35,411 results match your criteria mri spectroscopy


Expending the Phenotypic Spectrum of Encephalocraniocutaneous Lipomatosis: About a Prenatal Case With Complete Autopsy.

Pediatr Dev Pathol 2021 Sep 22:10935266211040802. Epub 2021 Sep 22.

Institute of Pathology, Hôpital Femme-Mère-Enfant, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France.

Encephalocraniocutaneous lipomatosis (ECCL) or Haberland syndrome (MIM #613001) is a rare congenital neurocutaneous disorder. It is characterized by unilateral ocular, cutaneous and central nervous system anomalies. Key clinical features include hairless fatty tissue nevus of the scalp, choristoma of the eye and intraspinal and intracerebral lipomas. Read More

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September 2021

The role of hepatic lipid composition in obesity-related metabolic disease.

Liver Int 2021 Sep 21. Epub 2021 Sep 21.

National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, UK.

Obesity is a primary antecedent to non-alcoholic fatty liver disease whose cardinal feature is excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates with hepatic and systemic metabolic dysfunction, accumulating evidence suggests that the composition of hepatic lipids may be more discriminatory. This review summarises cross-sectional human studies using liver biopsy/lipidomics and proton magnetic resonance spectroscopy to characterise hepatic lipid composition in people with obesity and related metabolic disease. Read More

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September 2021

Multiparametric MRI for the improved diagnostic accuracy of Alzheimer's disease and mild cognitive impairment: Research protocol of a case-control study design.

PLoS One 2021 21;16(9):e0252883. Epub 2021 Sep 21.

Gerontology Unit, Department of Medicine, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Background: Alzheimer's disease (AD) is a major neurocognitive disorder identified by memory loss and a significant cognitive decline based on previous level of performance in one or more cognitive domains that interferes in the independence of everyday activities. The accuracy of imaging helps to identify the neuropathological features that differentiate AD from its common precursor, mild cognitive impairment (MCI). Identification of early signs will aid in risk stratification of disease and ensures proper management is instituted to reduce the morbidity and mortality associated with AD. Read More

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September 2021

Remote Corticospinal Tract Degeneration After Cortical Stroke in Rats May Not Preclude Spontaneous Sensorimotor Recovery.

Neurorehabil Neural Repair 2021 Sep 21:15459683211041318. Epub 2021 Sep 21.

Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.

Recovery of motor function after stroke appears to be related to the integrity of axonal connections in the corticospinal tract (CST) and corpus callosum, which may both be affected after cortical stroke. In the present study, we aimed to elucidate the relationship of changes in measures of the CST and transcallosal tract integrity, with the interhemispheric functional connectivity and sensorimotor performance after experimental cortical stroke. We conducted in vivo diffusion magnetic resonance imaging (MRI), resting-state functional MRI, and behavior testing in twenty-five male Sprague Dawley rats recovering from unilateral photothrombotic stroke in the sensorimotor cortex. Read More

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September 2021

Structural MRI Signatures in Genetic Presentations of the Frontotemporal Dementia-Motor Neuron Disease Spectrum.

Neurology 2021 Sep 20. Epub 2021 Sep 20.

Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy

Objective: To assess cortical, subcortical and cerebellar grey matter (GM) atrophy using magnetic resonance imaging (MRI) in patients with disorders of the frontotemporal lobar degeneration (FTLD) spectrum with known genetic mutations.

Methods: Sixty-six patients carrying FTLD-related mutations were enrolled, including 44 with pure motor neuron disease (MND) and 22 with frontotemporal dementia (FTD). Sixty-one patients with sporadic FTLD (sFTLD) matched for age, sex and disease severity with genetic FTLD (gFTLD) were also included, as well as 52 healthy controls. Read More

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September 2021

Systematic Analysis of Brain MRI Findings in Adaptor Protein Complex 4-Associated Hereditary Spastic Paraplegia.

Neurology 2021 Sep 20. Epub 2021 Sep 20.

Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Background And Objectives: AP-4-associated hereditary spastic paraplegia (AP-4-HSP: SPG47, SPG50, SPG51, SPG52) is an emerging cause of childhood-onset hereditary spastic paraplegia and mimic of cerebral palsy. This study aims to define the spectrum of brain MRI findings in AP-4-HSP and to investigate radio-clinical correlations.

Methods: A systematic qualitative and quantitative analysis of 107 brain MRI studies from 76 individuals with genetically-confirmed AP-4-HSP and correlation with clinical findings including surrogates of disease severity. Read More

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September 2021

Red Fluorescent Emissive Gd-Phenolic Nanoparticles for Fluorescence and Magnetic Resonance Bimodal Imaging.

J Biomed Nanotechnol 2021 Aug;17(8):1635-1646

College of Science, Gansu Agricultural University, Lanzhou 730000, China.

Due to the combination of the high resolution of fluorescence imaging and the no limitation in penetration depth of magnetic resonance imaging, dual-mode imaging of magnetic resonance and fluorescence (MR/FI) have attracted extensive research in recent years. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by attaching the rhodamine fluorophore covalently to the surface of the Gd-phenolic coordination polymer nanoparticles. The contents of Gd and RB of the as prepared probe are calculated to be 8. Read More

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Obesity modifies the energetic phenotype of dilated cardiomyopathy.

Eur Heart J 2021 Sep 20. Epub 2021 Sep 20.

Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Level 0, John Radcliffe Hospital, Oxford OX3 9DU, UK.

Aims: We sought to determine if myocardial energetics could distinguish obesity cardiomyopathy as a distinct entity from dilated cardiomyopathy.

Methods And Results: Sixteen normal weight participants with dilated cardiomyopathy (DCMNW), and 27 with DCM and obesity (DCMOB), were compared to 26 normal weight controls (CTLNW). All underwent cardiac magnetic resonance imaging and 31P spectroscopy to assess function and energetics. Read More

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September 2021

Potentiometric MRI of a Superconcentrated Lithium Electrolyte: Testing the Irreversible Thermodynamics Approach.

ACS Energy Lett 2021 Sep 15;6(9):3086-3095. Epub 2021 Aug 15.

Department of Engineering Science, University of Oxford, Oxford OX1 3PJ, U.K.

Superconcentrated electrolytes, being highly thermodynamically nonideal, provide a stringent proving ground for continuum transport theories. Herein, we test an ostensibly complete model of LiPF in ethyl-methyl carbonate (EMC) based on the Onsager-Stefan-Maxwell theory from irreversible thermodynamics. We perform synchronous magnetic resonance imaging (MRI) and chronopotentiometry to examine how superconcentrated LiPF:EMC responds to galvanostatic polarization and open-circuit relaxation. Read More

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September 2021

The spectrum and differential diagnosis of acquired ocular motor nerve palsies: a clinical study of 502 patients.

J Neurol 2021 Sep 19. Epub 2021 Sep 19.

Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

Background: Ocular motor nerve palsies (OMNP) frequently cause patients to present in an emergency room. In the following study, we report the differential diagnosis of OMNP by use of magnetic resonance imaging (MRI) and CSF examination as a standard.

Method: We performed a data analysis of N = 502 patients who presented with oculomotor, trochlear, and/or abducens nerve palsy in the emergency room of the Department of Neurology, University of Ulm, between January 2006 and December 2019. Read More

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September 2021

Metabolic Magnetic Resonance Imaging in Neuroimaging: Magnetic Resonance Spectroscopy, Sodium Magnetic Resonance Imaging and Chemical Exchange Saturation Transfer.

Semin Ultrasound CT MR 2021 Oct 1;42(5):452-462. Epub 2021 Aug 1.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA.

Magnetic resonance (MR) is a powerful and versatile technique that offers much more beyond conventional anatomic imaging and has the potential of probing in vivo metabolism. Although MR spectroscopy (MRS) predates clinical MR imaging (MRI), its clinical application has been limited by technical and practical challenges. Other MR techniques actively being developed for in vivo metabolic imaging include sodium concentration imaging and chemical exchange saturation transfer. Read More

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October 2021

Revisiting the T Spectrum Imaging Inverse Problem: Bayesian Regularized Non-Negative Least Squares.

Neuroimage 2021 Sep 15:118582. Epub 2021 Sep 15.

Signal Processing Laboratory (LTS5), École Polytechnique Fédérale de Lausanne (EPFL), EPFL-STI-IEL-LTS5, Station 11, CH-1015, Lausanne, Switzerland; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Multi-echo T magnetic resonance images contain information about the distribution of T relaxation times of compartmentalized water, from which we can estimate relevant brain tissue properties such as the myelin water fraction (MWF). Regularized non-negative least squares (NNLS) is the tool of choice for estimating non-parametric T spectra. However, the estimation is ill-conditioned, sensitive to noise, and highly affected by the employed regularization weight. Read More

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September 2021

Cognitive control affects motor learning through local variations in GABA within the primary motor cortex.

Sci Rep 2021 Sep 17;11(1):18566. Epub 2021 Sep 17.

Division of Cerebral Integration, Department of System Neuroscience, National Institute for Physiological Sciences (NIPS), 38 Nishigonaka, Myodaiji, Okazaki, Aichi, 444-8585, Japan.

The primary motor cortex (M1) is crucial for motor learning; however, its interaction with other brain areas during motor learning remains unclear. We hypothesized that the fronto-parietal execution network (FPN) provides learning-related information critical for the flexible cognitive control that is required for practice. We assessed network-level changes during sequential finger tapping learning under speed pressure by combining magnetic resonance spectroscopy and task and resting-state functional magnetic resonance imaging. Read More

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September 2021

T-Cell Specificity Influences Disease Heterogeneity in Multiple Sclerosis.

Neurol Neuroimmunol Neuroinflamm 2021 Nov 17;8(6). Epub 2021 Sep 17.

From the Neuroimmunology and MS Research (NIMS) (C.C., M.P., P.T.O., I.J., M.J.D., R.P., P.M., C.W., I.J., A.L., R.M., M.S.), Department of Neurology, University Hospital and University Zurich, Switzerland; Department of Neuroscience DNS (M.P.), University-Hospital of Padova, Italy; Jung Diagnostics GmbH (R.O.), HIP - Health Innovation Port, Germany; Department of Health Sciences and Technology (C.W.), ETH Zurich, Switzerland; and Clinical Department of Neurology (M.R.), Medical University of Innsbruck, Austria.

Background And Objectives: Encouraged by the enormous progress that the identification of specific autoantigens added to the understanding of neurologic autoimmune diseases, we undertook here an in-depth study of T-cell specificities in the autoimmune disease multiple sclerosis (MS), for which the spectrum of responsible autoantigens is not fully defined yet. The identification of target antigens in MS is crucial for therapeutic strategies aimed to induce antigen-specific tolerance. In addition, knowledge of relevant T-cell targets can improve our understanding of disease heterogeneity, a hallmark of MS that complicates clinical management. Read More

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November 2021

Role of Neonatal Behavioral Neurological Assessment combined with magnetic resonance diffusion tensor imaging in evaluating white matter development in preterm infants.

Zhongguo Dang Dai Er Ke Za Zhi 2021 Sept 15;23(9):916-921

Department of Neonatology, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China (Xu F-L, Email: com).

Objectives: To study the correlation of fractional anisotropy (FA) on magnetic resonance diffusion tensor imaging with Neonatal Behavioral Neurological Assessment (NBNA) score in preterm infants, and to study the role of FA in evaluating white matter development from the perspective of imaging.

Methods: A prospective study was performed for 98 preterm infants who were admitted to the Neonatal Intensive Care Unit of the Third Affiliated Hospital of Zhengzhou University within 24 hours after birth from October 2016 to January 2020. According to the results of NBNA, they were divided into an abnormal group with 51 infants (NBNA score <37) and a normal group with 47 infants (NBNA score ≥37). Read More

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September 2021

Current emerging MRI tools for radionecrosis and pseudoprogression diagnosis.

Curr Opin Oncol 2021 Sep 16. Epub 2021 Sep 16.

Department of Neuroradiology, Sorbonne Université, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière-Charles Foix Sorbonne Université, INSERM, CNRS, Assistance Publique-Hôpitaux de Paris, Institut du Cerveau et de la Moelle épinière, boulevard de l'Hôpital, Paris Department of Research & Innovation, Olea Medical, avenue des Sorbiers, La Ciotat, France.

Purpose Of Review: This review aims to cover current MRI techniques for assessing treatment response in brain tumors, with a focus on radio-induced lesions.

Recent Findings: Pseudoprogression and radionecrosis are common radiological entities after brain tumor irradiation and are difficult to distinguish from real progression, with major consequences on daily patient care. To date, shortcomings of conventional MRI have been largely recognized but morphological sequences are still used in official response assessment criteria. Read More

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September 2021

Overconnectivity of the right Heschl's and inferior temporal gyrus correlates with symptom severity in preschoolers with autism spectrum disorder.

Autism Res 2021 Sep 16. Epub 2021 Sep 16.

Department of Electronics and Information Engineering, Korea University, Sejong, Republic of Korea.

Previous studies have reported varying findings regarding the association of brain connectivity in autism spectrum disorder (ASD) with overconnectivity, underconnectivity, or both. Despite the emerging understanding that ASD is a developmental disconnection syndrome, very little is known about structural brain networks in preschool-aged children with low-functioning ASD. We aimed to investigate the structural brain connectivity of low-functioning ASD using diffusion magnetic resonance imaging and graph theory to examine alterations in different brain network topologies and identify any correlations with the clinical severity of ASD in preschool-aged children. Read More

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September 2021

Neural correlates of schema-dependent episodic memory and association with behavioral flexibility in autism spectrum disorders and typical development.

J Neurodev Disord 2021 Sep 15;13(1):35. Epub 2021 Sep 15.

Children's Research Institute, Children's National Health System, Washington, DC, 20010, USA.

Background: Conceptual knowledge frameworks termed schemas facilitate memory formation and are posited to support flexible behavior. In adults, the medial temporal lobe (MTL) and medial prefrontal cortex (mPFC) trade-off in supporting schema-based memory formation, such that encoding of subsequently remembered schema-congruent information relies on mPFC, whereas schema-incongruent information relies on MTL. Whether this is true in the immature brain and relates to behavioral flexibility is unknown. Read More

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September 2021

Biomarkers for autism spectrum disorder: opportunities for magnetoencephalography (MEG).

J Neurodev Disord 2021 Sep 15;13(1):34. Epub 2021 Sep 15.

Dept. of Radiology, Lurie Family Foundations MEG Imaging Center, Children's Hospital of Philadelphia, 3401 Civic Center Blvd., Philadelphia, PA, 19104, USA.

This paper reviews a candidate biomarker for ASD, the M50 auditory evoked response component, detected by magnetoencephalography (MEG) and presents a position on the roles and opportunities for such a biomarker, as well as converging evidence from allied imaging techniques (magnetic resonance imaging, MRI and spectroscopy, MRS). Data is presented on prolonged M50 latencies in ASD as well as extension to include children with ASD with significant language and cognitive impairments in whom M50 latency delays are exacerbated. Modeling of the M50 latency by consideration of the properties of auditory pathway white matter is shown to be successful in typical development but challenged by heterogeneity in ASD; this, however, is capitalized upon to identify a distinct subpopulation of children with ASD whose M50 latencies lie well outside the range of values predictable from the typically developing model. Read More

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September 2021

Liver Fat, Adipose Tissue, and Body Composition Changes After Switching from a Protease Inhibitor or Efavirenz to Raltegravir.

AIDS Patient Care STDS 2021 Sep;35(9):335-341

Department of Infectious Diseases, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Integrase inhibitors appear to increase body weight, but paradoxically some data indicate that raltegravir (RAL) may decrease liver fat. Our objective was to study the effects of switching from a protease inhibitor (PI) or efavirenz (EFV) to RAL on liver fat, body composition, and metabolic parameters among people living with HIV (PLWH) with high risk for nonalcoholic fatty liver disease (NAFLD). We randomized overweight PLWH with signs of metabolic syndrome to switch a PI or EFV to RAL ( = 19) or to continue unchanged antiretroviral therapy (control,  = 24) for 24 weeks. Read More

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September 2021

Comparison of indocyanine green fluorescence lymphangiography and magnetic resonance lymphangiography to investigate lymphedema of the extremities.

Ann Ital Chir 2021 ;92:452-459

Purpose: The aim of this study is to compare two dynamic imaging modalities employed to study peripheral lymphatic system, Magnetic Resonance Lymphangiography (MRL) and Indocyanine Green Lymphangiography (ICGL), evaluating their role for planning lymphaticovenular anastomosis (LVA) or other surgical-nonsurgical treatments in patients with lymphedema of the extremities.

Materials And Methods: We conducted a retrospective study of 32 patients (26 women) with a mean age of 38 years (range 18-73) enrolled from January 2014 to December 2018; 20 out of 32 were affected by lower limb lymphedema with 6 cases of primary lymphedema; all of them had stage II disease. All the patient underwent ICGL and MRL within a month of one another, by injecting different contrast medium into interdigital web spaces. Read More

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September 2021

Leigh syndrome-like MRI changes in a patient with biallelic variants treated with ketogenic diet.

Mol Genet Metab Rep 2021 Dec 4;29:100800. Epub 2021 Sep 4.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

Biallelic 4-hydroxyphenylpyruvate dioxygenase-like protein () variants were recently reported as a cause of progressive and incurable neurodegenerative diseases ranging from neonatal-onset leukoencephalopathy with severe neurodevelopmental delay to spastic paraplegia. Although the physiological function of HPDL remains unknown, its subcellular localization in the mitochondria has been reported. Here, we report a case of -related neurological disease that was clinically and neuroimaging compatible with Leigh syndrome, previously unreported, and was treated with a ketogenic diet. Read More

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December 2021

Magnetic Resonance Imagery Findings in Androgen Insensitivity: A case series.

Sultan Qaboos Univ Med J 2021 Aug 29;21(3):472-476. Epub 2021 Aug 29.

Sapthagiri Institute of Medical Science and Research Centre, Bengaluru, Karnataka, India.

Androgen insensitivity syndrome (AIS) is a sex-development disorder resulting from mutations in the androgen receptor. In its complete form, patients are genetically male but phenotypically female, presenting with primary amenorrhea. We report three cases of AIS highlighting the multifaceted role of magnetic resonance imaging (MRI) for presurgical planning by evaluating location and type of gonads and detecting complications. Read More

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Predicting brain age during typical and atypical development based on structural and functional neuroimaging.

Hum Brain Mapp 2021 Sep 14. Epub 2021 Sep 14.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.

Exploring typical and atypical brain developmental trajectories is very important for understanding the normal pace of brain development and the mechanisms by which mental disorders deviate from normal development. A precise and sex-specific brain age prediction model is desirable for investigating the systematic deviation and individual heterogeneity of disorders associated with atypical brain development, such as autism spectrum disorders. In this study, we used partial least squares regression and the stacking algorithm to establish a sex-specific brain age prediction model based on T1-weighted structural magnetic resonance imaging and resting-state functional magnetic resonance imaging. Read More

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September 2021

Classification and biomarker identification of prostate tissue from TRAMP mice with hyperpolarized C-SIRA.

Talanta 2021 Dec 20;235:122812. Epub 2021 Aug 20.

Center for Hyperpolarization in Magnetic Resonance, Department of Health Technology, Ørsteds plads 349, 2800, Kongens Lyngby, Denmark. Electronic address:

Hyperpolarized C isotope resolved spectroscopy boosts NMR signal intensity, which improves signal detection and allows metabolic fluxes to be analyzed. Such hyperpolarized flux data may offer new approaches to tissue classification and biomarker identification that could be translated in vivo. Here we used hyperpolarized stable isotope resolved analysis (SIRA) to measure metabolite specific C isotopic enrichments in the central carbon metabolism of mouse prostate. Read More

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December 2021

A line-broadening free real-time P pure shift NMR method for phosphometabolomic analysis.

Analyst 2021 Sep 13;146(18):5502-5507. Epub 2021 Sep 13.

National Institute of Chemical Physics and Biophysics, Akadeemia tee 23, Tallinn 12618, Estonia.

Phosphometabolomics by P NMR can be challenging, since overlapping multiplets of homonuclear coupled phosphorus nuclei complicate spectral analysis. Pure shift NMR allows to simplify such spectra by collapsing multiplets into singlets, but most pure shift methods require substantially elongated measurement times or cause disturbing spectral line broadening. Herein, we combine established pure shift NMR and artefact suppression techniques to record P pure shift NMR spectra without penalties in measurement time or line width. Read More

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September 2021

MRS-measured glutamate versus GABA reflects excitatory versus inhibitory neural activities in awake mice.

J Cereb Blood Flow Metab 2021 Sep 13:271678X211045449. Epub 2021 Sep 13.

Department of Functional Brain Imaging, Institute of Quantum Medical Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan.

To assess if magnetic resonance spectroscopy (MRS)-measured Glutamate (Glu) and GABA reflect excitatory and inhibitory neural activities, respectively, we conducted MRS measurements along with two-photon mesoscopic imaging of calcium signals in excitatory and inhibitory neurons of living, unanesthetized mice. For monitoring stimulus-driven activations of a brain region, MRS signals and mesoscopic neural activities were measured during two consecutive sessions of 15-min prolonged sensory stimulations. In the first session, putative excitatory neuronal activities were increased, while inhibitory neuronal activities remained at the baseline level. Read More

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September 2021

Pediatric septic thrombosis of intracranial venous sinuses: from diagnosis to discharge. Twenty years of experience.

Rev Neurol 2021 Sep;73(6):187-193

Hospital Infantil Niño Jesús, Madrid, España.

Introduction: Septic thrombosis of intracranial venous sinuses (STSV) is a rare and severe complication of cranial infections.

Materials And Methods: The main objective of this paper is to describe the clinical data, diagnostic procedures, treatment and evolution of a series of cases of STSV. In addition, the current literature is reviewed. Read More

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September 2021

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: state of the art and prospects.

J Biophotonics 2021 Sep 12:e202100149. Epub 2021 Sep 12.

Skolkovo Institute of Science and Technology, Moscow, Russia.

The status of sentinel lymph nodes (SLNs) has a substantial prognostic value because these nodes are the first place where cancer cells accumulate along their spreading route. Routine SLN biopsy ("gold standard") involves peritumoral injections of radiopharmaceuticals, such as technetium-99m, which has obvious disadvantages. This review examines the methods used as "gold standard" analogs to diagnose SLNs. Read More

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September 2021

Reduction of Tissue Na Accumulation After Renal Transplantation.

Kidney Int Rep 2021 Sep 28;6(9):2338-2347. Epub 2021 Jun 28.

Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Introduction: Chronic kidney disease (CKD) engenders salt-sensitive hypertension. Whether or not tissue Na accumulation is increased in CKD patients remains uncertain. How tissue Na is affected after renal transplantation has not been assessed. Read More

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September 2021