37,925 results match your criteria mrsa

Ward-level factors associated with methicillin-resistant Staphylococcus aureus acquisition-an electronic medical records study in Singapore.

PLoS One 2021 22;16(7):e0254852. Epub 2021 Jul 22.

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.

Background: Methicillin-Resistant Staphylococcus aureus (MRSA) is endemic in hospitals worldwide. Intrahospital transfers may impact MRSA acquisition risk experienced by patients. In this study, we investigated ward characteristics and connectivity that are associated with MRSA acquisition. Read More

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Staquorsin: A Novel Agr-Mediated Quorum Sensing Inhibitor Impairing Virulence Without Notable Resistance Development.

Front Microbiol 2021 5;12:700494. Epub 2021 Jul 5.

Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

The emergence of microbial resistance to the available antibiotics is a major public health concern, especially with the limited rate of developing new antibiotics. The utilization of anti-virulence agents is a non-conventional approach that can be used to combat microbial infection. In , many virulence factors are regulated by the Agr-mediated quorum sensing (QS). Read More

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Molecular characterization and antimicrobial susceptibility of methicillin-resistant isolates from clinical samples and asymptomatic nasal carriers in Istanbul (Turkey).

Niger J Clin Pract 2021 Jul;24(7):997-1004

University of Health Sciences, Umraniye Education and Research Hospital, Medical Microbiology, Istanbul, Turkey.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) has been a widespread problem in Turkish hospitals.

Aims: The aim of this study was to investigate the staphylococcal toxin genes of the clinical and nasal MRSA isolates, and their antibiotic resistance profiles.

Materials And Methods: Isolation of nasal and clinical bacteria was done following standard microbiological methods. Read More

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Lipoproteins from Drive Neutrophil Extracellular Trap Formation in a TLR2/1- and PAD-Dependent Manner.

J Immunol 2021 Jul 21. Epub 2021 Jul 21.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX;

Neutrophils, polymorphonuclear leukocytes (PMN), play a critical role in the innate immune response to , a pathogen that continues to be associated with significant morbidity and mortality. Neutrophil extracellular trap (NET) formation is involved in ensnaring and killing of , but this host-pathogen interaction also leads to host tissue damage. Importantly, NET components including neutrophil proteases are under consideration as therapeutic targets in a variety of disease processes. Read More

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[Rate of methicillin-resistant Staphylococcus aureus in pediatric emergency departments in Spain].

An Pediatr (Barc) 2021 Jul 18. Epub 2021 Jul 18.

Hospital Universitario Infantil Niño Jesús, Madrid, España.

Introduction: Staphylococcusaureus (S. aureus) is a common germ present in bacterial infections in children. Lately, the rate of methicillin-resistant S. Read More

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Observation of synergistic antibacterial properties of prodigiosin from jx-1 with metal ions in clinical isolates of .

Prep Biochem Biotechnol 2021 Jul 21:1-7. Epub 2021 Jul 21.

College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing, China.

Methicillin-resistant (MRSA) infections are a major global health problem, and novel and effective antimicrobial drugs are urgently required to combat this life-threatening pathogen. Prodigiosin (PG) is a bacterial secondary metabolite with excellent anticancer and antibacterial properties. However, little is known about the antibacterial function of PG against MRSA. Read More

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Genomic Update of Phenotypic Prediction Rule for Methicillin-Resistant Staphylococcus aureus (MRSA) USA300 Discloses Jail Transmission Networks with Increased Resistance.

Microbiol Spectr 2021 Jul 21:e0037621. Epub 2021 Jul 21.

Division of Infectious Diseases, Rush University Medical Centergrid.240684.c/Cook County Health, Chicago, Illinois, USA.

Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of health care-associated (HA) and community-associated (CA) infections. USA300 strains are historically CA-MRSA, while USA100 strains are HA-MRSA. Here, we update an antibiotic prediction rule to distinguish these two genotypes based on antibiotic resistance phenotype using whole-genome sequencing (WGS), a more discriminatory methodology than pulsed-field gel electrophoresis (PFGE). Read More

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An ether-linked halogenated phenazine-quinone prodrug model for antibacterial applications.

Org Biomol Chem 2021 Jul 20. Epub 2021 Jul 20.

Department of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA.

Antibiotic-resistant infections present significant challenges to patients. As a result, there is considerable need for new antibacterial therapies that eradicate pathogenic bacteria through non-conventional mechanisms. Our group has identified a series of halogenated phenazine (HP) agents that induce rapid iron starvation that leads to potent killing of methicillin-resistant Staphylococcus aureus biofilms. Read More

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Risk of methicillin-resistant (MRSA) and vancomycin-resistant (VRE) acquisition during ambulance transport: A retrospective propensity-score-matched cohort analysis.

Infect Control Hosp Epidemiol 2021 Jul 21:1-6. Epub 2021 Jul 21.

Duke Center for Antimicrobial Stewardship and Infection Prevention, Duke University School of Medicine, Durham, North Carolina.

Objective: To estimate the relative risk (RR) of developing methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) colonization or infection within 30 days of ambulance transport.

Methods: We performed a retrospective cohort study of patients with a principal diagnosis of chest pain presenting to our emergency department (ED) over a 4-year period. Patients were included if they presented from and were discharged to nonhealthcare locations without being admitted. Read More

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Nasal screening for methicillin-resistant Staphylococcus aureus does not reduce surgical site infection after primary lumbar fusion.

Spine J 2021 Jul 17. Epub 2021 Jul 17.

Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Preoperative methicillin-resistant Staphylococcus aureus (MRSA) testing and decolonization has demonstrated success for arthroplasty patients in surgical site infections (SSIs) prevention. Spine surgery, however, has seen varied results.

Purpose: The purpose of this study was to determine the impact of nasal MRSA testing and operative debridement rates on surgical site infection after primary lumbar fusion. Read More

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DNA microarray analysis of Staphylococcus aureus from Nigeria and South Africa.

PLoS One 2021 20;16(7):e0237124. Epub 2021 Jul 20.

Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait.

Staphylococcus aureus is an important human pathogen with an arsenal of virulence factors and a propensity to acquire antibiotic resistance genes. The understanding of the global epidemiology of S. aureus through the use of various typing methods is important in the detection and tracking of novel and epidemic clones in countries and regions. Read More

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Differential Analysis of Longitudinal Methicillin-Resistant Staphylococcus aureus Colonization in Relation to Microbial Shifts in the Nasal Microbiome of Neonatal Piglets.

mSystems 2021 Jul 20:e0015221. Epub 2021 Jul 20.

Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands.

Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen and often colonizes pigs. To lower the risk of MRSA transmission to humans, a reduction of MRSA prevalence and/or load in pig farms is needed. The nasal microbiome contains commensal species that may protect against MRSA colonization and may be used to develop competitive exclusion strategies. Read More

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Dialdehyde Nanocrystalline Cellulose as Antibiotic Substitutes against Multidrug-Resistant Bacteria.

ACS Appl Mater Interfaces 2021 Jul 20. Epub 2021 Jul 20.

Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Road, Nanshan District, Shenzhen, Guangdong 518055, P. R. China.

Antibiotic abuse resulted in the emergence of multidrug-resistant Gram-positive pathogens, which pose a severe threat to public health. It is urgent to develop antibiotic substitutes to kill multidrug-resistant Gram-positive pathogens effectively. Herein, the antibacterial dialdehyde nanocrystalline cellulose (DNC) was prepared and characterized. Read More

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Skin tolerant inactivation of multiresistant pathogens using far-UVC LEDs.

Sci Rep 2021 Jul 19;11(1):14647. Epub 2021 Jul 19.

Ferdinand-Braun-Institut gGmbH, Leibniz-Institut für Höchstfrequenztechnik, Gustav-Kirchhoff-Str. 4, 12489, Berlin, Germany.

Multiresistant pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) cause serious postoperative infections. A skin tolerant far-UVC (< 240 nm) irradiation system for their inactivation is presented here. It uses UVC LEDs in combination with a spectral filter and provides a peak wavelength of 233 nm, with a full width at half maximum of 12 nm, and an irradiance of 44 µW/cm. Read More

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Hospitalization and colonization by methicillin-resistant Staphylococcus aureus in the surgical department of 03 health facilities in the Ndé division, West-Cameroon.

Ann Clin Microbiol Antimicrob 2021 Jul 19;20(1):48. Epub 2021 Jul 19.

School of Pharmacy, Higher Institute of Health Sciences, Université Des Montagnes, Bangangté, Cameroon.

Background: Commensal flora colonization during hospitalization by bacteria is the first step for nosocomial infections while antibiotic resistance reduces therapeutic options. In aim to control this phenomenon, we initiated this study to describe the impact of hospitalization on colonization by methicillin-resistant Staphylococcus aureus in the surgical department of 03 health facilities in the Ndé division, West-Cameroon.

Methods: This study was carried out on patients admitted for surgery in 03 health facilities of the Ndé division, West-Cameroon (District Hospital of Bangangté, Protestant Hospital of Bangwa and Cliniques Universitaires des Montagnes). Read More

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Anti-staphylococcal lysin, LSVT-1701, activity: In vitro susceptibility of Staphylococcus aureus and coagulase-negative staphylococci (CoNS) clinical isolates from around the world collected from 2002 to 2019.

Diagn Microbiol Infect Dis 2021 Jun 26;101(3):115471. Epub 2021 Jun 26.

Lysovant Sciences, Inc., New York, NY, USA.

LSVT-1701 (previously known as SAL200), is a novel, recombinantly-produced, bacteriophage-encoded lysin that specifically targets staphylococci via cell wall enzymatic hydrolysis. In vitro activities of LSVT-1701 and comparators were tested against 415 Staphylococcus aureus and coagulase-negative staphylococci (CoNS) clinical isolates expressing various resistance phenotypes. The isolates were collected worldwide from 2002 to 2019 and tested for in vitro susceptibility using broth microdilution methodology performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. Read More

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Plasma and Lung Tissue Pharmacokinetics of Ceftaroline Fosamil in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: An Microdialysis Study.

Antimicrob Agents Chemother 2021 Jul 19:AAC0067921. Epub 2021 Jul 19.

Medical University of Vienna, Department of Anesthesia, Intensive Care Medicine and Pain Medicine, Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Background: Ceftaroline fosamil, a 5th generation cephalosporin antibiotic with activity against MRSA, is currently approved for the treatment of pneumonia and complicated skin and soft tissue infections. However, pharmacokinetic data on free lung tissue concentrations in critical patient populations are lacking.

Objectives: The aim of this study was to evaluate the pharmacokinetics of the high-dose regimen of ceftaroline in plasma and lung tissue in cardiac surgery patients during intermittent and continuous administration. Read More

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Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation.

Molecules 2021 Jul 2;26(13). Epub 2021 Jul 2.

Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.

Background: Infectious diseases still affect large populations causing significant morbidity and mortality. Bacterial and fungal infections for centuries were the main factors of death and disability of millions of humans. Despite the progress in the control of infectious diseases, the appearance of resistance of microbes to existing drugs creates the need for the development of new effective antimicrobial agents. Read More

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High-Density Three-Dimensional Network of Covalently Linked Nitric Oxide Donors to Achieve Antibacterial and Antibiofilm Surfaces.

ACS Appl Mater Interfaces 2021 Jul 19. Epub 2021 Jul 19.

Centre for Antimicrobial Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore.

Bacterial colonization on biomedical devices often leads to biofilms that are recalcitrant to antibiotic treatment and the leading cause of hospital-acquired infections. We have invented a novel pretreatment chemistry for device surfaces to produce a high-density three-dimensional (3-D) network of covalently linked S-nitrosothiol (RSNO), which is a nitric oxide (NO) donor. Poly(polyethylene glycol-hydroxyl-terminated) (i. Read More

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Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards.

Front Cell Infect Microbiol 2021 30;11:681731. Epub 2021 Jun 30.

Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Infection is the leading cause of complications and deaths after burns. However, the difference in infection patterns between the burn intensive care unit (BICU) and burn common wards (BCW) have not been clearly investigated. The present study aimed to compare the infection profile, antimicrobial resistance, and their changing patterns in burn patients in BICU and BCW. Read More

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A Strong Synergy Between the Thiopeptide Bacteriocin Micrococcin P1 and Rifampicin Against MRSA in a Murine Skin Infection Model.

Front Immunol 2021 2;12:676534. Epub 2021 Jul 2.

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway.

Antibiotic-resistant bacterial pathogens have become a serious threat worldwide. One of these pathogens is methicillin-resistant (MRSA), a major cause of skin and soft tissue infections. In this study we identified a strain of producing a substance with high antimicrobial activity against many Gram-positive bacteria, including MRSA. Read More

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Inhibitory Effect of Puroindoline Peptides on Growth and Biofilm Formation.

Front Microbiol 2021 2;12:702762. Epub 2021 Jul 2.

School of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States.

Puroindolines are small, amphipathic, wheat proteins that determine the hardness of the wheat kernel and protect crops from different pathogens. Puroindoline A (PinA) and puroindoline B (PinB) are two major isoforms of puroindolines. These proteins have antibacterial and antifungal properties mainly attributed to their characteristic tryptophan-rich domains (TRDs). Read More

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Metabolite Profiling of Malaysian Reveals Eplerenone as Novel Antibacterial Compound for Drug Repurposing Against MDR Bacteria.

Front Microbiol 2021 30;12:653562. Epub 2021 Jun 30.

Department of Biological Sciences, Sunway University, Petaling Jaya, Malaysia.

With a continuous threat of antimicrobial resistance on human health worldwide, efforts for new alternatives are ongoing for the management of bacterial infectious diseases. Natural products of land and sea, being conceived to be having fewer side effects, pose themselves as a welcome relief. In this respect, we have taken a scaffolded approach to unearthing the almost unexplored chemical constituents of Malaysian red seaweed, . Read More

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Antimicrobial and antioxidant activity of catechin-3-o-rhamnoside isolated from the stem bark of Lannea kerstingii Engl. and K. Krause (Anacardiaceae).

Pak J Pharm Sci 2021 Mar;34(2):629-634

Department of Pharmacognosy and Drug Development, University of Ilorin, Ilorin, Nigeria.

Various epidemiological researches have shown that consumption of vegetables and fruits are essential to maintain health and prevent diseases but the emergence of more and more drug resistance bacteria has led to high mortality. Thus the study of the antimicrobial and antioxidant activities of a flavonoid (Catechin-3-o-rhamnoside) isolated for the first time from Lannea kerstingii. Catechin-3-o-rhamnoside was isolated using dry vacuum liquid chromatography. Read More

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Epidemiology of bacteremia in a pediatric population - A 10-year study.

Enferm Infecc Microbiol Clin 2021 Jul 15. Epub 2021 Jul 15.

Department of Pediatrics, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.

Introduction: With the widespread introduction of conjugate meningococcal and pneumococcal vaccines, the prevalence and etiology of invasive bacterial infections have changed. We aimed to review all cases of bacteremia in a level II pediatric department over a ten-year period in the post-pneumococcal conjugate vaccine era.

Methods: We reviewed all positive blood cultures (BC) obtained in our department between 2007 and 2016. Read More

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Synthetic cajaninstilbene acid derivatives eradicate methicillin-resistant Staphylococcus aureus persisters and biofilms.

Eur J Med Chem 2021 Jul 10;224:113691. Epub 2021 Jul 10.

College of Pharmacy, Jinan University, Guangzhou, 510632, PR China. Electronic address:

The Staphylococcus aureus can switch to a transient genotype-invariant dormancy, known as a persister, to survive treatment with high doses of antibiotics. This transient persister is an important reason underlying its resistance. There is an urgent need to find new antibacterial agents capable of eradicating methicillin-resistant S. Read More

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Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature.

Ital J Pediatr 2021 Jul 17;47(1):158. Epub 2021 Jul 17.

University of Milan, Milan, Italy.

Background: Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. Read More

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Bacterial spectrum analysis and antimicrobial susceptibility study of osteoradionecrosis of the jaw in Southern China.

Oral Dis 2021 Jul 17. Epub 2021 Jul 17.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China, 510055.

Objective: Osteoradionecrosis of the jaw (ORNJ) is one of the most common and serious complications after radiotherapy of head and neck malignancies due to the high incidence of nasopharyngeal cancer in Southern China. Clinicians lack understanding and consensus on anti-infective treatment in ORNJ lesions. This research aims to provide evidence for rational use of antibiotics by reviewing the bacterial spectrums and antimicrobial susceptibility test of ORNJ patients. Read More

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Multi-country cross-sectional study of colonization with multidrug-resistant organisms: protocol and methods for the Antibiotic Resistance in Communities and Hospitals (ARCH) studies.

BMC Public Health 2021 Jul 16;21(1):1412. Epub 2021 Jul 16.

Division of Healthcare Quality Promotion, U.S. Centers for Disease Control and Prevention, Office of the Director, 1600 Clifton Rd NE, MS H16-2, Atlanta, GA, 30029, USA.

Background: Antimicrobial resistance is a global health emergency. Persons colonized with multidrug-resistant organisms (MDROs) are at risk for developing subsequent multidrug-resistant infections, as colonization represents an important precursor to invasive infection. Despite reports documenting the worldwide dissemination of MDROs, fundamental questions remain regarding the burden of resistance, metrics to measure prevalence, and determinants of spread. Read More

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