10,588 results match your criteria mta

Elimination of oxacillin, its toxicity and antibacterial activity by using ionizing radiation.

Chemosphere 2021 Jul 9;286(Pt 1):131467. Epub 2021 Jul 9.

Radiation Chemistry Department, Institute for Energy Security and Environmental Safety, Centre for Energy Research, H-1121, Konkoly-Thege Miklós út 29-33, Budapest, Hungary.

The chemical changes caused by electron beam and γ irradiations and the biochemical characteristics of degradation products of a frequently used antibiotic oxacillin were investigated and compared with those of cloxacillin by applying pulse radiolysis, chemical and biochemical oxygen demand, total organic carbon content, oxygen uptake rate, toxicity and antibacterial activity measurements. Oxacillin was found to be non-toxic, but poorly biodegradable by the mixed microbial population of the activated sludge of a wastewater treatment plant. Therefore, it can significantly contribute to the spread of β-lactam antibiotic resistant bacteria. Read More

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Factors Associated with Cognitive Outcomes After First-Ever Ischemic Stroke: The Impact of Small Vessel Disease Burden and Neurodegeneration.

J Alzheimers Dis 2021 Jul 27. Epub 2021 Jul 27.

Department of Neurology, National Cheng KungUniversity Hospital, College of Medicine, National Cheng KungUniversity, Tainan, Taiwan.

Background: Differences exist regarding post-stroke cognitive outcomes.

Objective: The aim of this study investigates the potential factors associated with post-stroke cognitive performance and trajectories.

Methods: We performed a prospective cohort study using serial monitoring of cognitive function over a 1-year period after a first-ever ischemic stroke. Read More

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New next-generation microwave thermosphere ablation for small hepatocellular carcinoma.

Clin Mol Hepatol 2021 Aug 2. Epub 2021 Aug 2.

Department of Hepatology, Wakayama Rosai Hospital, Wakayama, Japan.

Background/aims: In July 2017, the EmprintTM next-generation microwave ablation system using thermosphere technology (Covidien, Boulder, CO, USA) was approved for use in Japan. This system can produce a predictable spherical ablation zone at higher temperatures than radiofrequency ablation (RFA). The aim of the present study was to elucidate whether this new microwave thermosphere ablation (MTA) could safely improve outcome compared to RFA, which is the standard of care for small hepatocellular carcinoma (HCC). Read More

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Size-resolved, quantitative evaluation of the magnetic mineralogy of airborne brake-wear particulate emissions.

Environ Pollut 2021 Jul 21;288:117808. Epub 2021 Jul 21.

Centre for Advanced Innovative Technologies, VSB-Technical University of Ostrava, 708 00, Ostrava-Poruba, Czech Republic; Faculty of Materials Science and Technology, VSB-Technical University of Ostrava, 708 00, Ostrava, Czech Republic.

Exposure to particulate air pollution has been associated with a variety of respiratory, cardiovascular and neurological problems, resulting in increased morbidity and mortality worldwide. Brake-wear emissions are one of the major sources of metal-rich airborne particulate pollution in roadside environments. Of potentially bioreactive metals, Fe (especially in its ferrous form, Fe) might play a specific role in both neurological and cardiovascular impairments. Read More

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Inter-modality assessment of medial temporal lobe atrophy in a non-demented population: application of a visual rating scale template across radiologists with varying clinical experience.

Eur Radiol 2021 Jul 30. Epub 2021 Jul 30.

Department of Imaging and Function, Skåne University Hospital, Lund, Sweden.

Objectives: To assess inter-modality agreement and accuracy for medial temporal lobe atrophy (MTA) ratings across radiologists with varying clinical experience in a non-demented population.

Methods: Four raters (two junior radiologists and two senior neuroradiologists) rated MTA on CT and MRI scans using Scheltens' MTA scale. Ratings were compared to a consensus rating by two experienced neuroradiologists for estimation of true positive and negative rates (TPR and TNR) and over- and underestimation of MTA. Read More

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Cytotoxicity and Bioactivity of Mineral Trioxide Aggregate and Bioactive Endodontic Type Cements: A Systematic Review.

Int J Clin Pediatr Dent 2021 Jan-Feb;14(1):30-39

Department of Pediatric and Preventive Dentistry, DY Patil School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India.

Background: Knowledge of the cytotoxicity and bioactivity of endodontic materials may assist in understanding their ability to promote dental pulp stem cell activity and pulp healing in primary teeth.

Materials And Methods: This systematic review was carried out by searching the electronic databases such as PubMed, Google Scholar, and Cochrane reviews for the articles published between January 2000 and December 2018 using the appropriate MeSH keywords. An independent investigator evaluated the abstracts and titles for possible inclusion, as per the stipulated inclusion and exclusion criteria. Read More

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Anti-ANX A1 Antibody Therapy in MRL/lpr Murine Model of Systemic Lupus Erythematosus.

Arch Immunol Ther Exp (Warsz) 2021 Jul 28;69(1):19. Epub 2021 Jul 28.

Laboratory of Experimental Immunology, Stefan Angelov Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Street, Block 26, 1113, Sofia, Bulgaria.

Systemic lupus erythematosus (SLE) is a severe autoimmune disease characterized by dysfunction of immune regulation, overproduction of inflammatory cytokines and attack on normal tissues by self-reactive cells and antibodies. The main role in the pathogenesis plays the autoreactive tandem of B-T cells, responsible for lupus progression and acceleration. Both activated B and T cells express a phospholipid binding protein Annexin A1 and abnormal levels of the protein were found in murine and human autoimmune syndromes, potentiating its role as a therapeutic target. Read More

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Formin3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior.

Development 2021 Jul 29. Epub 2021 Jul 29.

Neuroscience Institute, Georgia State University, Atlanta, GA, 30303, USA.

Dendrite shape impacts functional connectivity and is mediated by organization and dynamics of cytoskeletal fibers. Identifying molecular factors that regulate dendritic cytoskeletal architecture is therefore important in understanding mechanistic links between cytoskeletal organization and neuronal function. We identified Formin3 (Form3) as a critical regulator of cytoskeletal architecture in nociceptive sensory neurons in Drosophila larvae. Read More

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Prediction of Subtle Cognitive Decline in Normal Aging: Added Value of Quantitative MRI and PET Imaging.

Front Aging Neurosci 2021 12;13:664224. Epub 2021 Jul 12.

Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.

Quantitative imaging processing tools have been proposed to improve clinic-radiological correlations but their added value at the initial stages of cognitive decline is still a matter of debate. We performed a longitudinal study in 90 community-dwelling elders with three neuropsychological assessments during a 4.5 year follow-up period, and visual assessment of medial temporal atrophy (MTA), white matter hyperintensities, cortical microbleeds (CMB) as well as amyloid positivity, and presence of abnormal FDG-PET patterns. Read More

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The effect of mineral trioxide aggregate on dental pulp healing in the infected pulp by direct pulp capping.

Dent Mater J 2021 Jul 27. Epub 2021 Jul 27.

Department of Pulp Biology and Endodontics, Graduate School of Dentistry, Kanagawa Dental University.

This study aimed to clarify the effect of mineral trioxide aggregate (MTA) on pulp healing in the infected pulp by direct pulp capping (DPC). Thirty-six male ICR mice were divided into infected and uninfected groups. The pulp tissue was exposed to the oral flora for 24 h after pulp exposure in the infected group, or not exposed in the uninfected group, followed by sealing with MTA, calcium hydroxide cement (CH), or no DPC. Read More

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A Randomized Controlled Trial Comparing the Success of Mineral Trioxide Aggregate and Ferric Sulfate as Pulpotomy Medicaments for Primary Molars.

J Dent Child (Chic) 2021 May;88(2):120-128

Dr. Alapati is an associate professor, Department of Endodontics, all in the College of Dentistry, University of Illinois at Chicago, Chicago, Ill., USA.

To evaluate and compare the clinical and radiographic performance of a new type of mineral trioxide aggregate (MTA, NuSmile NeoMTA) and ferric sulfate (FS) as pulpotomy medicaments for primary molars over 12 months.
Fifty participants (25 per group) were enrolled, according to specific inclusion criteria. Each participant received a single primary molar pulpotomy either with MTA or FS, depending on random digit table method allocation. Read More

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Intentional Replantation of a Second Premolar with Internal Resorption and Root Fracture: A Case Report.

J Contemp Dent Pract 2021 May 1;22(5):562-567. Epub 2021 May 1.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China, e-mail:

Aim: This case aims to detail intentional replantation as a last resort to save an otherwise hopeless premolar with perforated internal resorption and root fracture.

Background: Internal root resorption, progressive destruction of intraradicular dentin, is a condition that sometimes renders a tooth non-restorable. In the rare cases reported where severe internal resorption leads to root fracture, extraction of the tooth seemed to be a common treatment of choice, and a few literatures had reported endodontic surgery as an alternative treatment option. Read More

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Sense of coherence, social support and religiosity as resources for medical personnel during the COVID-19 pandemic: A web-based survey among 4324 health care workers within the German Network University Medicine.

PLoS One 2021 26;16(7):e0255211. Epub 2021 Jul 26.

Department of Psychosomatic Medicine and Psychotherapy, Medical Faculty, University Hospital Bonn, Bonn, Germany.

Introduction: The COVID-19 pandemic resulted in severe detrimental effects on the mental well-being of health care workers (HCW). Consequently, there has been a need to identify health-promoting resources in order to mitigate the psychological impact of the pandemic on HCW.

Objective: Our objective was to investigate the association of sense of coherence (SOC), social support and religiosity with self-reported mental symptoms and increase of subjective burden during the COVID-19 pandemic in HCW. Read More

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Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons.

Elife 2021 Jul 26;10. Epub 2021 Jul 26.

MTA-SZTE Research Group for Cortical Microcircuits, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.

Summation of ionotropic receptor-mediated responses is critical in neuronal computation by shaping input-output characteristics of neurons. However, arithmetics of summation for metabotropic signals are not known. We characterized the combined ionotropic and metabotropic output of neocortical neurogliaform cells (NGFCs) using electrophysiological and anatomical methods in the rat cerebral cortex. Read More

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Management of internal root resorption in the maxillary central incisor with fractured root using Biodentine.

Clin Case Rep 2021 Jul 21;9(7):e04502. Epub 2021 Jul 21.

Department of Oral medicine School of Dentistry Arak University of Medical Sciences Arak Iran.

Biodentine is desirable to successfully manage internal root resorption, and the MTA apical plug backfilled with thermoplasticized gutta-percha is suggested for the tooth with external apical root resorption. Read More

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Agronomic, Physiological and Genetic Changes Associated With Evolution, Migration and Modern Breeding in Durum Wheat.

Front Plant Sci 2021 8;12:674470. Epub 2021 Jul 8.

Sustainable Field Crops Programme, Institute for Food and Agricultural Research and Technology (IRTA), Lleida, Spain.

A panel of 172 Mediterranean durum wheat landraces and 200 modern cultivars was phenotyped during three years for 21 agronomic and physiological traits and genotyped with 46,161 DArTseq markers. Modern cultivars showed greater yield, number of grains per spike (NGS) and harvest index (HI), but similar number of spikes per unit area (NS) and grain weight than the landraces. Modern cultivars had earlier heading but longer heading-anthesis and grain-filling periods than the landraces. Read More

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The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies.

Front Neural Circuits 2021 8;15:701080. Epub 2021 Jul 8.

MTA-SZTE 'Momentum' Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged, Hungary.

The medial septum (MS), as part of the basal forebrain, supports many physiological functions, from sensorimotor integration to cognition. With often reciprocal connections with a broad set of peers at all major divisions of the brain, the MS orchestrates oscillatory neuronal activities throughout the brain. These oscillations are critical in generating sensory and emotional salience, locomotion, maintaining mood, supporting innate anxiety, and governing learning and memory. Read More

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Validity and reliability of the medial temporal lobe atrophy scale in a memory clinic population.

BMC Neurol 2021 Jul 24;21(1):289. Epub 2021 Jul 24.

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Background: Visual rating of medial temporal lobe atrophy (MTA) is often performed in conjunction with dementia workup. Most prior studies involved patients with known or probable Alzheimer's disease (AD). This study investigated the validity and reliability of MTA in a memory clinic population. Read More

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Modelling Health in University Students: Are Young Women More Complicated Than Men?

Int J Environ Res Public Health 2021 Jul 8;18(14). Epub 2021 Jul 8.

Department of Behavioural Sciences, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

The biopsychosocial model of health in a limited life course perspective was tested among students in higher education using data from a nationwide cross-sectional survey of students on track to become teachers in Hungary. Health determinants were grouped into categories of biological, psychological, and social determinants and arranged in a temporal manner from childhood to the present. The model was tested by canonical correlation analysis followed by multivariate analysis of covariance. Read More

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Stromal Cells Serve Drug Resistance for Multiple Myeloma via Mitochondrial Transfer: A Study on Primary Myeloma and Stromal Cells.

Cancers (Basel) 2021 Jul 10;13(14). Epub 2021 Jul 10.

Central Hospital of Southern Pest, National Institute of Hematology and Infectious Diseases, 1097 Budapest, Hungary.

Recently, it has become evident that mitochondrial transfer (MT) plays a crucial role in the acquisition of cancer drug resistance in many hematologic malignancies; however, for multiple myeloma, there is a need to generate novel data to better understand this mechanism. Here, we show that primary myeloma cells (MMs) respond to an increasing concentration of chemotherapeutic drugs with an increase in the acquisition of mitochondria from autologous bone marrow stromal cells (BM-MSCs), whereupon survival and adenosine triphosphate levels of MMs increase, while the mitochondrial superoxide levels decrease in MMs. These changes are proportional to the amount of incorporated BM-MSC-derived mitochondria and to the concentration of the used drug, but seem independent from the type and mechanism of action of chemotherapeutics. Read More

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Drivers of seedling establishment success in dryland restoration efforts.

Nat Ecol Evol 2021 Jul 22. Epub 2021 Jul 22.

Institute of Applied Sciences, Malta College for Arts, Sciences and Technology, Fgura, Malta.

Restoration of degraded drylands is urgently needed to mitigate climate change, reverse desertification and secure livelihoods for the two billion people who live in these areas. Bold global targets have been set for dryland restoration to restore millions of hectares of degraded land. These targets have been questioned as overly ambitious, but without a global evaluation of successes and failures it is impossible to gauge feasibility. Read More

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Neurotransmitters and Neuropeptides decrease PD-1 in T cells of healthy subjects and patients with hepatocellular carcinoma (HCC), and increase their proliferation and eradication of HCC cells.

Neuropeptides 2021 May 12;89:102159. Epub 2021 May 12.

Institute of Gene Therapy, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem 91120, Israel.

T cells of aged people, and of patients with either cancer or severe infections (including COVID-19), are often exhausted, senescent and dysfunctional, leading to increased susceptibilities, complications and mortality. Neurotransmitters and Neuropeptides bind their receptors in T cells, and induce multiple beneficial T cell functions. Yet, T cells of different people vary in the expression levels of Neurotransmitter and Neuropeptide receptors, and in the magnitude of the corresponding effects. Read More

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Self-report instruments for assessing adherence to warfarin therapy: a systematic review.

Eur J Clin Pharmacol 2021 Jul 22. Epub 2021 Jul 22.

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Pampulha, Belo Horizonte, MG, 31270-901, Brazil.

Background: The assessment of adherence to warfarin therapy is useful in clinical practice due to its wide variability in dose-response and risks of complications. The aim of this study was to investigate validated instruments used to assess adherence to warfarin therapy.

Methods: Information was collected from the MEDLINE (PubMed), LILACS, EMBASE, and Cochrane Library databases. Read More

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BCR activated CLL B cells use both CR3 (CD11b/CD18) and CR4 (CD11c/CD18) for adhesion while CR4 has a dominant role in migration towards SDF-1.

PLoS One 2021 20;16(7):e0254853. Epub 2021 Jul 20.

Department of Immunology, Eötvös Loránd University, Budapest, Hungary.

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the western world. In previous studies, various proportion of patients was found to carry CD11b+ or CD11c+ B cells whose presence was an unfavourable prognostic factor. The exact mechanism however, how these receptors contribute to the pathogenesis of CLL has not been revealed so far. Read More

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Functionalized Nanoplastics (NPs) Increase the Toxicity of Metals in Fish Cell Lines.

Int J Mol Sci 2021 Jul 1;22(13). Epub 2021 Jul 1.

Immunobiology for Aquaculture Group, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.

Nanoplastics (NPs) are one of the most abundant environment-threatening nanomaterials on the market. The objective of this study was to determine in vitro if functionalized NPs are cytotoxic by themselves or increase the toxicity of metals. For that, we used 50 nm polystyrene nanoparticles with distinct surface functionalization (pristine, PS-Plain; carboxylic, PS-COOH; and amino PS-NH) alone or combined with the metals arsenic (As) and methylmercury (MeHg), which possess an environmental risk to marine life. Read More

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Corrigendum to "Surface Enhanced Raman Spectroscopic (SERS) behavior of phenylpyruvates used in heterogeneous catalytic asymmetric cascade reaction" [Spectrochim. Acta A: Mol. Biomol. Spectrosc. 260 (2021) 119912].

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 16;263:120112. Epub 2021 Jul 16.

Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Eötvös Loránd Research Network (ELKH), H-1117 Budapest, Magyar Tudósok körútja 2, Hungary; Department of Chemistry, Eszterházy Károly University, H-3300 Eger, Leányka u. 6, Hungary. Electronic address:

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Pregnancy and deep brain stimulation therapy for epilepsy.

Epileptic Disord 2021 Aug;23(4):633-638

Department of Neurology, Medical School, University of Pécs, Pécs, Hungary, MTA-PTE Clinical Neuroscience MRI Research Group, Hungary, Pécs, Hungary.

Neuromodulation therapy -vagus nerve stimulation (VNS) and deep brain stimulation (DBS)- is one of the therapeutic options for drug-resistant epilepsy. With the increasing number of DBS implantations in women with epilepsy, it has become a burning issue whether DBS is safe in pregnancy. We report here two women with epilepsy who gave birth to healthy children with DBS therapy. Read More

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Triapine Analogues and Their Copper(II) Complexes: Synthesis, Characterization, Solution Speciation, Redox Activity, Cytotoxicity, and mR2 RNR Inhibition.

Inorg Chem 2021 Aug 19;60(15):11297-11319. Epub 2021 Jul 19.

Institute of Inorganic Chemistry, University of Vienna, Währinger Strasse 42, A-1090 Vienna, Austria.

Three new thiosemicarbazones (TSCs) - as triapine analogues bearing a redox-active phenolic moiety at the terminal nitrogen atom were prepared. Reactions of - with CuCl·2HO in anoxic methanol afforded three copper(II) complexes, namely, (), [ (), and (), in good yields. Solution speciation studies revealed that the metal-free ligands are stable as - at pH 7. Read More

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Evaluation of Endosequence Root Repair Material and Endocem MTA as direct pulp capping agents: An in vivo study.

Aust Endod J 2021 Jul 18. Epub 2021 Jul 18.

Department of Conservative Dentistry and Endodontics, Maulana Azad Institute of Dental Sciences, New Delhi, India.

The study aimed to assess the human pulpal response to direct pulp capping using Endosequence Root Repair Material (ERRM) and Endocem MTA against ProRoot MTA as control. Intentional direct pulp capping was done using the three materials in 30 caries-free human premolars. After 30 days, the teeth were extracted, fixed and decalcified. Read More

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