis and Testing Center, Department of Chemistry, Northeast Normal University, Changchun, Jilin Province, 130024, China. Electronic address:

In this study, a clustered carbon aerogel interconnected by carbon balls (CCAI-CB) was prepared as an electrode material to construct a multi-functional electrochemical sensor. CCAI-CB derived from taros (Colocasia esculenta (L). Schott) possesses meso-macroporous structure and plenty of defective sites, and shows notable activity in electrocatalysis as an electrode material. Read More

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Decoupling manufacturing from application in additive manufactured antimicrobial materials.

Biomater Sci 2021 Aug 14;9(16):5397-5406. Epub 2021 May 14.

Institute of Advanced Materials (INAM), Universitat Jaume I, 12071, Castellon, Spain.

3D printable materials based on polymeric ionic liquids (PILs) capable of controlling the synthesis and stabilisation of silver nanoparticles (AgNPs) and their synergistic antimicrobial activity are reported. The interaction of the ionic liquid moieties with the silver precursor enabled the controlled in situ formation and stabilisation of AgNPs via extended UV photoreduction after the printing process, thus demonstrating an effective decoupling of the device manufacturing from the on-demand generation of nanomaterials, which avoids the potential aging of the nanomaterials through oxidation. The printed devices showed a multi-functional and tuneable microbicidal activity against Gram positive (B. Read More

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Multi-functional cerium oxide nanoparticles regulate inflammation and enhance osteogenesis.

Mater Sci Eng C Mater Biol Appl 2021 May 24;124:112041. Epub 2021 Mar 24.

Biionix Cluster, Department of Internal Medicine, College of Medicine, University of Central Florida, Orlando, FL, USA. Electronic address:

Oxidative stress increases bone loss and limits repair, in part, through immunoregulation and the formation and maintenance of low-grade chronic inflammation. The aim of this study was to investigate the effect of cerium oxide nanoparticles (CeONPs) on (i) macrophage phenotype and cytokine expression under normal and simulated acute and chronic inflammatory conditions and, (ii) human mesenchymal stem cell (hBMSCs) proliferation, osteoinduction and osteogenic differentiation. Spherical particles composed of 60% Ce with a hydrodynamic size of ~35 nm and surface charge of 25. Read More

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Translating Research for the Radiotheranostics of Nanotargeted Re-Liposome.

Int J Mol Sci 2021 Apr 8;22(8). Epub 2021 Apr 8.

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan 32546, Taiwan.

Nanoliposomes are one of the leading potential nano drug delivery systems capable of targeting chemotherapeutics to tumor sites because of their passive nano-targeting capability through the enhanced permeability and retention (EPR) effect for cancer patients. Recent advances in nano-delivery systems have inspired the development of a wide range of nanotargeted materials and strategies for applications in preclinical and clinical usage in the cancer field. Nanotargeted Re-liposome is a unique internal passive radiotheranostic agent for nuclear imaging and radiotherapeutic applications in various types of cancer. Read More

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A PDA-DTC/Cu-MnO nanoplatform for MR imaging and multi-therapy for triple-negative breast cancer treatment.

Chem Commun (Camb) 2021 Apr;57(34):4158-4161

Breast Cancer Center, Shanghai East Hospital, School of Medicine, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, P. R. China.

Herein, a multi-functional nanoplatform (PDA-DTC/Cu-MnO2) was established, which has been employed for MR imaging-guided multi-therapy (CDT, PTT and chemotherapy) for cancer treatment. The in vitro and in vivo results confirmed that the biocompatible nanoplatform could significantly induce tumor cell death and inhibit tumor growth. Read More

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Electrospun nanofibers promote wound healing: theories, techniques, and perspectives.

J Mater Chem B 2021 04 24;9(14):3106-3130. Epub 2021 Mar 24.

College of Life Sciences, Anhui Medical University, Hefei 230022, Anhui, China.

At present, the clinical strategies for treating chronic wounds are limited, especially when it comes to pain relief and rapid wound healing. Therefore, there is an urgent need to develop alternative treatment methods. This paper provides a systematic review on recent researches on how electrospun nanofiber scaffolds promote wound healing and how the electrospinning technology has been used for fabricating multi-dimensional, multi-pore and multi-functional nanofiber scaffolds that have greatly promoted the development of wound healing dressings. Read More

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Fabrication of an electrochemical biosensor composed of multi-functional Ag ion intercalated DNA four-way junctions/rhodium nanoplate heterolayer on a micro-gap for C-reactive protein detection in human serum.

Analyst 2021 Apr 19;146(7):2131-2137. Epub 2021 Mar 19.

Department of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-Gu, Seoul 01897, Republic of Korea.

As inflammation plays a role in the pathogenesis of acute coronary syndromes, C-reactive protein (CRP) can be used as a biomarker. To detect CRP precisely, the authors prepared a CRP electrochemical biosensor consisting of an eight Ag ion-intercalated multifunctional DNA four-way junction (MF-DNA-4WJ) and a porous rhodium nanoparticle (pRhNP) heterolayer on a micro-gap electrode. To increase conductivity, we used eight Ag ion-inserted DNA four-way junctions through a C-C mismatch. Read More

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Removal and degradation of mixed dye pollutants by integrated adsorption-photocatalysis technique using 2-D MoS/TiO nanocomposite.

Chemosphere 2021 Sep 8;279:130467. Epub 2021 Apr 8.

School of Engineering and Innovation, The Open University, Milton Keynes, MK7 6AA, United Kingdom. Electronic address:

Two-dimensional (2D) Molybdenum disulfide (MoS) has become one of the most exciting areas of research for adsorbents due to its high surface area and abundant active sites. Mainly, 2D MoS show promising removal of textile dye pollutants by adsorption process, but it show high affinity for anionic type of dyes, that limits its performance in mixed dye pollutants treatment. Herein, we demonstrate an integrated approach to remove mixed dye pollutants (anionic and cationic) concurrently by combining adsorption and photocatalysis process. Read More

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September 2021

Curcumin-laden dual-targeting fucoidan/chitosan nanocarriers for inhibiting brain inflammation via intranasal delivery.

Int J Biol Macromol 2021 Jun 18;181:835-846. Epub 2021 Apr 18.

Graduate Institute of Biomedical Materials and Tissue Engineering, International PhD Program in Biomedical Engineering, Graduate Institute of Biomedical Optomechatronics, School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan; Research Center of Biomedical Device, Taipei Medical University, Taipei, Taiwan; Cell Physiology and Molecular Image Research Center, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan. Electronic address:

Curcumin can reduce the production of brain inflammatory mediators and symptoms of brain diseases. However, a large amount of free curcumin needs to be administered to achieve an effective level in the brain because of its poor water-solubility. Fucoidan and chitosan were reported to respectively target P-selectin and acidic microenvironment expressed by pathologically inflammatory cells/tissues. Read More

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The biomedical significance of multifunctional nanobiomaterials: The key components for site-specific delivery of therapeutics.

Life Sci 2021 Jul 29;277:119400. Epub 2021 Mar 29.

Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box: 14176-14411, Tehran, Iran. Electronic address:

The emergence of nanotechnology has provided the possibilities to overcome the potential problems associated with the development of pharmaceuticals including the low solubility, non-specific cellular uptake or action, and rapid clearance. Regarding the biomaterials (BMs), huge efforts have been made for improving their multi-functionalities via incorporation of various nanomaterials (NMs). Nanocomposite hydrogels with suitable properties could exhibit a variety of beneficial effects in biomedicine particularly in the delivery of therapeutics or tissue engineering. Read More

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Fabrication of super-high transparent cellulose films with multifunctional performances via postmodification strategy.

Carbohydr Polym 2021 May 12;260:117760. Epub 2021 Feb 12.

College of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, PR China; National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu, 610065, PR China. Electronic address:

A transparent versatile cellulose platform film was prepared from Eucalyptus pulp in this work. Based on such cellulose platform, multifunctional cellulose films with ultraviolet-shielding, photochromism, and strong mechanical strength were fabricated via nucleophilic postmodification strategy by introducing a versatile spiropyran moiety into cellulose molecules. The fabricated cellulose films exhibited super-high transmittance up to 96% and performed notable ultraviolet-shielding capacity at 200-400 nm. Read More

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Aptamer-Gated Ion Channel for Ultrasensitive Mucin 1 Detection.

Anal Chem 2021 03 10;93(11):4825-4831. Epub 2021 Mar 10.

International Joint Research Laboratory for Biointerface and Biodetection, State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China.

Detection of cancer markers is important for early diagnosis and timely treatment of cancer. In this study, we fabricated a tailorable gold nanofilm-anodized aluminum oxide (Au-AAO) ion channel through nanoparticle self-assembly and proposed a highly sensitive and selective Mucin 1 (MUC1) detection method. By engineering the optimal layers of the Au-AAO ion channel and encoding the aptamer between the interlayers, a highly controllable ion rectification phenomenon was observed. Read More

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[Development of Drug Delivery Technology and Nanomedicine by Using Gold Nanoparticles].

Yakugaku Zasshi 2021 ;141(3):323-326

Graduate School of Pharmaceutical Sciences, Nagoya City University.

Nanomedicine is a new medical field involving the use of nanoparticles. Early examples of biocompatible nanomedicines include liposomes (Doxil) and albumin nanoparticles (Abraxane), and promising new nanomedicines include nanocarriers such as nanomicelles and nanoemulsions. A new trend towards the use of metal-based nanoparticles, including gold nanoparticles, has led to global clinical trials. Read More

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Polydopamine-carbon dots functionalized hollow carbon nanoplatform for fluorescence-imaging and photothermal-enhanced thermochemotherapy.

Mater Sci Eng C Mater Biol Appl 2021 Mar 28;122:111908. Epub 2021 Jan 28.

Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province 110016, PR China. Electronic address:

The low power photothermal therapy can reduce the tissue damage caused by laser irradiation, thus the near-infrared (NIR) absorbing vehicles with high photothermal conversion efficiency are demanded in the low power treatment. Herein, the NIR-absorbing agent polydopamine (PDA) and carbon dots (CDs) were gated on the openings of hollow mesoporous carbon (HMC) to construct a photothermal enhanced multi-functional system ([email protected]). Interestingly, the fluorescence emission wavelength of [email protected] was red-shifted by FRET effect between PDA and CDs, which solved the dilemma of fluorescence quenching of carbon-based materials and was more conducive to cell imaging. Read More

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Precise positioning of enzymes within hierarchical polymer nanostructures for switchable bioelectrocatalysis.

Biosens Bioelectron 2021 May 18;179:113045. Epub 2021 Feb 18.

Institute of Bioengineering, Queen Mary University of London, Mile End Road, London, E1 4NS, UK; School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. Electronic address:

The ability to reversibly switch bioelectrocatalytic sensors is attractive for the design of biomonitoring platforms displaying a complex environmental response, or for the protection of biosensors. However, the retention of reversible biocatalytic properties upon multiple environmental cycles, with broad detection range, low signal-to-noise and limit of detection remains challenging. In this report, we demonstrate the precise positioning of the enzyme glucose oxidase within block-copolymer brush nanostructures, via the re-initiation of N-isopropylacrylamide (NIPAM) polymerisation from enzyme-decorated poly(dimethylaminoethyl methacrylate) (PDMAEMA) blocks. Read More

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The capabilities of nanoelectronic 2-D materials for bio-inspired computing and drug delivery indicate their significance in modern drug design.

Life Sci 2021 Aug 22;279:119272. Epub 2021 Feb 22.

Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 13169-43551, Iran. Electronic address:

Remarkable advancements in the computational techniques and nanoelectronics have attracted considerable interests for development of highly-sophisticated materials (Ms) including the theranostics with optimal characteristics and innovative delivery systems. Analyzing the huge amounts of multivariate data and solving the newly-emerged complicated problems including the healthcare-related ones have created increasing demands for improving the computational speed and minimizing the consumption of energy. Shifting towards the non-von Neumann approaches enables performing specific computational tasks and optimizing the processing of signals. Read More

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