46,164 results match your criteria mortality icu


Increased Incidence of COVID-19 Infections Amongst Interpersonal Violence Patients.

J Surg Res 2021 Apr 30;266:62-68. Epub 2021 Apr 30.

Division of Acute Care Surgery, University of Southern California, Los Angeles, California.

Objective: To investigate whether any specific acute care surgery patient populations are associated with a higher incidence of COVID-19 infection.

Background: Acute care providers may be exposed to an increased risk of contracting the COVID-19 infection since many patients present to the emergency department without complete screening measures. However, it is not known which patients present with the highest incidence. Read More

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In vivo fitness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains in murine infection is associated with treatment failure in human infections.

Clin Microbiol Infect 2021 May 10. Epub 2021 May 10.

Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, National Institute for Antibiotic Resistance and Infection Control, Israel Ministry of Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Mortality among patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections varies between studies. We examined whether in vivo fitness of CRAB strains is associated with clinical outcomes in patients with CRAB infections.

Methods: Isolates were collected from patients enrolled in the AIDA trial with hospital-acquired pneumonia, bloodstream infections, and/or urinary tract infections caused by CRAB. Read More

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Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program.

PLoS One 2021 13;16(5):e0251651. Epub 2021 May 13.

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America.

Background: The risk factors associated with the stages of Coronavirus Disease-2019 (COVID-19) disease progression are not well known. We aim to identify risk factors specific to each state of COVID-19 progression from SARS-CoV-2 infection through death.

Methods And Results: We included 648,202 participants from the Veteran Affairs Million Veteran Program (2011-). Read More

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Intra-abdominal hypertension and abdominal compartment syndrome in the critically ill liver cirrhotic patient-prevalence and clinical outcomes. A multicentric retrospective cohort study in intensive care.

PLoS One 2021 13;16(5):e0251498. Epub 2021 May 13.

University of Tartu, Tartu University Hospital, Tartu, Estonia.

Background: Liver cirrhosis and ascites are risk factors for intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS); however, data is scarce. We aimed to determine the prevalence of IAH/ACS in a population of critically ill cirrhotic patients with acute medical illness in intensive care and to assess for risk factors and clinical outcomes.

Methods: This was a multicentric retrospective cohort study including two general ICUs and pooled data from a multicentric study between January 2009 and October 2019. Read More

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Delirium in adult patients in intensive care: nursing interventions.

Br J Nurs 2021 May;30(9):534-538

Assistent Professor, Universidade Católica Portuguesa, Lisbon, Portugal.

Background: Delirium is a neuropsychiatric syndrome of high incidence in the critically ill patient. It is characterised by changes in acute attention and cognition, has a multifactorial aetiology and has a negative impact on the patient's clinical situation and future quality of life. Prevention of delirium and early identification can reduce associated morbidity and mortality. Read More

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The impact of exogenous nitric oxide during cardiopulmonary bypass for cardiac surgery.

Perfusion 2021 May 13:2676591211014821. Epub 2021 May 13.

Department of Cardiothoracic Surgery, Cork University Hospital, Cork, Ireland.

Objectives: Cardiac surgery using cardiopulmonary bypass frequently provokes a systemic inflammatory response syndrome. This can lead to the development of low cardiac output syndrome (LCOS). Both of these can affect morbidity and mortality. Read More

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Tocilizumab reduces the risk of ICU admission and mortality in patients with SARS-CoV-2 infection.

Rev Esp Quimioter 2021 May 13. Epub 2021 May 13.

Objective: The study aims to describe characteristics and clinical outcome of patients with SARS-CoV-2 infection that received siltuximab according to a protocol that aimed to early block the activity of IL-6 to avoid the progression of the inflammatory flare.

Methods: Retrospective review of the first 31 patients with SARS-CoV-2 treated with siltuximab, in Hospital Clinic of Barcelona or Hospital Universitario Salamanca, from March to April 2020 with positive polymerase-chain reaction (PCR) from a nasopharyngeal swab.

Results: The cohort included 31 cases that received siltuximab with a median (IQR) age of 62 (56-71) and 71% were males. Read More

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Low Circulating Vitamin D in Intensive Care Unit-Admitted COVID-19 Patients as a Predictor of Negative Outcomes.

J Nutr 2021 May 12. Epub 2021 May 12.

Intensive Care Unit, Federal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies of the Federal Medical and Biological Agency of Russia, Moscow, Russia.

Background: Vitamin D deficiency has been associated with an increased risk of respiratory infections.

Objectives: The study aimed to evaluate the serum 25-hydroxyvitamin D [25(OH)D] concentration in patients admitted to the intensive care unit (ICU) as a predictor of coronavirus disease 2019 (COVID-19) mortality.

Methods: A single-center retrospective observational study was conducted. Read More

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Outcomes of Sepsis and Septic Shock in Cancer Patients: Focus on Lactate.

Front Med (Lausanne) 2021 26;8:603275. Epub 2021 Apr 26.

Departamento de Paciente Crítico, Clínica Alemana de Santiago, Santiago, Chile.

The number of oncological patients (OP) admitted to intensive care units (ICU) for sepsis/septic shock has dramatically increased in recent years. The definition of septic shock has been modified, adding hyperlactatemia as a severity biomarker for mortality. However, it remains poorly reported in septic OP. Read More

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Impact of Acute Kidney Injury on Critically Ill Children and Neonates.

Front Pediatr 2021 26;9:635631. Epub 2021 Apr 26.

Pediatric Nephrology and Hypertension Division, Sidra Medicine, Doha, Qatar.

Acute kidney injury (AKI) is a clinical syndrome that manifests as an abrupt impairment of kidney function. AKI is common in critically ill pediatric patients admitted to the pediatric intensive care units. AKI is a deleterious complication in critically ill children as it is associated with increased morbidity and mortality. Read More

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Application of Machine Learning in Intensive Care Unit (ICU) Settings Using MIMIC Dataset: Systematic Review.

Informatics (MDPI) 2021 Mar 3;8(1). Epub 2021 Mar 3.

Department of Biomedical Informatics, University of Arkansas for Medical Sciences (UAMS), Little Rock, Arkansas 72205, USA.

Modern Intensive Care Units (ICUs) provide continuous monitoring of critically ill patients susceptible to many complications affecting morbidity and mortality. ICU settings require a high staff-to-patient ratio and generates a sheer volume of data. For clinicians, the real-time interpretation of data and decision-making is a challenging task. Read More

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Clinical course and risk factors of fatal adverse outcomes in COVID-19 patients in Korea: a nationwide retrospective cohort study.

Sci Rep 2021 May 12;11(1):10066. Epub 2021 May 12.

Department of Emergency Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.

We investigated association between epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients and clinical outcomes in Korea. This nationwide retrospective cohort study included 5621 discharged patients with COVID-19, extracted from the Korea Disease Control and Prevention Agency (KDCA) database. We compared clinical data between survivors (n = 5387) and non-survivors (n = 234). Read More

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Impact of early low-calorie low-protein versus standard-calorie standard-protein feeding on outcomes of ventilated adults with shock: design and conduct of a randomised, controlled, multicentre, open-label, parallel-group trial (NUTRIREA-3).

BMJ Open 2021 May 11;11(5):e045041. Epub 2021 May 11.

Service de Médecine Intensive Réanimation, Centre Hospitalier de Valenciennes, Valenciennes, France.

Introduction: International guidelines include early nutritional support (≤48 hour after admission), 20-25 kcal/kg/day, and 1.2-2 g/kg/day protein at the acute phase of critical illness. Recent data challenge the appropriateness of providing standard amounts of calories and protein during acute critical illness. Read More

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Forecasting the SARS COVID-19 pandemic and critical care resources threshold in the Gulf Cooperation Council (GCC) countries: population analysis of aggregate data.

BMJ Open 2021 May 11;11(5):e044102. Epub 2021 May 11.

Social Statistics and Demography, and Centre for Global Health and Policy, University of Southampton, Southampton, UK

Objective: To generate cross-national forecasts of COVID-19 trajectories and quantify the associated impact on essential critical care resources for disease management in Gulf Cooperation Council (GCC) countries.

Design: Population-level aggregate analysis.

Setting: Bahrain, Kuwait, Oman, Qatar, United Arab Emirates (UAE) and Saudi Arabia. Read More

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Convalescent plasma therapy and mortality in COVID-19 patients admitted to the ICU: a prospective observational study.

Ann Intensive Care 2021 May 12;11(1):73. Epub 2021 May 12.

Intensive Care Unit, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

Background: This study aimed to quantify the potential survival benefit of convalescent plasma therapy (CVP) in critically ill patients with acute respiratory failure related to coronavirus disease-2019 (COVID-19).

Methods: This is a single-center prospective observational cohort study in COVID-19 patients with acute respiratory failure. Immediately after intensive care unit (ICU) admission patients were allocated to CVP treatment following pre-specified criteria to rapidly identify those patients potentially susceptible for this treatment. Read More

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Vasopressor Discontinuation Order in Septic Shock With Reduced Left Ventricular Function.

J Pharm Pract 2021 May 12:8971900211015080. Epub 2021 May 12.

Department of Pharmacy, Augusta University Medical Center, Augusta, GA, USA.

Background: The optimal vasopressor management for septic patients with left ventricular (LV) dysfunction has not been well established, and current evidence is conflicting regarding the optimal vasopressor discontinuation order.

Objective: The objective was to evaluate the impact of LV dysfunction on the hemodynamic management of septic shock by assessing the incidence of clinically significant hypotension after vasopressor discontinuation.

Methods: In this single-center, retrospective cohort study, adult patients were included if they met the Sepsis-3 definition of septic shock, had LV dysfunction (defined as an ejection fraction ≤40%), and received norepinephrine and vasopressin as the last vasopressors discontinued. Read More

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Cardiovascular medication and long-term outcome among intensive care unit survivors: a retrospective study.

Ann Palliat Med 2021 Apr 27. Epub 2021 Apr 27.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: We aimed to investigate the association between cardiovascular medications prescribed at ICU discharge and 1-year mortality in intensive care unit (ICU) survivors.

Methods: This retrospective observational study was conducted at a single tertiary academic hospital. The study population comprised adult patients (aged ≥18 years) who were admitted to the general ICU between January 2012 and December 2016, survived, and were discharged. Read More

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ERCP within 6 or 12 h for acute cholangitis: a propensity score-matched analysis.

Surg Endosc 2021 May 11. Epub 2021 May 11.

Center for Advanced Endoscopy, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Rabb-Rose 101, Boston, MA, 02215, USA.

Background: The optimal timing of biliary drainage by endoscopic retrograde cholangiopancreatography (ERCP) for patients with acute cholangitis remains controversial. The aim of our study was to determine if ERCP performed within 6 or 12 h of presentation was associated with improved clinical outcomes.

Methods: Medical records for all patients with acute cholangitis who underwent ERCP at our institution between 2009 and 2018 were reviewed. Read More

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Evaluation of Lung Contusion, Associated Injuries, and Outcome in a Major Trauma Center in Shiraz, Southern Iran.

Emerg Med Int 2021 22;2021:3789132. Epub 2021 Apr 22.

Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Science, Shiraz, Iran.

Objective: Blunt chest trauma as one of the most common injuries in trauma cases can cause significant morbidity and mortality. The purpose of this study was to determine the clinical course of traumatic injuries with an initial diagnosis of a pulmonary contusion in patients.

Method: In this retrospective study, we evaluated the demographic and clinical features of patients who were referred to a major trauma center in southern Iran. Read More

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Safety measures for COVID-19 do not compromise the outcomes of patients undergoing primary percutaneous coronary intervention: a single center retrospective study.

Sci Rep 2021 05 11;11(1):9959. Epub 2021 May 11.

Center of Cardiology, Beijing Chaoyang Hospital, Capital Medical University, 5 Jingyuan Road, Beijing, 100043, China.

Coronavirus disease 2019 (COVID-19) is a global pandemic impacting nearly 170 countries/regions and millions of patients worldwide. Patients with acute myocardial infarction (AMI) still need to be treated at percutaneous coronary intervention (PCI) centers with relevant safety measures. This retrospective study was conducted to assess the therapeutic outcomes of PCI performed under the safety measures and normal conditions. Read More

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Incidence, characteristics, and outcomes of delirium in patients with noninvasive ventilation: a prospective observational study.

BMC Pulm Med 2021 May 11;21(1):157. Epub 2021 May 11.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Yuzhong District, Chongqing, 400016, China.

Background: Factors that may increase the risk for delirium and the firm knowledge around mechanism for delirium in noninvasive ventilation (NIV) patients is lacking. We investigated the incidence, characteristics, and outcomes of delirium in NIV patients.

Methods: A prospective observational study was performed in an intensive care unit (ICU) of a teaching hospital. Read More

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Management of COPD patients during COVID: difficulties and experiences.

Expert Rev Respir Med 2021 May 11. Epub 2021 May 11.

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Introduction: : The role of COPD in COVID-19 is not yet well understood. However, there is increasing evidence showing that COPD patients with COVID-19 have a higher risk of presenting a serious infection, a greater likelihood of requiring ICU support, and a higher mortality than other groups.

Areas Covered: : In this article we address some critical questions on COVID-19 as they pertain to COPD. Read More

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The effect of early vasopressin use on patients with septic shock: A systematic review and meta-analysis.

Am J Emerg Med 2021 May 6;48:203-208. Epub 2021 May 6.

Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang 310018, Hangzhou, China. Electronic address:

Background: The effect of early vasopressin initiation on clinical outcomes in patients with septic shock is uncertain. A systematic review and meta-analysis was performed to evaluate the impact of early start of vasopressin support within 6 h after the diagnosis on clinical outcomes in septic shock patients.

Methods: We searched the PubMed, Cochrane, and Embase databases for randomized controlled trials (RCTs) and cohort studies from inception to the 1st of February 2021. Read More

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Rhabdomyolysis in Severe COVID-19: Male Sex, High BMI, and Prone Positioning Confer High Risk.

J Surg Res 2021 Apr 6;266:35-43. Epub 2021 Apr 6.

Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Bedside experience and studies of critically ill patients with coronavirus disease 2019 (COVID-19) indicate COVID-19 to be a devastating multisystem disease. We aim to describe the incidence, associated variables, and outcomes of rhabdomyolysis in critically ill COVID-19 patients.

Materials And Methods: Data for all critically ill adult patients (≥18 years old) admitted to the ICU at a large academic medical center with confirmed COVID-19 between March 13, 2020 and April 18, 2020 were prospectively collected. Read More

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Commentary on Eosinophilic inflammation, COVID-19, and asthma - are inhaled corticosteroids the missing link?

Ann Allergy Asthma Immunol 2021 May 8. Epub 2021 May 8.

Department of Pulmonary & Critical Care, Mount Sinai Beth Israel, Mount Sinai Morningside, & Mount Sinai West Hospitals, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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Therapy with lopinavir/ritonavir and hydroxychloroquine is associated with acute kidney injury in COVID-19 patients.

PLoS One 2021 11;16(5):e0249760. Epub 2021 May 11.

Department of Medicine IV, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany.

Background: Acute kidney injury (AKI) is an independent risk factor for mortality, which affects about 5% of hospitalized coronavirus disease-2019 (COVID-19) patients and up to 25-29% of severely ill COVID-19 patients. Lopinavir/ritonavir and hydroxychloroquine show in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and have been used for the treatment of COVID-19. Both, lopinavir and hydroxychloroquine are metabolized by cytochrome P450 (CYP) 3A4. Read More

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Development and validation of a laboratory-based risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19.

Scand J Clin Lab Invest 2021 May 11:1-8. Epub 2021 May 11.

Laboratory Medicine Department, Virgen Macarena University Hospital, Seville, Spain.

Background: Early identification of patients with COVID-19 who may develop critical illness is of great importance.

Methods: In this study a retrospective cohort of 264 COVID-19 cases admitted at Macarena University was used for development and internal validation of a risk score to predict the occurrence of critical illness in hospitalized patients with COVID-19. Backward stepwise logistic regression was used to derive the model, including clinical and laboratory variables predictive of critical illness. Read More

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Natural history, trajectory, and management of mechanically ventilated COVID-19 patients in the United Kingdom.

Intensive Care Med 2021 May 11. Epub 2021 May 11.

Brain & Behaviour Lab, Dept. Of Computing, Imperial College London, London, UK.

Purpose: The trajectory of mechanically ventilated patients with coronavirus disease 2019 (COVID-19) is essential for clinical decisions, yet the focus so far has been on admission characteristics without consideration of the dynamic course of the disease in the context of applied therapeutic interventions.

Methods: We included adult patients undergoing invasive mechanical ventilation (IMV) within 48 h of intensive care unit (ICU) admission with complete clinical data until ICU death or discharge. We examined the importance of factors associated with disease progression over the first week, implementation and responsiveness to interventions used in acute respiratory distress syndrome (ARDS), and ICU outcome. Read More

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Mortality and Morbidity of Infants Born Extremely Preterm at Tertiary Medical Centers in China From 2010 to 2019.

JAMA Netw Open 2021 May 3;4(5):e219382. Epub 2021 May 3.

Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Importance: Extreme prematurity is associated with a substantial burden on health care systems worldwide. However, little is known about the prognosis of infants born extremely preterm in developing countries, such as China.

Objective: To describe survival and major morbidity among infants born extremely preterm in China over the past decade. Read More

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Perioperative Risk Factors Predisposing to Atrial Fibrillation After CABG Surgery.

Heart Surg Forum 2021 Apr 27;24(2):E402-E406. Epub 2021 Apr 27.

Department of Cardiothoracic Surgery, Faculty of Medicine, Cairo University, Giza, Egypt.

Objectives: To detect perioperative risk factors for atrial fibrillation (AF) after coronary artery bypass graft (CABG) and to assess the impact of AF on outcome and postoperative complications.

Methods: We undertook a prospective observational study of 1000 consecutive patients who underwent isolated CABG in Cairo University hospitals and other centers from March 2019 to November 2020. Patients were subsequently divided into 2 groups depending on the occurrence of postoperative AF. Read More

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