20,160 results match your criteria mri derived

Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH.

Mol Metab 2021 Jun 9:101270. Epub 2021 Jun 9.

Department of Integrative Biology & Physiology, University of Minnesota, Minneapolis, MN 55455, USA; Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

Objective: Non-alcoholic fatty liver disease (NAFLD) covers a wide spectrum of liver pathology ranging from simple fatty liver to non-alcoholic steatohepatitis (NASH). Notably, immune cell-driven inflammation is a key mechanism in the transition from fatty liver to the more serious NASH. Although exercise training is effective at ameliorating obesity-related diseases, the underlying mechanisms of the beneficial effects of exercise remain unclear. Read More

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Association of Age with Risk of Adverse Pathological Findings in Men Undergoing Delayed Radical Prostatectomy Following Active Surveillance.

Urology 2021 Jun 9. Epub 2021 Jun 9.

Department of Urology, UCSF - Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA, USA. Electronic address:

Objectives: To determine if older men with Gleason grade group (GG) 1 prostate cancer have a higher risk of having adverse pathology at radical prostatectomy after initially being managed with active surveillance (AS).

Methods: A total of 365 patients with GG1 prostate cancer initially managed with AS followed by delayed radical prostatectomy were identified. The primary outcome was adverse pathology after delayed radical prostatectomy in the men that were <65 years versus men ≥65 years at the initiation of AS. Read More

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Quantitative Susceptibility Mapping for Staging Acute Cerebral Hemorrhages: Comparing the Conventional and Multiecho Complex Total Field Inversion magnetic resonance imaging MR Methods.

J Magn Reson Imaging 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: The perceived acuity of intracerebral hemorrhage (ICH) impacts the management of patients, both within emergent and outpatient/urgent settings. Morphology enabled dipole inversion (MEDI) quantitative susceptibility imaging (QSM) has improved characterization of ICH acuity, despite outstanding limitations in distinguishing blood products.

Purpose/hypothesis: Using improved susceptibility quantification, novel postprocessing QSM method from multiecho complex total field inversion (mcTFI) may better discriminate between acute and subacute ICH, compared to MEDI. Read More

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Preoperative histogram parameters of dynamic contrast-enhanced MRI as a potential imaging biomarker for assessing the expression of Ki-67 in prostate cancer.

Cancer Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Purpose: To investigate whether preoperative histogram parameters of dynamic contrast-enhanced MRI (DCE-MRI) can assess the expression of Ki-67 in prostate cancer (PCa).

Materials And Methods: A consecutive series of 76 patients with pathology-proven PCa who underwent routine DCE-MRI scans were retrospectively recruited. Quantitative parameters including the volume transfer constant (K ), rate contrast (K ), extracellular-extravascular volume fraction (V ), and plasma volume (V ) by outlining the three-dimensional volume of interest (VOI) of all lesions were processed. Read More

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Is Contrast Medium Really Needed for Follow-up MRI of Untreated Intracranial Meningiomas?

AJNR Am J Neuroradiol 2021 Jun 11. Epub 2021 Jun 11.

From the Division of Neuroradiology (J.B., A.F., M.I.V.), Geneva University Hospital and Faculty of Medicine of Geneva, Geneva, Switzerland.

Background And Purpose: Recent concerns relating to tissue deposition of gadolinium are favoring the use of noncontrast MR imaging whenever possible. The purpose of this study was to assess the necessity of gadolinium contrast for follow-up MR imaging of untreated intracranial meningiomas.

Materials And Methods: One-hundred twenty-two patients (35 men, 87 women) with meningiomas who underwent brain MR imaging between May 2007 and May 2019 in our institution were included in this retrospective cohort study. Read More

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Left ventricle motion estimation for cine MR images using sparse representation with shape constraint.

Phys Med 2021 Jun 9;87:49-64. Epub 2021 Jun 9.

College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, Guangdong, China.

Purpose: To propose a left ventricle (LV) motion estimation method based on sparse representation, in order to handle the spatial-varying intensity distortions caused by tissue deformation.

Methods: For each myocardial landmark, an adaptive dictionary was generated by learning transformations from a training dataset. Then the landmark was tracked using sparse representation. Read More

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The effects of multi-echo fMRI combination and rapid T*-mapping on offline and real-time BOLD sensitivity.

Neuroimage 2021 Jun 8;238:118244. Epub 2021 Jun 8.

Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands; Department of Research and Development, Epilepsy Centre Kempenhaeghe, Heeze, the Netherlands; School for Mental Health and Neuroscience, Maastricht, the Netherlands; Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Ghent University Hospital, Ghent, Belgium; Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.

A variety of strategies are used to combine multi-echo functional magnetic resonance imaging (fMRI) data, yet recent literature lacks a systematic comparison of the available options. Here we compare six different approaches derived from multi-echo data and evaluate their influences on BOLD sensitivity for offline and in particular real-time use cases: a single-echo time series (based on Echo 2), the real-time T*-mapped time series (T*FIT) and four combined time series (T*-weighted, tSNR-weighted, TE-weighted, and a new combination scheme termed T*FIT-weighted). We compare the influences of these six multi-echo derived time series on BOLD sensitivity using a healthy participant dataset (N = 28) with four task-based fMRI runs and two resting state runs. Read More

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Arterial Spin Labeling Reveals Elevated Cerebral Blood Flow with Distinct Clusters of Hypo- and Hyperperfusion after Traumatic Brain Injury.

J Neurotrauma 2021 Jun 10. Epub 2021 Jun 10.

The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Imaging detection of brain perfusion alterations after traumatic brain injury (TBI) may provide prognostic insights. In this study, we used arterial spin labeling (ASL) to quantify cross-sectional and longitudinal changes in cerebral blood flow (CBF) after TBI and correlated changes with clinical outcome. We analyzed magnetic resonance imaging scans from adult participants with TBI requiring hospitalization in the acute (2 weeks post-injury,  = 33) and chronic (6 months post-injury,  = 16) phases, with 13 participants scanned longitudinally at both time points. Read More

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Association of serum levels of inflammatory markers and adipokines with joint symptoms and structures in participants with knee osteoarthritis.

Rheumatology (Oxford) 2021 Jun 11. Epub 2021 Jun 11.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.

Objective: To investigate the longitudinal associations of serum inflammatory markers and adipokines with joint symptoms and structures in participants with knee osteoarthritis (OA).

Methods: Two hundred participants (46.5% female, mean age 63. Read More

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Diagnostic accuracy of apparent diffusion coefficient (ADC) value in differentiating malignant from benign solid liver lesions: a systematic review and meta-analysis.

Br J Radiol 2021 Jun 11:20210059. Epub 2021 Jun 11.

Department of Radiology, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Objectives: We undertook a systematic review and meta-analysis of the diagnostic performance of mean apparent diffusion coefficient (ADC) values derived by diffusion-weighted (DW)-MRI in the characterization of solid benign and malignant liver lesions, and to assess their value in discriminating these lesions in daily routine practice.

Methods: A systematic review of PubMed, Embase, Scopus, and Web of Science was conducted to retrieve studies that used ADC values for differentiating solid benign/dysplastic nodules and malignant liver lesions. A bivariate random-effects model with pooled sensitivity and specificity values with 95% CI (confidence interval) was used. Read More

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Quantitative T2*-Weighted Imaging and Reduced Field-of-View Diffusion-Weighted Imaging of Rectal Cancer: Correlation of R2* and Apparent Diffusion Coefficient With Histopathological Prognostic Factors.

Front Oncol 2021 24;11:670156. Epub 2021 May 24.

Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, United States.

Purpose: To assess T2*-weighted imaging (T2*WI) and reduced field-of-view diffusion-weighted Imaging (rDWI) derived parameters and their relationships with histopathological factors in patients with rectal cancer.

Methods: Fifty-four patients with pathologically-proven rectal cancer underwent preoperative T2*-weighted imaging and rDWI in this retrospective study. R2* values from T2*-weighted imaging and apparent diffusion coefficient (ADC) values from rDWI were compared in terms of different histopathological prognostic factors using student's t-test or Mann-Whitney U-test. Read More

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Toward PET/MRI as one-stop shop for radiotherapy planning in cervical cancer patients.

Acta Oncol 2021 Jun 9:1-9. Epub 2021 Jun 9.

Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Radiotherapy (RT) planning for cervical cancer patients entails the acquisition of both Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Further, molecular imaging by Positron Emission Tomography (PET) could contribute to target volume delineation as well as treatment response monitoring. The objective of this study was to investigate the feasibility of a PET/MRI-only RT planning workflow of patients with cervical cancer. Read More

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Phase Saturation Control on Mixing-Driven Reactions in 3D Porous Media.

Environ Sci Technol 2021 Jun 9. Epub 2021 Jun 9.

Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600 Dübendorf, Switzerland.

Transported chemical reactions in unsaturated porous media are relevant to environmental and industrial applications. Continuum scale models are based on equivalent parameters derived from analogy with saturated conditions and cannot appropriately account for incomplete mixing. It is also unclear how the third dimension controls mixing and reactions. Read More

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Adult Age Differences in Self-Reported Pain and Anterior CSF Space in Chiari Malformation.

Cerebellum 2021 Jun 9. Epub 2021 Jun 9.

Department of Psychology, The University of Akron, Akron, OH, 44325-4301, USA.

Chiari malformation type I (CMI) is a neural disorder with sensory, cognitive, and motor defects, as well as headaches. Radiologically, the cerebellar tonsils extend below the foramen magnum. To date, the relationships among adult age, brain morphometry, surgical status, and symptom severity in CMI are unknown. Read More

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Magnetoencephalography reveals increased slow-to-fast alpha power ratios in patients with chronic pain.

Pain Rep 2021 Jul-Aug;6(2):e928. Epub 2021 Jun 3.

Center for Pain Medicine, Department of Anesthesiology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Introduction: Objective disease markers are a key for diagnosis and personalized interventions. In chronic pain, such markers are still not available, and therapy relies on individual patients' reports. However, several pain studies have reported group-based differences in functional magnetic resonance imaging, electroencephalography, and magnetoencephalography (MEG). Read More

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Soluble CD163 Identifies Those at Risk for Increased Hepatic Inflammation & Fibrosis.

Open Forum Infect Dis 2021 Jun 22;8(6):ofab203. Epub 2021 Apr 22.

Florida International University, Miami, Florida, USA.

Background: Liver disease remains a significant cause of morbidity and mortality in HIV-infected persons. Soluble CD163 is a marker of Kupffer cell activation that is highly associated with development of hepatic fibrosis. The relative contributions of HIV-associated systemic immune activation vs other etiologies of injury are poorly characterized. Read More

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MRI Evaluation of Complete Response of Locally Advanced Rectal Cancer After Neoadjuvant Therapy: Current Status and Future Trends.

Cancer Manag Res 2021 1;13:4317-4328. Epub 2021 Jun 1.

Department of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People's Republic of China.

Complete tumor response can be achieved in a certain proportion of patients with locally advanced rectal cancer, who achieve maximal response to neoadjuvant therapy (NAT). For these patients, a watch-and-wait (WW) or nonsurgical strategy has been proposed and is becoming widely practiced in order to avoid unnecessary surgical complications. Therefore, a non-invasive, reliable diagnostic tool for accurately evaluating complete tumor response is needed. Read More

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BOLD Lag Patterns Differ Between Rest And Task Conditions, But Are Largely Typical in Autism.

Brain Connect 2021 Jun 9. Epub 2021 Jun 9.

San Diego State University, 7117, Brain Development Imaging Laboratories, San Diego, California, United States;

Autism spectrum disorder (ASD) is characterized by atypical functional connectivity (FC) within and between distributed brain networks. However, FC findings have often been inconsistent, possibly due to focus on static FC rather than brain dynamics. Lagged connectivity analyses aim to evaluate temporal latency, and presumably neural propagation, between regions. Read More

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Diagnosis and staging of hepatobiliary malignancies: Potential incremental value of (18)F-FDG-PET/MRI compared to MRI of the liver.

Nuklearmedizin 2021 Jun 8. Epub 2021 Jun 8.

Radiology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, United States.

Objective:  The purpose of the study was to investigate the potential added value of F-FDG-PET/MRI (functional information derived from PET) over standard diagnostic liver MRI (excellent soft tissue characterization) in diagnosing and staging suspected primary hepatobiliary malignancies including extrahepatic cholangiocarcinoma (ECC), intrahepatic cholangiocellular carcinoma (ICC) and gallbladder cancer (GBCA).

Methods:  Twenty consecutive patients with suspected hepatobiliary malignancy were included in this retrospective study. All patients underwent combined whole-body (WB) F-FDG-PET/MRI including contrast-enhanced MRI of the liver, contrast-enhanced WB-MRI and WB F-FDG-PET. Read More

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Three-Dimensional Magnetic Resonance Fingerprinting in Neonates: Quantifying Regional Difference and Maturation in the Brain.

Invest Radiol 2021 Jun 8. Epub 2021 Jun 8.

From the Departments of Pediatrics Radiology, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea Siemens Healthineers Ltd Department of Electrical and Electronic Engineering, College of Engineering, Yonsei University, Seoul, Republic of Korea.

Objectives: Magnetic resonance fingerprinting (MRF) allows the simultaneous measurement of multiple tissue properties in a single acquisition. Three-dimensional (3D) MRF with high spatial resolution can be used for neonatal brain imaging. The aim of this study is to apply 3D MRF to neonates and show regional differences and maturation in the brain. Read More

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Multiple Functional Brain Networks Related to Pain Perception Revealed by fMRI.

Neuroinformatics 2021 Jun 8. Epub 2021 Jun 8.

ICORD, Blusson Spinal Cord Centre, 818 West 10th Ave, Vancouver, BC, V5Z 1M9, Canada.

The rise of functional magnetic resonance imaging (fMRI) has led to a deeper understanding of cortical processing of pain. Central to these advances has been the identification and analysis of "functional networks", often derived from groups of pre-selected pain regions. In this study our main objective was to identify functional brain networks related to pain perception by examining whole-brain activation, avoiding the need for a priori selection of regions. Read More

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Feasibility and validation of trans-valvular flow derived by four-dimensional flow cardiovascular magnetic resonance imaging in patients with atrial fibrillation.

Wellcome Open Res 2021 18;6:73. Epub 2021 May 18.

Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.

: Four-dimensional (4D) flow cardiovascular magnetic resonance imaging (MRI) is an emerging technique used for intra-cardiac blood flow assessment. The role of 4D flow cardiovascular MRI in the assessment of trans-valvular flow in patients with atrial fibrillation (AF) has not previously been assessed. The purpose of this study was to assess the feasibility, image quality, and internal validity of 4D flow cardiovascular MRI in the quantification of trans-valvular flow in patients with AF. Read More

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Feasibility of deuterium magnetic resonance spectroscopy of 3-O-Methylglucose at 7 Tesla.

PLoS One 2021 7;16(6):e0252935. Epub 2021 Jun 7.

Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Deuterium Magnetic Resonance Spectroscopy (DMRS) is a non-invasive technique that allows the detection of deuterated compounds in vivo. DMRS has a large potential to analyze uptake, perfusion, washout or metabolism, since deuterium is a stable isotope and therefore does not decay during biologic processing of a deuterium labelled substance. Moreover, DMRS allows the distinction between different deuterated substances. Read More

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Inter-Cohort Validation of SuStaIn Model for Alzheimer's Disease.

Front Big Data 2021 20;4:661110. Epub 2021 May 20.

Laboratory of Neuroinformatics, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Alzheimer's disease (AD) is a neurodegenerative disorder which spans several years from preclinical manifestations to dementia. In recent years, interest in the application of machine learning (ML) algorithms to personalized medicine has grown considerably, and a major challenge that such models face is the transferability from the research settings to clinical practice. The objective of this work was to demonstrate the transferability of the Subtype and Stage Inference (SuStaIn) model from well-characterized research data set, employed as training set, to independent less-structured and heterogeneous test sets representative of the clinical setting. Read More

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KIT Mutation in Gastric Gastrointestinal Stromal Tumor in a Patient With Familial Paraganglioma Syndrome Type 4.

AACE Clin Case Rep 2021 May-Jun;7(3):174-176. Epub 2021 Jan 7.

Department of Medicine, Queen's University, Kingston, Ontario, Canada.

Objective: Familial paraganglioma syndrome type 4 is associated with mutations in the succinate dehydrogenase complex subunit B (SDHB) gene. We report the case of a patient with familial paraganglioma syndrome type 4 with the mutation c.600G>T; p. Read More

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January 2021

Assessment of Hypoxic Tissue Fraction and Prediction of Survival in Cervical Carcinoma by Dynamic Contrast-Enhanced MRI.

Front Oncol 2021 20;11:668916. Epub 2021 May 20.

Group of Radiation Biology and Tumor Physiology, Department of Radiation Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

Tumor hypoxia is a major cause of treatment resistance and poor survival in locally-advanced cervical carcinoma (LACC). It has been suggested that and maps derived by dynamic contrast-enhanced magnetic resonance imaging can provide information on the oxygen supply and oxygen consumption of tumors, but it is not clear whether and how these maps can be combined to identify tumor hypoxia. The aim of the current study was to find the optimal strategy for calculating hypoxic fraction and predicting survival from and maps in cervical carcinoma. Read More

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Head and neck paragangliomas: Ten years of experience in a third health center. A cohort study.

Ann Med Surg (Lond) 2021 Jun 20;66:102412. Epub 2021 May 20.

Otorhinolaryngology and Head and Neck Surgery Department, 20 August 1953 Hospital, Casablanca, Morocco.

Head and neck paragangliomas are rare vascular tumors derived from the paraganglionic system, located at the carotid body, jugular vein, tympanic cavity and vagal nerve. From 2010 to 2020, a cohort of 26 patients divided in two groups, 15 with cervical paragangliomas and 11 with temporal bone paragangliomas, was reviewed by analysing the medical history, the epidemiological and clinical parameters, the imaging results and classification, the modality of treatment and outcome. Cervical paragangliomas present as firm and pulsatile mass with the characteristic aspect of "salt and pepper" on MRI T1 weighted sequences. Read More

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Single-centre evaluation and staging of rectal carcinoma on a 3-Tesla magnetic resonance imaging and correlation with histological profile.

Pol J Radiol 2021 20;86:e217-e224. Epub 2021 Apr 20.

Department of Medical Oncology, Kazakh Institute of Oncology and Radiology, Kazakhstan.

Purpose: To assess magnetic resonance imaging (MRI) features of rectal carcinoma in correlation with pathology, and to evaluate the diagnostic accuracy of 3-Tesla MRI.

Material And Methods: A total of 86 patients were included. 3T MR imaging was conducted pre-operatively, with imaging data correlated to pathology results. Read More

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Polygenic Risk Scores for Alcohol Involvement Relate to Brain Structure in Substance-Naïve Children: Results from the ABCD Study.

Genes Brain Behav 2021 Jun 6:e12756. Epub 2021 Jun 6.

Department of Psychology & Brain Sciences, Washington University St. Louis, Pittsburgh, PA.

Background And Aims: Brain imaging-derived structural correlates of alcohol involvement have largely been speculated to arise as a consequence of alcohol exposure. However, they may also reflect predispositional risk.

Methods: In substance naïve children of European ancestry who completed the baseline session of the Adolescent Brain Cognitive Development (ABCD) Study (n=3,013), mixed-effects models estimated whether polygenic risk scores (PRS) for Problematic Alcohol Use (PAU-PRS) and Drinks Per Week (DPW-PRS) are associated with magnetic resonance imaging-derived brain structure phenotypes (i. Read More

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