96,078 results match your criteria mortality ischemic


The CHA2DS2-VASc risk score predicts successful endovascular treatment in patients with acute ischemic stroke.

Acta Neurol Scand 2021 Dec 4. Epub 2021 Dec 4.

Department of Cardiology, Faculty of Medicine, İnönü University, Malatya, Turkey.

Objectives: Acute ischemic stroke is a common cause of mortality and morbidity worldwide. Percutaneous endovascular intervention is an important treatment method in ischemic stroke. Endovascular procedure success is associated with the clinical outcome of the patients. Read More

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December 2021

Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES.

Diabetes Care 2021 Dec 3. Epub 2021 Dec 3.

Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, China

Objective: Despite that periodical monitoring of cobalamin (vitamin B12) in metformin-treated patients with diabetes is recommended, cobalamin-associated mortality benefits or risks remain unclear. We investigated the association between cobalamin intake and related biomarkers and mortality risk in adults with diabetes using metformin or not.

Research Design And Methods: This study included 3,277 adults with type 2 diabetes from The National Health and Nutrition Examination Survey (NHANES) and followed up until 31 December 2015. Read More

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December 2021

The Impact of Charlson Comorbidity Index on De Novo Cardiac Implantable Electronic Device Procedural Outcomes in the United States.

Mayo Clin Proc 2021 Dec 1. Epub 2021 Dec 1.

Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences, Keele University, UK; Royal Stoke University Hospital, Stoke-on-Trent, UK. Electronic address:

Objective: To investigate the utility of Charlson comorbidity index (CCI) as a measure of comorbidity burden to predict procedural outcomes after de novo cardiac implantable electronic device (CIED) implantation.

Methods: All de novo CIED implantations in the United States National Inpatient Sample between 2015 and 2018 were retrospectively analyzed, stratified by CCI score (0=no comorbidity burden, 1=mild, 2=moderate, ≥3=severe). Multivariable logistic regression models were performed to examine the association between unit CCI score (scale) and in-hospital outcomes (major adverse cerebrovascular and cardiovascular events [MACCE]: composite of all-cause mortality, acute ischemic stroke, thoracic and cardiac complications, and device-related complications; and MACCE individual components). Read More

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December 2021

Characteristics and outcomes of octogenarians with revascularized critical limb ischemia: Impact of altered cardiac function for early mortality.

J Med Vasc 2021 Oct-Dec;46(5-6):224-231. Epub 2021 Nov 5.

Vascular medicine department, groupe hospitalier Paris Saint-Joseph, Paris, France.

Objective: Patients with critical limb ischemia (CLI) present with advanced age and end-stage organ damage, in particular heart failure. The aim of the present study is to describe clinical and biological characteristics in octogenarian patients with CLI compared to their younger counterparts and to determine the peri-procedural risk and early mortality after endovascular procedure.

Methods: From November 2013 to May 2019, 315 consecutive patients were retrospectively included. Read More

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November 2021

Palliative Care Interventions for Peripheral Artery Disease: A Systematic Review and Narrative Synthesis.

J Palliat Med 2021 Dec 2. Epub 2021 Dec 2.

Leeds Vascular Institute, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.

Peripheral artery disease (PAD) encompasses conditions with poor outcome and severe suffering, both mentally and physically, yet utilization and research into palliative care interventions remain sparse. The purpose of this study is to identify existing evidence on palliative care intervention for chronic limb threatening ischaemia (CLTI) and abdominal aortic aneurysm (AAA). We conducted a PROSPERO-registered systematic review of studies published between 1991 and 2020 in which people with PAD received palliative care interventions and at least one patient outcome was recorded. Read More

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December 2021

Endoplasmic Reticulum-Mitochondria Contacts: A Potential Therapy Target for Cardiovascular Remodeling-Associated Diseases.

Front Cell Dev Biol 2021 10;9:774989. Epub 2021 Nov 10.

Innovation Research Institute of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.

Cardiovascular remodeling occurs in cardiomyocytes, collagen meshes, and vascular beds in the progress of cardiac insufficiency caused by a variety of cardiac diseases such as chronic ischemic heart disease, chronic overload heart disease, myocarditis, and myocardial infarction. The morphological changes that occur as a result of remodeling are the critical pathological basis for the occurrence and development of serious diseases and also determine morbidity and mortality. Therefore, the inhibition of remodeling is an important approach to prevent and treat heart failure and other related diseases. Read More

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November 2021

Noninvasive and early diagnosis of acquired brain injury using fluorescence imaging in the NIR-II window.

Biomed Opt Express 2021 Nov 18;12(11):6984-6994. Epub 2021 Oct 18.

Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China.

Acquired brain injury (ABI), which is the umbrella term for all brain injuries, is one of the most dangerous diseases resulting in high morbidity and mortality, making it extremely significant to early diagnosis of ABI. Current methods, which are mainly composed of X-ray computed tomography and magnetic resonance angiography, remain limited in diagnosis of ABI with respect to limited spatial resolution and long scanning times. Here, we reported through-skull fluorescence imaging of mouse cerebral vasculature without craniotomy, utilizing the fluorescence of down-conversion nanoparticles (DCNPs) in the 1. Read More

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November 2021

Promising Nutritional Fruits Against Cardiovascular Diseases: An Overview of Experimental Evidence and Understanding Their Mechanisms of Action.

Vasc Health Risk Manag 2021 23;17:739-769. Epub 2021 Nov 23.

Faculty of Pharmacy & Centre of Excellence for Biomaterials Engineering, AIMST University, Kedah, 08100, Malaysia.

Cardiovascular diseases (CVDs) are one of the leading causes of morbidity and mortality in both developed and developing countries, affecting millions of individuals each year. Despite the fact that successful therapeutic drugs for the management and treatment of CVDs are available on the market, nutritional fruits appear to offer the greatest benefits to the heart and have been proved to alleviate CVDs. Experimental studies have also demonstrated that nutritional fruits have potential protective effects against CVDs. Read More

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November 2021

Valuing burden of premature mortality attributable to air pollution in major million-plus non-attainment cities of India.

Sci Rep 2021 Dec 2;11(1):22771. Epub 2021 Dec 2.

CSIR-National Environmental Engineering Research Institute (NEERI), Nagpur, MH, India.

Accelerating growth due to industrialization and urbanization has improved the Indian economy but simultaneously has deteriorated human health, environment, and ecosystem. In the present study, the associated health risk mortality (age > 25) and welfare loss for the year 2017 due to excess PM concentration in ambient air for 31 major million-plus non-attainment cities (NACs) in India is assessed. The cities for the assessment are prioritised based on population and are classified as 'X' (> 5 million population) and 'Y' (1-5 million population) class cities. Read More

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December 2021

Machine learning-based prediction of 1-year mortality for acute coronary syndrome.

J Cardiol 2021 Nov 29. Epub 2021 Nov 29.

Department of Cardiology, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel; Department of Cardiology, Tel Aviv Jaffa district, Clalit Health Services, Israel; Department of Cardiology, Samson Assuta Ashdod Hospital, Israel.

Background: Clinical risk assessment with quantitative formal risk scores may add to intuitive physician risk assessment and are advised by the international guidelines for the management of acute coronary syndrome (ACS) patients. Most previous studies have used the binary regression/classification approach (dead/alive) for long-term mortality post-ACS, without considering the time-to-event as in survival analysis. The use of machine learning (ML)-based survival models has yet to be validated. Read More

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November 2021

Delivery of coenzyme Q10 with mitochondria-targeted nanocarrier attenuates renal ischemia-reperfusion injury in mice.

Mater Sci Eng C Mater Biol Appl 2021 Dec 8;131:112536. Epub 2021 Nov 8.

Department of Anesthesiology, Cangzhou Central Hospital, Teaching Hospital of Tianjin Medical University, Cangzhou 061000, Hebei, China.

Ischemia-reperfusion (I/R) injury causes high morbidity, mortality, and healthcare costs. I/R induces acute kidney injury through exacerbating the mitochondrial damage and increasing inflammatory and oxidative responses. Here, we developed the mitochondria-targeted nanocarrier to delivery of Coenzyme Q10 (CoQ10) for renal I/R treatment in animal model. Read More

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December 2021

Acquired anomalies of the coronary arteries after arterial switch operation. Usefulness of coronary computed tomography angiography and impact on follow-up.

Rev Port Cardiol (Engl Ed) 2021 Oct;40(10):707-712

Department of Pediatric Cardiology, Hospital Santa Marta, Lisbon, Portugal.

Introduction: Mortality and morbidity in patients with transposition of the great arteries after an arterial switch operation depends mainly on the status of coronary perfusion. Coronary computed tomography angiography (CCTA) provides accurate information on coronary morphology, however its use in these patients is not yet routine procedure.

Objective: We sought to assess its accuracy to identify acquired coronary anomalies in this population, compared to conventional angiography in a subset of patients, and assess its impact on postoperative management. Read More

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October 2021

Blood lactate concentration in COVID-19: a systematic literature review.

Clin Chem Lab Med 2021 Dec 2. Epub 2021 Dec 2.

Department of Neurosciences, Section of Clinical Biochemistry, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Coronavirus disease 2019 (COVID-19) is an infectious respiratory condition sustained by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which manifests prevalently as mild to moderate respiratory tract infection. Nevertheless, in a number of cases the clinical course may deteriorate, with onset of end organ injury, systemic dysfunction, thrombosis and ischemia. Given the clinical picture, baseline assessment and serial monitoring of blood lactate concentration may be conceivably useful in COVID-19. Read More

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December 2021

Influence of polyvascular disease on clinical outcome in patients undergoing transcatheter aortic valve implantation via transfemoral access.

PLoS One 2021 2;16(12):e0260385. Epub 2021 Dec 2.

Department of Cardiology, Keio University School of Medicine, Tokyo, Japan.

Background: The influence of polyvascular disease (PVD) on the short- and long-term clinical outcomes of patients undergoing transcatheter aortic valve implantation via trans-femoral access (TF-TAVI) has not been fully elucidated.

Methods: A total of 2167 patients from the Optimized CathEter vAlvular iNtervention-TAVI (OCEAN-TAVI) registry who underwent TF-TAVI was studied. PVD was defined as the presence of at least two of the following vascular bed (VB) diseases: concomitant coronary artery disease (CAD), cerebrovascular disease (CVD), and peripheral artery disease (PAD). Read More

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December 2021

Door to Needle Count Down: A 3 Years Experience in an Egyptian University Stroke Center.

Neurologist 2021 Nov 30. Epub 2021 Nov 30.

Department of Neurology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Background: The purpose of this study is to share our experience in changing hospital strategies to achieve rapid thrombolysis in acute ischemic stroke (AIS) patients in 2 university stroke centers. Rapid reperfusion by shortening door to needle time (DTN) reduces morbidity and mortality for patients with AIS. Our aim is to evaluate the effect of applying certain logistic strategies to reduce DTN for thrombolysis and its impact on clinical outcome. Read More

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November 2021

Rhythm- or rate-control strategies according to 4S-AF characterization scheme and long-term outcomes in atrial fibrillation patients: the FAMo (Fibrillazione Atriale in Modena) cohort.

Intern Emerg Med 2021 Dec 2. Epub 2021 Dec 2.

Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Via del Pozzo, 71, 41124, Modena, Italy.

The 4S-AF scheme [Stroke risk, Symptom severity, Severity of atrial fibrillation (AF) burden, Substrate severity] was recently proposed to characterize AF patients. In this post hoc analysis we evaluated the agreement between the therapeutic strategy (rate or rhythm control, respectively), as suggested by the 4S-AF scheme, and the actual strategy followed in a patients cohort. Outcomes of interest were as follows: all-cause death, a composite of all-cause death/any thromboembolism/acute coronary syndrome, and a composite of all-cause death, any thrombotic/ischemic event, and major bleeding (net clinical outcome). Read More

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December 2021

A First-in-Man Clinical Evaluation of Sirolimus and Ascorbic Acid-Eluting Stent Systems: a Multicenter, Subject-Blinded, Randomized Study.

Korean Circ J 2021 Dec;51(12):1001-1014

Department of Internal Medicine and Cardiovascular Center, Seoul National University College of Medicine, Seoul, Korea.

Background And Objectives: This clinical trial was conducted to evaluate the safety and efficacy of D+Storm™ drug-eluting stent (DES) and BioMatrix Flex™ DES.

Methods: This study was a multicenter, subject-single-blind, randomized, and confirmed comparative clinical trial. According to the inclusion criteria, those diagnosed with stable angina, unstable angina, silent ischemia, or non-ST-segment myocardial infarction were selected among patients with coronary artery stenosis as subjects. Read More

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December 2021

Relationship between Mean Platelet Volume and Critical Limb Ischemia in Diabetes Mellitus Patients.

Int J Angiol 2021 Dec 20;30(4):257-261. Epub 2021 Apr 20.

Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Dr. Sardjito Hospital, Yogyakarta, Indonesia.

The prevalence of diabetes mellitus continues to increase from year to year. Critical limb ischemia (CLI) is one of the complications of diabetes mellitus with a high mortality rate and requires amputation if not treated properly. Mean platelet volume (MPV) is an indicator of platelet activation and is expected to be a predictor of CLI in diabetes mellitus patients. Read More

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December 2021

Cancer-Associated Atherothrombosis: The Challenge.

Int J Angiol 2021 Dec 19;30(4):249-256. Epub 2021 Jul 19.

The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.

The association between venous thrombosis and malignancy, having typical features of a paraneoplastic syndrome, has been established for a century. Currently, it is recognized that arterial thromboembolism (ATE) may also behave as a paraneoplastic syndrome. Recent matched cohort studies, systematic reviews, and observational studies concur in showing an increased incidence of acute coronary events, ischemic stroke, accelerated peripheral arterial disease, and in-stent thrombosis during the 6-month period before cancer diagnosis, peaking for 30 days immediately before cancer diagnosis. Read More

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December 2021

High Human Antimicrobial Peptide LL-37 Level Predicts Lower Major Adverse Cardiovascular Events after an Acute ST-Segment Elevation Myocardial Infarction.

J Atheroscler Thromb 2021 Dec 1. Epub 2021 Dec 1.

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College.

Aims: We previously associated acute ST-elevation myocardial infarction (STEMI) with decreased plasma LL-37 levels. Therefore, this study investigated whether plasma LL-37 levels could predict ischemic cardiovascular events in patients after STEMI.

Methods: We prospectively collected peripheral plasma samples and clinical and laboratory data from consecutive patients who presented with STEMI and underwent primary percutaneous coronary intervention at Fuwai Hospital between April and November 2017. Read More

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December 2021

Epidemiology of Cardiovascular Diseases in Morocco: A Systematic Review.

Rev Diabet Stud 2021 Nov;17(2):57-67

Laboratory of Genetics and Biometry. Faculty of Science. Ibn Tofail University. Kenitra. Morocco.

To provide a systematic review of studies on cardiovascular diseases (CVD) and their risk factors in the Moroccan population. A systematic analysis was performed based on PRISMA guidelines by retrieving data bases (Medline, Embase, and other) using technical keywords in addition to manual research on official websites. Published studies in the English or French language, conducted in Morocco or concerning the Moroccan population within the last two decades, were identified. Read More

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November 2021

Assessment of Sumatriptan on Sepsis-Induced Kidney injury in the Cecal Ligation and Puncture Mice Model.

Drug Res (Stuttg) 2021 Dec 1. Epub 2021 Dec 1.

Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Sepsis is a severe systemic inflammatory response with high mortality rate resulting from different microorganisms. Cytokines activation is essential for the immune response, but in painful conditions like sepsis, cytokines act as a double-edged sword and dysregulate immune response which is life-threatening owing to multiple organ dysfunction. The abnormality in 5-HT function is involved in pathological conditions like irritable bowel syndrome, inflammation, myocardial ischemia, itch and renal injury. Read More

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December 2021

Neuropeptides: Potential neuroprotective agents in ischemic injury.

Life Sci 2021 Nov 28;288:120186. Epub 2021 Nov 28.

Chitkara College of Pharmacy, Chitkara University, 140401, Punjab, India. Electronic address:

Aim: Ischemic damage to the brain is linked to an increased rate of morbidity and mortality worldwide. In certain parts of the world, it remains a leading cause of mortality and the primary cause of long-term impairment. Ischemic injury is exacerbated when particular neuropeptides are removed, or their function in the brain is blocked, whereas supplying such neuropeptides lowers ischemic harm. Read More

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November 2021

Prolonged corrected QT interval in hospitalized patients with coronavirus disease 2019 in Dubai, United Arab Emirates: a single-center, retrospective study.

J Int Med Res 2021 Nov;49(11):3000605211056834

Rashid Hospital, Dubai, U.A.E.

Objective: To evaluate the association of a prolonged corrected QT (QTc) interval in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its association with in-patient mortality.

Methods: A cohort of 745 patients were recruited from a single center between 1 March 2020 and 31 May 2020. We analyzed the factors associated with a prolonged QTc and mortality. Read More

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November 2021

IGF-1 is not related to long-term outcome in hyperglycemic acute coronary syndrome patients.

Diab Vasc Dis Res 2021 Nov-Dec;18(6):14791641211047436

Department of Cardiology, Erasmus MC, 6993University Medical Center Rotterdam, Rotterdam, Netherlands.

Purpose: Insulin-like growth factor-1 (IGF-1) has been associated with both protective and detrimental effects on the development of ischemic heart disease. The relationship between IGF-1 levels and major adverse cardiovascular events (MACE) in acute coronary syndrome (ACS) patients remains unclear. This study aimed to investigate the relationship between IGF-1 admission levels in hyperglycemic ACS patients and: (1) MACE over a 5 years follow-up, (2) type 2 diabetes at discharge, and (3) post-ACS myocardial infarct size and dysfunction. Read More

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December 2021

Brain atrophy in acute ischaemic stroke patients treated with reperfusion therapy: a systematic review.

Acta Radiol 2021 Dec 1:2841851211060427. Epub 2021 Dec 1.

Neurovascular Imaging Laboratory, Clinical Sciences Stream, 550242Ingham Institute for Applied Medical Research, Sydney, NSW, Australia.

Background: Brain atrophy (BA) may have a role in acute ischemic stroke (AIS) in mediating outcomes after reperfusion therapy. The extent of this association is not well understood.

Purpose: To examine the impact of pre-existing BA on functional outcome, survival, symptomatic intracerebral hemorrhage (sICH), and early neurological change in patients with AIS treated with intravenous thrombolysis (IVT) and/or endovascular thrombectomy (EVT). Read More

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December 2021

The association of PRECISE-DAPT score with ischemic outcomes in patients taking dual antiplatelet therapy following percutaneous coronary intervention: a meta analysis.

Eur Heart J Cardiovasc Pharmacother 2021 Nov 24. Epub 2021 Nov 24.

Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.

Aims: The PRECISE-DAPT score identifies patients at high risk of bleeding complications following percutaneous coronary intervention (PCI). International guidelines recommend the PRECISE-DAPT to identify patients at high risk for bleeding, who may benefit from shortened dual antiplatelet therapy (DAPT). The association of the PRECISE-DAPT score to ischemic outcomes remains unclear. Read More

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November 2021

The relationship between major food sources of fructose and cardiovascular disease, cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of cohort studies.

Crit Rev Food Sci Nutr 2021 Nov 30:1-14. Epub 2021 Nov 30.

Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

We aimed to summarize the associations between food sources of fructose and cardiovascular diseases (CVD), cancer, and all-cause mortality risk using a systematic review and meta-analysis. We searched PubMed, Scopus, and Web of Science up to November 2020. We included cohort studies that investigated the relationship between mortality risk (all-cause, CVD, specific CVD, and total and site-specific cancers) and intake of ≥1 food source of fructose (fruit, fruit juice, breakfast cereals, sugar-sweetened beverages (SSBs), sweets, and yogurt) in general adult population. Read More

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November 2021

Hyperbaric oxygen for thermal burns.

Undersea Hyperb Med 2021 Fourth Quarter;48(4):449-468

Hyperbaric Medicine Department, Doctors Medical Center, San Pablo, California U.S.

A significant and consistently positive body of evidence from animal and human studies of thermal injury supports the use of hyperbaric oxygen as a means of preventing dermal ischemia, reducing edema, modulating the zone of stasis, preventing partial- to full-thickness conversion, preserving cellular metabolism and promoting healing. The vast majority of clinical reports have shown reduction in mortality, length of hospital stay, number of surgeries and cost of care. Hyperbaric oxygen has been demonstrated to be safe in the hands of those thoroughly trained in rendering this therapy in the critical care setting and with appropriate monitoring precautions. Read More

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November 2021

Prevalence, clinical characteristics and outcomes of hypoxic hepatitis in critically ill patients.

Scand J Gastroenterol 2021 Nov 30:1-8. Epub 2021 Nov 30.

Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Background: Hypoxic hepatitis (HH) is an important clinical entity in patients in the intensive care unit (ICU). The aims of the study were to assess the etiology, clinical characteristics and outcomes of HH in the ICU of a tertiary hospital. Secondary aim was to analyze the effects of concomitant ischemia in other organs than the liver. Read More

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November 2021