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COVID-19 and stroke: from the cases to the causes.

Rev Neurosci 2021 Feb 15. Epub 2021 Feb 15.

Fondazione Policlinico Universitario A. Gemelli, IRCCS, UOC Neurologia, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Largo A Gemelli, 8, 00168, Rome, Italy.

During COVID-19 pandemic, a wide variety of stroke typologies have been described in patients affected by SARS-CoV-2. Investigating the case reports of acute stroke in COVID-19 patients, published since the beginning of the pandemic, we tried to trace the pathogenic mechanisms of stroke during SARS-CoV-2 infection. We conducted a systematic review analyzing demographic data, cerebrovascular risk factors, NIHSS score, vascular territory involvement and laboratory findings of 168 patients described in 89 studies, from a pool of 1243 records. Read More

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February 2021

Efa6 protects axons and regulates their growth and branching by inhibiting microtubule polymerisation at the cortex.

Elife 2019 11 13;8. Epub 2019 Nov 13.

Manchester Academic Health Science Centre, Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, United Kingdom.

Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in , and by neurodevelopmental disorders linked to the mammalian kinesin Kif21A. How cortical collapse factors influence axon growth is little understood. Read More

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November 2019

A new music therapy engagement scale for persons with dementia.

Int Psychogeriatr 2019 01 25;31(1):49-58. Epub 2018 May 25.

Khoo Teck Puat Hospital,National Healthcare Group,Singapore.

ABSTRACTObjectives:To develop and validate a new scale to assess music therapy engagement in persons with dementia (PWDs).

Design: A draft scale was derived from literature review and >2 years of qualitative recording of PWDs during music therapy. Content validity was attained through iterative consultations, trial sessions, and revisions. Read More

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January 2019

An expression database for roots of the model legume Medicago truncatula under salt stress.

BMC Genomics 2009 Nov 11;10:517. Epub 2009 Nov 11.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, PR China.

Background: Medicago truncatula is a model legume whose genome is currently being sequenced by an international consortium. Abiotic stresses such as salt stress limit plant growth and crop productivity, including those of legumes. We anticipate that studies on M. Read More

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November 2009

Estimating the minimum therapeutically effective dose of a compound via regression modelling and percentile estimation.

Authors:
T G Filloon

Stat Med 1995 May 15-30;14(9-10):925-32; discussion 933

Biometrics & Statistical Sciences Department, Procter & Gamble Pharmaceuticals, Miami Valley Laboratories, Cincinnati, Ohio 45239-8707, USA.

Estimation of the minimum effective dose (MED) of a compound from a typical placebo-controlled dose-response study can be carried out in several ways. Current approaches compare treatment doses against a placebo dose via selected contrasts to determine the lowest dose level at which the contrast is statistically significant. Ruberg shows how this approach works for various choices of contrasts. Read More

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October 1995
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