334,891 results match your criteria mri patient

White matter alterations in Parkinson's disease with levodopa-induced dyskinesia.

Parkinsonism Relat Disord 2021 Jul 24;90:8-14. Epub 2021 Jul 24.

Department of Neurology, Faculty of Medicine, Juntendo University, Tokyo, Japan. Electronic address:

Introduction: Levodopa-induced dyskinesia is a complication of levodopa therapy and negatively impacts the quality of life of patients. We aimed to elucidate white matter alterations in Parkinson's disease with levodopa-induced dyskinesia using advanced diffusion magnetic resonance imaging techniques.

Methods: The enrolled subjects included 26 clinically confirmed Parkinson's disease patients without levodopa-induced dyskinesia, 25 Parkinson's disease patients with levodopa-induced dyskinesia, and 23 healthy controls. Read More

View Article and Full-Text PDF

Clinicopathological analysis of invasive cribriform carcinoma of the breast, with review of the literature.

Ann Diagn Pathol 2021 Jul 24;54:151794. Epub 2021 Jul 24.

Izmir Katip Celebi University Ataturk Training and Research Hospital, Department of Oncology, Turkey.

Invasive cribriform carcinoma (ICC) is a rare type of a primary breast carcinoma. It is subdivided into two groups as pure and mixed types. There are limited studies comparing the pure and mixed ICC at present. Read More

View Article and Full-Text PDF

Carotid Atherosclerosis and Longitudinal Changes of MRI Visual Rating Measures in Stroke Survivors: A Seven-Year Follow-Up Study.

J Stroke Cerebrovasc Dis 2021 Jul 26;30(10):106010. Epub 2021 Jul 26.

Bærum Hospital- Vestre Viken Hospital Trust, Department of Medicine, Drammen, Norway; Oslo Stroke Unit, Department of Neurology, Oslo University Hospital, Ullevål, Norway.

Objectives: We aimed to assess longitudinal changes in MRI measures of brain atrophy and white matter lesions in stroke and transient ischemic attack (TIA) survivors, and explore whether carotid stenosis predicts progression of these changes, assessed by visual rating scales.

Materials And Methods: All patients with a first-ever stroke or TIA admitted to Bærum Hospital, Norway, in 2007/2008, were invited in the acute phase and followed for seven years. Carotid ultrasound was performed during the hospital stay. Read More

View Article and Full-Text PDF

Expedited and Comprehensive Management of Low-Risk TIA Patients in the Emergency Department is Safe and Less Costly.

J Stroke Cerebrovasc Dis 2021 Jul 26;30(10):106016. Epub 2021 Jul 26.

Department of Neurology, Yale School of Medicine, 15 York St., LLCI 1003C, New Haven, New Haven, CT 06511, USA. Electronic address:

Objectives: Transient ischemic attack (TIA) can be a warning sign of an impending stroke. The objective of our study is to assess the feasibility, safety, and cost savings of a comprehensive TIA protocol in the emergency room for low-risk TIA patients.

Materials And Methods: This is a retrospective, single-center cohort study performed at an academic comprehensive stroke center. Read More

View Article and Full-Text PDF

Treatment response of colorectal cancer liver metastases to neoadjuvant or conversion therapy: a prospective multicentre follow-up study using MRI, diffusion-weighted imaging and H-MR spectroscopy compared with histology (subgroup in the RAXO trial).

ESMO Open 2021 Jul 26;6(4):100208. Epub 2021 Jul 26.

Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Colorectal cancer liver metastases respond to chemotherapy and targeted agents not only by shrinking, but also by morphologic and metabolic changes. The aim of this study was to evaluate the value of advanced magnetic resonance imaging (MRI) methods in predicting treatment response and survival.

Patients And Methods: We investigated contrast-enhanced MRI, apparent diffusion coefficient (ADC) in diffusion-weighted imaging and H-magnetic resonance spectroscopy (H-MRS) in detecting early morphologic and metabolic changes in borderline or resectable liver metastases, as a response to first-line neoadjuvant or conversion therapy in a prospective substudy of the RAXO trial (NCT01531621, EudraCT2011-003158-24). Read More

View Article and Full-Text PDF

Serial improvement of medial meniscus extrusion following medial open-wedge high tibial osteotomy does not reflect clinical outcomes and arthroscopic articular cartilage improvement.

Arthroscopy 2021 Jul 26. Epub 2021 Jul 26.

Department of Orthopaedic Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

Purpose: To assess serial change up to 2 years in medial meniscus extrusion (MME) following medial open-wedge high tibial osteotomy (MOWHTO) and to determine if postoperative changes in MME correlated with clinical outcomes and arthroscopic articular cartilage status.

Methods: This study included 26 patients from December 2016 to March 2018 who underwent MOWHTO for primary medial osteoarthritis (OA) with varus malalignment. Second-look arthroscopy with plate removal was performed at postoperative 2 years. Read More

View Article and Full-Text PDF

Recent Advances in Radio-Frequency Coil Technologies: Flexible, Wireless, and Integrated Coil Arrays.

J Magn Reson Imaging 2021 Jul 29. Epub 2021 Jul 29.

Brain Imaging and Analysis Center, Duke University, Durham, North Carolina, USA.

Radio-frequency (RF) coils are to magnetic resonance imaging (MRI) scanners what eyes are to the human body. Because of their critical importance, there have been constant innovations driving the rapid development of RF coil technologies. Over the past four decades, the breadth and depth of the RF coil technology evolution have far exceeded the space allowed for this review article. Read More

View Article and Full-Text PDF

Improving CPMG liver iron estimates with a -corrected proton density estimator.

Magn Reson Med 2021 Jul 29. Epub 2021 Jul 29.

Cardiology, Children's Hospital of Los Angeles, Los Angeles, CA, USA.

Purpose: CPMG spin echo acquisitions are attractive for diagnosing and monitoring liver iron concentration in iron overload disorders due to their time efficiency and potential to reveal unique information about tissue iron distribution. Clinical adoption remains low due to the insensitivity of CPMG-based estimates to liver iron concentration (LIC) when common fitting techniques are applied. In this work, we demonstrate that the inclusion of a proton density estimator (PDE) derived from the CPMG acquisition increase the sensitivity of CPMG estimates to LIC in both simulated and in-vivo human data. Read More

View Article and Full-Text PDF

Structuro-functional surrogates of response to subcallosal cingulate deep brain stimulation for depression.

Brain 2021 Jul 29. Epub 2021 Jul 29.

Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, M5T 2S8, Canada.

Subcallosal cingulate deep brain stimulation (SCC-DBS) produces long-term clinical improvement in approximately half of patients with severe treatment-resistant depression (TRD). We hypothesized that both structural and functional brain attributes may be important in determining responsiveness to this therapy. In a TRD SCC-DBS cohort, we retrospectively examined baseline and longitudinal differences in MRI-derived brain volume (n = 65) and 18F-fluorodeoxyglucose-PET glucose metabolism (n = 21) between responders and non-responders. Read More

View Article and Full-Text PDF

Magnetic resonance radiomics features and prognosticators in different molecular subtypes of pediatric Medulloblastoma.

PLoS One 2021 29;16(7):e0255500. Epub 2021 Jul 29.

Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan.

Purpose: Medulloblastoma (MB) is a highly malignant pediatric brain tumor. In the latest classification, medulloblastoma is divided into four distinct groups: wingless (WNT), sonic hedgehog (SHH), Group 3, and Group 4. We analyzed the magnetic resonance imaging radiomics features to find the imaging surrogates of the 4 molecular subgroups of MB. Read More

View Article and Full-Text PDF

Can Deep Learning Replace Gadolinium in Neuro-Oncology?: A Reader Study.

Invest Radiol 2021 Jul 28. Epub 2021 Jul 28.

From the Imaging Department, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif BioMaps (UMR1281), Université Paris-Saclay, CNRS, Inserm, CEA, Villejuif Guerbet Research, Villepinte Center for Visual Computing, CentraleSupélec, Inria, Université Paris-Saclay, Gif-sur-Yvette, France.

This study proposes and evaluates a deep learning method that predicts surrogate images for contrast-enhanced T1 from multiparametric magnetic resonance imaging (MRI) acquired using only a quarter of the standard 0.1 mmol/kg dose of gadolinium-based contrast agent. In particular, the predicted images are quantitatively evaluated in terms of lesion detection performance. Read More

View Article and Full-Text PDF

Intra-Articular Injection of BPC 157 for Multiple Types of Knee Pain.

Altern Ther Health Med 2021 Jul;27(4):8-13

Introduction: Knee pain, a common complaint in primary care, has many causes, the most common of which is osteoarthritis (OA). Other common causes are meniscus tears, tendinosis, ligament tears or sprains, rheumatoid arthritis, lupus and septic arthritis. Also, referred pain from hip joint pathology like slipped capital femoral epiphysis can result in knee pain. Read More

View Article and Full-Text PDF

Brain tumor classification using fine-tuned GoogLeNet features and machine learning algorithms: IoMT enabled CAD system.

IEEE J Biomed Health Inform 2021 Jul 29;PP. Epub 2021 Jul 29.

In the healthcare research community, Internet of Medical Things (IoMT) is transforming the healthcare system into the world of the future internet. In IoMT enabled Computer aided diagnosis (CAD) system, the Health-related information is stored via the internet, and supportive data is provided to the patients. The development of various smart devices is interconnected via the internet, which helps the patient to communicate with a medical expert using IoMT based remote healthcare system for various life threatening diseases, e. Read More

View Article and Full-Text PDF

Role of multiparametric MRI in long-term surveillance following focal laser ablation of prostate cancer.

Br J Radiol 2021 Jul 29:20210414. Epub 2021 Jul 29.

Joint Department of Medical Imaging, University of Toronto, University Health Network - Mount Sinai Hospital - Women's College Hospital, Toronto, ON, Canada.

Objective: Determine the multiparametric magnetic resonance imaging (mpMRI) appearance of the prostate following focal laser ablation (FLA) for PCa and to identify imaging characteristics associated with recurrent disease.

Methods: Retrospective analysis of patients who underwent FLA for low-intermediate risk PCa between 2010 and 2014 was performed. Early (median 4 months) and late mpMRI (median 49 months) follow-up were qualitatively assessed for -weighted, dynamic contrast enhanced (DCE) and diffusion weighted imaging (DWI) appearances and also compared to corresponding PSA values and biopsy results. Read More

View Article and Full-Text PDF

The challenge of prostate biopsy guidance in the era of mpMRI detected lesion: ultrasound-guided versus in-bore biopsy.

Br J Radiol 2021 Jul 29:20210363. Epub 2021 Jul 29.

Department of Urology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

The current recommendation in patients with a clinical suspicion for prostate cancer is to perform systematic biopsies extended with targeted biopsies, depending on mpMRI results. Following a positive mpMRI [i.e. Read More

View Article and Full-Text PDF

Grading the severity of the rotator cuff tendinosis on MRI: Assessment of inter-observer agreement and evaluation of a novel objective assessment tool.

J Med Imaging Radiat Oncol 2021 Jul 29. Epub 2021 Jul 29.

Alfred Imaging Group, Sydney, New South Wales, Australia.

Introduction: MRI is generally considered the modality of choice for the assessment of rotator cuff pathology including tendinosis. Assessment of severity is currently subjective primarily based on tendon morphology and signal intensity. Limited data are available evaluating the inter-observer agreement regarding the assessment of tendinosis severity. Read More

View Article and Full-Text PDF

Dynamic tractography-based localization of spike sources and animation of spike propagations.

Epilepsia 2021 Jul 29. Epub 2021 Jul 29.

Department of Pediatrics, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.

Objective: This study was undertaken to build and validate a novel dynamic tractography-based model for localizing interictal spike sources and visualizing monosynaptic spike propagations through the white matter.

Methods: This cross-sectional study investigated 1900 spike events recorded in 19 patients with drug-resistant temporal lobe epilepsy (TLE) who underwent extraoperative intracranial electroencephalography (iEEG) and resective surgery. Twelve patients had mesial TLE (mTLE) without a magnetic resonance imaging-visible mass lesion. Read More

View Article and Full-Text PDF

Invasive Lobular Breast Cancer: Data to Support Surgical Decision Making.

Ann Surg Oncol 2021 Jul 29. Epub 2021 Jul 29.

Division of Breast Surgery, Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA.

Background: Invasive lobular carcinoma (ILC) is thought be a unique entity with higher rates of multifocal/multicentric and bilateral disease. This study aimed to evaluate the true extent of the disease, risk of bilaterality, lymph node involvement, and impact of preoperative imaging to help guide surgical decision making.

Methods: A retrospective analysis identified patients treated for ILC between 2004 and 2017. Read More

View Article and Full-Text PDF

[Radiological aspects in the diagnostics of pathological fractures].

Unfallchirurg 2021 Jul 29. Epub 2021 Jul 29.

Klinik für Unfallchirurgie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Radiological diagnostics play a key role in the identification and assessment of pathological fractures. Conventional projection radiography is still the mainstay of imaging investigations. With knowledge of the patient history, the morphology and location of a fracture as well as concomitant findings, such as osteolysis or periosteal reactions can add valuable information on the origin of the fracture. Read More

View Article and Full-Text PDF

Respiratory anomalies associated with gadoxetate disodium and gadoterate meglumine: compressed sensing MRI revealing physiologic phenomena during the entire injection cycle.

Eur Radiol 2021 Jul 29. Epub 2021 Jul 29.

Department of Radiology, University Hospital Basel, Basel, Switzerland.

Objectives: The goal of this study was to investigate the precise timeline of respiratory events occurring after the administration of two gadolinium-based contrast agents, gadoxetate disodium and gadoterate meglumine.

Materials And Methods: This retrospective study examined 497 patients subject to hepatobiliary imaging using the GRASP MRI technique (TR/TE = 4/2 ms; ST = 2.5 mm; 384 × 384 mm). Read More

View Article and Full-Text PDF

Effect of upper airway fat on tongue dilation during inspiration in awake people with obstructive sleep apnea.

Sleep 2021 Jul 29. Epub 2021 Jul 29.

Neuroscience Research Australia, Sydney, New South Wales, Australia.

Study Objectives: To investigate the effect of upper airway fat composition on tongue inspiratory movement and obstructive sleep apnea (OSA).

Methods: Participants without or with untreated OSA underwent a 3T magnetic resonance imaging (MRI) scan. Anatomical measurements were obtained from T2-weighted images. Read More

View Article and Full-Text PDF

Diagnostic measures for patients with systemic sclerosis-associated myopathy.

Clin Exp Rheumatol 2021 Jul-Aug;39 Suppl 131(4):85-93. Epub 2021 Jul 15.

Department of Rheumatology and Immunology, University Hospital Bern, Switzerland.

Objectives: To evaluate the clinico-serological profile and to assess diagnostic parameters of myopathy in patients with systemic sclerosis (SSc)-associated myopathy.

Methods: We explored the profiles of SSc-myopathy patients and matched non-myopathy SSc patients as well as different diagnostic measures for muscle affection. Additionally, the muscle performance of SSc-myopathy patients, assessed by the Manual Muscle Test for 8 muscle groups (MMT-8) and the Functional Index-2 (FI-2), was compared with that of patients with primary myositis. Read More

View Article and Full-Text PDF

Secondary spinal cord changes and spinal deformity following traumatic spinal cord injury.

Aging Male 2021 Dec;24(1):95-100

Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Secondary spinal cord changes can follow spinal cord injuries (SCIs). This retrospective study was to uncover the chronic secondary changes that affect the spinal cord following severe injuries and to evaluate the influence of residual spinal deformity in the development of posttraumatic spinal cord changes. Fifty-eight patients (39 male, 19 female) with complete traumatic SCI and recent Magnetic resonance imaging (MRI) follow-up were reviewed retrospectively. Read More

View Article and Full-Text PDF
December 2021

Lunate morphology: association with the severity of scapholunate ligament injuries and carpal instability patterns.

J Plast Surg Hand Surg 2021 Jul 29:1-9. Epub 2021 Jul 29.

Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Trauma Center, Eberhard Karls University Tuebingen, Tuebingen, Germany.

Type II lunate has been associated with a lower incidence of dorsal intercalated segment instability (DISI) in the case of scapholunate dissociation. We aimed to evaluate the frequency of different lunate types and their influence on the prevalence and severity of scapholunate ligament (SLIL) injuries and the development of DISI. The surgical records of 414 arthroscopies were reviewed retrospectively. Read More

View Article and Full-Text PDF

Gadoteridol-enhanced MRI of the breast: can contrast agent injection rate impact background parenchymal enhancement?

Acta Radiol 2021 Jul 29:2841851211034038. Epub 2021 Jul 29.

Department of Radiological, Oncological and Pathological Sciences, 9311Sapienza University of Rome, Sapienza University of Rome, Rome, Italy.

Background: Normal background parenchymal enhancement (BPE) is a dynamic parameter affected by multiple factors.

Purpose: To determine whether contrast agent injection rate affects the degree of BPE in women undergoing breast magnetic resonance imaging (MRI).

Material And Methods: A total of 85 patients included in our prospective study randomly received 0. Read More

View Article and Full-Text PDF

Conservative Treatment for Giant Lumbar Disc Herniation: Clinical Study in 409 Cases.

Pain Physician 2021 Aug;24(5):E639-E648

Department of Orthopaedic Surgery, Suzhou Hospital of Traditional Chinese Medicine, Jiangsu, China.

Background: There have been several recent reports of lumbar disc herniation (LDH) resorption; however, large sample studies are lacking, and the mechanism(s) underlying this phenomenon is unclear.

Objectives: To explore the feasibility and clinical outcomes of conservative treatment for giant LDH and to analyze the factors affecting the resorption of giant LDH.

Study Design: Observational study and original research. Read More

View Article and Full-Text PDF

The Impact of Vitamin D Deficiency to Treatment Success of Transforaminal Epidural Steroid Injection.

Pain Physician 2021 Aug;24(5):E619-E624

Department of Physical Medicine and Rehabilitation, Division of Pain Medicine, Faculty of Medicine, Marmara University, Istanbul, Turkey.

Background: Transforaminal epidural steroid injection (TFESI) is an interventional technique used to relieve disc herniation related back and radicular pain. Although few studies have investigated the factors predicting positive outcomes after TFESI, there is no data concerning the possible relationship between pre-procedure serum 25-hydroxyvitamin D (25(OH)D) levels and the response to TFESI.

Objectives: To investigate the effect of vitamin D deficiency to treatment success of fluoroscopy-guided transforaminal epidural steroid injection. Read More

View Article and Full-Text PDF

Altered Neurovascular Coupling in Patients with Chronic Myofascial Pain.

Pain Physician 2021 Aug;24(5):E601-E610

Department of Anatomy, Zunyi Medical College, Zunyi, Guizhou, China.

Background: Despite previous reports on cerebral structures and functional connectivity in patients with myofascial pain (MFP), it is not clear whether alterations in neurovascular coupling occur in these patients.

Objectives: We analyzed the coupling between resting-state cerebral blood flow (CBF) and functional connectivity strength (FCS) for observation of neurovascular coupling in patients with chronic MFP.

Study Design: Observational study. Read More

View Article and Full-Text PDF

CB R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky-Pudlak syndrome.

Clin Transl Med 2021 Jul;11(7):e471

Section of Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder which, in its most common and severe form, HPS-1, leads to fatal adult-onset pulmonary fibrosis (PF) with no effective treatment. We evaluated the role of the endocannabinoid/CB R system and inducible nitric oxide synthase (iNOS) for dual-target therapeutic strategy using human bronchoalveolar lavage fluid (BALF), lung samples from patients with HPS and controls, HPS-PF patient-derived lung fibroblasts, and bleomycin-induced PF in pale ear mice (HPS1 ). We found overexpression of CB R and iNOS in fibrotic lungs of HPSPF patients and bleomycin-infused pale ear mice. Read More

View Article and Full-Text PDF

A novel approach for assessing hypoperfusion in stroke using spatial independent component analysis of resting-state fMRI.

Hum Brain Mapp 2021 Jul 29. Epub 2021 Jul 29.

Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Individualized treatment of acute stroke depends on the timely detection of ischemia and potentially salvageable tissue in the brain. Using functional MRI (fMRI), it is possible to characterize cerebral blood flow from blood-oxygen-level-dependent (BOLD) signals without the administration of exogenous contrast agents. In this study, we applied spatial independent component analysis to resting-state fMRI data of 37 stroke patients scanned within 24 hr of symptom onset, 17 of whom received follow-up scans the next day. Read More

View Article and Full-Text PDF