13,948 results match your criteria mps

Disease burden, management patterns and multidisciplinary clinical approaches for patients with MPS IVA and VI in selected Latin American Countries.

Mol Genet Metab Rep 2021 Sep 25;28:100769. Epub 2021 May 25.

Hospital Dr. Verdi Cevallos Balda, Portoviejo, Ecuador.

Background: There is a paucity of real-world epidemiological data on patients with mucopolysaccharidoses (MPS) in Latin America. This real-world study assessed the disease burden, management patterns and multidisciplinary clinical approaches for MPS-IVA and MPS-VI patients in Latin America (Colombia, Ecuador, Mexico, Peru).

Methods: Data were collected from physicians/specialists experienced in treating MPS patients between April-June 2020, via an online patient-diary survey. Read More

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September 2021

Physicochemical properties, digestibility and anti-osteoporosis effect of yak bone powder with different particle sizes.

Food Res Int 2021 Jul 11;145:110401. Epub 2021 May 11.

Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:

As a kind of promising resource, animal bone has been widely processed into functional foods. However, there is little research about the effect of particle size on the physicochemical properties and digestibility of yak bone powder (YBP), as well as its anti-osteoporosis activity. In this study, the YBP with median particle sizes (MPS) ranging from 19. Read More

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Microplastics as an emerging source of particulate air pollution: A critical review.

J Hazard Mater 2021 May 28;418:126245. Epub 2021 May 28.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Uttar Pradesh, India; CSIR-National Institute of Oceanography, Dona Paula 403004, Goa, India. Electronic address:

Accumulation of plastic litter exerts pressure on the environment. Microplastics (MPs) pollution has become a universal challenge due to the overexploitation of plastic products and unsystematic dumping of plastic waste. Initial studies on MPs and their implications had been confined to aquatic and terrestrial ecosystems, but recent research has also focused on MPs in the air. Read More

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Occurrence and characterization of microplastics in white shrimp, Metapenaeus affinis, living in a habitat highly affected by anthropogenic pressures, northwest Persian Gulf.

Mar Pollut Bull 2021 Jun 7;169:112581. Epub 2021 Jun 7.

Shrimp Research Center, Iranian Fisheries Sciences Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Bushehr 75169-89177, Iran. Electronic address:

Microplastics (MPs) are a modern societal concern and recognized as a growing environmental hazard by careless disposal. This study aimed to assess the MPs content in white shrimp (Metapenaeus affinis) inhabiting in a natural habitat affected by high anthropogenic pressures, and recognize if the shrimp could be a suitable bioindicator for MPs pollution. To assess spatial changes of MPs presence in shrimps, sampling was carried out by a trawl net from 13 stations across the entire Musa Bay. Read More

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Extraction and identification methods of microplastics and nanoplastics in agricultural soil: A review.

J Environ Manage 2021 Jun 7;294:112997. Epub 2021 Jun 7.

The UWA Institute of Agriculture and School of Agriculture & Environment, The University of Western Australia, Perth, WA, 6001, Australia.

As the abundance of microplastics and nanoplastics (MPs/NPs) increases in the environment, their presence in agricultural soil has become of interest. MPs/NPs can affect soil physical and chemical properties and be absorbed by plants and soil animals, causing physical and chemical damage. Soil MPs exceeding a certain concentration cause significant harm. Read More

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Intake of microplastics by commercial fish: A Bayesian approach.

Environ Monit Assess 2021 Jun 10;193(7):402. Epub 2021 Jun 10.

Universidade Federal do Sul da Bahia, Centro de Formação em Ciências Agroflorestais, Itabuna, Bahia, Brazil.

The disordered growth of large cities around water bodies causes environmental damage due to discarded plastics and microplastics (MPs) that aquatic organisms can ingest. This study analyzed the occurrence, type, and abundance of MPs in the gastrointestinal contents of four species of commercial fish (120 total specimens), namely, Brazilian mojarra (Eugerres brasilianus) and mullets (Mugil curema, Mugil curvidens, and Mugil liza), obtained in Porto Seguro in Bahia, Brazil, between March and May 2019. A priori probability distributions were generated using a Bayesian approach and simulations to assess MP intake based on varying exposure amounts (θ = 0. Read More

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Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders.

Nat Commun 2021 06 9;12(1):3495. Epub 2021 Jun 9.

Telethon Institute of Genetics and Medicine, Pozzuoli, Naples, Italy.

Lysosomal storage disorders characterized by altered metabolism of heparan sulfate, including Mucopolysaccharidosis (MPS) III and MPS-II, exhibit lysosomal dysfunctions leading to neurodegeneration and dementia in children. In lysosomal storage disorders, dementia is preceded by severe and therapy-resistant autistic-like symptoms of unknown cause. Using mouse and cellular models of MPS-IIIA, we discovered that autistic-like behaviours are due to increased proliferation of mesencephalic dopamine neurons originating during embryogenesis, which is not due to lysosomal dysfunction, but to altered HS function. Read More

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Iminosugar-C-glycosides work as pharmacological chaperones of NAGLU, a glycosidase involved in MPS IIIB rare disease.

Chemistry 2021 Jun 9. Epub 2021 Jun 9.

Toyama Medical and Pharmaceutical University: Toyama Daigaku, hospital pharmacy, JAPAN.

Mucopolysaccharidosis type IIIB is a devastating neurological disease caused by a lack of the lysosomal enzyme,  α -N-acetylglucosaminidase (NAGLU), leading to a toxic accumulation of heparan sulfate. Herein we explored a pharmacological chaperone approach to enhance the residual activity of NAGLU in patient fibroblasts. Capitalizing on the three-dimensional structures of two modest homoiminosugar-based NAGLU inhibitors in complex with bacterial homolog of NAGLU, CpGH89, we have synthesized a library of 17 six-membered iminosugar- C -glycosides mimicking  N -acetyl-D-glucosamine and bearing various pseudo-anomeric substituents of both  α - and  β -configuration. Read More

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Improving health through multisectoral collaboration: enablers and barriers.

Can J Public Health 2021 Jun 8. Epub 2021 Jun 8.

Department of Community Health and Epidemiology, College of Medicine, University of Saskatchewan, 107 Wiggins Rd, Saskatoon, SK, S7N 5E5, Canada.

Objective: Multisectoral partnerships (MPs) are increasingly viewed as an excellent strategy for promoting population health, although the Canadian evidence on MPs remains scant. The objective of this research was to identify enablers and barriers to multisectoral collaboration across three MPs (focused on food systems, urban development, and active transportation) in a Canadian urban centre.

Methods: This study is part of a pan-Canadian research program-MUSE (Multisectoral Urban Systems for health and Equity in Canadian cities). Read More

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Consumption of High-Leucine-Containing Protein Bar Following Breakfast Impacts Aminoacidemia and Subjective Appetite in Older Persons.

Curr Dev Nutr 2021 Jun 8;5(6):nzab080. Epub 2021 May 8.

Exercise Metabolism Research Group, Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.

Background: Limited data are available examining dietary interventions for optimizing protein and leucine intake to stimulate muscle protein synthesis (MPS) in older humans.

Objectives: We aimed to investigate the aminoacidemia and appetite responses of older adults after consuming breakfast, a meal frequently consumed with high-carbohydrate and below-par amounts of protein and leucine for stimulating MPS.

Methods: Five men and 3 women (means ± SD; age: 74 ± 7 y, BMI: 25. Read More

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Experiment and simulation of single inhibitor SH110 for void-free TSV copper filling.

Sci Rep 2021 Jun 8;11(1):12108. Epub 2021 Jun 8.

School of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, HN Province, People's Republic of China.

Three-dimensional integration with through-silicon vias (TSVs) is a promising microelectronic interconnection technology. Three-component additives are commonly used for void-free TSV filling. However, optimising the additive concentrations is an expensive process. Read More

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Spatial distribution of microplastics in sandy beach and inshore-offshore sediments of the southern Caspian Sea.

Mar Pollut Bull 2021 Jun 5;169:112578. Epub 2021 Jun 5.

Iranian National Institute for Oceanography and Atmospheric Science, Tehran 1411813389, Iran.

The occurrence of microplastics (MPs) in nearshore zones of the southern Caspian coasts is well documented; however, no data are available on MP occurrence in offshore sediments. In this study, six sandy beach stations and 18 inshore-offshore stations (six transects) were surveyed. MPs were detected in all sediment samples. Read More

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Characterization and Functional Analysis of Tumor-Derived Microparticles.

Curr Protoc 2021 Jun;1(6):e144

Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.

Microparticles (MPs) are heterogeneous populations of cell-derived vesicles that play an important role in intercellular communications. The release of MPs by tumor cells is a very common event in tumor microenvironments (TMEs). Tumor cell-derived MPs (T-MPs) contain a variety of bioactive molecules, thus modulating various biological processes, including the regulation of immune cell phenotype and function, as well as immune responses. Read More

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Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals.

Drug Deliv Transl Res 2021 Jun 8. Epub 2021 Jun 8.

Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Center for Infection Research (HZI), Campus E8.1, 66123, Saarbrucken, Germany.

Pulmonary delivery of nanocarriers for novel antimycobacterial compounds is challenging because the aerodynamic properties of nanomaterials are sub-optimal for such purposes. Here, we report the development of dry powder formulations for nanocarriers containing benzothiazinone 043 (BTZ) or levofloxacin (LVX), respectively. The intricacy is to generate dry powder aerosols with adequate aerodynamic properties while maintaining both nanostructural integrity and compound activity until reaching the deeper lung compartments. Read More

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The occurrence and dietary intake related to the presence of microplastics in drinking water in Saudi Arabia.

Environ Monit Assess 2021 Jun 7;193(7):390. Epub 2021 Jun 7.

The Executive Department of Monitoring and Risk Assessment, Saudi Food and Drug Authority, Riyadh, Saudi Arabia.

The implications and health effects of microplastics (MPs) ingestion are still unclear, yet researchers and organizations around the world are increasingly examining the levels of microplastics and nanoplastics in the environment. This study investigated the presence and the quantity of microplastics in bottled and tap water from five regions in Saudi Arabia and estimated the dietary intake of microplastics. Thirty samples of drinking water were collected from the retail markets in Saudi Arabia. Read More

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How to get the optimal defibrillation lead parameters using myocardial perfusion scintigraphy in patients with coronary artery disease.

Int J Cardiovasc Imaging 2021 Jun 7. Epub 2021 Jun 7.

Department of Surgical Arrhythmology and Cardiac Pacing, Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Kievskaya st., 111a, Tomsk, Russian Federation, 634012.

The conventional criteria for a defibrillation lead (DL) implantation don't take into account presence of scar or deep ischemia in the myocardium. This may impair a proper functioning of the DL. We sought to optimize the DL implantation placement using rest myocardial perfusion scintigraphy (MPS), which allow detecting areas of myocardial hypoperfusion (MH). Read More

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Understanding the fragmentation of microplastics into nano-plastics and removal of nano/microplastics from wastewater using membrane, air flotation and nano-ferrofluid processes.

Chemosphere 2021 May 31;282:131053. Epub 2021 May 31.

School of Engineering, RMIT University, Melbourne, VIC, 3000, Australia.

Nano/microplastics (NPs/MPs), a tiny particle of plastic pollution, are known as one of the most important environmental threats to marine ecosystems. Wastewater treatment plants can act as entrance routes for NPs/MPs to the aquatic environment as they breakdown of larger fragments of the plastic component during the treatment process; therefore, it is necessary to remove NPs/MPs during the wastewater treatment process. In this study, understanding the effect of water shear force on the fragmentation of larger size MPs into smaller MPs and NPs and their removal by air flotation and nano-ferrofluid (i. Read More

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Enzyme Mimic Facilitated Artificial Cell to Mammalian Cell Signal Transfer.

Angew Chem Int Ed Engl 2021 Jun 7. Epub 2021 Jun 7.

iNano, Aarhus University, Gustav Wieds Vej 14, 8000, 8000, Aarhus, DENMARK.

Catalyzing biochemical reactions with enzymes and communicating with neighboring cells via chemical signaling are two fundamental cellular features that play a critical role in maintaining the homeostasis of organisms. Herein, we present an artificial enzyme (AE) facilitated signal transfer between artificial cells (ACs) and mammalian HepG2 cells. We synthesize metalloporphyrins (MPs) based AEs that mimic cytochrome P450 enzymes (CYPs) to catalyze a dealkylation and a hydroxylation reaction, exemplified by the conversion of resorufin ethyl ether (REE) to resorufin and coumarin (COU) to 7-hydroxycoumarin (7-HC), respectively. Read More

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Hip surgery and radiology reporting for children with cerebral palsy prior to initiation of a hip surveillance program.

J Pediatr Rehabil Med 2021 Jun 5. Epub 2021 Jun 5.

Saskatchewan Health Authority, Regina, SK, Canada.

Purpose: Hip displacement impacts quality of life for many children with cerebral palsy (CP). While early detection can help avoid dislocation and late-stage surgery, formalized surveillance programs are not ubiquitous. This study aimed to examine: 1) surgical practices around pediatric hip displacement for children with CP in a region without formalized hip surveillance; and 2) utility of MP compared to traditional radiology reporting for quantifying displacement. Read More

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Activated carbon coupled with advanced biological wastewater treatment: A review of the enhancement in micropollutant removal.

Sci Total Environ 2021 May 27;790:148050. Epub 2021 May 27.

Department of Engineering, University of Ferrara, Via Saragat 1, 44122 Ferrara, Italy. Electronic address:

This study consists of a review on the removal efficiencies of a wide spectrum of micropollutants (MPs) in biological treatment (mainly membrane bioreactor) coupled with activated carbon (AC) (AC added in the bioreactor or followed by an AC unit, acting as a post treatment). It focuses on how the presence of AC may promote the removal of MPs and the effects of dissolved organic matter (DOM) in wastewater. Removal data collected of MPs are analysed versus AC dose if powdered AC is added in the bioreactor, and as a function of the empty bed contact time in the case of a granular activated carbon (GAC) column acting as a post treatment. Read More

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Ultrasound findings of finger, wrist and knee joints in Mucopolysaccharidosis Type I.

Mol Genet Metab 2021 Jun 1. Epub 2021 Jun 1.

Ospedale Provinciale Madonna del Soccorso, Department of Internal Medicine, San Benedetto del Tronto, Marche, Italy.

Introduction: Musculoskeletal findings in MPS can progress after enzyme replacement. Our aim was to examine synovial recesses, tendons, retinacula and pulleys using ultrasonography for structural and inflammatory changes.

Material And Methods: The wrist, metacarpophalangeal (MCP), proximal and distal interphalangeal (PIP and DIP) joints, the finger flexor tendons and the knee including entheses of quadriceps and patella tendons were assessed clinically. Read More

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Analysis of spleen histopathology, splenocyte composition and haematological parameters in four strains of mice infected with Plasmodium berghei K173.

Malar J 2021 Jun 6;20(1):249. Epub 2021 Jun 6.

Tang Center for Herbal Medicine Research, Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medical Sciences, No. 16 Dongzhimen Nanxiaojie, Dongcheng District, Beijing, 100700, China.

Background: Malaria is a fatal disease that presents clinically as a continuum of symptoms and severity, which are determined by complex host-parasite interactions. Clearance of infection is believed to be accomplished by the spleen and mononuclear phagocytic system (MPS), independent of artemisinin treatment. The spleen filters infected red blood cells (RBCs) from circulation through immune-mediated recognition of the infected RBCs followed by phagocytosis. Read More

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The effects of continentality, marine nature and the recirculation of air masses on pollen concentration: Olea in a Mediterranean coastal enclave.

Sci Total Environ 2021 May 24;790:147999. Epub 2021 May 24.

Department of Chemical and Environmental Engineering, Technical University of Cartagena, Cartagena, Spain. Electronic address:

Olea pollen concentrations have been studied in relation to the typology of air masses, pollen grain sources and marine nature during advections in a coastal enclave in the south-eastern Iberian Peninsula. Since Spain is the world's leading olive producer, and olive growing extends throughout the Mediterranean basin, this location is ideal for the study of long-distance transport events (LTD) during the main pollen season (MPS). The air masses were classified using the calculation of 48-h back trajectories at 250, 500 and 750 m above ground level using the HYSPLIT model. Read More

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Photolysis of polycyclic aromatic hydrocarbons adsorbed on polyethylene microplastics.

Mar Pollut Bull 2021 Jun 2;169:112561. Epub 2021 Jun 2.

Research Institute of Environment, Agriculture and Fisheries, Osaka Prefecture, Habikino, Osaka 583-0862, Japan.

Contaminants adsorbed on microplastics (MPs) are a potential risk to aquatic environments. Several studies have demonstrated that polycyclic aromatic hydrocarbons (PAHs), which adsorb on MPs, can be photolyzed in aqueous solutions. We investigated photolysis of PAHs on MPs under sunlight conditions to estimate their environmental fate for the first time. Read More

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Microplastic pollution in aquatic environments with special emphasis on riverine systems: Current understanding and way forward.

J Environ Manage 2021 Jun 2;293:112860. Epub 2021 Jun 2.

University School of Environment Management, Guru Gobind Singh Indraprastha University, Sector-16C, Dwarka, New Delhi, 110078, India. Electronic address:

Microplastics (MPs) are emerging as a severe threat in our environment. Their diverse existence in marine environments is being researched globally and thus a widely known fact; however, their presence in the freshwater counterpart has gained attention lately only. Riverine systems, the most critical freshwater resources serve as an essential link between terrestrial and marine environments and their contamination with MPs is going to create severe environmental issues. Read More

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The ESCRT-III complex contributes to macromitophagy in yeast.

Traffic 2021 Jun 5. Epub 2021 Jun 5.

College of Life Sciences, Key Laboratory of Agricultural Environmental Microbiology of Ministry of Agriculture and Rural Affairs, Nanjing Agricultural University, Nanjing, China.

Mitochondria play important roles in energy generation and homeostasis maintenance in eukaryotic cells. The damaged or superfluous mitochondria can be nonselectively or selectively removed through the autophagy/lysosome pathway, which was referred as mitophagy. According to the molecular machinery for degrading mitochondria, the selectively removed mitochondria can occur through macromitophagy or micromitophagy. Read More

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Evidence-based meta-analysis of the genotoxicity induced by microplastics in aquatic organisms at environmentally relevant concentrations.

Sci Total Environ 2021 Aug 14;783:147076. Epub 2021 Apr 14.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai 264003, PR China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, PR China; Center for Ocean Mega-Science, Chinese Academy of Sciences (CAS), Qingdao 266071, PR China. Electronic address:

Microplastics (MPs) attract global concern due to their ubiquitous existence in aquatic environments. However, the genotoxic effect of MPs on aquatic organisms in the natural environment remains controversial. Therefore, this meta-analysis was conducted by recompiling 44 individual studies from 12 publications to determine whether MPs could induce genotoxicity in aquatic organisms at environmentally relevant concentrations (≤1 mg/L, median = 0. Read More

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Suborganismal responses of the aquatic midge Chironomus riparius to polyethylene microplastics.

Sci Total Environ 2021 Aug 9;783:146981. Epub 2021 Apr 9.

Environmental Toxicology and Biology Group, Mathematical and Fluid Physics, Department, Sciences Faculty, UNED, Madrid, Spain.

Freshwater riverbeds are a major repository of microplastics (MPs) from inland activities. Benthic macroinvertebrates that live in close contact with sediments seem to ingest a considerable amount of such plastic particles. The effects of MPs on life-history traits are relatively well-known, but the suborganismal mechanisms underlying such effects remain unclear. Read More

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Insight into the immune and microbial response of the white-leg shrimp Litopenaeus vannamei to microplastics.

Mar Environ Res 2021 May 30;169:105377. Epub 2021 May 30.

Joint Laboratory of Guangdong Province and Hong Kong Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, 510642, China. Electronic address:

Microplastics (MPs) are a new type of environmental pollutant. To investigate the response of shrimp and their microflora to MPs, Litopenaeus vannamei (L. vannamei) was exposed to different concentrations of MPs (0, 50, 500, and 5000 μg/L, i. Read More

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