203,316 results match your criteria mucosa human

Immunophenotyping and transcriptional profiling of human plasmablasts in dengue.

J Virol 2021 Sep 15:JVI0061021. Epub 2021 Sep 15.

ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.

Plasmablasts represent a specialized class of antibody secreting effector B cell population that transiently appear in blood circulation following infection or vaccination. The expansion of these cells generally tends to be massive in patients with systemic infections leading to viral hemorrhagic fevers such as dengue or ebola. To gain a detailed understanding of the human plasmablast responses beyond antibody expression, here we performed immunophenotyping and RNA seq analysis of the plasmablasts from dengue febrile children in India. Read More

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September 2021

Human papillomaviruses: diversity, infection and host interactions.

Alison A McBride

Nat Rev Microbiol 2021 Sep 14. Epub 2021 Sep 14.

Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Human papillomaviruses (HPVs) are an ancient and highly successful group of viruses that have co-evolved with their host to replicate in specific anatomical niches of the stratified epithelia. They replicate persistently in dividing cells, hijack key host cellular processes to manipulate the cellular environment and escape immune detection, and produce virions in terminally differentiated cells that are shed from the host. Some HPVs cause benign, proliferative lesions on the skin and mucosa, and others are associated with the development of cancer. Read More

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September 2021

Correction to: Interplay of stromal tumor-infiltrating lymphocytes, normal colonic mucosa, cancer-associated fibroblasts, clinicopathological data and the immunoregulatory molecules of patients diagnosed with colorectal cancer.

Cancer Immunol Immunother 2021 Sep 13. Epub 2021 Sep 13.

Department of Human Morphology and Embryology, Division of Histology and Embryology, Wroclaw Medical University, Chałubińskiego 6a, 50-368, Wrocław, Poland.

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September 2021

Acquired Esophageal Strictures in Children: Morphometric and Immunohistochemical Analyses.

Pediatr Dev Pathol 2021 Sep 13:10935266211041086. Epub 2021 Sep 13.

Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Background: Esophageal strictures (ES) in children are not well characterized pathologically. We report unique histopathologic analyses of resected acquired ES and control esophagi (CE).

Methods: Muscle layer thicknesses were measured in intact well-oriented areas; inflammatory cells were counted in the most inflamed high power field (hpf). Read More

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September 2021

A Convolutional Neural Network Deep Learning Model Trained on CD Ulcers Images Accurately Identifies NSAID Ulcers.

Front Med (Lausanne) 2021 27;8:656493. Epub 2021 Aug 27.

Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Affiliated to Sackler Medical School, Tel Aviv University, Tel Aviv, Israel.

Deep learning (DL) for video capsule endoscopy (VCE) is an emerging research field. It has shown high accuracy for the detection of Crohn's disease (CD) ulcers. Non-steroidal anti-inflammatory drugs (NSAIDS) are commonly used medications. Read More

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A Diagnostic Method for Gastric Cancer Using Two-Photon Microscopy With Enzyme-Selective Fluorescent Probes: A Pilot Study.

Front Oncol 2021 27;11:634219. Epub 2021 Aug 27.

Department of Gastroenterology, Ajou University School of Medicine, Suwon, South Korea.

Background: Endoscopy is the most important tool for gastric cancer diagnosis. However, it relies on naked-eye evaluation by endoscopists, and the histopathologic confirmation is time-consuming. We aimed to visualize and measure the activity of various enzymes through two-photon microscopy (TPM) using fluorescent probes and assess its diagnostic potential in gastric cancer. Read More

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Putative Immunological Functions of Inducible Skin-Associated Lymphoid Tissue in the Context of Mucosa-Associated Lymphoid Tissue.

Front Immunol 2021 26;12:733484. Epub 2021 Aug 26.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Acquired immunity is orchestrated in various lymphoid organs, including bone marrow, thymus, spleen, and lymph nodes in humans. However, mucosa-associated lymphoid tissue (MALT) is evolutionally known to be emerged in the oldest vertebrates as an immunological tissue for acquired immunity, much earlier than the advent of lymph nodes which appeared in endotherms. Furthermore, the lymphocytes which developed in MALT are known to circulate within the limited anatomical areas. Read More

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[Clinical characteristics of five patients with gastric emphysema].

Nihon Shokakibyo Gakkai Zasshi 2021 ;118(9):851-858

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Gastric emphysema is a rare condition in which gas from a nonbacterial source accumulates within the gastric wall. In this study, we retrospectively analyzed the cases of five patients who were diagnosed with gastric emphysema at the Okayama University Hospital between January 2010 and April 2021, to reveal the clinical features of the disease. Based on their reviews, we revealed that:i) gastric emphysema occurred in hospitalized bedridden patients (n=5), such as those during/after endotracheal intubation (n=3), those undergoing gastric tube placement (n=3), those undergoing percutaneous endoscopic gastrostomy (n=1), and those undergoing treatment for cerebral infarction (n=1);ii) gastric emphysema was accompanied by the accumulation of gas in the portal (n=4) or gastric veins (n=1);iii) gastric emphysema was accompanied by colon wall thickness increase (n=4);iv) esophagogastroduodenoscopy showed redness, erosions, coarse mucosa, and/or ulcers (n=5);v) a clear boundary between the damaged area and the intact mucosa was observed (n=5);vi) the anterior wall of the stomach was less affected (n=4);vii) mucosal damage was predominant in the gastric folds, whereas the furrow of the mucosa was less affected;and viii) treatment with enteral nutrition suspension and the administration of proton pump inhibitors and antibiotics resulted in the recovery of patients from gastric emphysema (n=5). Read More

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September 2021


Georgian Med News 2021 Jul-Aug(316-317):154-158

2I. Beritashvili Center for Experimental Biomedicine, Tbilisi, Georgia.

Malignant tumors are one of the leading courses of mortality in the world, and it is believed that 19% of malignant tumors are associated with environmental risk factors. The aim of the study was to establish the spectrum of distributions of an informative biomarker of the unfavorable (genotoxic) effect of the external environment on the body by determining the level of micronuclei (LMN) in buccal epithelium cells in populations of villages of the Sachkhera region (Georgia). In the inhabitants of the Sachkhere district (both sexes, 50-65 years old) living in the villages of Sareki, Sairkhe, and Chorvila, LMN was determined in the cells of the buccal epithelium. Read More

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September 2021


Georgian Med News 2021 Jul-Aug(316-317):70-73

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, of the Ministry of health of Russia.

Objective - to study the effect of braces on the dentoalveolar system and the occurrence of changes in the body as a whole. The study involved 25 patients, 15 women and 10 men aged 20 to 45 years, with an anomaly of occlusion of the dentition in the transversal and sagittal plane, crowded position of the teeth of the upper and lower dentition. All patients were treated orthodontically on the MBT prescription bracket system made of high-quality steel grade 17-4. Read More

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September 2021

[Integrin α5 promotes the proliferation, invasion and adhesion of gastric cancer by regulating the FAK/Src/Rac1 signaling pathway].

Zhonghua Yi Xue Za Zhi 2021 Sep;101(34):2692-2697

Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, China.

To elucidate the biological role and potential mechanism of integrin α5 (ITGA5) in gastric cancer (GC). From January 2019 to December 2020, 35 pairs of GC tissue [21 males and 14 females, aged (53.8±5. Read More

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September 2021

Generation of a novel model of bioengineered human oral mucosa with increased vascularization potential.

J Periodontal Res 2021 Sep 12. Epub 2021 Sep 12.

Department of Histology (Tissue Engineering Group), University of Granada, Granada, Spain.

Objective: The aim of this study was to generate novel models of bioartificial human oral mucosa with increased vascularization potential for future use as an advanced therapies medicinal product, by using different vascular and mesenchymal stem cell sources.

Background: Oral mucosa substitutes could contribute to the clinical treatment of complex diseases affecting the oral cavity. Although several models of artificial oral mucosa have been described, biointegration is a major issue that could be favored by the generation of novel substitutes with increased vascularization potential once grafted in vivo. Read More

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September 2021

Characteristics of mucosal-associated invariant T cells and their roles in immune diseases.

Int Immunol 2021 Sep 11. Epub 2021 Sep 11.

Department of Immunology, Juntendo University School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan.

Mucosal-associated invariant T (MAIT) cells are a subset of innate-like T cells that express a semi-invariant T cell receptor and are restricted by the molecule major histocompatibility complex class I-related molecule 1 (MR1). MAIT cells recognize biosynthetic derivatives of the riboflavin synthesis pathway present in microbes. MAIT cells have attracted increased interest related to various immune responses because of their unique features including their abundance in humans, nonpeptidic antigens, and ability to respond to antigenic and non-antigenic stimuli. Read More

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September 2021

Arteriovenous Malformations in Proximal Part of Ileum: A Case Report.

JNMA J Nepal Med Assoc 2021 Jul 30;59(239):706-708. Epub 2021 Jul 30.

Kathamndu Medical College Teaching Hospital, Sinamangal, Kathmandu, Nepal.

Arteriovenous malformations in the ileum are a rare cause of gastrointestinal bleeding in young adults with few reported cases and pose difficulty in diagnosing. They usually present with chronic gastrointestinal bleed. A 30-year-old woman presented with an acute episode of hematochezia with a history of intermittent melena for 1. Read More

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Reprogramming of human olfactory neurosphere-derived cells from olfactory mucosal biopsies of a control cohort.

Stem Cell Res 2021 Sep 1;56:102527. Epub 2021 Sep 1.

The University of Queensland, Australian Institute for Bioengineering & Nanotechnology (AIBN), St. Lucia, Brisbane, QLD 4072, Australia. Electronic address:

Human olfactory neurosphere-derived (ONS) cells are derived from the olfactory mucosa and display some progenitor- and neuronal cell-like properties, making them useful models of neurological disorders. However, they lack several important characteristics of true neurons, which can be overcome using induced pluripotent stem cell (iPSC) -derived neurons. Here we describe, for the first time, the generation and validation of an iPSC line from an olfactory biopsy from a control cohort member. Read More

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September 2021

A mini-review on the impact of COVID 19 on vital organs.

Biomed Pharmacother 2021 Sep 4;143:112158. Epub 2021 Sep 4.

Biotechnology Research Institute, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia. Electronic address:

COVID-19 (Corona Virus Disease-2019) is an infectious disease caused by a novel coronavirus, known as the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is a highly contagious disease that has already affected more than 220 countries globally, infecting more than 212 million people and resulting in the death of over 4.4 million people. Read More

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September 2021

A Combination Strategy of Solubility Enhancers for Effective Production of Soluble and Bioactive Human Enterokinase.

J Biotechnol 2021 Sep 7. Epub 2021 Sep 7.

Department of Biochemistry, Kangwon National University, Chuncheon 24341, South Korea; Institute of Life Sciences (ILS), Kangwon National University, Chuncheon 24341, South Korea; Global/Gangwon Innovative Biologics-Regional Leading Research Center (GIB-RLRC), Kangwon National University, Chuncheon 24341, South Korea. Electronic address:

Enterokinase is one of the hydrolases that catalyze hydrolysis to regulate biological processes in intestinal visceral mucosa. Enterokinase plays an essential role in accelerating the process of protein digestion as it converts trypsinogen into active trypsin by accurately recognizing and cleaving a specific peptide sequence, (Asp)4-Lys. Due to its exceptional substrate specificity, enterokinase is widely used as a versatile molecular tool in various bioprocessing, especially in removing fusion tags from recombinant proteins. Read More

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September 2021

A variant ECE1 allele contributes to reduced pathogenicity of Candida albicans during vulvovaginal candidiasis.

PLoS Pathog 2021 Sep 10;17(9):e1009884. Epub 2021 Sep 10.

Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

Vulvovaginal candidiasis (VVC), caused primarily by the human fungal pathogen Candida albicans, results in significant quality-of-life issues for women worldwide. Candidalysin, a toxin derived from a polypeptide (Ece1p) encoded by the ECE1 gene, plays a crucial role in driving immunopathology at the vaginal mucosa. This study aimed to determine if expression and/or processing of Ece1p differs across C. Read More

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September 2021

Safety, environmental and technological characterization of beneficial autochthonous lactic bacteria, and their vaginal administration to pregnant cows for the design of homologous multi-strain probiotic formulas.

Braz J Microbiol 2021 Sep 9. Epub 2021 Sep 9.

Centro de Referencia Para Lactobacilos, Consejo Nacional de Investigaciones Científicas y Técnicas, Chacabuco 145, 4000, San Miguel de Tucumán, Argentina.

In recent years, veterinary probiotic formulations constitute an interesting alternative to the use of antibiotics in animals for human consumption, but beneficial microorganisms must meet certain requirements to be included in these products. The objective of this work was to evaluate the safety and innocuity of beneficial autochthonous lactic bacteria (BALB) as well as to determine their beneficial, environmental, and technological characterization. Antibiotic resistance was assayed using phenotypic and genotypic methodology. Read More

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September 2021

Intracellular TLRs of Mast Cells in Innate and Acquired Immunity.

Handb Exp Pharmacol 2021 Sep 10. Epub 2021 Sep 10.

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.

Mast cells (MCs) distribute to interface tissues with environment, such as skin, airway, and gut mucosa, thereby functioning as the sentinel against invading allergens and pathogens. To respond to and exclude these external substances promptly, MCs possess granules containing inflammatory mediators, including heparin, proteases, tumor necrosis factor, and histamine, and produce these mediators as a consequence of degranulation within minutes of activation. As a delayed response to external substances, MCs de novo synthesize inflammatory mediators, such as cytokines and chemokines, by sensing pathogen- and damage-associated molecular patterns through their pattern recognition receptors, including Toll-like receptors (TLRs). Read More

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September 2021

Biophysical determinants of biofilm formation in the gut.

Curr Opin Biomed Eng 2021 Jun 13;18. Epub 2021 Feb 13.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850.

The gastrointestinal (GI) tract harbors the most complex microbial ecosystem in the human body. The mucosal layer that covers the GI tract serves as a polymer-based defensive barrier that prevents the microbiome from reaching the epithelium and disseminating inside the body. Colonization of the mucus may result in the formation of structured polymicrobial communities or biofilms, a hallmark in pathologies such as colorectal cancer, inflammatory bowel disease, and chronic gut wounds. Read More

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Saliva-derived microcosm biofilms grown on different oral surfaces in vitro.

NPJ Biofilms Microbiomes 2021 Sep 9;7(1):74. Epub 2021 Sep 9.

Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

The microbial composition of a specific oral niche could be influenced by initial bacterial adherence, nutrient and physiological property of the local surface. To investigate the influence of nutrient and surface properties on microbial composition, saliva-derived biofilms were grown in agar on three substrata: Reconstructed Human Gingiva (RHG), a hydroxyapatite (HAP) surface, and a titanium (TI) surface. Agar was mixed with either Brain Heart Infusion (BHI) or Thompson (TP) medium. Read More

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September 2021

Mucosal Melanoma.

Clin Plast Surg 2021 Oct 7;48(4):707-711. Epub 2021 Jul 7.

Department of Surgery, The Elvin G Zook Endowed Chair - Institute for Plastic Surgery, Southern Illinois University, 747 N Rutledge Street #3, Springfield, IL 62702, USA.

Mucosal melanoma is a rare but aggressive cancer arising in mucosal surfaces most commonly in the head and neck. The clinical presentation is often nonspecific and differs in relation to the site of origin so often diagnosis is delayed resulting in poor prognosis. Mucosal melanoma has a 5-year survival of only 25%. Read More

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October 2021

The CagY Protein Drives Gastric Th1 and Th17 Inflammation and B Cell Proliferation in Gastric MALT Lymphoma.

Int J Mol Sci 2021 Aug 31;22(17). Epub 2021 Aug 31.

Department of Experimental and Clinical Medicine, University of Florence, 50134 Florence, Italy.

Background: the neoplastic B cells of the -related low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma proliferate in response to , however, the nature of the antigen responsible for proliferation is still unknown. The purpose of the study was to dissect whether CagY might be the antigen able to drive B cell proliferation.

Methods: the B cells and the clonal progeny of T cells from the gastric mucosa of five patients with MALT lymphoma were compared with those of T cell clones obtained from five -infected patients with chronic gastritis. Read More

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CBX2 Expression in Colorectal Mucosa-adenoma-adenocarcinoma Sequence.

J Coll Physicians Surg Pak 2021 Sep;31(9):1051-1056

Department of Digestive Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Objective: To investigate the expression of chromobox 2 (CBX2) in colorectal adenoma (CRA) and colorectal cancer (CRC), and analyse its correlation with various clinicopathological parameters.

Study Design: Observational study.

Place And Duration Of Study: Pathology Department, Huashan Hospital, Fudan University, from December 2019 to December 2020. Read More

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September 2021

BBA gene regulation mechanisms research paper analysis of the proximal promoter of the human colon-specific B4GALNT2 (Sd synthase) gene: B4GALNT2 is transcriptionally regulated by ETS1.

Biochim Biophys Acta Gene Regul Mech 2021 Sep 6:194747. Epub 2021 Sep 6.

Univ. Lille, CNRS, UMR 576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, F-59000 Lille, France. Electronic address:

Background: The Sd antigen and corresponding biosynthetic enzyme B4GALNT2 are primarily expressed in normal colonic mucosa and are down-regulated to a variable degree in colon cancer tissues. Although their expression profile is well studied, little is known about the underlying regulatory mechanisms.

Methods: To clarify the molecular basis of Sd expression in the human gastrointestinal tract, we investigated the transcriptional regulation of the human B4GALNT2 gene. Read More

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September 2021

A comprehensive risk pathway of the qualitative likelihood of human exposure to SARS-CoV-2 from the food chain.

J Food Prot 2021 Sep 9. Epub 2021 Sep 9.

Canadian Food Inspection Agency.

A group of experts from all Canadian federal food safety partners was formed to monitor the potential issues relating to SARS-CoV-2 food contamination, to gather and consider all of the relevant evidence and to determine the impact for Canadian food safety. A comprehensive risk pathway was generated to consider the likelihood of a SARS-CoV-2 contamination event at any of the relevant steps of the food processing and handling chain, and potential for exposure and transmission of the virus to the consumer. The scientific evidence was reviewed and assessed for each event in the pathway, taking into consideration relevant elements that could increase or mitigate the risk of contamination. Read More

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September 2021

Reduced CCR6IL-17ATreg Cells in Blood and CCR6-Dependent Accumulation of IL-17ATreg Cells in Lungs of Patients With Allergic Asthma.

Front Immunol 2021 23;12:710750. Epub 2021 Aug 23.

Institute of Translation Medicine, First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

Human regulatory T (Treg) cells play a central role in controlling allergic inflammation in the airways. A reduced number of peripheral Treg cells and decreased suppressive function have been previously reported in the pathogenesis of allergic asthma. However, the characteristic role of specific Treg cell subsets and their mechanisms in the pathogenesis of allergic asthma remain unclear. Read More

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Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility.

Front Endocrinol (Lausanne) 2021 23;12:700884. Epub 2021 Aug 23.

Department of Biochemistry, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.

Motilin, produced in endocrine cells in the mucosa of the upper intestine, is an important regulator of gastrointestinal (GI) motility and mediates the phase III of interdigestive migrating motor complex (MMC) in the stomach of humans, dogs and house musk shrews through the specific motilin receptor (MLN-R). Motilin-induced MMC contributes to the maintenance of normal GI functions and transmits a hunger signal from the stomach to the brain. Motilin has been identified in various mammals, but the physiological roles of motilin in regulating GI motility in these mammals are well not understood due to inconsistencies between studies conducted on different species using a range of experimental conditions. Read More

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Plexiform angiomyxoid myofibroblastic tumor treated by endoscopic submucosal dissection: A case report and review of the literature.

World J Gastroenterol 2021 Aug;27(31):5288-5296

Division of Gastroenterology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.

Background: Plexiform angiomyxoid myofibroblastic tumor (PAMT) is a rare mesenchymal tumor characterized by multiple nodular plexiform growth patterns and an immunophenotype with myofibroblasts. The pathological characteristics, immunohistochemistry, diagnostic criteria, differential diagnosis, and gene-level changes of PAMT have been reported in many studies. At present, the main treatment for PAMT in the reported cases is surgery; only eight cases were treated endoscopy (excluding 1 thoracoscopic resection), and the lesions were all smaller than 5 cm. Read More

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