478 results match your criteria mta proroot


Evaluation of Endosequence Root Repair Material and Endocem MTA as direct pulp capping agents: An in vivo study.

Aust Endod J 2021 Jul 18. Epub 2021 Jul 18.

Department of Conservative Dentistry and Endodontics, Maulana Azad Institute of Dental Sciences, New Delhi, India.

The study aimed to assess the human pulpal response to direct pulp capping using Endosequence Root Repair Material (ERRM) and Endocem MTA against ProRoot MTA as control. Intentional direct pulp capping was done using the three materials in 30 caries-free human premolars. After 30 days, the teeth were extracted, fixed and decalcified. Read More

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Influence of Preoperative Pulp Inflammation in the Outcome of Full Pulpotomy Using a Dog Model.

J Endod 2021 Jul 3. Epub 2021 Jul 3.

Institute of Endodontics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; Center for Innovation and Research in Oral Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Introduction: This study aimed to evaluate the impact of preoperative pulp inflammation on the histologic outcome of full pulpotomy performed in mature permanent posterior teeth using 4 different biomaterials.

Methods: Five beagle dogs (providing a total of 120 roots) were selected. Dentin exposure was performed in teeth from the second and third quadrants. Read More

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The effect of different calcium silicate-based pulp capping materials on tooth discoloration: an in vitro study.

BMC Oral Health 2021 07 2;21(1):330. Epub 2021 Jul 2.

Department of Public Health and Community Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Variation in the composition of calcium silicate-based pulp capping materials could influence the discoloration potential of some of these materials, thus affecting the color and aesthetic appearance of the coronal tooth structure. Furthermore, contact with blood if hemostasis is not fully achieved may enhance this discoloration for some materials. Therefore the aim of this study was to evaluate in vitro the color change of coronal tooth structure after placing various calcium silicate-based materials in the pulp chamber in the presence or absence of blood. Read More

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Tooth discoloration induced by apical plugs with hydraulic calcium silicate-based cements in teeth with open apices-a 2-year in vitro study.

Clin Oral Investig 2021 Jun 21. Epub 2021 Jun 21.

Department of Conservative Dentistry and Periodontology and Center of Dental Traumatology, University Hospital of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.

Objectives: To assess tooth discoloration induced by different hydraulic calcium silicate-based cements (HCSCs), including effects of blood and placement method.

Materials And Methods: Eighty bovine teeth cut to a length of 18 mm (crown 8 mm, root 10 mm) were randomly assigned to 10 groups (n = 8), receiving orthograde apical plug treatment (APT). Apical plugs were 4 mm in length and made of ProRoot MTA (Dentsply), Medcem MTA (Medcem), TotalFill BC RRM Fast Set Putty (Brasseler), or Medcem Medical Portland Cement (Medcem) plus bismuth oxide (Bi2O3) with and without bovine blood. Read More

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Cytotoxicity of NeoMTA Plus, ProRoot MTA and Biodentine on human dental pulp stem cells.

J Dent Sci 2021 Jul 9;16(3):971-979. Epub 2020 Nov 9.

Istanbul University, Faculty of Dentistry, Department of Pedodontics, Istanbul Turkey.

Background/purpose: Dental pulp stem cells (DPSCs) play a crucial role in the tissue healing process through odontoblast like cell differentiation. The aim of this study was to evaluate the biocompatibility and compare the potential invitro cytotoxic effects of NeoMTA Plus, ProRootMTA and Biodentine on human dental pulp stem cells (hDPSCs).

Materials And Methods: To assess the effects of NeoMTA Plus, ProRoot MTA and Biodentine extracts at 1st, 3rd and 7th d on hDPCs, cell populations was determined by flow cytometry using an Annexin V detection kit. Read More

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The Osteogenic Assessment of Mineral Trioxide Aggregate-based Endodontic Sealers in an Organotypic Ex Vivo Bone Development Model.

J Endod 2021 Jun 11. Epub 2021 Jun 11.

BoneLab-Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, Porto, Portugal; Associated Laboratory for Green Chemistry/Network of Chemistry and Technology (LAQV/REQUIMTE), University of Porto, Porto, Portugal.

Introduction: Mineral trioxide aggregate (MTA)-based sealers are endodontic materials with widespread success in distinct clinical applications, potentially embracing direct contact with the bone tissue. Bone response to these materials has been traditionally addressed in vitro. Nonetheless, translational data are limited by the absence of native cell-to-cell and cell-to-matrix interactions that hinder the representativeness of the analysis. Read More

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Hard tissue formation after direct pulp capping with osteostatin and MTA .

Restor Dent Endod 2021 May 25;46(2):e17. Epub 2021 Feb 25.

Department of Conservative Dentistry, School of Dentistry, Dental Science Research Institute, Chonnam National University, Gwangju, Korea.

Objectives: In recent study, it was reported that osteostatin (OST) has an odontogenic effect and synergistic effect with mineral trioxide aggregate (MTA) in human dental pulp cells. Therefore, the aim of this study was to evaluate whether OST has a synergistic effect with MTA on hard tissue formation .

Materials And Methods: Thirty-two maxillary molars of Spraque-Dawley rats were used in this study. Read More

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Long-term effect of acidic pH on the surface microhardness of ProRoot mineral trioxide aggregate, Biodentine, and total fill root repair material putty.

Dent Res J (Isfahan) 2021 23;18. Epub 2021 Feb 23.

Department of Endodontics, Marmara University, Basibuyuk Saglik Yerleskesi, Istanbul, Turkey.

Background: The purpose of this study was to compare the microhardness values of ProRoot mineral trioxide aggregate (MTA), Biodentine, and total fill root repair material (TF-RRM) Putty at varying pH and times.

Materials And Methods: In this laboratory experiment, materials were mixed and placed in cylinder blocks with internal dimensions of 6 mm × 4 mm. Ten samples of each material were soaked in buffered solutions of butyric acid with 4. Read More

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February 2021

Biocompatibility and Antibiofilm Properties of Calcium Silicate-Based Cements: An In Vitro Evaluation and Report of Two Clinical Cases.

Biology (Basel) 2021 May 26;10(6). Epub 2021 May 26.

Department of Oral and Maxillofacial Science, Sapienza University of Rome, Via Caserta 6, 00161 Rome, Italy.

Calcium silicate-based cements have reached excellent levels of performance in endodontics, providing predictable and successful results. To better assess the properties of these bioactive materials, the present study aimed to compare the biocompatibility and antibiofilm properties of ProRoot MTA and Biodentine. Human osteogenic sarcoma (Saos-2) cells were cultured on ProRoot MTA and Biodentine samples or in the presence of both cement extracts. Read More

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Characterization of Histopathology and Microbiota in Contemporary Regenerative Endodontic Procedures: Still Coming up Short.

J Endod 2021 Aug 25;47(8):1285-1293.e1. Epub 2021 May 25.

Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital, Seoul National University School of Dentistry, Seoul, Republic of Korea; National Dental Care Center for Persons with Special Needs, Seoul National University Dental Hospital for Persons with Special Needs, Seoul, Republic of Korea. Electronic address:

Introduction: This study aimed to investigate microbiota and the histopathology of infected immature teeth microenvironments after disinfection with calcium hydroxide, triple antibiotic paste, and a synthetic antimicrobial peptide (synthetic human beta-defensin-3-C15) for regenerative endodontic procedures (REPs). The null hypothesis was that there is no difference among intracanal medications on disinfection in REPs.

Methods: Pulp necrosis and periapical lesions were induced in immature beagle dog premolars. Read More

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Direct Pulp Capping With ProRoot MTA Alone and in Combination With Er:YAG Laser Irradiation: A Clinical Trial.

J Lasers Med Sci 2020 30;11(Suppl 1):S60-S66. Epub 2020 Dec 30.

Faculty Member, Department of Endodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

Due to the complications of root canal treatment, conservative modalities to preserve pulp vitality are favorable. Direct pulp capping (DPC) refers to the coverage of the pulp tissue exposed by a biocompatible agent that can improve the prognosis of the tooth by 44% to 95%. Some recent studies have reported more predictable results (a success rate of about 90%) for DPC with laser and regenerative materials such as mineral trioxide aggregate (MTA). Read More

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December 2020

Tooth Discoloration Induced by Different Calcium Silicate-Based Cements: A Two-Year Spectrophotometric and Photographic Evaluation in Vitro.

J Clin Pediatr Dent 2021 Apr;45(2):112-116

Objective: Calcium silicate-based cements (CSCs) may lead to coronal staining in young permanent teeth over the time. The purpose of this study was to evaluate and compare the long-term tooth discoloration induced by different CSCs.

Study Design: Ninety freshly-extracted human molars were assigned randomly into 6 groups (n=15/group) according to the CSC used as a pulpotomy material: ProRoot MTA, MTA Angelus, NeoMTA, EndoSequence Putty, Biodentine and Negative control (No cement). Read More

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Human dental pulp stem cell responses to different dental pulp capping materials.

BMC Oral Health 2021 04 26;21(1):209. Epub 2021 Apr 26.

Dental Stem Cell Biology Research Unit, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.

Background: Direct pulp capping is a vital pulp therapy for a pin-point dental pulp exposure. Applying a pulp capping material leads to the formation of a dentin bridge and protects pulp vitality. The aim of this study was to compare the effects of four dental materials, DyCal, ProRoot MTA, Biodentine™, and TheraCal™ LC in vitro. Read More

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Effect of irrigation solutions on the coronal discoloration induced by mineral trioxide aggregate cements containing different radiopacifiers.

Dent Res J (Isfahan) 2020 Nov-Dec;17(6):447-451. Epub 2020 Dec 10.

Department of Prosthodontics, School of Dentistry, Islamic Azad University, Tehran, Iran.

Background: The aim of this study was to assess the discoloration of coronal tooth structure irrigated with different irrigation solutions and filled with calcium silicate-based materials containing bismuth oxide or calciumzirconia complex as radiopacifier.

Materials And Methods: In this study, 72 bovine enamel-dentin blocks were prepared and divided into three groups. The dentinal cavities in each group were irrigated with 5. Read More

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December 2020

Physical, Chemical, Mechanical, and Biological Properties of Four Different Commercial Root-End Filling Materials: A Comparative Study.

Materials (Basel) 2021 Mar 30;14(7). Epub 2021 Mar 30.

Department and Research Institute of Dental Biomaterials and Bioengineering, Yonsei University College of Dentistry, Seoul 03722, Korea.

Commercial mineral trioxide aggregate (MTA) materials such as Endocem MTA (EC), Dia-Root Bio MTA (DR), RetroMTA (RM), and ProRoot MTA (PR) are increasingly used as root-end filling materials. The aim of this study was to assess and compare the physicochemical and mechanical properties and cytotoxicity of these MTAs. The film thicknesses of EC and DR were considerably less than that of PR; however, RM's film thickness was greater than that of PR. Read More

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Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements.

BMC Oral Health 2021 03 9;21(1):106. Epub 2021 Mar 9.

Program of Molecular and Cell Biology, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.

Background: This study aimed to evaluate the biological response of human apical papilla cells to different calcium hydroxide formulations and three tricalcium silicate-based materials.

Methods: Primary cells were obtained from explants of young immature premolars. 20,000 cells adhered for 24 h over discs of Biodentine™, ProRoot®MTA, BioRoot®RCS and calcium hydroxide mixed either with sodium chloride 0. Read More

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Comparative Assessment of Tooth Color Change under the Influence of Nano Fast Cement and MTA.

J Dent (Shiraz) 2021 Mar;22(1):48-52

Dept. of Orthodontic, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Statement Of The Problem: Tooth color changes followed by treatment with bioceramic materials are always a matter of concern.

Purpose: The aim of the present study was to compare tooth discoloration that occurs in human teeth filled with ProRoot WMTA (DENTSPLY Tulsa Dental Specialties, Tulsa, OK) and those filled with Nano Fast Cement (NFC) over the course of 3 months.

Materials And Method: In this experimental study, Thirty human intact premolars were obtained. Read More

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Regeneration of pulp-dentin complex using human stem cells of the apical papilla: in vivo interaction with two bioactive materials.

Clin Oral Investig 2021 Feb 25. Epub 2021 Feb 25.

Institute of Endodontics, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Objectives: To compare the regenerative properties of human stem cells of the apical papilla (SCAPs) embedded in a platelet-rich plasma (PRP) scaffold, when implanted in vivo using an organotypic model composed of human root segments, with or without the presence of the bioactive cements - ProRoot MTA or Biodentine.

Material And Methods: SCAPs were isolated from third molars with incomplete rhizogenesis and expanded and characterized in vitro using stem cell and surface markers. The pluripotency of these cells was also assessed using adipogenic, chondrogenic, and osteogenic differentiation protocols. Read More

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February 2021

Dental stem cell signaling pathway activation in response to hydraulic calcium silicate-based endodontic cements: A systematic review of in vitro studies.

Dent Mater 2021 04 8;37(4):e256-e268. Epub 2021 Feb 8.

Department of Stomatology, Faculty of Medicine and Dentistry, Universitat de València, 46010 Valencia, Spain. Electronic address:

Objective: To present a qualitative synthesis of in vitro studies which analyzed human dental stem cell (DSC) molecular signaling pathway activation in response to hydraulic calcium silicate-based cements (HCSCs).

Methods: A systematic electronic search was performed in Medline, Scopus, Embase, Web of Science and SciELO databases on January 20 and last updated on March 20, 2020. In vitro studies assessing the implication of signaling pathways in activity related marker (gene/protein) expression and mineralization induced by HCSCs in contact with human DSCs were included. Read More

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Alterations of mitochondrial dynamics, inflammation and mineralization potential of lipopolysaccharide-induced human dental pulp cells after exposure to N-acetyl cysteine, Biodentine or ProRoot MTA.

Int Endod J 2021 Jun 19;54(6):951-965. Epub 2021 Feb 19.

Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

Aim: To investigate the effects of N-acetyl cysteine (NAC), Biodentine, ProRoot MTA and their combinations, on cell viability, mitochondrial reactive oxygen species (mtROS) production, mineralization and on the expression of genes related to inflammatory cytokine production, mitochondrial dynamics and cell apoptosis of lipopolysaccharide (LPS)-induced human dental pulp cells (hDPCs).

Methodology: Isolated hDPCs were exposed to 20 μg mL of Escherichia coli (E. coli) LPS for 24 h, before the experiment, except for the control group. Read More

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The calcium dynamics of human dental pulp stem cells stimulated with tricalcium silicate-based cements determine their differentiation and mineralization outcome.

Sci Rep 2021 01 12;11(1):645. Epub 2021 Jan 12.

Department of Basic And Applied Medical Sciences - Physiology Group, Ghent University, Ghent, Belgium.

Calcium (Ca) signalling plays an indispensable role in dental pulp and dentin regeneration, but the Ca responses of human dental pulp stem cells (hDPSCs) stimulated with tricalcium silicate-based (TCS-based) dental biomaterials remains largely unexplored. The objective of the present study was to identify and correlate extracellular Ca concentration, intracellular Ca dynamics, pH, cytotoxicity, gene expression and mineralization ability of human dental pulp stem cells (hDPSCs) stimulated with two different TCS-based biomaterials: Biodentine and ProRoot white MTA. The hDPSCs were exposed to the biomaterials, brought in contact with the overlaying medium, with subsequent measurements of extracellular Ca and pH, and intracellular Ca changes. Read More

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January 2021

The Role of Hydraulic Silicate Cements on Long-Term Properties and Biocompatibility of Partial Pulpotomy in Permanent Teeth.

Materials (Basel) 2021 Jan 8;14(2). Epub 2021 Jan 8.

Department of Conservative Dentistry and Oral Science Research Center, College of Dentistry, Yonsei University, Seoul 03722, Korea.

The use of hydraulic silicate cements (HSCs) for vital pulp therapy has been found to release calcium and hydroxyl ions promoting pulp tissue healing and mineralized tissue formation. The present study investigated whether HSCs such as mineral trioxide aggregate (MTA) affect their biological and antimicrobial properties when used as long-term pulp protection materials. The effect of variables on treatment outcomes of three HSCs (ProRoot MTA, OrthoMTA, and RetroMTA) was evaluated clinically and radiographically over a 48-78 month follow-up period. Read More

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January 2021

The effect of chlorhexidine and dimethyl sulfoxide on long-term sealing ability of two calcium silicate cements in root canal.

Dent Mater 2021 02 17;37(2):328-335. Epub 2020 Dec 17.

Department of Oral and Maxillofacial Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki, Finland, Research Unit of Oral Health Sciences, and Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and University of Oulu, Oulu, Finland. Electronic address:

Objectives: To evaluate the long-term effect of chlorhexidine (CHX) and dimethyl sulfoxide (DMSO) on the sealing ability and biomineralization of two different calcium silicate cements (CSC) in root canal.

Methods: Sixty human third molar root canals were obturated with ProRoot MTA or Biodentine. Before obturation the canals were irrigated with saline (control), 2% CHX or 5% DMSO. Read More

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February 2021

Cytocompatibility and Bioactive Properties of Hydraulic Calcium Silicate-Based Cements (HCSCs) on Stem Cells from Human Exfoliated Deciduous Teeth (SHEDs): A Systematic Review of In Vitro Studies.

J Clin Med 2020 Nov 28;9(12). Epub 2020 Nov 28.

Cellular Therapy and Hematopoietic Transplant Research Group, Biomedical Research Institute, Virgen de la Arrixaca Clinical University Hospital, IMIB-Arrixaca, University of Murcia, 30120 Murcia, Spain.

The implementation of hydraulic calcium silicate-based endodontic cements (HCSCs) in biologically based endodontic procedures for the primary dentition has been recently investigated, focusing on the biological response of stem cells from human exfoliated deciduous teeth (SHEDs) towards them. The present systematic review aimed to present a qualitative synthesis of the available literature consisting of in vitro assays, which assessed the cytocompatibility and bioactive properties of HCSCs in direct contact with SHEDs. Following the PRISMA statement, an electronic database search was carried out in Medline, Scopus, Embase, Web of Science, and SciELO on March 31st and updated on November 16th, 2020. Read More

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November 2020

Comparative evaluation of volumetric changes of three different retrograde calcium silicate materials placed under different pH condititions.

BMC Oral Health 2020 11 19;20(1):330. Epub 2020 Nov 19.

Department of Conservative Dentistry, Wonkwang University Daejeon Dental Hospital, 77 Dunsan-Ro, Seo-Gu, Daejeon, 35233, Republic of Korea.

Background: The present study aimed to compare the volumetric changes of three calcium silicate cements after retrofilling and placing under different pH conditions via micro-computed tomography (micro-CT) scan.

Methods: Forty-two extracted human single-rooted teeth were randomly assigned to three groups according to the retrofilling materials used (Biodentine, Endocem MTA, and ProRoot MTA). Each group was divided into two subgroups according to the setting condition. Read More

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November 2020

Effects of different pulp-capping materials on cell death signaling pathways of lipoteichoic acid-stimulated human dental pulp stem cells.

Odontology 2021 Apr 18;109(2):547-559. Epub 2020 Nov 18.

Department of Medical Biochemistry, Faculty of Medicine, University of Istanbul Aydın, Istanbul, Turkey.

Purpose: This study aimed to evaluate the response of dental pulp stem cells (DPSCs) cultured with and without lipoteichoic acid (LTA) to different pulp-capping materials.

Methods: The cells were cultured and seeded in 6-well plates and exposed to 1% LTA solution. Dycal, ProRoot MTA and Biodentine materials were applied on cells and all groups were evaluated by cell proliferation, viability, cell cycle and cell death signaling pathways for 24 and 72 h. Read More

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Effect of apexification on occlusal resistance of immature teeth.

BMC Oral Health 2020 11 12;20(1):325. Epub 2020 Nov 12.

Department of Comprehensive Treatment Center, Seoul National University Dental Hospital, Daehakro 101, Jongno-Gu, Seoul, 03080, Republic of Korea.

Background: Strain distribution was investigated to assess the occlusal resistance alterations in immature teeth under different occlusal force.

Methods: In vitro apexification models of teeth with a funnel-shaped immature apex were obturated with mineral trioxide aggregate (MTA; ProRoot MTA) using different combinations of core materials (10/group): group 1, full-length orthograde obturation of MTA; group 2, a 5-mm MTA apical plug with a composite core; group 3, a 5-mm MTA apical plug and back-filling with warm gutta-percha. Teeth with calcium hydroxide (CH)-medicated canals and untreated teeth with normal apices were tested as controls. Read More

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November 2020

Shear Bond Strength of a Resin Composite to Six Pulp Capping Materials Used in Primary Teeth.

J Clin Pediatr Dent 2020 Aug;44(4):234-239

Aim: The purpose of this in vitro study was to assess the shear bond strength (SBS) and bond failure types of a resin-composite to six pulp-capping materials used in primary teeth.

Study Design: Eight-disc specimens from each pulp-capping material (6 groups) to bond to Filtek™ Z350 XT Flowable using a standard PVC tube (2×2mm). All groups were prepared according to the instruction of the manufacturer. Read More

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Effect of exposure to root canal irrigants on the push-out bond strength of calcium silicate-based cements.

Clin Oral Investig 2021 May 28;25(5):3267-3274. Epub 2020 Oct 28.

Departamento de Odontología Conservadora y Prótesis Bucofacial, Facultad de Odontología, Universidad Complutense de Madrid, Pza. Ramón y Cajal, s/n. Ciudad Universitaria, 28040, Madrid, Spain.

Objectives: The aim of this study was to compare the push-out bond strength (POBS) of three calcium silicate-based cements (CSBC) after exposure to saline, sodium hypochlorite (NaOCl), ethylenediaminetetraacetic acid (EDTA), and a mixture of NaOCl and etidronic acid (NaOCl+HEBP) in simulated perforation.

Materials And Methods: A total of 180 dentin slices were perforated and then filled with either Biodentine (BD), ProRoot MTA (PMTA), or Total Fill (TF). After 1 week, specimens in each group were divided into 4 subgroups (n = 15) according to the root canal irrigant (RCI) that their coronal surface was exposed to: saline, 5. Read More

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Transcriptomic profiling of human dental pulp cells treated with tricalcium silicate-based cements by RNA sequencing.

Clin Oral Investig 2021 May 27;25(5):3181-3195. Epub 2020 Oct 27.

Department of Paediatric Dentistry & Special Care, PAECOMEDIS Research Cluster, Ghent University, Ghent University Hospital, 9000, Ghent, Belgium.

Objectives: Tricalcium silicate (TCS)-based biomaterials induce differentiation of human dental pulp cells (hDPCs) into odontoblasts/osteoblasts, which is regulated by the interplay between various intracellular pathways and their resultant secretome. The aim of this study was to compare the transcriptome-wide effects by next-generation RNA sequencing of custom-prepared hDPCs stimulated with TCS-based biomaterials: ProRoot white MTA (WMTA) (Dentsply, Tulsa; Tulsa, OK) and Biodentine (Septodont, Saint Maur des Fosses, France).

Methods: Self-isolated hDPCs were seeded in a 6-well plate at a density of 5 × 10 cells per well. Read More

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