Front Neural Circuits 2020 26;14:528993. Epub 2020 Oct 26.
Department of Neurosciences and Movement Sciences, Faculty of Science and Medicine, Section of Medicine, Fribourg Cognition Center, Platform of Translational Neurosciences (PTN), Swiss Primate Competence Center for Research (SPCCR), University of Fribourg, Fribourg, Switzerland.
Besides the main cortical inputs to the basal ganglia, the corticostriatal projection, there is another input the corticosubthalamic projection (CSTP), terminating in the subthalamic nucleus (STN). The present study investigated and compared the CSTPs originating from the premotor cortex (PM) or the primary motor cortex (M1) in two groups of adult macaque monkeys. The first group includes six intact monkeys, whereas the second group was made up of four monkeys subjected to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication producing Parkinson's disease (PD)-like symptoms and subsequently treated with an autologous neural cell ecosystem (ANCE) therapy. Read More