137 results match your criteria mortality non-respiratory

Chronic obstructive pulmonary disease exacerbation fundamentals: Diagnosis, treatment, prevention and disease impact.

Respirology 2021 Apr 24. Epub 2021 Apr 24.

Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized by an acute deterioration in respiratory symptoms, are fundamental events impacting negatively upon disease progression, comorbidities, wellbeing and mortality. ECOPD also represent the largest component of the socioeconomic burden of COPD. ECOPDs are currently defined as acute worsening of respiratory symptoms that require additional therapy. Read More

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The Weight of Obesity in Immunity from Influenza to COVID-19.

Front Cell Infect Microbiol 2021 17;11:638852. Epub 2021 Mar 17.

Laboratory of Immunothrombosis, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged in December 2019 and rapidly outspread worldwide endangering human health. The coronavirus disease 2019 (COVID-19) manifests itself through a wide spectrum of symptoms that can evolve to severe presentations as pneumonia and several non-respiratory complications. Increased susceptibility to COVID-19 hospitalization and mortality have been linked to associated comorbidities as diabetes, hypertension, cardiovascular diseases and, recently, to obesity. Read More

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COVID-19 Infection among Older People Admitted to Hospital: A Cross-Sectional Analysis.

Geriatrics (Basel) 2021 Mar 8;6(1). Epub 2021 Mar 8.

Geriatric Medicine Unit, Department of Medicine, University Malaya Medical Centre, Kuala Lumpur 59100, Malaysia.

(1) Background: Older people with COVID-19 infection report worse clinical outcomes. There is a paucity of local data and this study aimed to describe the clinical progression of older people admitted to a university hospital in Malaysia with COVID-19 infection. (2) Methods: Older people (≥60 years) admitted with COVID-19 infection confirmed with RT-PCR from 27 February 2020-25 May 2020 were included in this study. Read More

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Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated neonates.

Cochrane Database Syst Rev 2021 03 30;3:CD009969. Epub 2021 Mar 30.

School of Allied Health, Australian Catholic University, Brisbane, Australia.

Background: Preterm infants and neonates with respiratory conditions commonly require intubation and conventional mechanical ventilation (CMV) to maintain airway patency and support their respiration. Whilst this therapy is often lifesaving, it simultaneously carries the risk of lung injury. The use of lung recruitment manoeuvres (LRMs) has been found to reduce the incidence of lung injury, and improve oxygenation and lung compliance in ventilated adults. Read More

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Socioeconomic circumstances and lung function growth from early adolescence to early adulthood.

Pediatr Res 2021 Feb 18. Epub 2021 Feb 18.

EPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Background: A reduced lung function in early adulthood is associated with respiratory and non-respiratory diseases and is a long-term predictor of mortality. This study investigated the association between early socioeconomic circumstances (SEC) and lung function growth trajectories from early adolescence until early adulthood.

Methods: We analysed data from the EPITeen population-based study, including adolescents born in 1990. Read More

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February 2021

Noninvasive ventilation in critically ill very old patients with pneumonia: A multicenter retrospective cohort study.

PLoS One 2021 27;16(1):e0246072. Epub 2021 Jan 27.

Barcelona Institute for Global Health, ISGlobal, Barcelona, Spain.

Background: Very old patients (≥ 80 years-old, VOP) are increasingly admitted to intensive care units (ICUs). Community-acquired pneumonia (CAP) is a common reason for admission and the best strategy of support for respiratory failure in this scenario is not fully known. We evaluated whether noninvasive ventilation (NIV) would be beneficial compared to invasive mechanical ventilation (IMV) regarding hospital mortality. Read More

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January 2021

Delayed emergencies: The composition and magnitude of non-respiratory emergency department visits during the COVID-19 pandemic.

J Am Coll Emerg Physicians Open 2021 Feb 14;2(1):e12349. Epub 2021 Jan 14.

Departments of Emergency Medicine and Medical Ethics and Health Policy Blue Cross and Blue Shield of Louisiana USA.

Importance: COVID-19 has been associated with excess mortality among patients not diagnosed with COVID-19, suggesting disruption of acute health care provision may play a role.

Objective: To determine the degree of declines in emergency department (ED) visits attributable to COVID-19 and determine whether these declines were concentrated among patients with fewer comorbidities and lower severity visits.

Design: We conducted a differences-in-differences analysis of all commercial health insurance claims for ED visits in the first 20 weeks of 2018, 2019, and 2020. Read More

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February 2021

Impact of pneumococcal conjugate vaccine uptake on childhood pneumonia mortality across income levels in Brazil, Colombia, and Peru.

Gates Open Res 2020 22;4:136. Epub 2020 Sep 22.

Comprehensive Family Immunization Unit/FPL, Pan American Health Organization, World Health Organization, District of Columbia, USA.

Pneumococcal conjugate vaccines (PCVs) have prevented deaths due to pneumonia among children. The effect may differ between higher- and lower-income populations due to various factors, such as differences in the distribution of pneumococcal serotypes, healthcare access, and PCV uptake. This study aims to evaluate an association between increasing PCV coverage and population-level declines in death due to pneumonia and its variation by socioeconomic status of subnational regions. Read More

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September 2020

The impact of COVID-19 on morbidity and mortality in neck of femur fracture patients: a prospective case-control cohort study.

Bone Jt Open 2020 Nov 2;1(11):669-675. Epub 2020 Nov 2.

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Aims: Within the UK, around 70,000 patients suffer neck of femur (NOF) fractures annually. Patients presenting with this injury are often frail, leading to increased morbidity and a 30-day mortality rate of 6.1%. Read More

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November 2020

Epidemiology and outcomes of invasive mechanical ventilation without ICU admission in acute care hospitals in Texas: A population-based cohort study.

Lavi Oud John Garza

J Crit Care 2021 Feb 24;61:107-114. Epub 2020 Oct 24.

Texas Tech University Health Sciences Center at the Permian Basin, 701 W. 5(th) Street, Odessa, TX 79763, United States; Department of Mathematics, The University of Texas of the Permian Basin, 4901 E. University Blvd, Odessa, Texas 79762, United States.

Purpose: The high ICU bed capacity in the United States (US) allows ICU care of patients requiring invasive mechanical ventilation (IMV), absent public health crisis. The use of IMV without ICU admission (non-ICU) in acute care hospitals in the US and its impact on patients' outcomes were not examined.

Methods: A retrospective cohort study was performed using statewide inpatient data in Texas to identify hospitalizations aged ≥18 years receiving IMV in acute care hospitals with ICU care capability during January 2014 through September 2015. Read More

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February 2021

The Role of COVID-19 in the Death of SARS-CoV-2-Positive Patients: A Study Based on Death Certificates.

J Clin Med 2020 10 27;9(11). Epub 2020 Oct 27.

Statistical Service, Istituto Superiore di Sanità, 00161 Rome, Italy.

Death certificates are considered the most reliable source of information to compare cause-specific mortality across countries. The aim of the present study was to examine death certificates of persons who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to (a) quantify the number of deaths directly caused by coronavirus 2019 (COVID-19); (b) estimate the most common complications leading to death; and (c) identify the most common comorbidities. Death certificates of persons who tested positive for SARS-CoV-2 provided to the National Surveillance system were coded according to the 10th edition of the International Classification of Diseases. Read More

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October 2020

Effects of COPD on in-hospital outcomes of transcatheter aortic valve implantation: Results from the National Inpatient Sample database.

Clin Cardiol 2020 Dec 22;43(12):1524-1533. Epub 2020 Oct 22.

Department of Cardiovascular Surgery, Guangdong Provincial People's Hospital, Guangdong, China.

Background: Comorbid chronic obstructive pulmonary disease (COPD) increases morbidity and mortality among aortic valve replacement patients undergoing conventional surgery. The impact of COPD in patients undergoing less invasive transcatheter aortic valve insertion (TAVI) is unclear.

Hypothesis: This study evaluates the in-hospital outcomes of TAVI in patients with and without COPD. Read More

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December 2020

Atypical presentations in the hospitalised older adult testing positive for SARS-CoV-2: a retrospective observational study in Glasgow, Scotland.

Scott Med J 2021 May 11;66(2):89-97. Epub 2020 Oct 11.

Consultant Physician, Department of Medicine for the Elderly, Queen Elizabeth University Hospital, UK.

Understanding of how SARS-CoV-2 manifests itself in older adults was unknown at the outset of the pandemic. We undertook a retrospective observational analysis of all patients admitted to older people's services with confirmed COVID-19 in one of the largest hospitals in Europe. We detail presenting symptoms, prognostic features and vulnerability to nosocomial spread. Read More

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Non-respiratory presentations of COVID-19, a clinical review.

Am J Emerg Med 2020 Nov 24;38(11):2444-2454. Epub 2020 Sep 24.

Department of Emergency Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, United States. Electronic address:

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19) is a highly infectious viral syndrome currently threatening millions of people worldwide. It is widely recognized as a disease of the pulmonary system, presenting with fever, cough, and shortness of breath. However, a number of extrapulmonary manifestations have been described in the literature. Read More

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November 2020

Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study.

Crit Care 2020 10 6;24(1):597. Epub 2020 Oct 6.

CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

Background: Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFNO) with awake-PP prevents the need for intubation when compared to HFNO alone.

Methods: Prospective, multicenter, adjusted observational cohort study in consecutive COVID-19 patients with acute respiratory failure (ARF) receiving respiratory support with HFNO from 12 March to 9 June 2020. Read More

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October 2020

Evaluation of inpatient oxygen therapy in hypercapnic chronic obstructive pulmonary disease (COPD).

Intern Med J 2020 Sep 27. Epub 2020 Sep 27.

University of Queensland, Herston, Queensland, Australia.

Background And Objective: High concentration oxygen therapy in hypercapnic chronic obstructive pulmonary disease (COPD) is associated with increased mortality. In ward-based patients with acute exacerbation of COPD and hypercapnia, this study examines oxygen prescription and the association between high concentration oxygen therapy and adverse outcome.

Methods: Inpatients with acute exacerbation of hypercapnic COPD at a tertiary Australian hospital over a one year period were retrospectively identified. Read More

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September 2020

Mortality and prognostic factors of nontuberculous mycobacterial infection in Korea: A population-based comparative study.

Clin Infect Dis 2020 Sep 14. Epub 2020 Sep 14.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Population-based studies on the mortality burden of nontuberculous mycobacteria (NTM) infection are lacking. We compared the long-term mortality of NTM-infected patients with tuberculosis (TB)-patients and the general-population, and investigated mortality-associated factors.

Methods: We analyzed nationwide-data from the Korean National Health Insurance and Korea-Statistical Office between 2002 and 2017. Read More

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September 2020

Complications and mortality among patients hospitalised with COVID-19.

Tidsskr Nor Laegeforen 2020 08 24;140(11). Epub 2020 Jun 24.

Background: The course of disease, complications and hospital mortality among patients with COVID-19 admitted to Norwegian hospitals has not been widely described. The purpose of this study was to survey patients with COVID-19 admitted to a local hospital.

Material And Method: The data were retrieved from a prospective observational study of all patients admitted with COVID-19 to Bærum Hospital since the start of the coronavirus outbreak. Read More

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Increased mortality in patients with severe SARS-CoV-2 infection admitted within seven days of disease onset.

Intensive Care Med 2020 Sep 11;46(9):1714-1722. Epub 2020 Aug 11.

Université de Paris, Paris, France.

Purpose: Coronavirus disease 2019 (COVID-19) is creating an unprecedented healthcare crisis. Understanding the determinants of mortality is crucial to optimise intensive care unit (ICU) resource use and to identify targets for improving survival.

Methods: In a multicentre retrospective study, we included 379 COVID-19 patients admitted to four ICUs between 20 February and 24 April 2020 and categorised according to time from disease onset to ICU admission. Read More

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September 2020

Neutropenic Enterocolitis and Rapid Spontaneous Resolution of Portal Venous Gas: A Non-Respiratory Manifestation of COVID-19.

Cureus 2020 Jul 28;12(7):e9445. Epub 2020 Jul 28.

Critical Care Medicine, Guthrie Robert Packer Hospital, Sayre, USA.

The COVID-19 pandemic is affecting millions across the globe. The population of immunosuppressed individuals are at greatest risk of morbidity and mortality. Data on COVID-19 induced illness in the immunocompromised host are sparse. Read More

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Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis.

Clin Microbiol Infect 2020 Dec 22;26(12):1622-1629. Epub 2020 Jul 22.

Public Health Ontario, ON, Canada; University of Toronto, ON, Canada; Sunnybrook Research Institute, ON, Canada; ICES (formerly Institute for Clinical Evaluative Sciences), ON, Canada.

Background: Bacterial co-pathogens are commonly identified in viral respiratory infections and are important causes of morbidity and mortality. The prevalence of bacterial infection in patients infected with SARS-CoV-2 is not well understood.

Aims: To determine the prevalence of bacterial co-infection (at presentation) and secondary infection (after presentation) in patients with COVID-19. Read More

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December 2020

Clinical risk factors for early mortality in patients with community-acquired septic shock. The importance of adequate source control.

Med Intensiva 2020 Jul 9. Epub 2020 Jul 9.

Critical Care Department, Fundació Parc Taulí, Hospital Universitari Parc Taulí, Sabadell, Spain.

Objective: To evaluate the incidence and risk factors for early mortality (EM) in the ICU in patients with community-acquired septic shock (CASS).

Design: A retrospective cohort study of patients with CASS admitted to the ICU (2003-2016).

Setting: ICU at a University Hospital in Spain. Read More

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Early Predictors of Mortality in Patients with COPD, in Relation to Respiratory and Non-Respiratory Causes of Death - A National Register Study.

Int J Chron Obstruct Pulmon Dis 2020 25;15:1495-1505. Epub 2020 Jun 25.

Karolinska Institute, Department of Oncology-Pathology, Stockholm, Sweden.

Background: Both single factors and composite measures have been suggested to predict mortality in patients with chronic obstructive pulmonary disease (COPD) and there is a need to analyze the relative importance of each variable.

Objective: To explore the predictors of mortality for patients with COPD in relation to respiratory, cardiac, and malignant causes, as well as all causes of death.

Methods: After merging the Swedish Respiratory Tract Register (SRTR) and the Swedish Cause of Death Register, patients with respiratory, cardiac, and other causes of death were identified. Read More

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Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?

Respir Physiol Neurobiol 2020 08 6;279:103476. Epub 2020 Jun 6.

Florey Institute of Neuroscience and Mental Health, Melbourne Victoria, Australia; The Florey Department of Neuroscience, University of Melbourne, Melbourne Victoria, Australia.

A very recent epidemiological study provides preliminary evidence that living in habitats located at 2500 m above sea level (masl) might protect from the development of severe respiratory symptoms following infection with the novel SARS-CoV-2 virus. This epidemiological finding raises the question of whether physiological mechanisms underlying the acclimatization to high altitude identifies therapeutic targets for the effective treatment of severe acute respiratory syndrome pivotal to the reduction of global mortality during the COVID-19 pandemic. This article compares the symptoms of acute mountain sickness (AMS) with those of SARS-CoV-2 infection and explores overlapping patho-physiological mechanisms of the respiratory system including impaired oxygen transport, pulmonary gas exchange and brainstem circuits controlling respiration. Read More

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Clinical Characteristics of Hospitalized Individuals Dying With COVID-19 by Age Group in Italy.

J Gerontol A Biol Sci Med Sci 2020 09;75(9):1796-1800

Department of Cardiovascular, Endocrine-metabolic Diseases and Aging, Istituto Superiore di Sanità, Rome, Italy.

Background: Aim of the present study is to describe characteristics of COVID-19-related deaths and to compare the clinical phenotype and course of COVID-19-related deaths occurring in adults (<65 years) and older adults (≥65 years).

Method: Medical charts of 3,032 patients dying with COVID-19 in Italy (368 aged < 65 years and 2,664 aged ≥65 years) were revised to extract information on demographics, preexisting comorbidities, and in-hospital complications leading to death.

Results: Older adults (≥65 years) presented with a higher number of comorbidities compared to those aged <65 years (3. Read More

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September 2020

Clinical characteristics of patients with 2019 coronavirus disease in a non-Wuhan area of Hubei Province, China: a retrospective study.

BMC Infect Dis 2020 Apr 29;20(1):311. Epub 2020 Apr 29.

Department of Hematology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, No. 60, Jingzhong Road, Jingzhou Central Hospital, Jingzhou, 434020, Hubei Province, China.

Background: Since December 2019, the 2019 coronavirus disease (COVID-19) has expanded to cause a worldwide outbreak that more than 600,000 people infected and tens of thousands died. To date, the clinical characteristics of COVID-19 patients in the non-Wuhan areas of Hubei Province in China have not been described.

Methods: We retrospectively analyzed the clinical characteristics and treatment progress of 91 patients diagnosed with COVID-19 in Jingzhou Central Hospital. Read More

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Clinical Features and Outcomes of Tuberculosis in Inflammatory Bowel Disease Patients Treated with Anti-tumor Necrosis Factor Therapy.

Korean J Gastroenterol 2020 01;75(1):29-38

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: Anti-tumor necrosis factor (TNF) therapy is used widely for the treatment of inflammatory bowel disease (IBD). In the present study, the characteristics and outcomes of tuberculosis (TB) in IBD patients treated with anti-TNF therapy were compared with those of non-IBD TB patients.

Methods: Twenty-five IBD patients who initially developed TB during anti-TNF therapy were enrolled in this study. Read More

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January 2020

Risk of Readmission and Mortality Following Hospitalization with Hypercapnic Respiratory Failure.

Lung 2020 02 11;198(1):121-134. Epub 2019 Dec 11.

University of Vermont, Burlington, USA.

Purpose: Hypercapnic respiratory failure (HRF) is a frequent cause of hospitalization and a common comorbidity in hospitalized patients. There are few studies addressing what factors might predict poor outcomes in this patient population. The purpose of the current study was to investigate characteristics and outcomes of patients hospitalized with HRF. Read More

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February 2020

Can Waterlow score predict 30-day mortality and length of stay in acutely admitted medical patients (aged ≥65 years)? Evidence from a single centre prospective cohort study.

BMJ Open 2019 11 14;9(11):e032347. Epub 2019 Nov 14.

Cardiology, Lister Hospital, Stevenage, UK.

Objective: This study aimed to explore the potential for the Waterlow score (WS) to be used as a predictor of 30-day mortality and length of hospital stay (LHS) in acutely admitted medical patients aged 65 years and older.

Design: Prospective observational cohort study.

Setting: UK District General Hospital. Read More

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November 2019

Impact of Conservative Versus Conventional Oxygenation on Outcomes of Patients in Intensive Care Units: A Systematic Review and Meta-analysis.

Cureus 2019 Sep 15;11(9):e5662. Epub 2019 Sep 15.

Internal Medicine, Texas A&M Health Science Center, Temple, USA.

Background: There is mixed evidence in the superiority of conservative versus conventional approach to oxygen therapy among patients admitted into the intensive care unit (ICU). The purpose of this study was to determine if conservative versus conventional oxygenation results in a statistically significant difference in outcomes in ICU patients.

Methods: A systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) and performed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

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September 2019