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Outcomes of Fludarabine, Melphalan and Total Body Irradiation as a Reduced Intensity Conditioning Regimen in Matched Donor Allogeneic Peripheral Blood Stem Cell Transplantation: Outcomes of Flu-Mel-TBI.

Transplant Cell Ther 2021 May 12. Epub 2021 May 12.

Department of Oncology, Co-Director, Blood & Marrow Stem Cell Transplant Program, Barbara Ann Karmanos Cancer Institute, Wayne State University, 4100 John R, HW04H0, Detroit, MI 48201. Electronic address:

Background: Fludarabine 30 mg/m/day x 5 and melphalan 140 mg/m x 1 (Flu-Mel140) is a commonly used RIC regimen. We hypothesized that addition of 200cGy total body irradiation (TBI) to Flu-Mel140 may improve antitumor activity and transplant outcomes.

Objectives: Primary objectives was overall survival (OS) at 3-year. Read More

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A national level estimation of population need for blood in India.

Transfusion 2021 May 15. Epub 2021 May 15.

National AIDS Control Organization (NACO), New Delhi, India.

Background: The population need for blood is the total volume required to transfuse all the individuals who need transfusion in a defined population over a defined period. The clinical demand will arise when people with a disease or condition who require transfusion, access healthcare services, and subsequently the clinicians request blood. Essentially, the conversion of need to demand must be maximum to avoid preventable mortality and morbidity. Read More

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Gender-based outcomes of coronary bifurcation stenting: A report from the National Readmission Database.

Catheter Cardiovasc Interv 2021 May 15. Epub 2021 May 15.

Division of Cardiology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.

Background: There is a paucity of data focusing on women's outcomes after percutaneous coronary interventions (PCI) for coronary bifurcation lesions (CBLs).

Methods: Patients who received PCI for CBLs in the context of acute coronary syndrome (ACS) during the period of 01 October 2015- 31 December 2017, were identified from the United States National Readmission Database. The primary endpoint of this study was in-hospital major adverse events (MAEs). Read More

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Inotuzumab Ozogamicin with Bosutinib for Relapsed or Refractory Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia or Lymphoid Blast Phase of Chronic Myeloid Leukemia.

Am J Hematol 2021 May 15. Epub 2021 May 15.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.

Relapsed/refractory (R/R) Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) and lymphoid blast phase of chronic myeloid leukemia (LBP-CML) have poor outcomes. We designed a phase 1/2 study combining inotuzumab ozogamicin with bosutinib for this patient population. Patients with T315I mutation were excluded. Read More

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Development and Validation of a Clinical Predictive Model for Bacterial Infection in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure.

Infect Dis Ther 2021 May 15. Epub 2021 May 15.

Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, 430030, Hubei, China.

Introduction: Bacterial infection is one of the most frequent complications in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), which leads to high mortality. However, a predictive model for bacterial infection in HBV-ACLF has not been well established. This study aimed to establish and validate a predictive model for bacterial infection in two independent patient cohorts. Read More

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Percutaneous cholecystostomy versus emergency cholecystectomy for the treatment of acute calculous cholecystitis in high-risk surgical patients: a meta-analysis and systematic review.

Updates Surg 2021 May 15. Epub 2021 May 15.

Department of Gastrointestinal Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.

The present meta-analysis was performed to compare the efficacy and safety of percutaneous cholecystostomy (PC) versus emergency cholecystectomy (EC) for the treatment of acute calculous cholecystitis (ACC) in high-risk surgical patients. Literature searches for eligible studies were performed using MEDLINE, EMBASE and the Cochrane Library. Quality assessment was conducted in each study. Read More

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Epidemiology of Pediatric Meningitis in South Korea From 2010 to 2018: A Population-based Retrospective Cohort Study.

Pediatr Infect Dis J 2021 May 7. Epub 2021 May 7.

From the Department of Pediatrics, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Gangdong-gu, Seoul, Republic of Korea.

Background: Studies evaluating the epidemiology of pediatric meningitis are limited in our region. This study aimed to describe recent trends in the incidence of pediatric meningitis.

Methods: We estimated national trends in hospitalization rates for pediatric meningitis (<18 years) by analyzing data from the Health Insurance Review and Assessment database between 2010 and 2018. Read More

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In-kind donations to healthcare facilities during COVID-19: Experiences from a large medical center in northern Taiwan.

J Chin Med Assoc 2021 May 10. Epub 2021 May 10.

Supply Office, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Institute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Family Medicine, Kinmen Hospital, Kinmen, Taiwan, ROC Department of Long-Term Care, National Quemoy University, Kinmen, Taiwan, ROC School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department of Family Medicine, Taipei Veterans General Hospital, Taipei Taiwan, ROC Big Data Center, Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: In early 2020, a global outbreak of 2019 novel coronavirus disease (COVID-19) caused high mortality rates and public panic. Worldwide demand for personal protective equipment (PPE) has risen, with diminishing supplies and shortages reported. During the pandemic, charitable donations have been made by the public, aimed at helping medical staff. Read More

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Hospital safety-net burden is associated with increased inpatient mortality after elective total knee arthroplasty: a retrospective multistate review, 2007-2018.

Reg Anesth Pain Med 2021 May 14. Epub 2021 May 14.

Department of Anesthesiology, Weill Cornell Medicine, New York, New York, USA

Background: Total knee arthroplasty (TKA) is among the most common surgical procedures performed in the USA and comprises an outsized proportion of Medicare expenditures. Previous work-associated higher safety-net burden hospitals with increased morbidity and in-hospital mortality following total hip arthroplasty. Here, we examine the association of safety-net burden on postoperative outcomes after TKA. Read More

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Use of historical high-sensitivity cardiac troponin T levels to rule out myocardial infarction.

Open Heart 2021 May;8(1)

Department of Emergency and Reparative Medicine, Karolinska University Hospital, Huddinge, Karolinska Universitetssjukhuset, Stockholm, Sweden.

Objective: Several high-sensitivity cardiac troponin (hs-cTn)-based strategies exist for rule-out of myocardial infarction (MI). It is unknown whether historical hs-cTnT concentrations can be used. This study aim to evaluate the performance of a rule-out strategy based on the European Society of Cardiology (ESC) 0/1-hour algorithm, using historical hs-cTnT concentrations. Read More

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Forest malaria: the prevailing obstacle for malaria control and elimination in India.

BMJ Glob Health 2021 May;6(5)

ICMR-National Institute of Malaria Research, New Delhi, Delhi, India.

Despite the decrease in malaria mortality and morbidity, it remains a significant public health problem in India. India is targeting malaria elimination from the country by 2030. Different areas in India are in different phases of malaria elimination. Read More

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Long-term survival after Carpentier-Edwards Perimount aortic valve replacement in Western Denmark: a multi-centre observational study.

J Cardiothorac Surg 2021 May 14;16(1):130. Epub 2021 May 14.

Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital, J. B. Winsløws Vej 4, 5000, Odense C, Denmark.

Background: This study describes the long-term survival, risk of reoperation and clinical outcomes of patients undergoing solitary surgical aortic valve replacement (SAVR) with a Carpentier-Edwards Perimount (CE-P) bioprosthetic in Western Denmark. The renewed interest in SAVR is based on the questioning regarding the long-term survival since new aortic replacement technique such as transcatheter aortic-valve replacement (TAVR) probably have shorter durability, why assessment of long-term survival could be a key issue for patients.

Methods: From November 1999 to November 2013 a cohort of a total of 1604 patients with a median age of 73 years (IQR: 69-78) undergoing solitary SAVR with CE-P in Western Denmark was obtained November 2018 from the Western Danish Heart Registry (WDHR). Read More

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Mechanical thrombectomy versus medical care alone in large ischemic core: An up-to-date meta-analysis.

Interv Neuroradiol 2021 May 14:15910199211016258. Epub 2021 May 14.

Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Objective: We compared outcomes and adverse events of thrombectomy versus medical management in acute ischemic stroke (AIS) patients with baseline large infarct core.

Methods: We searched Ovid MEDLINE(R) ALL, Cochrane Library Clinical Controlled Trials and EMBASE from inception to January 2021 for studies comparing thrombectomy and medical management alone in AIS patients who had ASPECTS <=7 or ischemic core volume >=50 ml. Imaging modalities to valuate ASPECTS and core volume were without restriction. Read More

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Massive Transfusion Protocols in Obstetric Hemorrhage: Theory versus Reality.

Am J Perinatol 2021 May 14. Epub 2021 May 14.

Depatment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

Objective:  Massive transfusion protocols are widely implemented in obstetrical practice in case of severe hemorrhage; however, different recommendations exist regarding the appropriate ratios of blood product components to be transfused. We report our extensive experience with massive component transfusion in a referral center in which the standard massive transfusion protocol is modified by ongoing clinical and laboratory evaluation.

Study Design:  A retrospective chart review of all patients who had massive transfusion protocol activation in a level 4 referral center for obstetrical practice was performed from January 2014 to January 2020. Read More

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Life-Threatening Bleeding in Children: A Prospective Observational Study.

Crit Care Med 2021 May 12. Epub 2021 May 12.

Division of Emergency Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH. Department of Pathology & Laboratory Medicine, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, GA. Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA. Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Oklahoma College of Medicine, The Children's Hospital at University of Oklahoma Health Sciences Center, Oklahoma City, OK. Department of Anesthesia and Critical Care, ARCO Rome, Bambino Gesù Children's Hospital, Rome, Italy. Division of Pediatric Emergency Medicine, University of Toronto, Hospital for Sick Children, Toronto, ON, Canada. Division of Pediatric Emergency Medicine, Weill Cornell Medicine, New York Presbyterian Hospital, New York, NY. Department of Anesthesiology and Critical Care Medicine, Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Children's Hospital of Philadelphia, Philadelphia, PA. Division of Pediatric Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh, Pittsburgh, PA. Department of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston Children's Hospital, Boston, MA. Department of Pediatrics, Critical Care Section, Medical College of Wisconsin, Children's Wisconsin, Milwaukee, WI. Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Utah School of Medicine, Primary Children's Medical Center, Salt Lake City, UT. Division of Emergency Medicine, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Orange Park Medical Center, Orange Park, Florida. Division of Pediatric Surgery, Akron Children's Hospital, Akron, OH. Division of Critical Care Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH. Division of Neonatology, Department of Pediatrics, University of California San Francisco Pritzker School of Medicine, University of California San Francisco Medical Center Parnassus, San Francisco, CA. Division of Pediatric Critical Care Medicine, Department of Child Health, University of Arizona College of Medicine, Phoenix Children's Hospital, Phoenix, AZ. Department of Surgery, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN. Department of Emergency Medicine, University of Michigan, C.S. Mott Children's Hospital, Ann Arbor, MI. Department of Pediatrics, Dartmouth Hitchcock Medical Center, Children's Hospital at Dartmouth, Lebanon, NH. Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Minnesota Medical School, Department of Pediatric Critical Care Medicine, University of Minnesota Masonic Children's Hospital, Minneapolis, MN. Department of Pediatric Surgery, Vanderbilt University College of Medicine, Monroe Carell Jr Children's Hospital Nashville, TN. Keck School of Medicine of University of Southern California, Children's Hospital Los Angeles, Los Angeles, CA. Department of Pediatric Surgery, Baylor College of Medicine, Texas Children's Hospital, Houston, TX. Department of Surgery, Texas A&M University College of Medicine, McLane Children's Hospital, Temple TX. Division of Pediatric Surgery, Alpert Medical School of Brown University, Hasbro Children's Hospital, Providence, RI. Southlake Pediatrics, Birmingham, AL. Department of Pediatrics, University of Alabama School of Medicine, Children's of Alabama, Birmingham, AL. Division of Critical Care, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis Children's Hospital, St. Louis, MO.

Objectives: The purpose of our study was to describe children with life-threatening bleeding.

Design: We conducted a prospective observational study of children with life-threatening bleeding events.

Setting: Twenty-four childrens hospitals in the United States, Canada, and Italy participated. Read More

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Status epilepticus after intracranial neurosurgery: incidence and risk stratification by perioperative clinical features.

J Neurosurg 2021 May 14:1-13. Epub 2021 May 14.

Departments of1Neurosurgery and.

Objective: Status epilepticus (SE) is associated with significant mortality, cost, and risk of future seizures. In one of the first studies of SE after neurosurgery, the authors assess the incidence, risk factors, and outcome of postneurosurgical SE (PNSE).

Methods: Neurosurgical admissions from the MarketScan Claims and Encounters database (2007 through 2015) were assessed in a longitudinal cross-sectional sample of privately insured patients who underwent qualifying cranial procedures in the US and were older than 18 years of age. Read More

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Ten-year assessment of a cancer fast-track programme to connect primary care with oncology: reducing time from initial symptoms to diagnosis and treatment initiation.

ESMO Open 2021 May 11;6(3):100148. Epub 2021 May 11.

Department of Medical Oncology, Biomedical Research Institute INCLIVA, University of Valencia, Valencia, Spain. Electronic address:

Background: Cancer is the second leading cause of mortality worldwide. Integrating different levels of care by implementing screening programmes, extending diagnostic tools and applying therapeutic advances may increase survival. We implemented a cancer fast-track programme (CFP) to shorten the time between suspected cancer symptoms, diagnosis and therapy initiation. Read More

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What is Known About Burns in East Africa? A Scoping Review.

J Surg Res 2021 May 11;266:113-124. Epub 2021 May 11.

Program in Global Surgery and Social Change, Harvard Medical School, Boston, Massachusetts; Department of Hand Surgery, Plastic Surgery and Burns, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Background: Burns are a global public health concern, with the majority of the disease burden affecting low- and middle-income countries. Yet, as suggested by previous publications, there is a widespread belief that literature about burns in low- and middle-income countries is lacking. Therefore, we aimed to assess with a scoping review, the extent of the literature output on burns in East Africa, and to investigate patient demographics, injury characteristics, treatment and outcomes, as reported from the existing publications. Read More

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Efficacy and Safety of Oritavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections: A Systematic Review and Meta-analysis.

J Glob Antimicrob Resist 2021 May 11. Epub 2021 May 11.

Centre of Medicine Clinical Research, Department of Pharmacy, PLA General Hospital, Beijing 100853, China. Electronic address:

Objectives: In the present work, we aimed to evaluate the efficacy and safety of oritavancin (ORI) versus its comparators for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) based on available clinical studies.

Methods: PubMed, Cochrane Library, and Embase were searched from database inception to July 28, 2020 to identify clinical studies assessing the efficacy and safety of ORI and its comparators for the treatment of ABSSSIs. Primary efficacy outcome, investigator-assessed clinical cure, lesion size reduction ≥20%, additional post-treatment antibiotics, 30-day emergency room (ER) visits and readmission were assessed as efficacy outcomes, while adverse events (AEs) and mortality were assessed as safety outcomes. Read More

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Microvascular Disease and Cardiovascular Outcomes in Type 2 Diabetes: The Look AHEAD Study.

Diabetes Res Clin Pract 2021 May 11:108859. Epub 2021 May 11.

Department of Medicine, Division of Endocrinology, Diabetes & Metabolism, Johns Hopkins School of Medicine, Baltimore, MD, USA; Welch Prevention Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, MD, USA. Electronic address:

Aim: To evaluate the associations of microvascular disease (MVD) with incident cardiovascular disease (CVD) in individuals with type 2 diabetes.

Methods: A total of 4098 participants with type 2 diabetes and without CVD were assessed for MVD (diabetic kidney disease, retinopathy or neuropathy) in the Look AHEAD (Action for Health in Diabetes) study. Cox models were used to generate hazard ratios (HRs) for: (1) CVD composite (myocardial infarction, stroke, hospitalization for angina and/or death from cardiovascular causes), (2) coronary artery disease (CAD), (3) stroke, and (4) CVD-related deaths. Read More

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Nocardia farcinica cerebral abscess: a systematic review of treatment strategies.

Neurochirurgie 2021 May 11. Epub 2021 May 11.

Neurosurgery department, Timone University Hospital, APHM, 264 rue Saint-Pierre, 13005 Marseille, France; Aix-Marseille Univ, INSERM, MMG, Marseille, France.

Purpose: Nocardia farcinica is an opportunistic pathogen causing mainly pneumonia in immunocompromised patients, complicated in almost one-third of the cases by a thick-walled multiloculated cerebral abscess which induces significant morbidity and mortality. This review aims to assess the optimal treatment strategy for N. farcinica cerebral abscess. Read More

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The impact of chest CT body composition parameters on clinical outcomes in COVID-19 patients.

PLoS One 2021 14;16(5):e0251768. Epub 2021 May 14.

Epidemiology Unit, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

We assessed the impact of chest CT body composition parameters on outcomes and disease severity at hospital presentation of COVID-19 patients, focusing also on the possible mediation of body composition in the relationship between age and death in these patients. Chest CT scans performed at hospital presentation by consecutive COVID-19 patients (02/27/2020-03/13/2020) were retrospectively reviewed to obtain pectoralis muscle density and total, visceral, and intermuscular adipose tissue areas (TAT, VAT, IMAT) at the level of T7-T8 vertebrae. Primary outcomes were: hospitalization, mechanical ventilation (MV) and/or death, death alone. Read More

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The use of laser lead extraction sheath in the presence of supra-cardiac occlusion of the central veins for cardiac implantable electronic device lead upgrade or revision.

PLoS One 2021 14;16(5):e0251829. Epub 2021 May 14.

Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Baden-Würrtemberg, Germany.

Background: The implantation of cardiac implantable electronic devices (CIED) has increased in the last decades with improvement in the quality of life of patients with cardiac rhythm disorders. The presence of bilateral subclavian, innominate or superior vena cava obstruction is a major limitation to device revision and/or upgrade.

Methods And Material: This is retrospective study of patients who underwent laser-assisted lead extraction (LLE) (GlideLight laser sheath, Spectranetics Corporation, Colorado Springs, USA) with lead revision or upgrade using the laser sheath as a guide rail. Read More

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Incidence and predictors of mortality within the first year of antiretroviral therapy initiation at Debre-Markos Referral Hospital, Northwest Ethiopia: A retrospective follow up study.

PLoS One 2021 14;16(5):e0251648. Epub 2021 May 14.

Department of Anesthesiology, College of Medicine and Health Science, Debre-Tabor University, Debre-Tabor, Ethiopia.

Background: Acquired Immunodeficiency Syndrome (AIDS) is one of the most fatal infectious diseases in the world, especially in Sub-Saharan Africa, including Ethiopia. Even though Antiretroviral therapy (ART) significantly decreases mortality overall, death rates are still highest especially in the first year of ART initiation.

Objective: To assess the incidence and predictors of mortality within the first year of ART initiation among adults on ART at Debre-Markos Referral Hospital, Northwest Ethiopia. Read More

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A microfluidic-based filtration system to enrich for bone marrow disseminated tumor cells from breast cancer patients.

PLoS One 2021 14;16(5):e0246139. Epub 2021 May 14.

Dept. of Surgery, Washington University School of Medicine, St. Louis, MO, United States of America.

Disseminated tumors cells (DTCs) present in the bone marrow (BM) are believed to be the progenitors of distant metastatic spread, a major cause of mortality in breast cancer patients. To better understand the behavior and therapeutic vulnerabilities of these rare cell populations, unbiased methods for selective cell enrichment are required. In this study, we have evaluated a microfluidic-based filtration system (ParsortixR, Angle PLC), previously demonstrated for use in circulating tumor cell (CTC) capture, to capture BM DTCs. Read More

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Predictors and Sequelae of Postoperative Delirium in a Geriatric Patient Population With Hip Fracture.

J Am Acad Orthop Surg Glob Res Rev 2021 May 14;5(5). Epub 2021 May 14.

From the Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT (Ms. Haynes, Mr. Alder, Dr. Toombs, Dr. Rubin, and Dr. Grauer), and the Department of Orthopaedics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire (Mr. Amakiri).

Introduction: Postoperative delirium is common for patients with hip fracture. Predictors of postoperative delirium and its association with preexisting dementia and adverse postoperative outcomes in a geriatric hip fracture population were assessed.

Methods: Patients with hip fracture aged 60 years and older were identified in the 2016 and 2017 National Surgical Quality Improvement Program Procedure Targeted Databases. Read More

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Fetal Diagnosis is Associated with Improved Perioperative Condition of Neonates Requiring Surgical Intervention for Coarctation.

Pediatr Cardiol 2021 May 14. Epub 2021 May 14.

Fetal & Neonatal Cardiology Program, Division of Cardiology, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

To define the relative importance of fetal diagnosis and comorbidities in severity of preoperative compromise, outcomes and hospitalization in neonatal coarctation of the aorta (CoA). Retrospective comparison of preoperative condition and postoperative course of neonates prenatally (PreDx n = 48) or postnatally diagnosed (PostDx n = 67) with CoA. Congenital and non-congenital comorbidities were adjusted for. Read More

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Oral Proton Pump Inhibitors May Be as Effective as Intravenous in Peptic Ulcer Bleeding: A Systematic Review and Meta-analysis.

Clin Transl Gastroenterol 2021 Apr 14;12(4):e00341. Epub 2021 Apr 14.

Institute for Translational Medicine, Medical School, Szentágothai Research Center, University of Pécs, Pécs, Hungary.

Introduction: Current guidelines recommend intravenous (IV) proton pump inhibitor (PPI) therapy in peptic ulcer bleeding (PUB). We aimed to compare the efficacy of oral and IV administration of PPIs in PUB.

Methods: We performed a systematic search in 4 databases for randomized controlled trials, which compared the outcomes of oral PPI therapy with IV PPI therapy for PUB. Read More

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The relationship between serum lactate dehydrogenase level and mortality in critically ill patients.

Biomark Med 2021 May 14. Epub 2021 May 14.

Department of Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

To assess the association between serum lactate dehydrogenase (LDH) levels and mortality in intensive care unit patients. A total of 1981 patients in the eICU Collaborative Research Database were divided into four groups according to quartiles of LDH levels. Logistic regressions were performed. Read More

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Improvements in Functional Status Among Survivors of Orthotopic Heart Transplantation Following High-risk Bridging Modalities.

Transplantation 2021 Jan 7. Epub 2021 Jan 7.

1 Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA. 2 Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA. 3 Division of Cardiac Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA.

Background: The 2018 heart allocation change has resulted in greater frequency of high-risk bridging to orthotopic heart transplantation (OHT). Although survival has been studied in these patients, functional status outcomes are less established. This study evaluated changes in functional status of OHT survivors based on bridging strategy. Read More

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January 2021