679 results match your criteria motivated retrospective

Liver Transplantation for intrahepatic cholangiocarcinoma: ready for prime time?

Hepatology 2021 Dec 3. Epub 2021 Dec 3.

Divison of Transplant Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Cholangiocarcinoma (CCA) represents the second most common primary liver malignancy after hepatocellular carcinoma and has risen in incidence globally in the past decades. Intrahepatic cholangiocarcinoma (iCCA) comprises 20% of all CCAs, with the rest being extrahepatic (including perihilar [pCCA] and distal CCA). Though long representing an absolute contraindication for liver transplantation (LT), recent analyses of outcomes of LT for iCCA have suggested that iCCA may be a potentially feasible option for highly selected patients. Read More

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December 2021

Evidence of Arctic Fox Survival following Exposure to Rabies Virus.

J Wildl Dis 2021 Nov 23. Epub 2021 Nov 23.

US Department of Agriculture, National Wildlife Research Center, 4101 Laporte Avenue, Fort Collins, Colorado 80521, USA.

The arctic fox variant of the rabies virus (RABV) is enzootic in the circumpolar north. Reports of abortive RABV exposures motivated a retrospective analysis of sera from 41 arctic foxes captured at Karrak Lake in Nunavut, Canada, during 2011-2015. Estimated RABV antibody prevalence among foxes was 14% (95% confidence interval, 7-28%). Read More

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November 2021

A student-centered seminar course as a complementary approach to a traditional journal club.

Adv Physiol Educ 2021 Nov 18. Epub 2021 Nov 18.

Department of Physiology & Biophysics , UC Irvine, Irvine, CA, United States.

Graduate physiology programs strive to provide students with in-depth expertise in a particular academic discipline, often facilitating this process in the form of a departmental seminar course. Within the Department of Physiology and Biophysics at the University of California Irvine (UCI), students are required to attend a seminar course, most often designed as a journal club, each quarter until they are ready to graduate. While this format may work well in departments where research topics are closely related, it has historically been less successful in UCI's Department of Physiology and Biophysics, where wide-ranging interests make for little overlap in foundational knowledge, limiting meaningful engagement with the material or with peers in the class. Read More

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November 2021

Impact of Conformational Substates and Energy Landscapes on Understanding Hemoglobin Kinetics and Function.

William A Eaton

J Biol Phys 2021 Dec 11;47(4):337-353. Epub 2021 Nov 11.

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 5/104, Bethesda, MD, 20892-0520, United States.

Hans Frauenfelder's discovery of conformational substates in studies of myoglobin carbon monoxide geminate rebinding kinetics at cryogenic temperatures (Austin RH, Beeson KW, Eisenstein L, Frauenfelder H, & Gunsalus IC (1975) Dynamics of Ligand Binding to Myoglobin. Biochemistry 14(24):5355-5373) followed by his introduction of energy landscape theory with Peter Wolynes (Frauenfelder H, Sligar SG, & Wolynes PG (1991) The Energy Landscapes and Motions of Proteins. Science 254(5038):1598-1603) marked the beginning of a new era in the physics and physical chemistry of proteins. Read More

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December 2021

Characteristics of participants and decliners from a randomized controlled trial on physical activity in patients with rheumatoid arthritis: a retrospective register-based cross-sectional study.

Scand J Rheumatol 2021 Nov 2:1-8. Epub 2021 Nov 2.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

Objective: A randomized controlled trial [Joint Resources - Sedentary Behaviour (JR-SB) intervention] aimed to reduce sedentary behaviour and increase light-intensity physical activity in patients with rheumatoid arthritis (RA) through motivational counselling and text messages. Since a large proportion of invited patients declined to participate, this study aims to compare sociodemographic, clinical, and lifestyle factors between included patients and patients declining to participate (non-participants) in the JR-SB study and to investigate which characteristics were associated with participation.

Method: A register-based cross-sectional study was conducted. Read More

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November 2021

Management of bone defects using the Masquelet technique of induced membrane.

Rozhl Chir 2021 ;100(8):390-397

Introduction: Extensive bone defects are mostly caused by trauma, bone infection or bone tumours. The treatment is one of the most challenging issues of musculoskeletal surgery. Nowadays we have several techniques to deal with this problem. Read More

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October 2021

Electromagnetic muscle stimulation: A retrospective study of patient experience.

J Cosmet Dermatol 2021 Sep 24. Epub 2021 Sep 24.

Allergan Aesthetics, An AbbVie Company, Pleasanton, CA, USA.

Background: Electromagnetic muscle stimulation (EMMS) is a non-invasive body contouring technology for strengthening, firming, and toning the abdomen, buttocks, and thighs that is associated with high patient satisfaction.

Aims: To gain a greater understanding of factors contributing to patient satisfaction with EMMS.

Methods: This was a retrospective, non-comparative study of patient information and questionnaires regarding EMMS treatments to abdomen and/or buttocks collected July 1 to December 1, 2019 from clinical practices in the United States. Read More

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September 2021

Covid-19 vaccination during the third trimester of pregnancy: rate of vaccination and maternal and neonatal outcomes, a multicentre retrospective cohort study.

BJOG 2021 Sep 23. Epub 2021 Sep 23.

Department of Obstetrics & Gynecology, Shaare Zedek Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Objective: To evaluate the impact of Covid-19 vaccination (Pfizer-BioNTech BNT162b2) during the third trimester of pregnancy on maternal and neonatal outcomes.

Design: A multicentre, retrospective computerised database.

Population: Women who gave birth at >24 weeks of gestation in Israel, between January and April 2021, with full records of Covid-19 disease and vaccination status. Read More

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September 2021

Anaerobic infections in patients admitted in various surgical units of a tertiary care hospital of north India: neglected but important.

Iran J Microbiol 2021 Jun;13(3):274-281

Department of Medical Microbiology, Research Block A, PGIMER, Chandigarh, India.

Background And Objectives: Anaerobic infections are usually caused by the host's endogenous flora due to a breach in the anatomical barriers and spp. are the most notorious organisms associated with anaerobic infections. The identification of anaerobes has been a challenge since times. Read More

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Fewer Opioids but More Benzodiazepines? Prescription Trends by Specialty in Response to the Implementation of Michigan's Opioid Laws.

Pain Med 2021 Sep 10. Epub 2021 Sep 10.

Emergency Medicine/Medical Toxicology, Wayne State University.

Objectives: To characterize the effects of Michigan's controlled substance legislation on acute care prescriber behavior by specialty, in a single hospital system.

Design: A retrospective study of opioid and benzodiazepine prescription records from a hospital electronic medical record system between August 1, 2016 and March 31, 2019 in Detroit, MI.

Setting: Discharges from inpatient and emergency department visits. Read More

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September 2021

Deceptive Urine Studies and Inappropriate Antibiotic Use in Geriatric Psychiatry: The Impact of Bundled Interventions.

Int J Appl Basic Med Res 2021 Jul-Sep;11(3):166-170. Epub 2021 Jul 19.

Division Chief of Infectious Disease, Harvard Medical School, Cambridge Health Alliance, Cambridge, Massachusetts, USA.

Background: Indiscriminate orders for urinalysis and urine cultures (UC) drive inappropriate antibiotic treatment (Abx), especially in older adults with mental health disorders. Lack of data regarding the prevalence of and treatment for infections in acute geriatric psychiatric units (GPU) motivated us to initiate this project.

Aim: Our goal was to improve urine test utilization and reduce unnecessary Abx for asymptomatic bacteriuria (ASB) and contaminated UC. Read More

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Public-Private Mix Models of Tuberculosis Care in Pakistan: A High-Burden Country Perspective.

Front Public Health 2021 10;9:703631. Epub 2021 Aug 10.

Department of Pharmacy, Quaid-i-Azam University Islamabad, Islamabad, Pakistan.

Pakistan ranks fifth in the globally estimated burden of tuberculosis (TB) case incidence. Annually, a gap of 241,688 patients with TB exists between estimated TB incidence and actual TB case notification in Pakistan. These undetected/missed TB cases initiate TB care from providers in the private healthcare system who are less motivated to notify patients to the national database that leads to significant underdetection of actual TB cases in the Pakistani community. Read More

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October 2021

Switching infliximab in psoriatic patients during COVID-19 pandemics: A real-life retrospective study comparing intra-versus interclass switching strategies.

Dermatol Ther 2021 Sep 16;34(5):e15088. Epub 2021 Aug 16.

Dermatology Unit, Surgical, Medical, and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

During this pandemic, dermatological infusion centers were partially unavailable, suspended or even reconverted to guest COVID-19 patients, consequently infliximab (IFX) infusions became challenging for their both logistic arrangement and also for patients' COVID-19 phobia. This 48 weeks follow-up retrospective observational study included 37 PsO patients that underwent IFX SB2 during pandemic in two primary dermatological referral centers. In 23 (62. Read More

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September 2021

[The Relationship Between Symptoms and Nursing Diagnoses in Hospitalized Patients With Dengue Fever].

Hu Li Za Zhi 2021 Aug;68(4):32-42

MSN, RN, Director, Department of Nursing, Kaohsiung Armed Forces General Hospital, Taiwan, ROC.

Background: Supportive care is a primary method for treating dengue fever. Understanding the symptoms of dengue fever and its related nursing diagnosis is crucial for nurses as references for individual care. This research study was motivated by the few literature reviews available on this topic. Read More

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Four years of prevocational Community Based Attachments in New Zealand: a review.

N Z Med J 2021 07 30;134(1539):56-62. Epub 2021 Jul 30.

Medical Education Officer, Waikato District Health Board, Hamilton, New Zealand.

Aim: The aim of this study was to evaluate the learning environment of the 13-week Community Based Attachment (CBA) (or 'rotation') during the prevocational training years at a metropolitan hospital in New Zealand, and to compare the results with general hospital attachments' scores using an internationally validated survey, the Postgraduate Hospital Educational Environment Measure (PHEEM).

Method: A retrospective analysis of data gathered from the PHEEM over four years was conducted. Responses from interns who undertook a CBA attachment at Waikato District Health Board (DHB) were compared with those who undertook a hospital-based attachment at the same DHB during that time period. Read More

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The clinical applicability of current prognostic models in follicular lymphoma: A systematic review.

Crit Rev Oncol Hematol 2021 Aug 9;164:103418. Epub 2021 Jul 9.

Department of Haematology, Blackpool Victoria Hospital, Lancashire Haematology Centre, Blackpool, United Kingdom.

The Follicular Lymphoma International Prognostic Index (FLIPI) is widely used for risk stratification of patients with follicular lymphoma (FL). Motivated by evolvement in treatment modalities, several prognostic models for FL have been proposed recently. This systematic review aimed to identify available prognostic models for newly diagnosed FL and discuss their potential limitations. Read More

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Preventing Fragility Fractures: A 3-Month Critical Window of Opportunity.

Geriatr Orthop Surg Rehabil 2021 22;12:21514593211018168. Epub 2021 Jun 22.

Department of Orthopaedic Surgery, Atrium Health Musculoskeletal Institute, Charlotte, NC, USA.

Introduction: Low-energy falls are the leading cause of injury-related morbidity and mortality in the elderly. In the past, physicians focused on treating fractures resulting from falls rather than preventing them. The purpose of this study is to identify patients with a hospital encounter for fall prior to a fracture as an opportunity for pre-injury intervention when patients might be motivated to engage in falls prevention. Read More

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From Enchantment to Disillusion: A Narrative Exploration of Cannabis Use Disorder Among Young Israeli Combat Veterans.

Front Psychiatry 2021 18;12:643618. Epub 2021 Jun 18.

Psychology Department, Ariel University, Ariel, Israel.

Substance use is common among military personnel and war veterans, especially combat veterans. Despite substantially high prevalence of cannabis use and Cannabis Use Disorder (CUD) consistently reported among veterans, little is known about psychological factors which may underlie CUD among this population. In this study, we used narrative analysis in order to interpret retrospective in-depth interviews of combat veterans ( = 12) who were released from mandatory military duty during the past 5 years and currently qualified for a diagnosis of CUD. Read More

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Real World Practice Deviation from Nationwide Guidelines in Patients with Intermittent Claudication.

Eur J Vasc Endovasc Surg 2021 Sep 1;62(3):432-438. Epub 2021 Jul 1.

Medisch Spectrum Twente, Department of Vascular Surgery, Enschede, the Netherlands; University of Twente, Multi-Modality Medical Imaging group, TechMed Centre, Enschede, the Netherlands.

Objective: Patients with intermittent claudication (IC) are initially treated with supervised exercise therapy (SET), as advised by national and international guidelines. Dutch health insurance companies and the Dutch National Health Care Institute suggested an 87% compliance rate with these guidelines in the Netherlands in 2017 and judged this to be undesirably low. The aim of this study was to evaluate compliance with IC guidelines and to elaborate on the reasons for deviating from them (practice variation) in a large teaching hospital. Read More

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September 2021

Covid-19 Mortality in an Acute Care Hospital: Association of Patient Factors With Decision to Forego the Intensive Care Unit.

Am J Hosp Palliat Care 2021 Jun 29:10499091211028849. Epub 2021 Jun 29.

589981Luminis Health Research Institute, Luminis Health, Annapolis, MD, USA.

Background: Public awareness of the large mortality toll of COVID-19 particularly among elderly and frail persons is high. This public awareness represents an enhanced opportunity for early and urgent goals-of-care discussions to reduce medically ineffective care.

Objective: To assess the end-of-life experiences of hospitalized patients dying of COVID-19 with respect to identifying the clinical factors associated with utilization or non-utilization of the ICU. Read More

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Second redo surgery after two consecutive failures of a colorectal or coloanal anastomosis: is it reasonable?

Int J Colorectal Dis 2021 Sep 24;36(9):2057-2060. Epub 2021 Jun 24.

Department of Colorectal Surgery, Pôle Des Maladies de L'Appareil Digestif (PMAD), Beaujon Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), University of Paris, 100 Boulevard du Général Leclerc, 92110, Clichy, France.

Purpose: Colorectal redo surgery is well known to be a difficult procedure, associated with a high risk of failure. The aim of this study was to look into patients presenting two consecutive failed colorectal (CRA) or coloanal (CAA) anastomosis who underwent a second redo surgery (i.e. Read More

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September 2021

Military Service Members with Major Lower Extremity Fractures Return to Running with a Passive-dynamic Ankle-foot Orthosis: Comparison with a Normative Population.

Clin Orthop Relat Res 2021 11;479(11):2375-2384

Department of Orthopedic Surgery, Scripps Mercy Hospital, San Diego, CA, USA.

Background: Lower extremity fractures represent a high percentage of reported injuries in the United States military and can devastate a service member's career. A passive dynamic ankle-foot orthosis (PD-AFO) with a specialized rehabilitation program was initially designed to treat military service members after complex battlefield lower extremity injuries, returning a select group of motivated individuals back to running. For high-demand users of the PD-AFO, the spatiotemporal gait parameters, agility, and quality of life is not fully understood with respect to uninjured runners. Read More

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November 2021

NANS-CDG: Delineation of the Genetic, Biochemical, and Clinical Spectrum.

Front Neurol 2021 7;12:668640. Epub 2021 Jun 7.

Department of Pediatric Metabolic Diseases, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, Netherlands.

NANS-CDG is a recently described congenital disorder of glycosylation caused by biallelic genetic variants in , encoding an essential enzyme in sialic acid synthesis. Sialic acid at the end of glycoconjugates plays a key role in biological processes such as brain and skeletal development. Here, we present an observational cohort study to delineate the genetic, biochemical, and clinical phenotype and assess possible correlations. Read More

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Laparoscopic sacral hysteropexy versus laparoscopic sacral colpopexy plus supracervical hysterectomy in patients with pelvic organ prolapse.

Int Urogynecol J 2021 Jun 16. Epub 2021 Jun 16.

PID Ginecologia Oncologica e Chirurgia Ginecologica Miniinvasiva, Università degli studi di Messina, Policlinico G.Martino, Messina, Italy.

Introduction And Hypothesis: The choice of whether or not to preserve the uterus in the case of patients with urogenital prolapse who undergo sacral colpopexy is still debated. We compared objective and subjective outcomes of laparoscopic sacral hysteropexy (LSHP) and laparoscopic sacral colpopexy with concomitant supracervical hysterectomy (LSCP/SCH) in patients with symptomatic pelvic organ prolapse.

Methods: This is a multicenter retrospective cohort study conducted at the Urogynecology Department of the Fondazione Policlinico Universitario A. Read More

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Advanced Facial Rejuvenation After Bimaxillary Surgery in Three Different Facial Types.

Aesthetic Plast Surg 2021 Jun 15. Epub 2021 Jun 15.

Consultant of the Unit of Maxillo-Facial Surgery, IRCCS "Policlinico San Martino", Largo Rosanna Benzi 10, 16132, Genoa, Italy.

Purpose: Facial aging is the consequence of many mechanisms involving the bones and the "soft tissue" (skin, fat, ligaments, muscles, and periosteum) of the face such as downward migration of the soft tissue, adipose and muscular tissue atrophy, and skeletal resorption. The potential of orthognathic surgery (double jaw surgical advancement) of expanding the skeletal foundation to increase the facial drape support is now recognized and widely popularized by several authors. The aim of this study was to analyze the rejuvenation change of the face after bimaxillary advancement for orthognathic surgery, focusing on the previously mentioned stigmata of the middle and the lower third of the aging face. Read More

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Do patients who have newly identified prediabetes lose weight in the following year?

Fam Pract 2021 Nov;38(6):830-833

Cleveland Clinic Community Care, Center for Value Based Care, Cleveland Clinic, Cleveland, OH, USA.

Background: Identifying a window of opportunity when patients are motivated to lose weight might improve the effectiveness of weight loss counseling. The onset of chronic disease could create such a window.

Objective: To determine whether identifying prediabetes was associated with subsequent weight loss. Read More

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November 2021

Post-trip safety interventions: State-of-the-art, challenges, and practical implications.

J Safety Res 2021 06 31;77:67-85. Epub 2021 Mar 31.

Barraqueiro Transportes, Avenida Santos e Castro, 1750-265 Lisboa, Portugal.

Introduction: Currently, risky driving behaviour is a major contributor to road crashes and as a result, wide array of tools have been developed in order to record and improve driving behaviour. Within that group of tools, interventions have been indicated to significantly enhance driving behaviour and road safety. This study critically reviews monitoring technologies that provide post-trip interventions, such as retrospective visual feedback, gamification, rewards or penalties, in order to inform an appropriate driver mentoring strategy delivered after each trip. Read More

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Children hospitalized for myiasis in a reference center in Uruguay.

Bol Med Hosp Infant Mex 2021 06 2;78(4):287-292. Epub 2021 Jun 2.

Clínicas Pediátricas, Facultad de Medicina, Universidad de la República; Hospital Pediátrico, Centro Hospitalario Pereira Rossell. Montevideo, Uruguay.

Background: Myiasis is an emerging disease caused by tissue invasion of dipteran larvae. In Uruguay, Cochliomyia hominivorax and Dermatobia hominis are the most frequent species. This study aimed to describe the epidemiological and clinical characteristics and the follow-up of children < 15 years hospitalized for myiasis in a reference center in Uruguay between 2010 and 2019. Read More

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Thirteen-year trends in hospitalization and outcomes of patients with heart failure in Spain.

Eur J Clin Invest 2021 Nov 2;51(11):e13606. Epub 2021 Jun 2.

Cardiology Department, Hospital Virgen de la Arrixaca, Murcia, Spain.

Background: Heart failure is one of the most pressing current public health concerns. However, in Spain there is a lack of population data. We aimed to examine thirteen-year nationwide trends in heart failure hospitalization, in-hospital mortality and 30-day readmission rates in Spain. Read More

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November 2021

Experience of establishing and coordinating a nationwide network for bidirectional intussusception surveillance in India: lessons for multisite research studies.

BMJ Open 2021 05 28;11(5):e046827. Epub 2021 May 28.

The INCLEN Trust International, New Delhi, Delhi, India

Objectives: To document and share the process of establishing the nationally representative multisite surveillance network for intussusception in India, coordination, data management and lessons learnt from the implementation.

Design: This study combined both retrospective and prospective surveillance approaches.

Setting: 19 tertiary care institutions were selected in India considering the geographic representation and public and private mix PARTICIPANTS: All children under-2 years of age with intussusception PRIMARY AND SECONDARY OUTCOME MEASURES: The experience of site selection, regulatory approvals, data collection, quality assurance and network coordination were documented. Read More

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